{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:01:17Z","timestamp":1791298877207,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.phrs.2023.106645","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T21:36:14Z","timestamp":1672868174000},"page":"106645","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["pH-sensitive molybdenum (Mo)-based polyoxometalate nanoclusters have therapeutic efficacy in inflammatory bowel disease by counteracting ferroptosis"],"prefix":"10.1016","volume":"188","author":[{"given":"Fan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuechuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitai","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zebo","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengzhu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghui","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.phrs.2023.106645_bib1","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nrgastro.2015.150","article-title":"The global burden of IBD: from 2015 to 2025","volume":"12","author":"Kaplan","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"9","key":"10.1016\/j.phrs.2023.106645_bib2","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1097\/MIB.0000000000000403","article-title":"Therapeutic armamentarium for stricturing crohn's disease: medical versus endoscopic versus surgical approaches","volume":"21","author":"Bharadwaj","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"issue":"7","key":"10.1016\/j.phrs.2023.106645_bib3","first-page":"2727","article-title":"Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies","volume":"29","author":"Triantafillidis","year":"2009","journal-title":"Anticancer Res"},{"issue":"1","key":"10.1016\/j.phrs.2023.106645_bib4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/ibd.21048","article-title":"World gastroenterology organization practice guidelines for the diagnosis and management of IBD in 2010","volume":"16","author":"Bernstein","year":"2010","journal-title":"Inflamm. Bowel Dis."},{"issue":"2","key":"10.1016\/j.phrs.2023.106645_bib5","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41575-018-0079-5","article-title":"Control and dysregulation of redox signalling in the gastrointestinal tract","volume":"16","author":"Campbell","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.phrs.2023.106645_bib6","article-title":"The impact of oxidative stress in human pathology: focus on gastrointestinal disorders","volume":"10","author":"Vona","year":"2021","journal-title":"Antioxid. (Basel)"},{"issue":"17","key":"10.1016\/j.phrs.2023.106645_bib7","doi-asserted-by":"crossref","first-page":"11302","DOI":"10.1021\/acs.chemrev.7b00161","article-title":"Generation and detection of reactive oxygen species in photocatalysis","volume":"117","author":"Nosaka","year":"2017","journal-title":"Chem. Rev."},{"key":"10.1016\/j.phrs.2023.106645_bib8","doi-asserted-by":"crossref","first-page":"4535194","DOI":"10.1155\/2017\/4535194","article-title":"Pathomechanisms of oxidative stress in inflammatory bowel disease and potential antioxidant therapies","volume":"2017","author":"Tian","year":"2017","journal-title":"Oxid. Med Cell Longev."},{"issue":"7203","key":"10.1016\/j.phrs.2023.106645_bib9","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature07203","article-title":"From endoplasmic-reticulum stress to the inflammatory response","volume":"454","author":"Zhang","year":"2008","journal-title":"Nature"},{"issue":"26","key":"10.1016\/j.phrs.2023.106645_bib10","doi-asserted-by":"crossref","first-page":"8156","DOI":"10.1021\/jacs.6b03375","article-title":"A polyoxometalate cluster paradigm with self-adaptive electronic structure for acidity\/reducibility-specific photothermal conversion","volume":"138","author":"Zhang","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.phrs.2023.106645_bib11","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.biomaterials.2018.04.019","article-title":"Radiolabeled polyoxometalate clusters: kidney dysfunction evaluation and tumor diagnosis by positron emission tomography imaging","volume":"171","author":"Ni","year":"2018","journal-title":"Biomaterials"},{"issue":"43","key":"10.1016\/j.phrs.2023.106645_bib12","doi-asserted-by":"crossref","first-page":"14101","DOI":"10.1002\/anie.201808074","article-title":"Near-Infrared semiconducting polymer brush and pH\/GSH-Responsive polyoxometalate cluster hybrid platform for enhanced Tumor-Specific phototheranostics","volume":"57","author":"Yang","year":"2018","journal-title":"Angew. Chem. Int Ed. Engl."},{"key":"10.1016\/j.phrs.2023.106645_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.114084","article-title":"Review of paediatric gastrointestinal physiology relevant to the absorption of orally administered medicines","volume":"181","author":"Wollmer","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"11","key":"10.1016\/j.phrs.2023.106645_bib14","doi-asserted-by":"crossref","first-page":"13382","DOI":"10.1021\/acsnano.9b06780","article-title":"Intrathecal administration of nanoclusters for protecting neurons against oxidative stress in cerebral Ischemia\/Reperfusion injury","volume":"13","author":"Li","year":"2019","journal-title":"Acs Nano"},{"issue":"1","key":"10.1016\/j.phrs.2023.106645_bib15","doi-asserted-by":"crossref","first-page":"5421","DOI":"10.1038\/s41467-018-07890-8","article-title":"Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice","volume":"9","author":"Ni","year":"2018","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.phrs.2023.106645_bib16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.tcb.2015.12.002","article-title":"TNF and ROS crosstalk in inflammation","volume":"26","author":"Blaser","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.phrs.2023.106645_bib17","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.trsl.2017.10.004","article-title":"Macrophage polarization and meta-inflammation","volume":"191","author":"Li","year":"2018","journal-title":"Transl. Res"},{"issue":"1","key":"10.1016\/j.phrs.2023.106645_bib18","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1093\/ibd\/izaa075","article-title":"Transcriptional signatures that define ulcerative colitis in remission","volume":"27","author":"Fenton","year":"2021","journal-title":"Inflamm. Bowel Dis."},{"issue":"12","key":"10.1016\/j.phrs.2023.106645_bib19","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1097\/MIB.0000000000000235","article-title":"Transcriptional analysis of left-sided colitis, pancolitis, and ulcerative colitis-associated dysplasia","volume":"20","author":"Bjerrum","year":"2014","journal-title":"Inflamm. Bowel Dis."},{"issue":"2","key":"10.1016\/j.phrs.2023.106645_bib20","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.phrs.2023.106645_bib21","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jconrel.2012.01.028","article-title":"Nano- and microparticulate drug carriers for targeting of the inflamed intestinal mucosa","volume":"161","author":"Collnot","year":"2012","journal-title":"J. Control Release"},{"issue":"4","key":"10.1016\/j.phrs.2023.106645_bib22","doi-asserted-by":"crossref","first-page":"j2372","DOI":"10.1126\/sciadv.abj2372","article-title":"A nanoparticulate dual scavenger for targeted therapy of inflammatory bowel disease","volume":"8","author":"Shi","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.phrs.2023.106645_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2022.213126","article-title":"ROS responsive polydopamine nanoparticles to relieve oxidative stress and inflammation for ameliorating acute inflammatory bowel","volume":"142","author":"Yan","year":"2022","journal-title":"Biomater. Adv."},{"issue":"1\u20132","key":"10.1016\/j.phrs.2023.106645_bib24","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ijpharm.2014.07.009","article-title":"PH-sensitive nanoparticles for colonic delivery of curcumin in inflammatory bowel disease","volume":"473","author":"Beloqui","year":"2014","journal-title":"Int J. Pharm."},{"issue":"12","key":"10.1016\/j.phrs.2023.106645_bib25","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1023\/A:1016085108889","article-title":"Gastrointestinal uptake of biodegradable microparticles: effect of particle size","volume":"13","author":"Desai","year":"1996","journal-title":"Pharm. Res"},{"issue":"2","key":"10.1016\/j.phrs.2023.106645_bib26","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41564-018-0306-4","article-title":"Gut microbiome structure and metabolic activity in inflammatory bowel disease","volume":"4","author":"Franzosa","year":"2019","journal-title":"Nat. Microbiol"},{"issue":"2","key":"10.1016\/j.phrs.2023.106645_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms4020020","article-title":"Microbiome, metabolome and inflammatory bowel disease","volume":"4","author":"Ahmed","year":"2016","journal-title":"Microorganisms"},{"key":"10.1016\/j.phrs.2023.106645_bib28","doi-asserted-by":"crossref","DOI":"10.1039\/D2FO01283A","article-title":"Impact of Lycium barbarum arabinogalactan on the fecal metabolome in a DSS-induced chronic colitis mouse model","author":"Cao","year":"2022","journal-title":"Food Funct."},{"issue":"11","key":"10.1016\/j.phrs.2023.106645_bib29","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1039\/C5MB00454C","article-title":"A study on the effective substance of the Wu-tou formula based on the metabonomic method using UPLC-Q-TOF-HDMS","volume":"11","author":"Xu","year":"2015","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.phrs.2023.106645_bib30","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.freeradbiomed.2017.07.008","article-title":"Role of glutathione in the regulation of epigenetic mechanisms in disease","volume":"112","author":"Garcia-Gimenez","year":"2017","journal-title":"Free Radic. Biol. Med"},{"issue":"11","key":"10.1016\/j.phrs.2023.106645_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21113847","article-title":"Riboflavin deficiency-implications for general human health and inborn errors of metabolism","volume":"21","author":"Mosegaard","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.phrs.2023.106645_bib32","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bioorg.2013.08.004","article-title":"Effects of alpha-eleostearic acid on asolectin liposomes dynamics: relevance to its antioxidant activity","volume":"51","author":"de Sousa","year":"2013","journal-title":"Bioorg. Chem."},{"issue":"11","key":"10.1016\/j.phrs.2023.106645_bib33","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/j.freeradbiomed.2011.03.010","article-title":"Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency","volume":"50","author":"Crabtree","year":"2011","journal-title":"Free Radic. Biol. Med"},{"issue":"1","key":"10.1016\/j.phrs.2023.106645_bib34","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1186\/s12906-020-03132-x","article-title":"Neuroprotective effects of Hericium erinaceus (Bull.: Fr.) Pers. Against high-dose corticosterone-induced oxidative stress in PC-12 cells","volume":"20","author":"Lew","year":"2020","journal-title":"BMC Complement Med Ther."},{"issue":"8","key":"10.1016\/j.phrs.2023.106645_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024031","article-title":"Dietary alpha-eleostearic acid ameliorates experimental inflammatory bowel disease in mice by activating peroxisome proliferator-activated receptor-gamma","volume":"6","author":"Lewis","year":"2011","journal-title":"Plos One"},{"key":"10.1016\/j.phrs.2023.106645_bib36","article-title":"Ferroptosis: a critical moderator in the life cycle of immune cells","volume":"13","author":"Wang","year":"2022","journal-title":"Front Immunol."},{"issue":"4","key":"10.1016\/j.phrs.2023.106645_bib37","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41419-022-04775-z","article-title":"Interaction between macrophages and ferroptosis","volume":"13","author":"Yang","year":"2022","journal-title":"Cell Death Dis."},{"issue":"7826","key":"10.1016\/j.phrs.2023.106645_bib38","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/s41586-020-2732-8","article-title":"Plasticity of ether lipids promotes ferroptosis susceptibility and evasion","volume":"585","author":"Zou","year":"2020","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.phrs.2023.106645_bib39","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1046\/j.1365-2036.2000.00828.x","article-title":"Effects of iron and iron chelation in vitro on mucosal oxidant activity in ulcerative colitis","volume":"14","author":"Millar","year":"2000","journal-title":"Aliment Pharm. Ther."},{"key":"10.1016\/j.phrs.2023.106645_bib40","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bbrc.2021.08.018","article-title":"Ferrostatin-1 alleviated TNBS induced colitis via the inhibition of ferroptosis","volume":"573","author":"Xu","year":"2021","journal-title":"Biochem Biophys. Res Commun."},{"issue":"13","key":"10.1016\/j.phrs.2023.106645_bib41","doi-asserted-by":"crossref","first-page":"15560","DOI":"10.1021\/acsomega.9b01920","article-title":"Integrin alpha6-Targeted positron emission tomography imaging of colorectal cancer","volume":"4","author":"Xiao","year":"2019","journal-title":"ACS Omega"},{"key":"10.1016\/j.phrs.2023.106645_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2021.338881","article-title":"Fecal multi-omics analysis reveals diverse molecular alterations of gut ecosystem in COVID-19 patients","volume":"1180","author":"He","year":"2021","journal-title":"Anal. Chim. Acta"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661823000014?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661823000014?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:39:39Z","timestamp":1760913579000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661823000014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":42,"alternative-id":["S1043661823000014"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2023.106645","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"pH-sensitive molybdenum (Mo)-based polyoxometalate nanoclusters have therapeutic efficacy in inflammatory bowel disease by counteracting ferroptosis","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2023.106645","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106645"}}