{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T02:43:14Z","timestamp":1793760194322,"version":"4.6.1"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M720779"],"award-info":[{"award-number":["2022M720779"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872492"],"award-info":[{"award-number":["81872492"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Shanghai Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["22ZR1411200"],"award-info":[{"award-number":["22ZR1411200"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.phrs.2024.107082","type":"journal-article","created":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T11:45:00Z","timestamp":1706269500000},"page":"107082","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Identification of Fasudil as a collaborator to promote the anti-tumor effect of lenvatinib in hepatocellular carcinoma by inhibiting GLI2-mediated hedgehog signaling pathway"],"prefix":"10.1016","volume":"200","author":[{"given":"Yilan","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sikai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiwu","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.phrs.2024.107082_bib1","first-page":"7","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. Clin."},{"issue":"10360","key":"10.1016\/j.phrs.2024.107082_bib2","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S0140-6736(22)01200-4","article-title":"Hepatocellular carcinoma","volume":"400","author":"Vogel","year":"2022","journal-title":"Lancet"},{"issue":"10126","key":"10.1016\/j.phrs.2024.107082_bib3","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/S0140-6736(18)30207-1","article-title":"Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial","volume":"391","author":"Kudo","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2024.107082_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2021.100796","article-title":"Anticancer drug resistance: an update and perspective","volume":"59","author":"Nussinov","year":"2021","journal-title":"Drug Resist Updat"},{"issue":"7782","key":"10.1016\/j.phrs.2024.107082_bib5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41586-019-1730-1","article-title":"A view on drug resistance in cancer","volume":"575","author":"Vasan","year":"2019","journal-title":"Nature"},{"issue":"7869","key":"10.1016\/j.phrs.2024.107082_bib6","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/s41586-021-03741-7","article-title":"EGFR activation limits the response of liver cancer to lenvatinib","volume":"595","author":"Jin","year":"2021","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.phrs.2024.107082_bib7","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s43018-020-00168-3","article-title":"LXR\u03b1 activation and Raf inhibition trigger lethal lipotoxicity in liver cancer","volume":"2","author":"Rudalska","year":"2021","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.phrs.2024.107082_bib8","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.semcancer.2019.12.011","article-title":"Machine and deep learning approaches for cancer drug repurposing","volume":"68","author":"Issa","year":"2021","journal-title":"Semin Cancer Biol."},{"issue":"1","key":"10.1016\/j.phrs.2024.107082_bib9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrd.2018.168","article-title":"Drug repurposing: progress, challenges and recommendations","volume":"18","author":"Pushpakom","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"issue":"5795","key":"10.1016\/j.phrs.2024.107082_bib10","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1126\/science.1132939","article-title":"The connectivity map: using gene-expression signatures to connect small molecules, genes, and disease","volume":"313","author":"Lamb","year":"2006","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.phrs.2024.107082_bib11","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/bib\/bbv020","article-title":"A survey of current trends in computational drug repositioning","volume":"17","author":"Li","year":"2016","journal-title":"Brief. Bioinform"},{"key":"10.1016\/j.phrs.2024.107082_bib12","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.71880","article-title":"A survey of optimal strategy for signature-based drug repositioning and an application to liver cancer","volume":"11","author":"Yang","year":"2022","journal-title":"Elife"},{"issue":"2","key":"10.1016\/j.phrs.2024.107082_bib13","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ccell.2019.07.001","article-title":"A pharmacogenomic landscape in human liver cancers","volume":"36","author":"Qiu","year":"2019","journal-title":"Cancer Cell"},{"issue":"8","key":"10.1016\/j.phrs.2024.107082_bib14","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv1507","article-title":"TCGAbiolinks: an R\/Bioconductor package for integrative analysis of TCGA data","volume":"44","author":"Colaprico","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.phrs.2024.107082_bib15","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinforma."},{"issue":"12","key":"10.1016\/j.phrs.2024.107082_bib16","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1093\/bioinformatics\/btq170","article-title":"ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking","volume":"26","author":"Wilkerson","year":"2010","journal-title":"Bioinformatics"},{"issue":"11","key":"10.1016\/j.phrs.2024.107082_bib17","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1101\/gr.239244.118","article-title":"Maftools: efficient and comprehensive analysis of somatic variants in cancer","volume":"28","author":"Mayakonda","year":"2018","journal-title":"Genome Res"},{"issue":"18","key":"10.1016\/j.phrs.2024.107082_bib18","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"issue":"12","key":"10.1016\/j.phrs.2024.107082_bib19","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"3","key":"10.1016\/j.phrs.2024.107082_bib20","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"issue":"18","key":"10.1016\/j.phrs.2024.107082_bib21","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1093\/bioinformatics\/btw230","article-title":"Combenefit: an interactive platform for the analysis and visualization of drug combinations","volume":"32","author":"Di Veroli","year":"2016","journal-title":"Bioinformatics"},{"issue":"7","key":"10.1016\/j.phrs.2024.107082_bib22","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nmeth.1226","article-title":"Mapping and quantifying mammalian transcriptomes by RNA-Seq","volume":"5","author":"Mortazavi","year":"2008","journal-title":"Nat. Methods"},{"issue":"7","key":"10.1016\/j.phrs.2024.107082_bib23","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"issue":"2","key":"10.1016\/j.phrs.2024.107082_bib24","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jhep.2019.09.026","article-title":"mRECIST for HCC: performance and novel refinements","volume":"72","author":"Llovet","year":"2020","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.phrs.2024.107082_bib25","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1080\/15548627.2022.2117893","article-title":"Genome-Scale CRISPR screen identifies LAPTM5 driving lenvatinib resistance in hepatocellular carcinoma","volume":"19","author":"Pan","year":"2023","journal-title":"Autophagy"},{"issue":"7391","key":"10.1016\/j.phrs.2024.107082_bib26","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nature11003","article-title":"The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity","volume":"483","author":"Barretina","year":"2012","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.phrs.2024.107082_bib27","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1002\/hep4.1928","article-title":"Integrin subunit beta 8 contributes to lenvatinib resistance in HCC","volume":"6","author":"Hou","year":"2022","journal-title":"Hepatol. Commun."},{"issue":"6","key":"10.1016\/j.phrs.2024.107082_bib28","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1136\/gutjnl-2018-316408","article-title":"Molecular predictors of prevention of recurrence in HCC with sorafenib as adjuvant treatment and prognostic factors in the phase 3 STORM trial","volume":"68","author":"Pinyol","year":"2019","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.phrs.2024.107082_bib29","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12592","article-title":"Rab25 promotes erlotinib resistance by activating the \u03b21 integrin\/AKT\/\u03b2-catenin pathway in NSCLC","volume":"52","author":"Wang","year":"2019","journal-title":"Cell Prolif."},{"issue":"10","key":"10.1016\/j.phrs.2024.107082_bib30","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1002\/cam4.3819","article-title":"Fzd7\/Wnt7b signaling contributes to stemness and chemoresistance in pancreatic cancer","volume":"10","author":"Zhang","year":"2021","journal-title":"Cancer Med."},{"key":"10.1016\/j.phrs.2024.107082_bib31","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.semcancer.2021.04.003","article-title":"Hedgehog signaling mechanism and role in cancer","volume":"85","author":"Jiang","year":"2022","journal-title":"Semin Cancer Biol."},{"issue":"26","key":"10.1016\/j.phrs.2024.107082_bib32","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1801348115","article-title":"Hypoxic tumor microenvironment activates GLI2 via HIF-1\u03b1 and TGF-\u03b22 to promote chemoresistance in colorectal cancer","volume":"115","author":"Tang","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.phrs.2024.107082_bib33","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.canlet.2020.10.031","article-title":"HOTAIR and androgen receptor synergistically increase GLI2 transcription to promote tumor angiogenesis and cancer stemness in renal cell carcinoma","volume":"498","author":"Bai","year":"2021","journal-title":"Cancer Lett."},{"issue":"17","key":"10.1016\/j.phrs.2024.107082_bib34","first-page":"3857","article-title":"GLI2 induces PDGFRB expression and modulates cancer stem cell properties of gastric cancer","volume":"21","author":"Wang","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"7","key":"10.1016\/j.phrs.2024.107082_bib35","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.1111\/jcmm.15090","article-title":"Hedgehog signalling mediates drug resistance through targeting TAP1 in hepatocellular carcinoma","volume":"24","author":"Zhou","year":"2020","journal-title":"J. Cell Mol. Med."},{"issue":"8","key":"10.1016\/j.phrs.2024.107082_bib36","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jgg.2017.04.008","article-title":"The role of GLI2-ABCG2 signaling axis for 5Fu resistance in gastric cancer","volume":"44","author":"Yu","year":"2017","journal-title":"J. Genet Genom."},{"issue":"6","key":"10.1016\/j.phrs.2024.107082_bib37","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.3892\/or.2020.7798","article-title":"The Hedgehog signaling pathway promotes chemotherapy resistance via multidrug resistance protein 1 in ovarian cancer","volume":"44","author":"Zhang","year":"2020","journal-title":"Oncol. Rep."},{"issue":"4","key":"10.1016\/j.phrs.2024.107082_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/cells11040634","article-title":"Upregulation of USP22 and ABCC1 during sorafenib treatment of hepatocellular carcinoma contribute to development of resistance","volume":"11","author":"Chang","year":"2022","journal-title":"Cells"},{"issue":"8","key":"10.1016\/j.phrs.2024.107082_bib39","first-page":"3597","article-title":"ABCC1 is a predictive biomarker for prognosis and therapy in hepatocellular carcinoma","volume":"27","author":"Han","year":"2023","journal-title":"Eur. Rev. Med Pharm. Sci."},{"key":"10.1016\/j.phrs.2024.107082_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216122","article-title":"METTL3-m(6)A-EGFR-axis drives lenvatinib resistance in hepatocellular carcinoma","volume":"559","author":"Wang","year":"2023","journal-title":"Cancer Lett."},{"issue":"20","key":"10.1016\/j.phrs.2024.107082_bib41","doi-asserted-by":"crossref","first-page":"3845","DOI":"10.1158\/0008-5472.CAN-21-4140","article-title":"Inhibition of EGFR overcomes acquired lenvatinib resistance driven by STAT3-ABCB1 signaling in hepatocellular carcinoma","volume":"82","author":"Hu","year":"2022","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.phrs.2024.107082_bib42","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/emmm.201100201","article-title":"Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells","volume":"4","author":"Eberl","year":"2012","journal-title":"EMBO Mol. Med."},{"issue":"3","key":"10.1016\/j.phrs.2024.107082_bib43","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ccr.2011.12.028","article-title":"The crosstalk of mTOR\/S6K1 and hedgehog pathways","volume":"21","author":"Wang","year":"2012","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.phrs.2024.107082_bib44","doi-asserted-by":"crossref","first-page":"8","DOI":"10.17305\/bjbms.2018.2756","article-title":"The role of the Hedgehog signaling pathway in cancer: a comprehensive review","volume":"18","author":"Skoda","year":"2018","journal-title":"Bosn. J. Basic Med. Sci."},{"issue":"12","key":"10.1016\/j.phrs.2024.107082_bib45","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1158\/0008-5472.CAN-18-2693","article-title":"ROCK Inhibition induces terminal adipocyte differentiation and suppresses tumorigenesis in chemoresistant osteosarcoma cells","volume":"79","author":"Takahashi","year":"2019","journal-title":"Cancer Res."},{"issue":"8","key":"10.1016\/j.phrs.2024.107082_bib46","first-page":"4354","article-title":"Rho-kinase inhibition by Fasudil promotes tumor maturation and apoptosis in small-cell lung cancer","volume":"12","author":"Huo","year":"2020","journal-title":"Am. J. Transl. Res."},{"issue":"15","key":"10.1016\/j.phrs.2024.107082_bib47","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1056\/NEJMra1713263","article-title":"Hepatocellular Carcinoma","volume":"380","author":"Villanueva","year":"2019","journal-title":"N. Engl. J. Med"},{"issue":"9","key":"10.1016\/j.phrs.2024.107082_bib48","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1111\/liv.12818","article-title":"Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study","volume":"35","author":"Park","year":"2015","journal-title":"Liver Int."},{"issue":"4","key":"10.1016\/j.phrs.2024.107082_bib49","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1056\/NEJMoa0708857","article-title":"Sorafenib in advanced hepatocellular carcinoma","volume":"359","author":"Llovet","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.phrs.2024.107082_bib50","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.molcel.2020.05.031","article-title":"Rational cancer treatment combinations: an urgent clinical need","volume":"78","author":"Boshuizen","year":"2020","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.phrs.2024.107082_bib51","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41575-022-00704-9","article-title":"Evolving therapeutic landscape of advanced hepatocellular carcinoma","volume":"20","author":"Yang","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phrs.2024.107082_bib52","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/s12967-016-1031-5","article-title":"Repurposing of approved cardiovascular drugs","volume":"14","author":"Ishida","year":"2016","journal-title":"J. Transl. Med."},{"issue":"6","key":"10.1016\/j.phrs.2024.107082_bib53","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1021\/acs.jmedchem.5b00683","article-title":"Rho kinase (ROCK) inhibitors and their therapeutic potential","volume":"59","author":"Feng","year":"2016","journal-title":"J. Med. Chem."},{"issue":"11","key":"10.1016\/j.phrs.2024.107082_bib54","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/s41573-021-00252-y","article-title":"Trends in kinase drug discovery: targets, indications and inhibitor design","volume":"20","author":"Attwood","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1-2","key":"10.1016\/j.phrs.2024.107082_bib55","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jns.2005.06.003","article-title":"Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial","volume":"238","author":"Shibuya","year":"2005","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.phrs.2024.107082_bib56","doi-asserted-by":"crossref","first-page":"11363","DOI":"10.1038\/ncomms11363","article-title":"Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK","volume":"7","author":"Wang","year":"2016","journal-title":"Nat. Commun."},{"issue":"384","key":"10.1016\/j.phrs.2024.107082_bib57","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aai8504","article-title":"Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis","volume":"9","author":"Vennin","year":"2017","journal-title":"Sci. Transl. Med."},{"issue":"2","key":"10.1016\/j.phrs.2024.107082_bib58","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41419-017-0251-9","article-title":"Fasudil increases temozolomide sensitivity and suppresses temozolomide-resistant glioma growth via inhibiting ROCK2\/ABCG2","volume":"9","author":"Zhang","year":"2018","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.phrs.2024.107082_bib59","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/1878-0261.12155","article-title":"Emerging functions of the EGFR in cancer","volume":"12","author":"Sigismund","year":"2018","journal-title":"Mol. Oncol."},{"issue":"6","key":"10.1016\/j.phrs.2024.107082_bib60","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1053\/j.gastro.2023.01.023","article-title":"EGFR\/ERBB2 Amplifications and alterations associated with resistance to lenvatinib in hepatocellular carcinoma","volume":"164","author":"Lim","year":"2023","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.phrs.2024.107082_bib61","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3109\/03602532.2014.901348","article-title":"Importance of ABCC1 for cancer therapy and prognosis","volume":"46","author":"Kunick\u00e1","year":"2014","journal-title":"Drug Metab. Rev."},{"issue":"4797","key":"10.1016\/j.phrs.2024.107082_bib62","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1126\/science.3563490","article-title":"Identification of an amplified, highly expressed gene in a human glioma","volume":"236","author":"Kinzler","year":"1987","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.phrs.2024.107082_bib63","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/nrm3598","article-title":"The mechanisms of Hedgehog signalling and its roles in development and disease","volume":"14","author":"Briscoe","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"9","key":"10.1016\/j.phrs.2024.107082_bib64","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9091188","article-title":"The Role of smoothened-dependent and -independent hedgehog signaling pathway in tumorigenesis","volume":"9","author":"Chai","year":"2021","journal-title":"Biomedicines"},{"issue":"7020","key":"10.1016\/j.phrs.2024.107082_bib65","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/nature03179","article-title":"Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I","volume":"432","author":"Jia","year":"2004","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.phrs.2024.107082_bib66","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1111\/iwj.13800","article-title":"Dual efficacy of Fasudil at improvement of survival and reinnervation of flap through RhoA\/ROCK\/PI3K\/Akt pathway","volume":"19","author":"Wang","year":"2022","journal-title":"Int. Wound J."},{"issue":"1","key":"10.1016\/j.phrs.2024.107082_bib67","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1159\/000369692","article-title":"MiR-133b Promotes neurite outgrowth by targeting RhoA expression","volume":"35","author":"Lu","year":"2015","journal-title":"Cell Physiol. Biochem."},{"issue":"6654","key":"10.1016\/j.phrs.2024.107082_bib68","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/40187","article-title":"Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension","volume":"389","author":"Uehata","year":"1997","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.phrs.2024.107082_bib69","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1161\/01.RES.0000059987.90200.44","article-title":"Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle","volume":"92","author":"Seko","year":"2003","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.phrs.2024.107082_bib70","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1097\/HJH.0b013e3283440665","article-title":"Rho kinase inhibition activates the homologous angiotensin-converting enzyme-angiotensin-(1-9) axis in experimental hypertension","volume":"29","author":"Ocaranza","year":"2011","journal-title":"J. Hypertens."},{"issue":"1-3","key":"10.1016\/j.phrs.2024.107082_bib71","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ejphar.2012.07.016","article-title":"Fasudil improves the endothelial dysfunction in the aorta of spontaneously hypertensive rats","volume":"691","author":"Tsounapi","year":"2012","journal-title":"Eur. J. Pharm."},{"issue":"10","key":"10.1016\/j.phrs.2024.107082_bib72","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1161\/HYPERTENSIONAHA.122.19189","article-title":"Tacrolimus causes hypertension by increasing vascular contractility via RhoA (Ras Homolog Family Member A)\/ROCK (Rho-Associated Protein Kinase) pathway in mice","volume":"79","author":"Wang","year":"2022","journal-title":"Hypertension"},{"key":"10.1016\/j.phrs.2024.107082_bib73","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.pupt.2017.08.002","article-title":"Effects of fasudil on pulmonary hypertension in clinical practice","volume":"46","author":"Zhang","year":"2017","journal-title":"Pulm. Pharmacol. Ther."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661824000264?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661824000264?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:52:46Z","timestamp":1760914366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661824000264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":73,"alternative-id":["S1043661824000264"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2024.107082","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of Fasudil as a collaborator to promote the anti-tumor effect of lenvatinib in hepatocellular carcinoma by inhibiting GLI2-mediated hedgehog signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2024.107082","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107082"}}