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Chem."},{"issue":"5","key":"10.1016\/j.phrs.2023.106969_bib87","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/glia.23568","article-title":"Human immunodeficiency virus Type-1 single-stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia","volume":"67","author":"Rawat","year":"2019","journal-title":"Glia"},{"issue":"10","key":"10.1016\/j.phrs.2023.106969_bib88","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1002\/eji.202149275","article-title":"Abortive HIV-1 RNA induces pro-IL-1beta maturation via protein kinase PKR and inflammasome activation in humans.","volume":"51","author":"Stunnenberg","year":"2021","journal-title":"Eur. J. 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Clin. Invest"},{"issue":"17","key":"10.1016\/j.phrs.2023.106969_bib123","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00808-22","article-title":"Rapid loss of CD4 T cells by pyroptosis during acute SIV infection in rhesus macaques","volume":"96","author":"He","year":"2022","journal-title":"J. Virol."},{"issue":"11\u201312","key":"10.1016\/j.phrs.2023.106969_bib124","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1007\/s00018-016-2205-2","article-title":"The intersection of cell death and inflammasome activation","volume":"73","author":"Vince","year":"2016","journal-title":"Cell Mol. 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