{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T12:35:32Z","timestamp":1793795732887,"version":"4.6.1"},"reference-count":235,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002954","name":"Universit\u00e0 degli Studi di Milano-Bicocca","doi-asserted-by":"publisher","award":["2021-ATE-0042"],"award-info":[{"award-number":["2021-ATE-0042"]}],"id":[{"id":"10.13039\/501100002954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002954","name":"Universit\u00e0 degli Studi di Milano-Bicocca","doi-asserted-by":"publisher","award":["2022-ATEQC-0037"],"award-info":[{"award-number":["2022-ATEQC-0037"]}],"id":[{"id":"10.13039\/501100002954","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.phrs.2023.106698","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T21:37:45Z","timestamp":1676410665000},"page":"106698","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"special_numbering":"C","title":["Nicotinic acetylcholine receptors and epilepsy"],"prefix":"10.1016","volume":"189","author":[{"given":"Andrea","family":"Becchetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Clara","family":"Grandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Cerina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alida","family":"Amadeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2023.106698_bib1","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.0013-9580.2005.66104.x","article-title":"Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)","volume":"46","author":"Fisher","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.phrs.2023.106698_bib2","series-title":"Epilepsy. A Comprehensive Textbook","first-page":"1","article-title":"Introduction: what is epilepsy?","author":"Engel","year":"2008"},{"key":"10.1016\/j.phrs.2023.106698_bib3","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1146\/annurev-genom-120219-074937","article-title":"The genetics of epilepsy","volume":"21","author":"Perucca","year":"2020","journal-title":"Annu. Rev. Genom. Hum. Genet."},{"key":"10.1016\/j.phrs.2023.106698_bib4","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/epi.13670","article-title":"Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE commission for classification and terminology","volume":"58","author":"Fisher","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.phrs.2023.106698_bib5","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.tins.2006.05.009","article-title":"Human epilepsies: interaction of genetic and acquired factors","volume":"29","author":"Berkovic","year":"2006","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib6","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/epi.13709","article-title":"ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology","volume":"58","author":"Scheffer","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.phrs.2023.106698_bib7","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/ng1095-201","article-title":"A missense mutation in the neuronal nicotinic acetylcholine receptor \u03b14 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy","volume":"11","author":"Steinlein","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.phrs.2023.106698_bib8","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41386-019-0444-2","article-title":"Arousal and sleep circuits","volume":"45","author":"Jones","year":"2020","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.phrs.2023.106698_bib9","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.bcp.2013.04.001","article-title":"Importance of the nicotinic acetylcholine receptor system in the prefrontal cortex","volume":"85","author":"Wallace","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phrs.2023.106698_bib10","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s00702-016-1530-9","article-title":"Structural and functional considerations of the cholinergic brainstem","volume":"123","author":"Mena-Segovia","year":"2016","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.phrs.2023.106698_bib11","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.neuron.2016.09.006","article-title":"Basal forebrain cholinergic circuits and signaling in cognition and cognitive decline","volume":"91","author":"Ballinger","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2023.106698_bib12","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.tins.2007.07.008","article-title":"Re-emergence of striatal cholinergic interneurons in movement disorders","volume":"30","author":"Pisani","year":"2007","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib13","doi-asserted-by":"crossref","first-page":"5633","DOI":"10.1523\/JNEUROSCI.4647-06.2007","article-title":"Functional characterization of intrinsic cholinergic interneurons in the cortex","volume":"27","author":"von Engelhardt","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib14","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-2202-10-18","article-title":"Developmental and neurochemical features of cholinergic neurons in the murine cerebral cortex","volume":"10","author":"Consonni","year":"2009","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib15","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fnsyn.2016.00006","article-title":"Intrinsic cholinergic neurons in the hippocampus: fact or artifact","volume":"8","author":"Blusztajn","year":"2016","journal-title":"Front. Synaptic Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib16","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.conb.2017.03.018","article-title":"Principal cell types of sleep-wake regulatory circuits","volume":"44","author":"Jones","year":"2017","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.phrs.2023.106698_bib17","doi-asserted-by":"crossref","first-page":"e0270","DOI":"10.1523\/ENEURO.0270-18.2018","article-title":"Discharge and role of acetylcholine pontomesencephalic neurons in cortical activity and sleep-wake states examined by optogenetics and juxtacellular recording in mice","volume":"5","author":"Ciss\u00e8","year":"2018","journal-title":"eNeuro"},{"key":"10.1016\/j.phrs.2023.106698_bib18","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1146\/annurev.pharmtox.47.120505.105214","article-title":"Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system","volume":"47","author":"Dani","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.phrs.2023.106698_bib19","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neuron.2012.08.036","article-title":"Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behaviour","volume":"76","author":"Picciotto","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2023.106698_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fncir.2021.648624","article-title":"Neuromodulation of persistent activity and working memory circuitry in primate prefrontal cortex by muscarinic receptors","volume":"15","author":"Vijayraghavan","year":"2021","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.phrs.2023.106698_bib21","series-title":"Goodman & Gilman\u2019s The Pharmacological Basis of Therapeutics","first-page":"183","article-title":"Muscarinic receptor agonists and antagonists","author":"Brown","year":"2006"},{"key":"10.1016\/j.phrs.2023.106698_bib22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jneumeth.2008.04.019","article-title":"The pilocarpine model of temporal lobe epilepsy","volume":"172","author":"Curia","year":"2008","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.phrs.2023.106698_bib23","doi-asserted-by":"crossref","first-page":"13311","DOI":"10.1073\/pnas.94.24.13311","article-title":"Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice","volume":"94","author":"Hamilton","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.phrs.2023.106698_bib24","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.neubiorev.2021.08.020","article-title":"The pilocarpine model of mesial temporal lobe epilepsy: Over one decade later, with more rodent species and new investigative approaches","volume":"130","author":"Levesque","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.phrs.2023.106698_bib25","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.yebeh.2013.11.022","article-title":"Tobacco smoking, epilepsy, and seizures","volume":"31","author":"Rong","year":"2014","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.phrs.2023.106698_bib26","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.neuropharm.2005.01.015","article-title":"Pharmacological and histological characterization of nicotine-kindled seizures in mice","volume":"48","author":"Bastlund","year":"2005","journal-title":"Neuropharmacol"},{"key":"10.1016\/j.phrs.2023.106698_bib27","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3389\/fphys.2015.00022","article-title":"The role of nicotinic acetylcholine receptors in autosomal dominant nocturnal frontal lobe epilepsy","volume":"6","author":"Becchetti","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.phrs.2023.106698_bib28","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.3390\/molecules26082258","article-title":"Cholinergic signaling, neural excitability, and epilepsy","volume":"26","author":"Wang","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.phrs.2023.106698_bib29","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nature19785","article-title":"X-ray structure of the human \u03b14\u03b22 nicotinic receptor","volume":"538","author":"Morales-Perez","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2023.106698_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108086","article-title":"Progress in nicotinic receptor structural biology","volume":"171","author":"Gharpure","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phrs.2023.106698_bib31","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1113\/JP275100","article-title":"The dual-gate model for pentameric ligand-gated ion channels activation and desensitization","author":"Gielen","year":"2018","journal-title":"J. Physiol. 596. 10"},{"key":"10.1016\/j.phrs.2023.106698_bib32","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.bcp.2009.05.024","article-title":"Structural and functional diversity of native brain neuronal nicotinic receptors","volume":"78","author":"Gotti","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phrs.2023.106698_bib33","doi-asserted-by":"crossref","first-page":"6971","DOI":"10.1073\/pnas.90.15.6971","article-title":"Mutations at two distinct sites within the channel domain M2 alter calcium permeability of neuronal \u03b17 nicotinic receptors","volume":"90","author":"Bertrand","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.phrs.2023.106698_bib34","doi-asserted-by":"crossref","first-page":"7808","DOI":"10.1523\/JNEUROSCI.0448-08.2008","article-title":"The interface between extracellular and transmembrane domains of homomeric Cys-Loop receptors governs open-channel lifetime and rate of desensitization","volume":"28","author":"Bouzat","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib35","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1124\/mol.54.6.1124","article-title":"Four pharmacologically distinct subtypes of \u03b14\u03b22 nicotinic acetylcholine receptor expressed in Xenopus laevis oocytes","volume":"54","author":"Zwart","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.phrs.2023.106698_bib36","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0165-0270(99)00185-5","article-title":"Multiple components in the agonist concentration-response relationships of neuronal nicotinic acetylcholine receptors","volume":"96","author":"Covernton","year":"2000","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.phrs.2023.106698_bib37","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1046\/j.1471-4159.2001.00481.x","article-title":"Activity of cytisine and its brominated isosteres on recombinant human alpha7, alpha4beta2 and alpha4beta4 nicotinic acetylcholine receptors","volume":"78","author":"Houlihan","year":"2001","journal-title":"J. Neurochem"},{"key":"10.1016\/j.phrs.2023.106698_bib38","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1523\/JNEUROSCI.21-06-01819.2001","article-title":"Chronic exposure to nicotine upregulates the human \u03b14\u03b22 nicotinic acetylcholine receptor function","volume":"21","author":"Buisson","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib39","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1124\/mol.63.2.332","article-title":"Alternate stoichiometries of \u03b14\u03b22 nicotinic acetylcholine receptors","volume":"63","author":"Nelson","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.phrs.2023.106698_bib40","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1523\/JNEUROSCI.20-02-00529.2000","article-title":"A molecular link between inward rectification and calcium permeability of neuronal acetylcholine \u03b13\u03b24 and \u03b14\u03b22 receptors","volume":"20","author":"Haghighi","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib41","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1124\/mol.106.030445","article-title":"Ca2+ permeability of the (\u03b14)3(\u03b22)2 stoichiometry greatly exceeds that of (\u03b14)2(\u03b22)3 human acetylcholine receptors","volume":"71","author":"Tapia","year":"2007","journal-title":"Mol. Pharmacol."},{"issue":"3","key":"10.1016\/j.phrs.2023.106698_bib42","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1113\/jphysiol.2003.053447","article-title":"Nicotine is highly effective at producing desensitization of rat \u03b14\u03b22 neuronal nicotinic receptors","volume":"553","author":"Paradiso","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.phrs.2023.106698_bib43","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/380347a0","article-title":"Functional contribution of \u03b15 subunit to neuronal acetylcholine receptor channels","volume":"380","author":"Ramirez-Latorre","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2023.106698_bib44","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1471-4159.2007.04700.x","article-title":"Nicotinic \u03b15 subunit deletion locally reduces high-affinity agonist activation without altering nicotinic receptor numbers","volume":"103","author":"Brown","year":"2007","journal-title":"J. Neurochem"},{"key":"10.1016\/j.phrs.2023.106698_bib45","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.biopsych.2011.09.011","article-title":"Nicotinic \u03b15 subunits drive developmental changes in the activation and morphology of prefrontal cortex layer VI neurons","volume":"71","author":"Bailey","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2023.106698_bib46","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.neuropharm.2008.07.041","article-title":"Diversity of vertebrate nicotinic acetylcholine receptors","volume":"56","author":"Millar","year":"2009","journal-title":"Neuropharmacol"},{"issue":"2","key":"10.1016\/j.phrs.2023.106698_bib47","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1113\/jphysiol.2001.013847","article-title":"Rat nicotinic ACh receptor \u03b17 and \u03b22 subunits co-assemble to form functional heteromeric nicotinic receptor channels","volume":"540","author":"Khiroug","year":"2002","journal-title":"J. Physiol."},{"key":"10.1016\/j.phrs.2023.106698_bib48","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1523\/JNEUROSCI.3952-08.2009","article-title":"A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides","volume":"29","author":"Liu","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib49","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/1471-2202-13-155","article-title":"Functional \u03b17\u03b22 nicotinic acetylcholine receptors expressed in hippocampal interneurons exhibit high sensitivity to pathological level of amyloid \u03b2 peptides","volume":"13","author":"Liu","year":"2012","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib50","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1124\/mol.114.093377","article-title":"The novel \u03b17\u03b22-nicotinic acetylcholine receptor subtype is expressed in mouse and human basal forebrain: biochemical and pharmacological characterization","volume":"86","author":"Moretti","year":"2014","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.phrs.2023.106698_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0130572","article-title":"\u03b17 and \u03b22 nicotinic acetylcholine receptor subunits form heteromeric receptor complexes that are expressed in the human cortex and display distinct pharmacological properties","volume":"10","author":"Thomsen","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2023.106698_bib52","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1007\/s00018-017-2741-4","article-title":"Molecular function of the novel \u03b17\u03b22 nicotinic receptor","volume":"75","author":"Nielsen","year":"2018","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.phrs.2023.106698_bib53","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1046\/j.1460-9568.2000.00262.x","article-title":"Localization of nAChR subunit mRNAs in the brain of Macaca mulatta","volume":"12","author":"Han","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib54","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/1096-9861(20000911)425:1<58::AID-CNE6>3.0.CO;2-X","article-title":"Localization of nicotinic receptor subunit mRNAs in monkey brain by in situ hybridization","volume":"425","author":"Quik","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.phrs.2023.106698_bib55","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/cne.10659","article-title":"Localization of [3H]nicotine, [3H]cytisine, [3H]epibatidine, and [125I]\u03b1-bungarotoxin binding sites in the brain of Macaca mulatta","volume":"461","author":"Han","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.phrs.2023.106698_bib56","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.nbd.2007.06.004","article-title":"\u03b22* and \u03b24* nicotinic acetylcholine receptor expression changes with progressive parkinsonism in non-human primates","volume":"27","author":"Kulak","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.phrs.2023.106698_bib57","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0165-3806(98)00046-7","article-title":"Regional distribution of nicotinic receptors during prenatal development of human brain and spinal cord","volume":"108","author":"Hellstr\u00f6m-Lindahl","year":"1998","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.phrs.2023.106698_bib58","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1523\/JNEUROSCI.11-03-00837.1991","article-title":"Both \u03b1- and \u03b2-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors","volume":"11","author":"Luetje","year":"1991","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib59","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/cne.20762","article-title":"Comparison of \u03b12 nicotinic acetylcholine receptor subunit mRNA expression in the central nervous system of rats and mice","volume":"493","author":"Ishii","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.phrs.2023.106698_bib60","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jchemneu.2006.09.001","article-title":"Postnatal expression of \u03b12 nicotinic acetylcholine receptor subunit mRNA in developing cortex and hippocampus","volume":"32","author":"Son","year":"2006","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.phrs.2023.106698_bib61","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2001392","article-title":"Chrna2-Martinotti cells synchronize layer 5 type A pyramidal cells via rebound excitation","volume":"15","author":"Hilscher","year":"2017","journal-title":"PLoS Biol."},{"key":"10.1016\/j.phrs.2023.106698_bib62","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/978-1-4419-6066-5_2","article-title":"Introduction to ion channels","volume":"674","author":"Di Resta","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.phrs.2023.106698_bib63","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0896-6273(03)00322-2","article-title":"Modulation of presynaptic store calcium induces release of glutamate and postsynaptic firing","volume":"38","author":"Sharma","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2023.106698_bib64","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1124\/mol.108.046623","article-title":"Presynaptic \u03b17- and \u03b2-containing nicotinic acetylcholine receptors modulate excitatory amino acid release from rat prefrontal cortex nerve terminals via distinct cellular mechanisms","volume":"74","author":"Dickinson","year":"2008","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.phrs.2023.106698_bib65","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.tips.2018.01.002","article-title":"Beyond the channel: metabotropic signaling by nicotinic receptors","volume":"39","author":"Kabbani","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.phrs.2023.106698_bib66","doi-asserted-by":"crossref","first-page":"20060","DOI":"10.1074\/jbc.M115.647040","article-title":"Identification and characterization of a G protein-binding cluster in \u03b17 nicotinic acetylcholine receptors","volume":"290","author":"King","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2023.106698_bib67","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1002\/jnr.20850","article-title":"Microglial alpha7 nicotinic acetylcholine receptors drive a phospholipase C\/IP3 pathway and modulate the cell activation toward a neuroprotective role","volume":"83","author":"Suzuki","year":"2006","journal-title":"J. Neurosci. Res"},{"key":"10.1016\/j.phrs.2023.106698_bib68","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1002\/2211-5463.12270","article-title":"A G protein-coupled \u03b17 nicotinic receptor regulates signaling and TNF-\u03b1 release in microglia","volume":"7","author":"King","year":"2017","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.phrs.2023.106698_bib69","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/cercor\/bhr390","article-title":"Layer-specific modulation of the prefrontal cortex by nicotinic acetylcholine receptors","volume":"23","author":"Poorthuis","year":"2013","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.phrs.2023.106698_bib70","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF00403704","article-title":"Antagonism of intracerebrally induced nicotinic convulsions in mice: A method for measuring the central antinicotinic activity of CNS acting agents","volume":"19","author":"Dixit","year":"1971","journal-title":"Psychopharmacol"},{"key":"10.1016\/j.phrs.2023.106698_bib71","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/0091-3057(86)90476-4","article-title":"Nicotine-induced convulsion in cats and central nicotinic receptors","volume":"24","author":"Beleslin","year":"1986","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phrs.2023.106698_bib72","first-page":"1284","article-title":"Pharmacological characterization of nicotine-induced seizures in mice","volume":"291","author":"Damaj","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.phrs.2023.106698_bib73","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3109\/15563659609013830","article-title":"Self-poisoning among adults using multiple transdermal nicotine patches","volume":"34","author":"Woolf","year":"1996","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"10.1016\/j.phrs.2023.106698_bib74","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3390\/ijerph8020613","article-title":"Hazardous compounds in tobacco smoke","volume":"8","author":"Talhout","year":"2011","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.phrs.2023.106698_bib75","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1254\/jjp.59.449","article-title":"Tolerance to the convulsions induced by daily nicotine treatment in rats","volume":"59","author":"Okamoto","year":"1992","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.phrs.2023.106698_bib76","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0376-8716(99)00025-3","article-title":"Arterial nicotine kinetics during cigarette smoking and intravenous nicotine administration: implications for addiction","volume":"56","author":"Rose","year":"1999","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.phrs.2023.106698_bib77","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1001\/archpsyc.63.8.907","article-title":"Cigarette smoking saturates brain \u03b14\u03b22 nicotinic acetylcholine receptors","volume":"63","author":"Brody","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.phrs.2023.106698_bib78","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1523\/JNEUROSCI.17-15-05747.1997","article-title":"Influence of subunit composition on desensitization of neuronal acetylcholine receptors at low concentrations of nicotine","volume":"17","author":"Fenster","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib79","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1124\/mol.107.044545","article-title":"Human nocturnal frontal lobe epilepsy: pharmacogenomic profiles of pathogenic nicotinic acetylcholine receptor \u03b2-subunit mutations outside the ion channel pore","volume":"74","author":"Hoda","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.phrs.2023.106698_bib80","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.phrs.2014.02.005","article-title":"Pharmacological chaperoning of nAChRs: a therapeutic target for Parkinson\u2019s disease","volume":"84","author":"Srinivasan","year":"2014","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phrs.2023.106698_bib81","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1124\/jpet.103.053066","article-title":"GABAergic systems modulate nicotinic receptor-mediated seizures in mice","volume":"306","author":"Dobelis","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.phrs.2023.106698_bib82","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1016\/S0024-3205(01)01338-8","article-title":"Nicotine induced seizures blocked by mecamylamine and its stereoisomers","volume":"69","author":"Newman","year":"2001","journal-title":"Life Sci."},{"key":"10.1016\/j.phrs.2023.106698_bib83","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fphar.2017.00057","article-title":"Nicotine elicits convulsive seizures by activating amygdalar neurons","volume":"8","author":"Iha","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phrs.2023.106698_bib84","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1124\/mol.61.3.695","article-title":"Increased sensitivity to nicotine-induced seizures in mice expressing the L250T \u03b17-containing nicotinic acetylcholine receptor mutation","volume":"61","author":"Broide","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.phrs.2023.106698_bib85","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/00001756-200202110-00004","article-title":"Increased sensitivity to nicotine-induced seizures in mice heterozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor","volume":"13","author":"Gil","year":"2002","journal-title":"Neuroreport"},{"key":"10.1016\/j.phrs.2023.106698_bib86","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1523\/JNEUROSCI.23-07-02582.2003","article-title":"Increased sensitivity to agonist-induced seizures, straub tail, and hippocampal theta rhythm in knock-in mice carrying hypersensitive \u03b14 nicotinic receptors","volume":"23","author":"Fonck","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib87","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1124\/mol.63.5.1059","article-title":"The nicotinic acetylcholine receptor subunit alpha5 mediates short-term effects of nicotine in vivo","volume":"63","author":"Salas","year":"2003","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.phrs.2023.106698_bib88","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1152\/physiolgenomics.00202.2003","article-title":"Mice lacking neuronal nicotinic acetylcholine receptor \u03b24-subunit and mice lacking both \u03b15- and \u03b24-subunits are highly resistant to nicotine-induced seizures","volume":"17","author":"Kedmi","year":"2004","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.phrs.2023.106698_bib89","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1161\/01.CIR.102.10.1165","article-title":"Nicotine is a potent blocker of the cardiac A-type K+ channels. Effects on cloned Kv4.3 channels and native transient outward current","volume":"102","author":"Wang","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2023.106698_bib90","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1080\/14017430500200465","article-title":"Nicotine inhibits large conductance Ca2+-activated K+ channels and the NO\/-cGMP signaling pathway in cultured human endothelial cells","volume":"39","author":"Kuhlmann","year":"2005","journal-title":"Scand. Cardiovasc. J."},{"key":"10.1016\/j.phrs.2023.106698_bib91","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1152\/ajplegacy.1960.198.3.515","article-title":"Modification of cortical, reticular and hippocampal unit activity by nicotine in the rabbit","volume":"198","author":"Dunlop","year":"1960","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.phrs.2023.106698_bib92","first-page":"247","article-title":"Effects of nicotine on cortical, thalamic and hippocampal electrical activity in rabbits","volume":"5","author":"Floris","year":"1964","journal-title":"J. Neuropsychiatry"},{"key":"10.1016\/j.phrs.2023.106698_bib93","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1749-6632.1967.tb13720.x","article-title":"Actions of nicotine upon the limbic system","volume":"142","author":"St\u00fcmpf","year":"1967","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.phrs.2023.106698_bib94","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0364-7722(81)90089-8","article-title":"An EEG analysis of convulsive activity produced by cholinergic agents","volume":"5","author":"Cohen","year":"1981","journal-title":"Prog. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2023.106698_bib95","series-title":"Epilepsy. A Comprehensive Textbook","first-page":"337","article-title":"Limbic anatomy and physiology","author":"McIntyre","year":"2008"},{"key":"10.1016\/j.phrs.2023.106698_bib96","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0006-8993(88)90160-6","article-title":"Evidence for modulation of GABAergic neurotransmission by nicotine","volume":"453","author":"Freund","year":"1988","journal-title":"Brain Res"},{"key":"10.1016\/j.phrs.2023.106698_bib97","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1113\/jphysiol.2011.220095","article-title":"Regulation of hippocampal inhibitory circuits by nicotinic acetylcholine receptors","volume":"590","author":"Griguoli","year":"2012","journal-title":"J. Physiol."},{"key":"10.1016\/j.phrs.2023.106698_bib98","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.tins.2021.11.006","article-title":"\u03b17 nicotinic acetylcholine receptors in the hippocampal circuit: taming complexity","volume":"45","author":"Letsinger","year":"2022","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib99","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0169-328X(01)00309-6","article-title":"Absence of \u03b17-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures","volume":"98","author":"Franceschini","year":"2002","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.phrs.2023.106698_bib100","doi-asserted-by":"crossref","first-page":"7880","DOI":"10.1523\/JNEUROSCI.16-24-07880.1996","article-title":"Human \u03b14\u03b22 neuronal nicotinic acetylcholine receptor in HEK 293 cells: a patch-clamp study","volume":"16","author":"Buisson","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib101","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.neuropharm.2012.06.015","article-title":"How inhibition influences seizure propagation","volume":"69","author":"Trevelyan","year":"2013","journal-title":"Neuropharmacol"},{"key":"10.1016\/j.phrs.2023.106698_bib102","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/WCO.0b013e3282f52f5f","article-title":"Seizure-genesis through excessive GABAergic inhibition in autosomal dominant nocturnal frontal lobe epilepsy","volume":"21","author":"Mann","year":"2008","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.phrs.2023.106698_bib103","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.eplepsyres.2010.06.005","article-title":"Early hippocampal oxidative stress is a direct consequence of seizures in the rapid electrical amygdala kindling model","volume":"90","author":"Sashindranath","year":"2010","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.phrs.2023.106698_bib104","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/2141020a0","article-title":"Development of epileptic seizures through brain stimulation at low intensity","volume":"214","author":"Goddard","year":"1967","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2023.106698_bib105","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/BF00430762","article-title":"Repeated administration of subconvulsant doses of GABA antagonist drugs. I. Effect on seizure threshold (kindling)","volume":"76","author":"Nutt","year":"1982","journal-title":"Psychopharmacol"},{"key":"10.1016\/j.phrs.2023.106698_bib106","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1528-1157.1972.tb04401.x","article-title":"A permanent change in convulsive threshold in normal and brain-damaged rats with repeated small doses of pentylenetetrazol","volume":"13","author":"Mason","year":"1972","journal-title":"Epilepsia"},{"key":"10.1016\/j.phrs.2023.106698_bib107","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0306-3623(97)00423-0","article-title":"A neuropharmacological analysis of PTZ-induced kindling in mice","volume":"31","author":"da-Silva","year":"1998","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.phrs.2023.106698_bib108","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00213-012-2799-5","article-title":"Differences in vulnerability to nicotine-induced kindling between female and male periadolescent rats","volume":"225","author":"Gomes","year":"2013","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.phrs.2023.106698_bib109","first-page":"1","article-title":"Potential new roles for glycogen in epilepsy","volume":"00","author":"Dienel","year":"2022","journal-title":"Epilepsia"},{"key":"10.1016\/j.phrs.2023.106698_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2019.07.011","article-title":"Reactive oxygen species in status epilepticus","volume":"101","author":"Shekh-Ahmad","year":"2019","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.phrs.2023.106698_bib111","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0166-2236(96)10073-4","article-title":"Presynaptic nicotinic ACh receptors","volume":"20","author":"Wonnacott","year":"1997","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib112","series-title":"Epilepsy. A Comprehensive Textbook","first-page":"2495","article-title":"Familial frontal lobe epilepsy","author":"Picard","year":"2008"},{"key":"10.1016\/j.phrs.2023.106698_bib113","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1212\/WNL.0000000000002666","article-title":"Definition and diagnostic criteria of sleep-related hypermotor epilepsy","volume":"86","author":"Tinuper","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.phrs.2023.106698_bib114","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/hmg\/6.6.943","article-title":"An insertion mutation of the CHRNA4 gene in a family with autosomal dominant nocturnal frontal lobe epilepsy","volume":"6","author":"Steinlein","year":"1997","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.phrs.2023.106698_bib115","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1212\/WNL.53.8.1749","article-title":"A novel mutation of CHRNA4 responsible for autosomal dominant nocturnal frontal lobe epilepsy","volume":"53","author":"Hirose","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.phrs.2023.106698_bib116","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/81566","article-title":"The nicotinic receptor \u03b22 subunit is mutant in nocturnal frontal lobe epilepsy","volume":"26","author":"De Fusco","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.phrs.2023.106698_bib117","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1086\/316946","article-title":"CHRNB2 is the second acetylcholine receptor subunit associated with autosomal dominant nocturnal frontal lobe epilepsy","volume":"68","author":"Phillips","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.phrs.2023.106698_bib118","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1086\/506459","article-title":"Increased sensitivity of the neuronal nicotinic receptor \u03b12 subunit causes familial epilepsy with nocturnal wandering and ictal fear","volume":"79","author":"Aridon","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.phrs.2023.106698_bib119","article-title":"Autosomal dominant sleep-related hypermotor epilepsy caused by a previously unreported CHRNA4 variant","volume":"65","author":"\u00d8stergaard Nielsen","year":"2022","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.phrs.2023.106698_bib120","doi-asserted-by":"crossref","first-page":"12124","DOI":"10.3390\/ijms232012124","article-title":"Genetic variant in nicotinic receptor \u03b14-subunit causes sleep-related hyperkinetic epilepsy via increased channel opening","volume":"23","author":"Mazzaferro","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2023.106698_bib121","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1017\/cjn.2020.126","article-title":"Variants in CHRNB2 and CHRNA4 identified in patients with insular epilepsy","volume":"47","author":"Cadieux-Dion M","year":"2020","journal-title":"Can. J. Neurol. Sci."},{"key":"10.1016\/j.phrs.2023.106698_bib122","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.yebeh.2008.11.003","article-title":"Neuropsychological disturbances in frontal lobe epilepsy due to mutated nicotinic receptors","volume":"14","author":"Picard","year":"2009","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.phrs.2023.106698_bib123","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.seizure.2011.10.003","article-title":"Mutations in familial nocturnal frontal lobe epilepsy might be associated with distinct neurological phenotypes","volume":"21","author":"Steinlein","year":"2012","journal-title":"Seizure"},{"key":"10.1016\/j.phrs.2023.106698_bib124","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1038\/ng.2440","article-title":"Missense mutations in the sodium-gated potassium channel gene KCNT1 cause severe autosomal dominant nocturnal frontal lobe epilepsy","volume":"44","author":"Heron","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.phrs.2023.106698_bib125","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/ng.2599","article-title":"Mutations in DEPDC5 cause familial focal epilepsy with variable foci","volume":"45","author":"Dibbens","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.phrs.2023.106698_bib126","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/ng.2601","article-title":"Mutations of DEPDC5 cause autosomal dominant focal epilepsies","volume":"45","author":"Ishida","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.phrs.2023.106698_bib127","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1212\/WNL.0000000000000488","article-title":"DEPDC5 mutations in families presenting as autosomal dominant nocturnal frontal lobe epilepsy","volume":"82","author":"Picard","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.phrs.2023.106698_bib128","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/ana.20660","article-title":"Frontal lobe epilepsy and mutations of the corticotropin-releasing hormone gene","volume":"58","author":"Combi","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.phrs.2023.106698_bib129","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/ana.24547","article-title":"Mutations in the mammalian target of rapamycin pathway regulators NPRL2 and NPRL3 cause focal epilepsy","volume":"79","author":"Ricos","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.phrs.2023.106698_bib130","doi-asserted-by":"crossref","first-page":"907","DOI":"10.3390\/brainsci10120907","article-title":"Nicotinic receptors in sleep-related hypermotor epilepsy: pathophysiology and pharmacology","volume":"10","author":"Becchetti","year":"2020","journal-title":"Brain Sci."},{"key":"10.1016\/j.phrs.2023.106698_bib131","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0014-5793(96)01215-X","article-title":"An amino acid exchange in the second transmembrane segment of a neuronal nicotinic receptor causes partial epilepsy by altering its desensitization kinetics","volume":"398","author":"Weiland","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.phrs.2023.106698_bib132","doi-asserted-by":"crossref","first-page":"9035","DOI":"10.1523\/JNEUROSCI.17-23-09035.1997","article-title":"Mutation causing autosomal dominant nocturnal frontal lobe epilepsy alters Ca2+ permeability, conductance, and gating of human \u03b14\u03b22 nicotinic acetylcholine receptors","volume":"17","author":"Kuryatov","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib133","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/sj.bjp.0702154","article-title":"Properties of neuronal nicotinic acetylcholine receptor mutants from humans suffering from autosomal dominant nocturnal frontal lobe epilepsy","volume":"125","author":"Bertrand","year":"1998","journal-title":"Brit. J. Pharm."},{"key":"10.1016\/j.phrs.2023.106698_bib134","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0920-1211(01)00336-9","article-title":"Mutation (Ser284Leu) of neuronal nicotinic acetylcholine receptor \u03b14 subunit associated with frontal lobe epilepsy causes faster desensitization of the rat receptor expressed in oocytes","volume":"48","author":"Matsushima","year":"2002","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.phrs.2023.106698_bib135","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1469-7793.1998.655ba.x","article-title":"Two mutations linked to nocturnal frontal lobe epilepsy cause use-dependent potentiation of the nicotinic ACh response","volume":"513","author":"Figl","year":"1998","journal-title":"J. Physiol."},{"key":"10.1016\/j.phrs.2023.106698_bib136","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1046\/j.1528-1157.43.s.5.16.x","article-title":"How mutations in the nAChRs can cause ADNFLE epilepsy","volume":"43","author":"Bertrand","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.phrs.2023.106698_bib137","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.nbd.2005.05.013","article-title":"The CHRNB2 mutation I312M is associated with epilepsy and distinct memory deficits","volume":"20","author":"Bertrand","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.phrs.2023.106698_bib138","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0987-7053(02)00294-0","article-title":"Mutations of the neuronal nicotinic acetylcholine receptors and their association with ADNFLE","volume":"32","author":"Itier","year":"2002","journal-title":"Neurophysiol. Clin."},{"key":"10.1016\/j.phrs.2023.106698_bib139","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1113\/jphysiol.2003.036681","article-title":"Five ADNFLE mutations reduce the Ca2+ dependence of the mammalian \u03b14\u03b22 acetylcholine response","volume":"550","author":"Rodrigues-Pinguet","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.phrs.2023.106698_bib140","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1124\/mol.108.054494","article-title":"Nicotine normalizes intracellular subunit stoichiometry of nicotinic receptors carrying mutations linked to autosomal dominant nocturnal frontal lobe epilepsy","volume":"75","author":"Son","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.phrs.2023.106698_bib141","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158032","article-title":"Mutation linked to autosomal dominant nocturnal frontal lobe epilepsy reduces low-sensitivity \u03b14\u03b22, and increases \u03b15\u03b14\u03b22, nicotinic receptor surface expression","volume":"11","author":"Nichols","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.phrs.2023.106698_bib142","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.phrs.2018.11.031","article-title":"Revisiting autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) mutations in the nicotinic acetylcholine receptor reveal an increase in efficacy regardless of stoichiometry","volume":"139","author":"Indurthi","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phrs.2023.106698_bib143","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.eplepsyres.2008.10.009","article-title":"A novel mutation of the nicotinic acetylcholine receptor gene CHRNA4 in sporadic nocturnal frontal lobe epilepsy","volume":"83","author":"Chen","year":"2009","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.phrs.2023.106698_bib144","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.eplepsyres.2011.03.002","article-title":"The identification of a novel mutation of nicotinic acetylcholine receptor gene CHRNB2 in a Chinese patient: Its possible implication in non-familial nocturnal frontal lobe epilepsy","volume":"95","author":"Liu","year":"2011","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.phrs.2023.106698_bib145","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.neuropharm.2015.11.004","article-title":"effects of nicotinic receptor intracellular loop mutations associated with nocturnal frontal lobe epilepsy","volume":"102","author":"Weltzin","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phrs.2023.106698_bib146","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0247825","article-title":"Sleep-related hypermotor epilepsy associated mutations uncover important kinetic roles of \u03b14\u03b22-nicotinic acetylcholine receptor intracellular structures","volume":"16","author":"Weltzin","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2023.106698_bib147","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.febslet.2009.04.024","article-title":"Pleiotropic functional effects of the first epilepsy-associated mutation in the human CHRNA2 gene","volume":"583","author":"Hoda","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.phrs.2023.106698_bib148","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/nature01748","article-title":"Structure and gating mechanism of the acetylcholine receptor pore","volume":"423","author":"Miyazawa","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2023.106698_bib149","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1212\/WNL.0000000000001471","article-title":"Nocturnal frontal lobe epilepsy with paroxysmal arousals due to CHRNA2 loss of function","volume":"84","author":"Conti","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.phrs.2023.106698_bib150","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fnmol.2019.00017","article-title":"CHRNA2 and nocturnal frontal lobe epilepsy: identification and characterization of a novel loss of function mutation","volume":"12","author":"Villa","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib151","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1016\/j.sleep.2011.10.009","article-title":"Nocturnal frontal lobe epilepsy: new pathophysiological interpretations","volume":"12","author":"Tinuper","year":"2011","journal-title":"Sleep. Med"},{"key":"10.1016\/j.phrs.2023.106698_bib152","doi-asserted-by":"crossref","first-page":"19152","DOI":"10.1073\/pnas.0608215103","article-title":"Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy","volume":"103","author":"Klaassen","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.phrs.2023.106698_bib153","doi-asserted-by":"crossref","first-page":"10128","DOI":"10.1523\/JNEUROSCI.3042-07.2007","article-title":"Nicotine-induced dystonic arousal complex in a mouse line harboring a human autosomal-dominant nocturnal frontal lobe epilepsy mutation","volume":"27","author":"Teper","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib154","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/gim.2014.9","article-title":"Nicotinic acetylcholine receptors in human genetic disease","volume":"16","author":"Schaaf","year":"2014","journal-title":"Genet. Med."},{"key":"10.1016\/j.phrs.2023.106698_bib155","doi-asserted-by":"crossref","first-page":"12465","DOI":"10.1523\/JNEUROSCI.2961-08.2008","article-title":"Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype","volume":"28","author":"Zhu","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib156","doi-asserted-by":"crossref","first-page":"8142","DOI":"10.3390\/ijms21218142","article-title":"Age-dependent and sleep\/seizure-induced pathomechanisms of autosomal dominant sleep-related hypermotor epilepsy","volume":"21","author":"Fukuyama","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2023.106698_bib157","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1111\/bph.14974","article-title":"Pathogenesis and pathophysiology of autosomal dominant sleep-related hypermotor epilepsy with S284L-mutant \u03b14 subunit of nicotinic ACh receptor","volume":"177","author":"Fukuyama","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2023.106698_bib158","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110070","article-title":"Pathomechanism of nocturnal paroxysmal dystonia in autosomal dominant sleep-related hypermotor epilepsy with S284L-mutant \u03b14 subunit of nicotinic ACh receptor","volume":"126","author":"Fukuyama","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phrs.2023.106698_bib159","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1093\/cercor\/bhp214","article-title":"Tonic modulation of GABA release by nicotinic acetylcholine receptors, in layer V of the murine prefrontal cortex","volume":"20","author":"Aracri","year":"2010","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.phrs.2023.106698_bib160","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/syn.21655","article-title":"Regulation of glutamate release by heteromeric nicotinic receptors in layer V of the secondary motor region (Fr2) in the dorsomedial shoulder of prefrontal cortex in mouse","volume":"67","author":"Aracri","year":"2013","journal-title":"Synapse"},{"key":"10.1016\/j.phrs.2023.106698_bib161","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/mp.2010.78","article-title":"Altered activity-rest patterns in mice with a human autosomal-dominant nocturnal frontal lobe epilepsy mutation in the \u03b22 nicotinic receptor","author":"Xu","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.phrs.2023.106698_bib162","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.pbb.2012.10.014","article-title":"Mice expressing the ADNFLE valine 287 leucine mutation of the \u03b22 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function","volume":"103","author":"O'Neill","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phrs.2023.106698_bib163","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neures.2015.06.003","article-title":"Spontaneous epileptic seizures in transgenic rats harboring a human ADNFLE missense mutation in the \u03b22-subunit of the nicotinic acetylcholine receptor","volume":"100","author":"Shiba","year":"2015","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.phrs.2023.106698_bib164","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1093\/hmg\/ddp004","article-title":"Expression of mutant \u03b22 nicotinic receptors during development is crucial for epileptogenesis","volume":"18","author":"Manfredi","year":"2009","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.phrs.2023.106698_bib165","article-title":"The \u03b22V287L nicotinic subunit linked to sleep-related epilepsy differently affects fast-spiking and regular spiking somatostatin-expressing neurons in murine prefrontal cortex","volume":"421","author":"Meneghini","year":"2022","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.phrs.2023.106698_bib166","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/nn.4315","article-title":"An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior","volume":"19","author":"Jung","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib167","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1212\/WNL.58.5.723","article-title":"Clinical, EEG, and quantitative MRI differences in pediatric frontal and temporal lobe epilepsy","volume":"58","author":"Lawson","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.phrs.2023.106698_bib168","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1111\/j.1528-1167.2011.03085.x","article-title":"Widespread cortical thinning in children with frontal lobe epilepsy","volume":"52","author":"Widjaja","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.phrs.2023.106698_bib169","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s10072-019-04135-4","article-title":"Evaluation of cortical thickness and brain volume on 3 Tesla magnetic resonance imaging in children with frontal lobe epilepsy","volume":"41","author":"Rahatli","year":"2020","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.phrs.2023.106698_bib170","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neuroscience.2016.10.045","article-title":"\u03b14\u03b22* nicotinic receptors stimulate GABA release onto fast-spiking cells in layer V of mouse prefrontal (Fr2) cortex","volume":"340","author":"Aracri","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2023.106698_bib171","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.neubiorev.2014.05.012","article-title":"The role of nicotinic receptors in shaping and functioning of the glutamatergic system: a window into cognitive pathology","volume":"46","author":"Molas","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.phrs.2023.106698_bib172","doi-asserted-by":"crossref","first-page":"11567","DOI":"10.1073\/pnas.1006269107","article-title":"Alterations of cortical pyramidal neurons in mice lacking high-affinity nicotinic receptors","volume":"107","author":"Ballesteros-Y\u00e1\u00f1ez","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.phrs.2023.106698_bib173","doi-asserted-by":"crossref","first-page":"8391","DOI":"10.1523\/JNEUROSCI.6247-11.2012","article-title":"Induction of dendritic spines by \u03b22-containing nicotinic receptors","volume":"32","author":"Lozada","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib174","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.biopsych.2011.09.011","article-title":"Nicotinic \u03b15 subunits drive developmental changes in the activation and morphology of prefrontal cortex layer VI neurons","volume":"71","author":"Bailey","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2023.106698_bib175","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1038\/nature08928","article-title":"Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling","volume":"464","author":"Fazzari","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2023.106698_bib176","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1523\/JNEUROSCI.2538-10.2011","article-title":"Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons","volume":"31","author":"Ting","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib177","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201798858","article-title":"Neuregulin 3 promotes excitatory synapse formation on hippocampal interneurons","volume":"37","author":"M\u00fcller","year":"2018","journal-title":"EMBO J."},{"key":"10.1016\/j.phrs.2023.106698_bib178","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1038\/npp.2017.278","article-title":"Neuregulin 3 signaling mediates nicotine-dependent synaptic plasticity in the orbitofrontal cortex and cognition","volume":"43","author":"Zhou","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2023.106698_bib179","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0166-2236(91)90003-D","article-title":"GABA: an excitatory transmitter in early postnatal life","volume":"14","author":"Cherubini","year":"1991","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib180","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.neures.2010.02.010","article-title":"Developmental localization of potassium chloride co-transporter 2 (KCC2), GABA and vesicular GABA transporter (VGAT) in the postnatal mouse somatosensory cortex","volume":"67","author":"Takayama","year":"2010","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.phrs.2023.106698_bib181","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/16697","article-title":"The K+\/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation","volume":"397","author":"Rivera","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2023.106698_bib182","first-page":"4574","article-title":"Developmental expression patterns of KCC2 and functionally associated molecules in the human brain","volume":"26","author":"Sedmak","year":"2016"},{"issue":"19","key":"10.1016\/j.phrs.2023.106698_bib183","doi-asserted-by":"crossref","first-page":"4099","DOI":"10.1113\/jphysiol.2014.275529","article-title":"Novel determinants of the neuronal Cl- concentration","volume":"592","author":"Delpire","year":"2014","journal-title":"J. Physiol."},{"key":"10.1016\/j.phrs.2023.106698_bib184","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.3390\/cells9122607","article-title":"NKCC1, an elusive molecular target in brain development: making sense of the existing data","volume":"9","author":"Virtanen","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.phrs.2023.106698_bib185","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neuroscience.2018.06.030","article-title":"Postnatal changes in K+\/Cl- cotransporter-2 expression in the forebrain of mice bearing a mutant nicotinic subunit linked to sleep-related epilepsy","volume":"386","author":"Amadeo","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2023.106698_bib186","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1152\/physrev.00025.2021","article-title":"Chloride transporters controlling neuronal excitability","volume":"103","author":"Pressey","year":"2023","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phrs.2023.106698_bib187","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.eplepsyres.2013.08.018","article-title":"A novel prophylactic effect of furosemide treatment on autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE)","volume":"107","author":"Yamada","year":"2013","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.phrs.2023.106698_bib188","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.sleep.2011.11.007","article-title":"Physiologic autonomic arousal heralds motor manifestations of seizures in nocturnal frontal lobe epilepsy: Implications for pathophysiology","volume":"13","author":"Calandra-Buonaura","year":"2012","journal-title":"Sleep. Med"},{"key":"10.1016\/j.phrs.2023.106698_bib189","first-page":"805","article-title":"Sleep spindles: Mechanisms and functions","volume":"100","author":"Fernandez","year":"2020"},{"key":"10.1016\/j.phrs.2023.106698_bib190","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.clinph.2006.12.014","article-title":"Intracerebral recordings of nocturnal hyperkinetic seizures: demonstration of a longer duration of the pre-seizure sleep spindle","volume":"18","author":"Picard","year":"2007","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.phrs.2023.106698_bib191","doi-asserted-by":"crossref","DOI":"10.1111\/jsr.12800","article-title":"Nicotine increases sleep spindle activity","volume":"28","author":"O'Reilly","year":"2019","journal-title":"J. Sleep. Res."},{"key":"10.1016\/j.phrs.2023.106698_bib192","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1093\/brain\/awl156","article-title":"Alteration of the in vivo nicotinic receptor density in ADNFLE patients: a PET study","volume":"129","author":"Picard","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.phrs.2023.106698_bib193","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1523\/JNEUROSCI.3177-12.2013","article-title":"Biphasic cholinergic synaptic transmission controls action potential activity in thalamic reticular nucleus neurons","volume":"33","author":"Sun","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib194","series-title":"Epilepsy. A Comprehensive Textbook","first-page":"541","article-title":"Limbic seizures","author":"Engel","year":"2008"},{"key":"10.1016\/j.phrs.2023.106698_bib195","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1528-1167.2007.01304.x","article-title":"Development of spontaneous seizures after experimental status epilepticus: implications for understanding epileptogenesis","volume":"48","author":"Williams","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.phrs.2023.106698_bib196","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0166-4328(83)90136-5","article-title":"Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study","volume":"9","author":"Turski","year":"1983","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.phrs.2023.106698_bib197","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/0006-8993(79)90163-X","article-title":"A new model of focal status epilepticus: intra-amygdaloid application of kainic acid elicits repetitive secondarily generalized convulsive seizures","volume":"163","author":"Ben-Ari","year":"1979","journal-title":"Brain Res."},{"key":"10.1016\/j.phrs.2023.106698_bib198","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0306-4522(80)90049-4","article-title":"Injections of kainic acid into the amygdaloid complex of the rat: an electrographic, clinical and histological study in relation to the pathology of epilepsy","volume":"5","author":"Ben-Ari","year":"1980","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2023.106698_bib199","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/0306-4522(81)90193-7","article-title":"Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline or pentetrazole: metabolic mapping using the deoxyglucose method with special reference to the pathology of epilepsy","volume":"6","author":"Ben-Ari","year":"1981","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2023.106698_bib200","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0006-8993(84)90177-X","article-title":"Seizures produced by pilocarpine in mice: a behavioral, electroencephalographic and morphological analysis","volume":"321","author":"Turski","year":"1984","journal-title":"Brain Res."},{"key":"10.1016\/j.phrs.2023.106698_bib201","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0006-8993(86)91247-3","article-title":"Seizures produced by pilocarpine: neuropathological sequelae and activity of glutamate decarboxylase in the rat forebrain","volume":"398","author":"Turski","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.phrs.2023.106698_bib202","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s12640-020-00198-w","article-title":"Effects of prolonged seizures on basal forebrain cholinergic neurons: evidence and potential clinical relevance","volume":"38","author":"Giorgi","year":"2020","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.phrs.2023.106698_bib203","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.neuroscience.2006.06.057","article-title":"Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures","volume":"142","author":"Garrido Sanabria","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2023.106698_bib204","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1002\/cne.24235","article-title":"Reorganization of the septohippocampal cholinergic fiber system in experimental epilepsy","volume":"525","author":"Soares","year":"2017","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.phrs.2023.106698_bib205","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.nbd.2018.09.019","article-title":"Degeneration of cholinergic basal forebrain nuclei after focally evoked status epilepticus","volume":"121","author":"Biagioni","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.phrs.2023.106698_bib206","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/0306-4522(84)90289-6","article-title":"Maturation of kainic acid seizure-brain damage syndrome in the rat. II. Histopathological sequela","volume":"13","author":"Nitecka","year":"1984","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2023.106698_bib207","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.656752","article-title":"Nicotinic acetylcholine receptor \u03b17 subunit is an essential regulator of seizure susceptibility","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Neurol."},{"key":"10.1016\/j.phrs.2023.106698_bib208","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.biopsych.2019.11.014","article-title":"Direct septum-hippocampus cholinergic circuit attenuates seizure through driving somatostatin inhibition","volume":"87","author":"Wang","year":"2020","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2023.106698_bib209","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0014-2999(03)01542-5","article-title":"Are neuronal nicotinic receptors a target for antiepileptic drug development? Studies in different seizure models in mice and rats","volume":"466","author":"L\u00f6scher","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2023.106698_bib210","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.yebeh.2012.07.004","article-title":"The effect of dorsal hippocampal administration of nicotinic and muscarinic cholinergic ligands on pentylenetetrazol-induced generalized seizures in rat","volume":"25","author":"Gholami","year":"2012","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.phrs.2023.106698_bib211","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2019.106862","article-title":"Exploring the ameliorative role of \u03b17 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice","volume":"103","author":"Sharma","year":"2020","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.phrs.2023.106698_bib212","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1111\/j.1528-1157.1999.tb00848.x","article-title":"Mutated nicotinic receptors responsible for autosomal dominant nocturnal frontal lobe epilepsy are more sensitive to carbamazepine","volume":"40","author":"Picard","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.phrs.2023.106698_bib213","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ejphar.2010.05.063","article-title":"Effect of carbamazepine and oxcarbazepine on wild type and mutant neuronal nicotinic receptors linked to nocturnal frontal lobe epilepsy","volume":"643","author":"Di Resta","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2023.106698_bib214","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1124\/jpet.110.171108","article-title":"The anticonvulsive drug lamotrigine blocks neuronal \u03b14\u03b22 nicotinic acetylcholine receptors","volume":"335","author":"Zheng","year":"2010","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/j.phrs.2023.106698_bib215","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1046\/j.1528-1157.2003.58102.x-i1","article-title":"Nicotine as anti-epileptic agent in ADNFLE: An N-of-one study","volume":"44","author":"Willoughby","year":"2003","journal-title":"Epilepsia"},{"key":"10.1016\/j.phrs.2023.106698_bib216","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2020.106944","article-title":"Remarkable effect of transdermal nicotine in children with CHRNA4-related autosomal dominant sleep-related hypermotor epilepsy","volume":"105","author":"Lossius","year":"2020","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.phrs.2023.106698_bib217","article-title":"Precision treatment with nicotine in autosomal dominant sleep-related hypermotor epilepsy (ADSHE): an observational study of clinical outcome and serum cotinine levels in 17 patients","volume":"178","author":"Brodtkorb","year":"2021","journal-title":"Epilepsy\u00a0Res."},{"key":"10.1016\/j.phrs.2023.106698_bib218","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1177\/0883073820974851","article-title":"Nicotine: a targeted therapy for epilepsy due to nAChR gene variants","volume":"36","author":"Fox","year":"2021","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.phrs.2023.106698_bib219","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1111\/epi.17332","article-title":"Precision medicine for genetic epilepsy on the horizon: Recent advances, present challenges, and suggestions for continued progress","volume":"63","author":"Knowles","year":"2022","journal-title":"Epilepsia"},{"key":"10.1016\/j.phrs.2023.106698_bib220","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.celrep.2017.04.008","article-title":"NACHO mediates nicotinic acetylcholine receptor function throughout the brain","volume":"19","author":"Matta","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.phrs.2023.106698_bib221","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/j.1471-4159.2006.03915.x","article-title":"Chaperone protein 14-3-3 and protein kinase A increase the relative abundance of low agonist sensitivity human \u03b14\u03b22 nicotinic acetylcholine receptors in Xenopus oocytes","volume":"98","author":"Exley","year":"2006","journal-title":"J. Neurochem"},{"key":"10.1016\/j.phrs.2023.106698_bib222","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1007\/s00018-020-03592-x","article-title":"NACHO and 14-3-3 promote expression of distinct subunit stoichiometries of the \u03b14\u03b22 acetylcholine receptor","volume":"78","author":"Mazzaferro","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.phrs.2023.106698_bib223","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.stemcr.2021.11.009","article-title":"A functional hiPSC-cortical neuron differentiation and maturation model and its application to neurological disorders","volume":"17","author":"Autar","year":"2022","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.phrs.2023.106698_bib224","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.clinthera.2020.05.016","article-title":"Review of transcranial magnetic stimulation in epilepsy","volume":"42","author":"Tsuboyama","year":"2020","journal-title":"Clin. Ther."},{"key":"10.1016\/j.phrs.2023.106698_bib225","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.4103\/1673-5374.235251","article-title":"Effects of repetitive transcranial magnetic stimulation on cognitive function and cholinergic activity in the rat hippocampus after vascular dementia","volume":"13","author":"Zhang","year":"2018","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.phrs.2023.106698_bib226","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000330016","article-title":"A review of transcranial magnetic stimulation in the in vivo functional evaluation of central cholinergic circuits in dementia","volume":"32","author":"Nardone","year":"2011","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.phrs.2023.106698_bib227","doi-asserted-by":"crossref","first-page":"9165","DOI":"10.1523\/JNEUROSCI.17-23-09165.1997","article-title":"Mice deficient in the \u03b17 neuronal nicotinic acetylcholine receptor lack \u03b1-bungarotoxin binding sites and hippocampal fast nicotinic currents","volume":"17","author":"Orr-Urtreger","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2023.106698_bib228","doi-asserted-by":"crossref","first-page":"39941","DOI":"10.1038\/srep39941","article-title":"Chrna7 deficient mice manifest no consistent neuropsychiatric and behavioral phenotypes","volume":"7","author":"Yin","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2023.106698_bib229","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/ng.292","article-title":"15q13.3 microdeletions increase risk of idiopathic generalized epilepsy","volume":"41","author":"Helbig","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.phrs.2023.106698_bib230","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/ng.93","article-title":"A recurrent 15q13.3 microdeletion syndrome associated with mental retardation and seizures","volume":"40","author":"Sharp","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.phrs.2023.106698_bib231","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/ng.481","article-title":"A small recurrent deletion within 15q13.3 is associated with a range of neurodevelopmental phenotypes","volume":"41","author":"Shinawi","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.phrs.2023.106698_bib232","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.biopsych.2013.08.014","article-title":"A mouse model that recapitulates cardinal features of the 15q13.3 microdeletion syndrome including schizophrenia- and epilepsy-related alterations","volume":"76","author":"Fejgin","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2023.106698_bib233","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125116","article-title":"Pharmacological characterisation of nicotinic acetylcholine receptors expressed in human iPSC-derived neurons","volume":"10","author":"Chatzidaki","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2023.106698_bib234","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3389\/fncir.2014.00087","article-title":"Multi-electrode array study of neuronal cultures expressing nicotinic \u03b22-V287L subunits, linked to autosomal dominant nocturnal frontal lobe epilepsy. An in vitro model of spontaneous epilepsy","volume":"8","author":"Gullo","year":"2014","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.phrs.2023.106698_bib235","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-030-11135-9_1","article-title":"Past, present, and future of neuronal models in vitro","volume":"22","author":"Keller","year":"2019","journal-title":"Adv. Neurobiol."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661823000543?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661823000543?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T21:35:17Z","timestamp":1733866517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661823000543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":235,"alternative-id":["S1043661823000543"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2023.106698","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nicotinic acetylcholine receptors and epilepsy","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2023.106698","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106698"}}