{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:19:17Z","timestamp":1789435157010,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002642","name":"Korea University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2020R1C1C1003257"],"award-info":[{"award-number":["NRF-2020R1C1C1003257"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00221182"],"award-info":[{"award-number":["RS-2023-00221182"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.phrs.2023.106887","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T02:44:10Z","timestamp":1691721850000},"page":"106887","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Stabilization of activated mast cells by ORAI1 inhibitor suppresses peanut-induced anaphylaxis and acute diarrhea"],"prefix":"10.1016","volume":"196","author":[{"given":"Gyeongseo","family":"Suk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Hoon","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Roers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soman N.","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae Woong","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2 Suppl 2","key":"10.1016\/j.phrs.2023.106887_bib1","doi-asserted-by":"crossref","first-page":"S116","DOI":"10.1016\/j.jaci.2009.08.028","article-title":"Food allergy","volume":"125","author":"Sicherer","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"issue":"6","key":"10.1016\/j.phrs.2023.106887_bib2","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.jaci.2010.10.008","article-title":"Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-sponsored expert panel report","volume":"126","author":"Boyce","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.phrs.2023.106887_bib3","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1542\/peds.2011-0204","article-title":"The prevalence, severity, and distribution of childhood food allergy in the United States","volume":"128","author":"Gupta","year":"2011","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.phrs.2023.106887_bib4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/bph.12138","article-title":"Twenty-first century mast cell stabilizers","volume":"170","author":"Finn","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.phrs.2023.106887_bib5","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1067\/mai.2000.106485","article-title":"The diverse potential effector and immunoregulatory roles of mast cells in allergic disease","volume":"105","author":"Williams","year":"2000","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.phrs.2023.106887_bib6","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.advenzreg.2011.09.005","article-title":"Phospholipase C signaling and calcium influx","volume":"52","author":"Putney","year":"2012","journal-title":"Adv. Biol. Regul."},{"issue":"7108","key":"10.1016\/j.phrs.2023.106887_bib7","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature05122","article-title":"Orai1 is an essential pore subunit of the CRAC channel","volume":"443","author":"Prakriya","year":"2006","journal-title":"Nature"},{"issue":"7060","key":"10.1016\/j.phrs.2023.106887_bib8","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/nature04147","article-title":"STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane","volume":"437","author":"Zhang","year":"2005","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.phrs.2023.106887_bib9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/ni1550","article-title":"Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels","volume":"9","author":"Vig","year":"2008","journal-title":"Nat. Immunol."},{"issue":"7","key":"10.1016\/j.phrs.2023.106887_bib10","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nri3690","article-title":"Mast cell secretory granules: armed for battle","volume":"14","author":"Wernersson","year":"2014","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.phrs.2023.106887_bib11","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0092-8674(00)81594-9","article-title":"Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell surface projections regulates compound exocytosis in mast cells","volume":"94","author":"Guo","year":"1998","journal-title":"Cell"},{"issue":"29","key":"10.1016\/j.phrs.2023.106887_bib12","doi-asserted-by":"crossref","first-page":"19445","DOI":"10.1074\/jbc.M109.002550","article-title":"Synaptotagmin-2 controls regulated exocytosis but not other secretory responses of mast cells","volume":"284","author":"Melicoff","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.phrs.2023.106887_bib13","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1136\/jim-2020-001422","article-title":"Oral immunotherapy for treatment of peanut allergy","volume":"68","author":"Dunlop","year":"2020","journal-title":"J. Invest. Med"},{"issue":"3","key":"10.1016\/j.phrs.2023.106887_bib14","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/alr.21884","article-title":"Pitfalls in the use of epinephrine for anaphylaxis: patient and provider opportunities for improvement","volume":"7","author":"Cohen","year":"2017","journal-title":"Int Forum Allergy Rhinol."},{"issue":"10","key":"10.1016\/j.phrs.2023.106887_bib15","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1172\/JCI85538","article-title":"Different activation signals induce distinct mast cell degranulation strategies","volume":"126","author":"Gaudenzio","year":"2016","journal-title":"J. Clin. Invest"},{"issue":"4","key":"10.1016\/j.phrs.2023.106887_bib16","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1067\/mai.2002.123302","article-title":"Pathways of anaphylaxis in the mouse","volume":"109","author":"Strait","year":"2002","journal-title":"J. Allergy Clin. Immunol."},{"issue":"6415","key":"10.1016\/j.phrs.2023.106887_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/science.aao0666","article-title":"Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles","volume":"362","author":"Choi","year":"2018","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.phrs.2023.106887_bib18","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s11248-007-9153-4","article-title":"Mast cell-specific Cre\/loxP-mediated recombination in vivo","volume":"17","author":"Scholten","year":"2008","journal-title":"Transgenic Res."},{"issue":"7","key":"10.1016\/j.phrs.2023.106887_bib19","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.4049\/jimmunol.180.7.4742","article-title":"Homeostasis and effector function of lymphopenia-induced \"memory-like\" T cells in constitutively T cell-depleted mice","volume":"180","author":"Voehringer","year":"2008","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.phrs.2023.106887_bib20","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.immuni.2012.08.026","article-title":"Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells","volume":"37","author":"Zigmond","year":"2012","journal-title":"Immunity"},{"issue":"6077","key":"10.1016\/j.phrs.2023.106887_bib21","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1126\/science.1219179","article-title":"A lineage of myeloid cells independent of Myb and hematopoietic stem cells","volume":"336","author":"Schulz","year":"2012","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.phrs.2023.106887_bib22","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.immuni.2012.11.014","article-title":"Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4","volume":"38","author":"Egawa","year":"2013","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.phrs.2023.106887_bib23","doi-asserted-by":"crossref","DOI":"10.4110\/in.2022.22.e12","article-title":"Recent advances in allergen-specific immunotherapy in humans: a systematic review","volume":"22","author":"Lee","year":"2022","journal-title":"Immune Netw."},{"issue":"3","key":"10.1016\/j.phrs.2023.106887_bib24","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/all.13334","article-title":"Clinical implications of mast cell involvement in allergic conjunctivitis","volume":"73","author":"Elieh Ali Komi","year":"2018","journal-title":"Allergy"},{"issue":"1","key":"10.1016\/j.phrs.2023.106887_bib25","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1083\/jcb.200501111","article-title":"FcepsilonRI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane","volume":"170","author":"Nishida","year":"2005","journal-title":"J. Cell Biol."},{"issue":"11","key":"10.1016\/j.phrs.2023.106887_bib26","doi-asserted-by":"crossref","first-page":"5850","DOI":"10.4049\/jimmunol.164.11.5850","article-title":"Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment","volume":"164","author":"Paumet","year":"2000","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.phrs.2023.106887_bib27","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/cmdc.200800452","article-title":"Small-molecule inhibitors of store-operated calcium entry","volume":"4","author":"Sweeney","year":"2009","journal-title":"ChemMedChem"},{"issue":"11","key":"10.1016\/j.phrs.2023.106887_bib28","doi-asserted-by":"crossref","first-page":"5130","DOI":"10.4049\/jimmunol.1301677","article-title":"Calpain-1 contributes to IgE-mediated mast cell activation","volume":"192","author":"Wu","year":"2014","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.phrs.2023.106887_bib29","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.4049\/jimmunol.163.4.2160","article-title":"Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-\/- mice: the role of mast cells","volume":"163","author":"Campbell","year":"1999","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.phrs.2023.106887_bib30","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1182\/blood-2005-12-012781","article-title":"Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung","volume":"108","author":"Abonia","year":"2006","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.phrs.2023.106887_bib31","doi-asserted-by":"crossref","first-page":"6114","DOI":"10.4049\/jimmunol.0904177","article-title":"The role of the CCL2\/CCR2 axis in mouse mast cell migration in vitro and in vivo","volume":"184","author":"Collington","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.phrs.2023.106887_bib32","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ceca.2018.07.005","article-title":"CRAC channels as targets for drug discovery and development","volume":"74","author":"Stauderman","year":"2018","journal-title":"Cell Calcium"},{"issue":"6","key":"10.1016\/j.phrs.2023.106887_bib33","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.2741\/e540","article-title":"Physiological and pathophysiological functions of SOCE in the immune system","volume":"4","author":"Shaw","year":"2012","journal-title":"Front. Biosci. (Elite Ed.)"},{"issue":"11","key":"10.1016\/j.phrs.2023.106887_bib34","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1002\/eji.201040614","article-title":"T-cell-specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells","volume":"40","author":"Ma","year":"2010","journal-title":"Eur. J. Immunol."},{"issue":"2","key":"10.1016\/j.phrs.2023.106887_bib35","doi-asserted-by":"crossref","first-page":"573","DOI":"10.4049\/jimmunol.1501406","article-title":"Selective ORAI1 inhibition ameliorates autoimmune central nervous system inflammation by suppressing effector but not regulatory T cell function","volume":"196","author":"Kaufmann","year":"2016","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.phrs.2023.106887_bib36","first-page":"887","article-title":"Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation","volume":"123","author":"Gandhirajan","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"8","key":"10.1016\/j.phrs.2023.106887_bib37","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1096\/fba.2020-00008","article-title":"Anti-ORAI1 antibody DS-2741a, a specific CRAC channel blocker, shows ideal therapeutic profiles for allergic disease via suppression of aberrant T-cell and mast cell activation","volume":"2","author":"Aki","year":"2020","journal-title":"FASEB Bioadv."},{"issue":"5","key":"10.1016\/j.phrs.2023.106887_bib38","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00424-012-1160-5","article-title":"Airway smooth muscle STIM1 and Orai1 are upregulated in asthmatic mice and mediate PDGF-activated SOCE, CRAC currents, proliferation, and migration","volume":"464","author":"Spinelli","year":"2012","journal-title":"Pflug. Arch."},{"issue":"1","key":"10.1016\/j.phrs.2023.106887_bib39","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00418-010-0717-7","article-title":"Up-regulation of Orai1 in murine allergic rhinitis","volume":"134","author":"Lin","year":"2010","journal-title":"Histochem Cell Biol."},{"issue":"4","key":"10.1016\/j.phrs.2023.106887_bib40","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1074\/jbc.M111.275925","article-title":"Transcription factor NF-kappaB regulates expression of pore-forming Ca2+ channel unit, Orai1, and its activator, STIM1, to control Ca2+ entry and affect cellular functions","volume":"287","author":"Eylenstein","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.phrs.2023.106887_bib41","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ni.f.220","article-title":"Calcium signaling in immune cells","volume":"10","author":"Vig","year":"2009","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.phrs.2023.106887_bib42","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ceca.2015.04.002","article-title":"Store-operated calcium entry compensates fast ER calcium loss in resting hippocampal neurons","volume":"58","author":"Samtleben","year":"2015","journal-title":"Cell Calcium"},{"issue":"12","key":"10.1016\/j.phrs.2023.106887_bib43","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.1096\/fj.201600621R","article-title":"Orai1 enhances muscle endurance by promoting fatigue-resistant type I fiber content but not through acute store-operated Ca2+ entry","volume":"30","author":"Carrell","year":"2016","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.phrs.2023.106887_bib44","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1186\/s13054-020-03220-x","article-title":"Auxora versus standard of care for the treatment of severe or critical COVID-19 pneumonia: results from a randomized controlled trial","volume":"24","author":"Miller","year":"2020","journal-title":"Crit. Care"},{"issue":"1","key":"10.1016\/j.phrs.2023.106887_bib45","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13054-022-03964-8","article-title":"Auxora vs. placebo for the treatment of patients with severe COVID-19 pneumonia: a randomized-controlled clinical trial","volume":"26","author":"Bruen","year":"2022","journal-title":"Crit. Care"},{"issue":"12","key":"10.1016\/j.phrs.2023.106887_bib46","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1113\/JP277856","article-title":"The Orai Ca(2+) channel inhibitor CM4620 targets both parenchymal and immune cells to reduce inflammation in experimental acute pancreatitis","volume":"597","author":"Waldron","year":"2019","journal-title":"J. Physiol."},{"issue":"5","key":"10.1016\/j.phrs.2023.106887_bib47","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/cea.14279","article-title":"Strain matters in mouse models of peanut-allergic anaphylaxis: systemic IgE-dependent and Ara h 2-dominant sensitization in C3H mice","volume":"53","author":"Paolucci","year":"2023","journal-title":"Clin. Exp. Allergy"},{"issue":"3","key":"10.1016\/j.phrs.2023.106887_bib48","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.jaci.2018.10.009","article-title":"Genetic diversity between mouse strains allows identification of the CC027\/GeniUnc strain as an orally reactive model of peanut allergy","volume":"143","author":"Orgel","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"issue":"682","key":"10.1016\/j.phrs.2023.106887_bib49","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.add6373","article-title":"Peanut allergen inhibition prevents anaphylaxis in a humanized mouse model","volume":"15","author":"Alakhras","year":"2023","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.phrs.2023.106887_bib50","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jaci.2016.06.053","article-title":"Exploiting CD22 on antigen-specific B cells to prevent allergy to the major peanut allergen Ara h 2","volume":"139","author":"Orgel","year":"2017","journal-title":"J. Allergy Clin. Immunol."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661823002438?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661823002438?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:45:36Z","timestamp":1760913936000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661823002438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":50,"alternative-id":["S1043661823002438"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2023.106887","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stabilization of activated mast cells by ORAI1 inhibitor suppresses peanut-induced anaphylaxis and acute diarrhea","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2023.106887","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106887"}}