{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:41:51Z","timestamp":1792788111032,"version":"4.5.0"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018525","name":"Key Research and Development Program of Sichuan Province","doi-asserted-by":"publisher","award":["2022YFS0434"],"award-info":[{"award-number":["2022YFS0434"]}],"id":[{"id":"10.13039\/501100018525","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.phrs.2023.106807","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T12:38:16Z","timestamp":1685018296000},"page":"106807","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"special_numbering":"C","title":["Gut mycobiome and metabolic diseases: The known, the unknown, and the future"],"prefix":"10.1016","volume":"193","author":[{"given":"Lijie","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiao","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2023.106807_bib2","first-page":"13","article-title":"Health effects of overweight and obesity in 195 countries over 25 years","volume":"377","author":"Collaborators","year":"2017"},{"issue":"5","key":"10.1016\/j.phrs.2023.106807_bib3","first-page":"389","article-title":"Prevalence, incidence, and outcome of non-alcoholic fatty liver disease in Asia, 1999-2019: a systematic review and meta-analysis","volume":"4","author":"Li","year":"2019","journal-title":"Lancet Gastroenterol."},{"issue":"1","key":"10.1016\/j.phrs.2023.106807_bib4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","article-title":"Gut microbiota in human metabolic health and disease","volume":"19","author":"Fan","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.phrs.2023.106807_bib5","doi-asserted-by":"crossref","unstructured":"M. Chi, K. Ma, J. Wang, Z. Ding, Y. Li, S. Zhu, X. Liang, Q. Zhang, L. Song, C. Liu, The immunomodulatory effect of the gut microbiota in kidney disease, J. Immunol. Res. 2021 (2021) 5516035, https:\/\/doi.org\/10.1155\/2021\/5516035.","DOI":"10.1155\/2021\/5516035"},{"key":"10.1016\/j.phrs.2023.106807_bib6","first-page":"26191","article-title":"Dysbiosis of the gut microbiota in disease","volume":"26","author":"Carding","year":"2015","journal-title":"Microb. Ecol. Health Dis."},{"issue":"6","key":"10.1016\/j.phrs.2023.106807_bib7","first-page":"331","article-title":"The gut mycobiota: insights into analysis, environmental interactions and role in gastrointestinal diseases","volume":"16","author":"Richard","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"7","key":"10.1016\/j.phrs.2023.106807_bib8","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.tim.2013.04.002","article-title":"The emerging world of the fungal microbiome","volume":"21","author":"Huffnagle","year":"2013","journal-title":"Trends Microbiol"},{"issue":"12","key":"10.1016\/j.phrs.2023.106807_bib9","doi-asserted-by":"crossref","first-page":"e969","DOI":"10.1016\/S2666-5247(22)00203-8","article-title":"The gut mycobiome in health, disease, and clinical applications in association with the gut bacterial microbiome assembly","volume":"3","author":"Zhang","year":"2022","journal-title":"Lancet Microbe"},{"key":"10.1016\/j.phrs.2023.106807_bib10","doi-asserted-by":"crossref","DOI":"10.1177\/17562848211047130","article-title":"The role of gut mycobiome in health and diseases","volume":"14","author":"Zhang","year":"2021","journal-title":"Ther. Adv. Gastroenterol."},{"issue":"1","key":"10.1016\/j.phrs.2023.106807_bib11","doi-asserted-by":"crossref","first-page":"2121576","DOI":"10.1080\/19490976.2022.2121576","article-title":"Host-mycobiome metabolic interactions in health and disease","volume":"14","author":"Begum","year":"2022","journal-title":"Gut Microbes"},{"issue":"4","key":"10.1016\/j.phrs.2023.106807_bib12","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/femsre\/fuw047","article-title":"Forgotten fungi-the gut mycobiome in human health and disease","volume":"41","author":"Huseyin","year":"2017","journal-title":"FEMS Microbiol. Rev."},{"issue":"1","key":"10.1016\/j.phrs.2023.106807_bib13","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1053\/j.gastro.2020.09.014","article-title":"Population-level configurations of gut mycobiome across 6 ethnicities in urban and rural China","volume":"160","author":"Sun","year":"2021","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.phrs.2023.106807_bib14","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1038\/s42003-021-02753-3","article-title":"The gut commensal fungus, Candida parapsilosis, promotes high fat-diet induced obesity in mice","volume":"4","author":"Sun","year":"2021","journal-title":"Commun. Biol."},{"issue":"1","key":"10.1016\/j.phrs.2023.106807_bib15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s42003-021-01820-z","article-title":"The gut mycobiome of healthy mice is shaped by the environment and correlates with metabolic outcomes in response to diet","volume":"4","author":"Mims","year":"2021","journal-title":"Commun. Biol."},{"issue":"2","key":"10.1016\/j.phrs.2023.106807_bib16","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00986-22","article-title":"Host factors associated with gut mycobiome structure","volume":"8","author":"Sz\u00f3stak","year":"2023","journal-title":"mSystems"},{"issue":"4","key":"10.1016\/j.phrs.2023.106807_bib17","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/00362178585380391","article-title":"Effect of various antibiotics on gastrointestinal colonization and dissemination by Candida albicans","volume":"23","author":"Kennedy","year":"1985","journal-title":"Sabouraudia"},{"key":"10.1016\/j.phrs.2023.106807_bib18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3389\/fnagi.2018.00159","article-title":"Infection of fungi and bacteria in brain tissue from elderly persons and patients with Alzheimer\u2019s disease","volume":"10","author":"Alonso","year":"2018","journal-title":"Front. Aging Neurosci."},{"issue":"9","key":"10.1016\/j.phrs.2023.106807_bib19","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1136\/gutjnl-2021-326298","article-title":"Mapping the human gut mycobiome in middle-aged and elderly adults: multiomics insights and implications for host metabolic health","volume":"71","author":"Shuai","year":"2022","journal-title":"Gut"},{"issue":"12","key":"10.1016\/j.phrs.2023.106807_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0243077","article-title":"Gut mycobiomes are altered in people with type 2 diabetes mellitus and diabetic retinopathy","volume":"15","author":"Jayasudha","year":"2020","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.phrs.2023.106807_bib21","doi-asserted-by":"crossref","first-page":"9624","DOI":"10.1038\/s41598-020-66598-2","article-title":"Revealing links between gut microbiome and its fungal community in type 2 diabetes mellitus among Emirati subjects: a pilot study","volume":"10","author":"Al Bataineh","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2023.106807_bib22","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3389\/fmicb.2017.00214","article-title":"Gut microbial diversity assessment of Indian type-2-diabetics reveals alterations in eubacteria, archaea, and eukaryotes","volume":"8","author":"Bhute","year":"2017","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.phrs.2023.106807_bib23","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13099-014-0043-z","article-title":"Quantitative evaluation of fungi of the genus Candida in the feces of adult patients with type 1 and 2 diabetes-a pilot study","volume":"6","author":"Gosiewski","year":"2014","journal-title":"Gut Pathog."},{"key":"10.1016\/j.phrs.2023.106807_bib24","doi-asserted-by":"crossref","first-page":"14600","DOI":"10.1038\/srep14600","article-title":"Obesity changes the human gut mycobiome","volume":"5","author":"Mar Rodriguez","year":"2015","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.phrs.2023.106807_bib25","doi-asserted-by":"crossref","first-page":"e00351","DOI":"10.1128\/mSphere.00351-17","article-title":"High-fat diet changes fungal microbiomes and interkingdom relationships in the murine gut","volume":"2","author":"Heisel","year":"2017","journal-title":"mSphere"},{"issue":"4","key":"10.1016\/j.phrs.2023.106807_bib26","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/jhn.12864","article-title":"The intestinal mycobiota and its relationship with overweight, obesity and nutritional aspects","volume":"34","author":"Garcia-Gamboa","year":"2021","journal-title":"J. Hum. Nutr. Diet."},{"issue":"2","key":"10.1016\/j.phrs.2023.106807_bib27","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/oby.23073","article-title":"Fecal fungi dysbiosis in nonalcoholic fatty liver disease","volume":"29","author":"You","year":"2021","journal-title":"Obes. (Silver Spring)"},{"issue":"4","key":"10.1016\/j.phrs.2023.106807_bib28","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.jhep.2021.11.029","article-title":"The fecal mycobiome in non-alcoholic fatty liver disease","volume":"76","author":"Demir","year":"2022","journal-title":"J. Hepatol."},{"issue":"10","key":"10.1016\/j.phrs.2023.106807_bib29","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/nri.2017.55","article-title":"Fungal dysbiosis: immunity and interactions at mucosal barriers","volume":"17","author":"Iliev","year":"2017","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.phrs.2023.106807_bib30","article-title":"Gut mycobiome: a promising target for colorectal cancer","volume":"1875","author":"Qin","year":"2021","journal-title":"Bba-Rev. Cancer"},{"issue":"8","key":"10.1016\/j.phrs.2023.106807_bib31","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/bies.20441","article-title":"The structure and synthesis of the fungal cell wall","volume":"28","author":"Bowman","year":"2006","journal-title":"Bioessays"},{"key":"10.1016\/j.phrs.2023.106807_bib32","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.semcdb.2018.03.003","article-title":"Pattern recognition receptors in fungal immunity","volume":"89","author":"Patin","year":"2019","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.phrs.2023.106807_bib33","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.mib.2017.11.004","article-title":"C-type lectin receptors in anti-fungal immunity","volume":"40","author":"Shiokawa","year":"2017","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.phrs.2023.106807_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2020.591970","article-title":"Intracellular PRRs activation in targeting the immune response against fungal infections","volume":"10","author":"Jannuzzi","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"6","key":"10.1016\/j.phrs.2023.106807_bib35","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/ni.3155","article-title":"Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses","volume":"16","author":"Deng","year":"2015","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.phrs.2023.106807_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001259","article-title":"Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2","volume":"7","author":"Gringhuis","year":"2011","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.phrs.2023.106807_bib37","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1086\/375784","article-title":"Candida albicans phospholipomannan is sensed through toll-like receptors","volume":"188","author":"Jouault","year":"2003","journal-title":"JID"},{"issue":"10","key":"10.1016\/j.phrs.2023.106807_bib38","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1093\/infdis\/jix469","article-title":"Aspergillus fumigatus cell wall \u03b1-(1,3)-glucan stimulates regulatory T-cell polarization by inducing PD-L1 expression on human dendritic cells","volume":"216","author":"Stephen-Victor","year":"2017","journal-title":"JID"},{"issue":"6","key":"10.1016\/j.phrs.2023.106807_bib39","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1172\/JCI27114","article-title":"Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and toll-like receptors","volume":"116","author":"Netea","year":"2006","journal-title":"J. Clin. Invest"},{"issue":"42","key":"10.1016\/j.phrs.2023.106807_bib40","doi-asserted-by":"crossref","first-page":"39320","DOI":"10.1074\/jbc.M201683200","article-title":"Toll-like receptor (TLR) signaling in response to Aspergillus fumigatus","volume":"277","author":"Mambula","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.phrs.2023.106807_bib41","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1002\/eji.201141490","article-title":"Recognition of yeast nucleic acids triggers a host-protective type I interferon response","volume":"41","author":"Biondo","year":"2011","journal-title":"Eur. J. Immunol."},{"issue":"5","key":"10.1016\/j.phrs.2023.106807_bib42","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1128\/IAI.00047-08","article-title":"Toll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNA","volume":"76","author":"Ramirez-Ortiz","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.phrs.2023.106807_bib43","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3389\/fimmu.2014.00461","article-title":"Toll-like receptor signaling pathways","volume":"5","author":"Kawasaki","year":"2014","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.phrs.2023.106807_bib44","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"issue":"7839","key":"10.1016\/j.phrs.2023.106807_bib45","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41586-020-2996-z","article-title":"Galactosaminogalactan activates the inflammasome to provide host protection","volume":"588","author":"Briard","year":"2020","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.phrs.2023.106807_bib46","doi-asserted-by":"crossref","first-page":"e00351","DOI":"10.4049\/jimmunol.0901323","article-title":"Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome","volume":"183","author":"Joly","year":"2009","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.phrs.2023.106807_bib47","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.cmet.2010.11.011","article-title":"The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity","volume":"12","author":"Stienstra","year":"2010","journal-title":"Cell Metab."},{"issue":"7384","key":"10.1016\/j.phrs.2023.106807_bib48","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10809","article-title":"Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity","volume":"482","author":"Henao-Mejia","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2023.106807_bib49","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.exer.2014.07.025","article-title":"Aspergillus fumigatus triggers innate immune response via NOD1 signaling in human corneal epithelial cells","volume":"127","author":"Zhang","year":"2014","journal-title":"Exp. Eye. Res."},{"issue":"6","key":"10.1016\/j.phrs.2023.106807_bib50","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s00011-012-0456-4","article-title":"Role of NOD2 in regulating the immune response to Aspergillus fumigatus","volume":"61","author":"Li","year":"2012","journal-title":"Inflamm. Res."},{"issue":"2","key":"10.1016\/j.phrs.2023.106807_bib51","first-page":"70","article-title":"Fungal-bacterial interactions in health and disease","volume":"8","author":"Kruger","year":"2019","journal-title":"Pathogenetics"},{"issue":"11","key":"10.1016\/j.phrs.2023.106807_bib52","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.dld.2017.08.025","article-title":"The mycobiome: role in health and disease, and as a potential probiotic target in gastrointestinal disease","volume":"49","author":"Hager","year":"2017","journal-title":"Dig. Liver Dis."},{"issue":"7597","key":"10.1016\/j.phrs.2023.106807_bib53","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature17625","article-title":"Candidalysin is a fungal peptide toxin critical for mucosal infection","volume":"532","author":"Moyes","year":"2016","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.phrs.2023.106807_bib54","doi-asserted-by":"crossref","first-page":"e02221","DOI":"10.1128\/mBio.02221-18","article-title":"Candidalysin crucially contributes to nlrp3 Inflammasome activation by Candida albicans hyphae","volume":"10","author":"Rogiers","year":"2019","journal-title":"mBio"},{"issue":"3","key":"10.1016\/j.phrs.2023.106807_bib55","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jhep.2019.09.029","article-title":"The Candida albicans exotoxin candidalysin promotes alcohol-associated liver disease","volume":"72","author":"Chu","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phrs.2023.106807_bib56","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3389\/fcimb.2019.00359","article-title":"Fungal symbionts produce prostaglandin E2 to promote their intestinal colonization","volume":"9","author":"Tan","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.phrs.2023.106807_bib57","doi-asserted-by":"crossref","first-page":"1830693","DOI":"10.1080\/19490976.2020.1830693","article-title":"Therapeutic manipulation of gut microbiota by polysaccharides of Wolfiporia cocos reveals the contribution of the gut fungi-induced PGE2 to alcoholic hepatic steatosis","volume":"12","author":"Sun","year":"2020","journal-title":"Gut Microbes"},{"issue":"3","key":"10.1016\/j.phrs.2023.106807_bib58","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/hep.23064","article-title":"Aggravation by prostaglandin E2 of interleukin-6-dependent insulin resistance in hepatocytes","volume":"50","author":"Henkel","year":"2009","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.phrs.2023.106807_bib59","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1038\/labinvest.2012.128","article-title":"Stimulation of fat accumulation in hepatocytes by PGE(2)-dependent repression of hepatic lipolysis, beta-oxidation and VLDL-synthesis","volume":"92","author":"Henkel","year":"2012","journal-title":"Lab. Invest."},{"issue":"8","key":"10.1016\/j.phrs.2023.106807_bib60","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1507\/endocrj.EJ19-0015","article-title":"Opposing effects of IL-1beta\/COX-2\/PGE2 pathway loop on islets in type 2 diabetes mellitus","volume":"66","author":"Wang","year":"2019","journal-title":"Endocr. J."},{"issue":"4","key":"10.1016\/j.phrs.2023.106807_bib61","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1124\/mol.117.108829","article-title":"Altenusin, a nonsteroidal microbial metabolite, attenuates nonalcoholic fatty liver disease by activating the farnesoid X receptor","volume":"92","author":"Zheng","year":"2017","journal-title":"Mol. Pharmacol."},{"issue":"1","key":"10.1016\/j.phrs.2023.106807_bib62","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cyto.2012.10.011","article-title":"Inhibition of TGF-beta signaling by the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclododecindione and galiellalactone","volume":"61","author":"Rudolph","year":"2013","journal-title":"Cytokine"},{"issue":"1","key":"10.1016\/j.phrs.2023.106807_bib63","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.cmet.2011.04.013","article-title":"Protection from obesity and diabetes by blockade of TGF-beta\/Smad3 signaling","volume":"14","author":"Yadav","year":"2011","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.phrs.2023.106807_bib64","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1124\/jpet.112.192047","article-title":"The anti-inflammatory fungal compound (S)-curvularin reduces proinflammatory gene expression in an in vivo model of rheumatoid arthritis","volume":"343","author":"Schmidt","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.phrs.2023.106807_bib65","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3389\/fphys.2017.00566","article-title":"Anti-inflammatory effects of fungal metabolites in mouse intestine as revealed by in vitro models","volume":"8","author":"Schreiber","year":"2017","journal-title":"Front. Physiol."},{"issue":"8","key":"10.1016\/j.phrs.2023.106807_bib66","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.it.2011.05.004","article-title":"NLRP3 inflammasomes link inflammation and metabolic disease","volume":"32","author":"De Nardo","year":"2011","journal-title":"Trends Immunol."},{"issue":"6","key":"10.1016\/j.phrs.2023.106807_bib67","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/j.1365-2036.2007.03442.x","article-title":"Review article: yeast as probiotics-Saccharomyces boulardii","volume":"26","author":"Czerucka","year":"2007","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.phrs.2023.106807_bib68","series-title":"Recent advancement in white biotechnology through fungi, Fungal Biology","article-title":"Fungal probiotics: Opportunity, challenge, and prospects","author":"Banik","year":"2019"},{"issue":"3","key":"10.1016\/j.phrs.2023.106807_bib69","doi-asserted-by":"crossref","first-page":"e01011","DOI":"10.1128\/mBio.01011-14","article-title":"Saccharomyces boulardii administration changes gut microbiota and reduces hepatic steatosis, low-grade inflammation, and fat mass in obese and type 2 diabetic db\/db mice","volume":"5","author":"Everard","year":"2014","journal-title":"mBio"},{"issue":"1","key":"10.1016\/j.phrs.2023.106807_bib70","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bbrc.2006.02.080","article-title":"Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-kappaB-mediated IL-8 gene expression","volume":"343","author":"Sougioultzis","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"39","key":"10.1016\/j.phrs.2023.106807_bib71","doi-asserted-by":"crossref","first-page":"6165","DOI":"10.3748\/wjg.v11.i39.6165","article-title":"Effects of Saccharomyces boulardii on fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition","volume":"11","author":"Schneider","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phrs.2023.106807_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112839","article-title":"Gut microbiota-derived metabolites as key actors in type 2 diabetes mellitus","volume":"149","author":"Du","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"24","key":"10.1016\/j.phrs.2023.106807_bib73","doi-asserted-by":"crossref","first-page":"8683","DOI":"10.1021\/bi972071p","article-title":"Insulin signaling in the yeast Saccharomyces cerevisiae1. Stimulation of glucose metabolism and Snf1 kinase by human insulin","volume":"37","author":"M\u00fcller","year":"1998","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.phrs.2023.106807_bib74","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2337\/diab.27.1.49","article-title":"Comparison and effects of natural and synthetic glucose tolerance factor in normal and genetically diabetic mice","volume":"27","author":"Tuman","year":"1978","journal-title":"Diabetes"},{"key":"10.1016\/j.phrs.2023.106807_bib75","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jnutbio.2017.02.014","article-title":"Kefir alleviates obesity and hepatic steatosis in high-fat diet-fed mice by modulation of gut microbiota and mycobiota: targeted and untargeted community analysis with correlation of biomarkers","volume":"44","author":"Kim","year":"2017","journal-title":"J. Nutr. Biochem"},{"issue":"7","key":"10.1016\/j.phrs.2023.106807_bib76","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1172\/JCI90562","article-title":"Intestinal fungi contribute to development of alcoholic liver disease","volume":"127","author":"Yang","year":"2017","journal-title":"J. Clin. Invest"},{"issue":"3","key":"10.1016\/j.phrs.2023.106807_bib77","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1900\/RDS.2006.3.118","article-title":"Diet, exercise and the metabolic syndrome","volume":"3","author":"Pitsavos","year":"2006","journal-title":"Rev. Diabet. Stud."},{"issue":"6","key":"10.1016\/j.phrs.2023.106807_bib78","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0066019","article-title":"Archaea and fungi of the human gut microbiome: correlations with diet and bacterial residents","volume":"8","author":"Hoffmann","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.phrs.2023.106807_bib79","doi-asserted-by":"crossref","first-page":"e00020","DOI":"10.1128\/mSphere.00020-15","article-title":"Manipulation of host diet to reduce gastrointestinal colonization by the opportunistic pathogen Candida albicans","volume":"1","author":"Gunsalus","year":"2016","journal-title":"mSphere"},{"key":"10.1016\/j.phrs.2023.106807_bib80","unstructured":"W.J. Chen, A chewable natural coconut oil and preparation method thereof CN108208201A[P]. (2018)."},{"issue":"5","key":"10.1016\/j.phrs.2023.106807_bib81","first-page":"472","article-title":"Roles of the gut virome and mycobiome in faecal microbiota transplantation","volume":"7","author":"Lam","year":"2022","journal-title":"Lancet Gastroenterol."},{"issue":"1","key":"10.1016\/j.phrs.2023.106807_bib82","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1038\/s41467-018-06103-6","article-title":"Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection","volume":"9","author":"Zuo","year":"2018","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.phrs.2023.106807_bib83","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.chom.2020.03.006","article-title":"Fungal trans-kingdom dynamics linked to responsiveness to fecal microbiota transplantation (FMT) therapy in ulcerative colitis","volume":"27","author":"Leonardi","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.phrs.2023.106807_bib84","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3389\/fcimb.2019.00455","article-title":"Promising treatment for type 2 diabetes: fecal microbiota transplantation reverses insulin resistance and impaired islets","volume":"9","author":"Wang","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.phrs.2023.106807_bib85","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1038\/s41598-017-01751-y","article-title":"Total fecal microbiota transplantation alleviates high-fat diet-induced steatohepatitis in mice via beneficial regulation of gut microbiota","volume":"7","author":"Zhou","year":"2017","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.phrs.2023.106807_bib86","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1053\/j.gastro.2012.06.031","article-title":"Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome","volume":"143","author":"Vrieze","year":"2012","journal-title":"Gastroenterology"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661823001639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661823001639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:42:00Z","timestamp":1760913720000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661823001639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":85,"alternative-id":["S1043661823001639"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2023.106807","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gut mycobiome and metabolic diseases: The known, the unknown, and the future","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2023.106807","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106807"}}