{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:31:20Z","timestamp":1792643480781,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.phrs.2022.106536","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T12:44:42Z","timestamp":1667306682000},"page":"106536","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Enhanced efficacy of formoterol-montelukast salt in relieving asthma features and in preserving \u03b22-agonists rescue therapy"],"prefix":"10.1016","volume":"186","author":[{"given":"Ida","family":"Cerqua","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Granato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Petti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Pavese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraia K\u00e1tia Pereira","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla Barroso","family":"Feitosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Garcia","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Muscara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Camerlingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Rea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinando","family":"Fiorino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Santagada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Frecentese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Cirino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Caliendo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Severino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiorentina","family":"Roviezzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2022.106536_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114112","article-title":"The management of severe asthma in 2020","volume":"179","author":"C\u00f4t\u00e9","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phrs.2022.106536_bib2","article-title":"The need for physiological phenotyping to develop new drugs for airways disease","volume":"159","author":"David","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phrs.2022.106536_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106280","article-title":"Molecular and immunomodulatory actions of new antiasthmatic agents: exploring the diversity of biologics in Th2 endotype asthma","volume":"181","author":"Okwuofu","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phrs.2022.106536_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104782","article-title":"Biologics or immunotherapeutics for asthma?","volume":"158","author":"Tay","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phrs.2022.106536_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105189","article-title":"Why do some asthma patients respond poorly to glucocorticoid therapy?","volume":"160","author":"Henderson","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.phrs.2022.106536_bib6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41533-017-0014-1","article-title":"The impact of poor asthma control among asthma patients treated with inhaled corticosteroids plus long-acting \u03b22-agonists in the United Kingdom: a cross-sectional analysis","volume":"27","author":"Pavord","year":"2017","journal-title":"NPJ Prim. Care Respir. Med."},{"issue":"2","key":"10.1016\/j.phrs.2022.106536_bib7","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s12016-018-8712-1","article-title":"Understanding asthma phenotypes, endotypes, and mechanisms of disease","volume":"56","author":"Kuruvilla","year":"2019","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.phrs.2022.106536_bib8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/164_2016_64","article-title":"\u03b22 agonists","volume":"237","author":"Billington","year":"2017","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.phrs.2022.106536_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105801","article-title":"Indacaterol, glycopyrronium, and mometasone: pharmacological interaction and anti-inflammatory profile in hyperresponsive airways","volume":"172","author":"Rogliani","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phrs.2022.106536_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104995","article-title":"Mechanopharmacology of Rho-kinase antagonism in airway smooth muscle and potential new therapy for asthma","volume":"159","author":"Wang","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"6379","key":"10.1016\/j.phrs.2022.106536_bib11","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1126\/science.aan4829","article-title":"\u03b22-adrenergic receptor-mediated negative regulation of group 2 innate lymphoid cell responses","volume":"359","author":"Moriyama","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.phrs.2022.106536_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105030","article-title":"Blame the signaling: role of cAMP for the resolution of inflammation","volume":"159","author":"Tavares 1","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"12","key":"10.1016\/j.phrs.2022.106536_bib13","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/j.cellsig.2006.04.008","article-title":"Targeting G protein-coupled receptor signaling in asthma","volume":"18","author":"Deshpande","year":"2006","journal-title":"Cell. Signal."},{"issue":"17","key":"10.1016\/j.phrs.2022.106536_bib14","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1056\/NEJM199210223271703","article-title":"effects of a long-acting beta 2-adrenoceptor agonist, salmeterol, on airway hyperresponsiveness in patients with mild asthma","volume":"22","author":"Cheung","year":"1992","journal-title":"N. Engl. J. Med."},{"issue":"11","key":"10.1016\/j.phrs.2022.106536_bib15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s40248-016-0073-0","article-title":"Asthma-related deaths","volume":"12","author":"D'Amato","year":"2016","journal-title":"Multidiscip. Respir. Med."},{"issue":"4","key":"10.1016\/j.phrs.2022.106536_bib16","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01872-2019","article-title":"Overuse of short-acting \u03b22-agonists in asthma is associated with increased risk of exacerbation and mortality: a nationwide cohort study of the global SABINA programme","volume":"55","author":"Nwaru","year":"2020","journal-title":"Eur. Respir. J."},{"issue":"4","key":"10.1016\/j.phrs.2022.106536_bib17","doi-asserted-by":"crossref","first-page":"521","DOI":"10.2147\/COPD.S1353","article-title":"Long-acting beta2-agonists (LABA) in chronic obstructive pulmonary disease: efficacy and safety","volume":"3","author":"Rossi","year":"2008","journal-title":"Int. J. Chron. Obstruct Pulmon. Dis."},{"key":"10.1016\/j.phrs.2022.106536_bib18","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaip.2021.10.001","article-title":"Global initiative for asthma strategy 2021: executive summary and rationale for key changes","volume":"10","author":"Reddel","year":"2022","journal-title":"J. Allergy Clin. Immun."},{"issue":"11","key":"10.1016\/j.phrs.2022.106536_bib19","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.bbagen.2011.02.005","article-title":"Leukotrienes and airway inflammation","volume":"1810","author":"Okunishi","year":"2011","journal-title":"Biochim Biophys. Acta"},{"key":"10.1016\/j.phrs.2022.106536_bib20","doi-asserted-by":"crossref","unstructured":"R.He, Y. Chen and Q. Cai. The role of the LTB4-BLT1 axis in health and disease. 158 (2020)104857.","DOI":"10.1016\/j.phrs.2020.104857"},{"key":"10.1016\/j.phrs.2022.106536_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104881","article-title":"Granulocyte-targeted therapies for airway diseases","volume":"157","author":"Tavares","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phrs.2022.106536_bib22","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.phrs.2018.11.024","article-title":"Leukotriene-mediated sex dimorphism in murine asthma-like features during allergen sensitization","volume":"139","author":"Rossi","year":"2019","journal-title":"Pharmacol. Res"},{"key":"10.1016\/j.phrs.2022.106536_bib23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s40733-016-0026-6","article-title":"Asthma phenotypes: the intriguing selective intervention with Montelukast","volume":"2","author":"Marcello","year":"2016","journal-title":"Asthma Res Pract."},{"issue":"1","key":"10.1016\/j.phrs.2022.106536_bib24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1177\/2040622310383343","article-title":"Montelukast in asthma: a review of its efficacy and place in therapy","volume":"2","author":"Paggiaro","year":"2011","journal-title":"Ther. Adv. Chronic Dis."},{"key":"10.1016\/j.phrs.2022.106536_bib25","doi-asserted-by":"crossref","first-page":"839","DOI":"10.2147\/DDDT.S39100","article-title":"Clinical effectiveness and safety of montelukast in asthma. What are the conclusions from clinical trials and meta-analyses?","volume":"8","author":"Hon","year":"2014","journal-title":"Drug Des. Dev. Ther."},{"issue":"7","key":"10.1016\/j.phrs.2022.106536_bib26","doi-asserted-by":"crossref","first-page":"647","DOI":"10.2174\/138955708784567395","article-title":"Leukotrienes, antileukotrienes and asthma","volume":"8","author":"Montuschi","year":"2008","journal-title":"Mini Rev. Med. Chem."},{"issue":"6","key":"10.1016\/j.phrs.2022.106536_bib27","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.pupt.2013.06.006","article-title":"Protective effect of high-dose montelukast on salbutamol-induced homologous desensitisation in airway smooth muscle","volume":"26","author":"Fogli","year":"2013","journal-title":"Pulm. Pharmacol. Ther."},{"issue":"11","key":"10.1016\/j.phrs.2022.106536_bib28","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.rmed.2004.05.008","article-title":"Comparison of the effects of oral montelukast and inhaled salmeterol on response to rescue bronchodilation after challenge","volume":"98","author":"Storms","year":"2004","journal-title":"Respir. Med."},{"issue":"1","key":"10.1016\/j.phrs.2022.106536_bib29","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1183\/09031936.00063106","article-title":"Montelukast as add-on therapy to beta-agonists and late airway response","volume":"30","author":"Rosewich","year":"2007","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.phrs.2022.106536_bib30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3109\/21556660.2013.791300","article-title":"Effects of add-on montelukast on airway hyperresponsiveness in patients with well-controlled asthma - a pilot study","volume":"2","author":"Kononowa","year":"2013","journal-title":"J. Drug Assess."},{"issue":"6","key":"10.1016\/j.phrs.2022.106536_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLOS Biol."},{"key":"10.1016\/j.phrs.2022.106536_bib32","unstructured":"G. Caliendo, G. Cirino, F. Fiorino. Montelukast salts and pharmaceutical compositions containing the same. (2020) WO2020245358."},{"key":"10.1016\/j.phrs.2022.106536_bib33","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.phrs.2016.09.014","article-title":"Disodium cromoglycate inhibits asthma-like features induced by sphingosine-1-phosphate","volume":"113","author":"Roviezzo","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phrs.2022.106536_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104905","article-title":"5\u03b1-dihydrotestosterone abrogates sex bias in asthma like features in the mouse","volume":"158","author":"Cerqua","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phrs.2022.106536_bib35","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.phrs.2018.11.024","article-title":"Leukotriene-mediated sex dimorphism in murine asthma-like features during allergen sensitization","volume":"139","author":"Rossi","year":"2019","journal-title":"Pharmacol. Res."},{"issue":"1\u20133","key":"10.1016\/j.phrs.2022.106536_bib36","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ejphar.2005.12.060","article-title":"Beta-adrenoceptor responses of the airways: for better or worse?","volume":"533","author":"Broadley","year":"2006","journal-title":"Eur. J. Pharmacol."},{"issue":"5\u20136","key":"10.1016\/j.phrs.2022.106536_bib37","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000324315","article-title":"Sex hormones modulate salbutamol-elicited long-term relaxation in isolated bovine tracheal strips","volume":"87","author":"Su\u00e1rez","year":"2011","journal-title":"Pharmacology"},{"issue":"1","key":"10.1016\/j.phrs.2022.106536_bib38","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0014-2999(84)90437-0","article-title":"Pulmonary responses of salbutamol tolerant guinea-pigs to aminophylline and ipratropium bromide","volume":"99","author":"Ward","year":"1984","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.phrs.2022.106536_bib39","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02338-2017","article-title":"The inhaled corticosteroid\/long-acting \u03b2-agonist maintenance and reliever therapy regimen: where to from here?","volume":"51","author":"Beasley","year":"2018","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.phrs.2022.106536_bib40","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13223-020-00472-8","article-title":"Treatment strategies for asthma: reshaping the concept of asthma management","volume":"16","author":"Papi","year":"2020","journal-title":"Allergy Asthma Clin. Immunol."},{"issue":"3","key":"10.1016\/j.phrs.2022.106536_bib41","doi-asserted-by":"crossref","DOI":"10.1542\/peds.108.3.e48","article-title":"Montelukast, a leukotriene receptor antagonist, for the treatment of persistent asthma in children aged 2 to 5 years","volume":"108","author":"Knorr","year":"2001","journal-title":"Pediatrics"},{"issue":"11","key":"10.1016\/j.phrs.2022.106536_bib42","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1001\/archinte.158.11.1213","article-title":"Montelukast, a once-daily leukotriene receptor antagonist, in the treatment of chronic asthma: a multicenter, randomized, double-blind trial. Montelukast Clinical Research Study Group","volume":"158","author":"Reiss","year":"1998","journal-title":"Arch. Intern Med."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661822004820?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661822004820?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:39:40Z","timestamp":1760913580000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661822004820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":42,"alternative-id":["S1043661822004820"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2022.106536","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced efficacy of formoterol-montelukast salt in relieving asthma features and in preserving \u03b22-agonists rescue therapy","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2022.106536","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106536"}}