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Sci."},{"key":"10.1016\/j.phrs.2023.106741_bib87","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/fnana.2011.00041","article-title":"The striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neurons","volume":"5","author":"Lobo","year":"2011","journal-title":"Front Neuroanat."},{"issue":"7","key":"10.1016\/j.phrs.2023.106741_bib88","doi-asserted-by":"crossref","first-page":"583","DOI":"10.4161\/epi.5.7.12762","article-title":"Maternal cigarette smoking during pregnancy is associated with downregulation of miR-16, miR-21, and miR-146a in the placenta","volume":"5","author":"Maccani","year":"2010","journal-title":"Epigenetics"},{"issue":"4","key":"10.1016\/j.phrs.2023.106741_bib89","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/ADM.0000000000000128","article-title":"Knowledge, attitudes, and practice of electronic cigarette use among pregnant women","volume":"9","author":"Mark","year":"2015","journal-title":"J. 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Natl. Acad. Sci. U. S. A."},{"issue":"42","key":"10.1016\/j.phrs.2023.106741_bib126","doi-asserted-by":"crossref","first-page":"16356","DOI":"10.1073\/pnas.0808699105","article-title":"Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons","volume":"105","author":"Satta","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.phrs.2023.106741_bib127","doi-asserted-by":"crossref","first-page":"16022","DOI":"10.1038\/s41598-020-72783-0","article-title":"Sperm DNA methylation altered by THC and nicotine: Vulnerability of neurodevelopmental genes with bivalent chromatin","volume":"10","author":"Schrott","year":"2020","journal-title":"Sci. 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U.S. Department of Health and Human Services, Public Health Service, Office of the Surgeon General."},{"issue":"12","key":"10.1016\/j.phrs.2023.106741_bib148","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0144287","article-title":"Poly(ADP-ribosyl)ation affects histone acetylation and transcription","volume":"10","author":"Verdone","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2023.106741_bib149","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.cotox.2017.02.004","article-title":"The aryl hydrocarbon receptor repressor - more than a simple feedback inhibitor of AhR signaling: clues for its role in inflammation and cancer","volume":"2","author":"Vogel","year":"2017","journal-title":"Curr. Opin. Toxicol."},{"issue":"7672","key":"10.1016\/j.phrs.2023.106741_bib150","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nature24029","article-title":"The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation","volume":"549","author":"Wallrapp","year":"2017","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.phrs.2023.106741_bib151","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.taap.2011.09.016","article-title":"Nicotine induced CpG methylation of Pax6 binding motif in StAR promoter reduces the gene expression and cortisol production","volume":"257","author":"Wang","year":"2011","journal-title":"Toxicol. Appl. Pharm."},{"issue":"1","key":"10.1016\/j.phrs.2023.106741_bib152","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22010387","article-title":"How the AHR became important in cancer: the role of chronically active AHR in cancer aggression","volume":"22","author":"Wang","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.phrs.2023.106741_bib153","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.3389\/fimmu.2020.01474","article-title":"Nicotine changes the microRNA profile to regulate the FOXO memory program of CD8(+) T cells in rheumatoid arthritis","volume":"11","author":"Was\u00e9n","year":"2020","journal-title":"Front Immunol."},{"issue":"1\u20132","key":"10.1016\/j.phrs.2023.106741_bib154","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0376-8716(98)00072-6","article-title":"Neuroadaptations involved in amphetamine and cocaine addiction","volume":"51","author":"White","year":"1998","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.phrs.2023.106741_bib155","unstructured":"WHO. (2017). Tobacco and its environmental impact: an overview."},{"key":"10.1016\/j.phrs.2023.106741_bib156","unstructured":"WHO. (2022). Tobacco. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/tobacco#:\u223c:text=Tobacco%20kills%20more%20than%208,%2D%20and%20middle%2Dincome%20countries."},{"key":"10.1016\/j.phrs.2023.106741_bib157","doi-asserted-by":"crossref","first-page":"636","DOI":"10.2741\/2708","article-title":"Long-term consequences of maternal smoking and developmental chronic nicotine exposure","volume":"13","author":"Winzer-Serhan","year":"2008","journal-title":"Front Biosci."},{"issue":"5","key":"10.1016\/j.phrs.2023.106741_bib158","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1165\/rcmb.2011-0028OC","article-title":"Prenatal nicotine exposure alters lung function and airway geometry through alpha7 nicotinic receptors","volume":"46","author":"Wongtrakool","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.phrs.2023.106741_bib159","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tox.2016.01.002","article-title":"DNA hypermethylation of acetoacetyl-CoA synthetase contributes to inhibited cholesterol supply and steroidogenesis in fetal rat adrenals under prenatal nicotine exposure","volume":"340","author":"Wu","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.phrs.2023.106741_bib160","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fpsyt.2010.00016","article-title":"Determination of methylated CpG sites in the promoter region of catechol-O-methyltransferase (COMT) and their Involvement in the etiology of tobacco smoking","volume":"1","author":"Xu","year":"2010","journal-title":"Front Psychiatry"},{"issue":"1","key":"10.1016\/j.phrs.2023.106741_bib161","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.tibs.2013.10.002","article-title":"Long noncoding RNAs: fresh perspectives into the RNA world","volume":"39","author":"Yang","year":"2014","journal-title":"Trends Biochem Sci."},{"issue":"6","key":"10.1016\/j.phrs.2023.106741_bib162","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s00439-011-1102-x","article-title":"Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence","volume":"131","author":"Yoon","year":"2012","journal-title":"Hum. 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