{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T11:40:48Z","timestamp":1792755648119,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017607","name":"Shenzhen Basic Research Program","doi-asserted-by":"publisher","award":["GXWD20201231165807007-20200818123312001"],"award-info":[{"award-number":["GXWD20201231165807007-20200818123312001"]}],"id":[{"id":"10.13039\/501100017607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["RCBS20200714114820147"],"award-info":[{"award-number":["RCBS20200714114820147"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870324"],"award-info":[{"award-number":["81870324"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["20200714114820147"],"award-info":[{"award-number":["20200714114820147"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association Inc","doi-asserted-by":"publisher","award":["23POST1026238"],"award-info":[{"award-number":["23POST1026238"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association Inc","doi-asserted-by":"publisher","award":["19TPA34910043"],"award-info":[{"award-number":["19TPA34910043"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association Inc","doi-asserted-by":"publisher","award":["22TPA968801"],"award-info":[{"award-number":["22TPA968801"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.phrs.2024.107156","type":"journal-article","created":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T13:50:06Z","timestamp":1711201806000},"page":"107156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Blockade of endothelial adenosine receptor 2\u202fA suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition"],"prefix":"10.1016","volume":"203","author":[{"given":"Yongfeng","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuhua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiean","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingen","family":"Da","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingwei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Fulton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal L.","family":"Weintraub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunzhe","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suowen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2024.107156_bib1","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.1161\/CIR.0000000000001052","article-title":"Heart Disease and Stroke Statistics-2022 Update: a report from the American Heart Association","volume":"145","author":"Tsao","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2024.107156_bib2","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2024.107156_bib3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/35025203","article-title":"Atherosclerosis","volume":"407","author":"Lusis","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2024.107156_bib4","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/s44161-023-00278-y","article-title":"Systems immunology-based drug repurposing framework to target inflammation in atherosclerosis","volume":"2","author":"Amadori","year":"2023","journal-title":"Nat. Cardiovasc Res"},{"key":"10.1016\/j.phrs.2024.107156_bib5","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1124\/pharmrev.120.000096","article-title":"Endothelial dysfunction in atherosclerotic cardiovascular diseases and beyond: from mechanism to pharmacotherapies","volume":"73","author":"Xu","year":"2021","journal-title":"Pharm. Rev."},{"key":"10.1016\/j.phrs.2024.107156_bib6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis--an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.phrs.2024.107156_bib7","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"Libby","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2024.107156_bib8","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.molmed.2020.11.006","article-title":"Permeability of the endothelial barrier: identifying and reconciling controversies","volume":"27","author":"Claesson-Welsh","year":"2021","journal-title":"Trends Mol. Med"},{"key":"10.1016\/j.phrs.2024.107156_bib9","first-page":"565","article-title":"Endothelial-mesenchymal transition in atherosclerosis","volume":"114","author":"Souilhol","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2024.107156_bib10","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/cvr\/cvx253","article-title":"Endothelial-mesenchymal transition in atherosclerosis","volume":"114","author":"Souilhol","year":"2018","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.phrs.2024.107156_bib11","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00109-013-0997-1","article-title":"Adenosine signaling during acute and chronic disease states","volume":"91","author":"Karmouty-Quintana","year":"2013","journal-title":"J. Mol. Med (Berl. )"},{"key":"10.1016\/j.phrs.2024.107156_bib12","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fimmu.2013.00085","article-title":"Regulation of inflammation by adenosine","volume":"4","author":"Hasko","year":"2013","journal-title":"Front Immunol."},{"key":"10.1016\/j.phrs.2024.107156_bib13","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrd3955","article-title":"Adenosine receptors as drug targets--what are the challenges?","volume":"12","author":"Chen","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.phrs.2024.107156_bib14","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/s41467-017-00551-2","article-title":"Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis","volume":"8","author":"Liu","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2024.107156_bib15","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1111\/bph.14673","article-title":"Inactivation of endothelial adenosine A(2A) receptors protects mice from cerebral ischaemia-induced brain injury","volume":"176","author":"Zhou","year":"2019","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.phrs.2024.107156_bib16","doi-asserted-by":"crossref","first-page":"4514","DOI":"10.1172\/JCI82719","article-title":"Endothelial-to-mesenchymal transition drives atherosclerosis progression","volume":"125","author":"Chen","year":"2015","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.phrs.2024.107156_bib17","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/ng.3396","article-title":"A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease","volume":"47","author":"Nikpay","year":"2015","journal-title":"Nat. Genet"},{"key":"10.1016\/j.phrs.2024.107156_bib18","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1161\/ATVBAHA.109.188839","article-title":"Inactivation of the adenosine A2A receptor protects apolipoprotein E-deficient mice from atherosclerosis","volume":"29","author":"Wang","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.phrs.2024.107156_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11853","article-title":"Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability","volume":"7","author":"Evrard","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2024.107156_bib20","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1172\/JCI119590","article-title":"Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung","volume":"100","author":"Sime","year":"1997","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.phrs.2024.107156_bib21","doi-asserted-by":"crossref","first-page":"20533","DOI":"10.1016\/S0021-9258(17)30535-5","article-title":"Distinct transforming growth factor-beta (TGF-beta) receptor subsets as determinants of cellular responsiveness to three TGF-beta isoforms","volume":"265","author":"Cheifetz","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2024.107156_bib22","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0092-8674(92)90152-3","article-title":"Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine\/threonine kinase.","volume":"68","author":"Lin","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2024.107156_bib23","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1093\/emboj\/21.7.1743","article-title":"Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors","volume":"21","author":"Goumans","year":"2002","journal-title":"Embo J."},{"key":"10.1016\/j.phrs.2024.107156_bib24","doi-asserted-by":"crossref","first-page":"9052","DOI":"10.1002\/jcp.27583","article-title":"Foxm1 is a critical driver of TGF-\u03b2-induced EndMT in endothelial cells through Smad2\/3 and binds to the Snail promoter","volume":"234","author":"Song","year":"2019","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.phrs.2024.107156_bib25","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm1613","article-title":"Endothelial-to-mesenchymal transition contributes to cardiac fibrosis","volume":"13","author":"Zeisberg","year":"2007","journal-title":"Nat. Med"},{"key":"10.1016\/j.phrs.2024.107156_bib26","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abg5060","article-title":"Mechanical forces regulate endothelial-to-mesenchymal transition and atherosclerosis via an Alk5-Shc mechanotransduction pathway","volume":"7","author":"Mehta","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.phrs.2024.107156_bib27","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35085068","article-title":"Transcriptional regulation by the phosphorylation-dependent factor CREB","volume":"2","author":"Mayr","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phrs.2024.107156_bib28","doi-asserted-by":"crossref","first-page":"5616","DOI":"10.1523\/JNEUROSCI.20-15-05616.2000","article-title":"Developmental regulation of neuronal KCa channels by TGFbeta 1: transcriptional and posttranscriptional effects mediated by Erk MAP kinase","volume":"20","author":"Lhuillier","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2024.107156_bib29","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1161\/01.ATV.0000196747.79349.d1","article-title":"Role of cAMP response element binding protein in cardiovascular remodeling: good, bad, or both?","volume":"26","author":"Ichiki","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.phrs.2024.107156_bib30","doi-asserted-by":"crossref","first-page":"25184","DOI":"10.1074\/jbc.M102932200","article-title":"Vascular endothelial cell growth factor activates CRE-binding protein by signaling through the KDR receptor tyrosine kinase","volume":"276","author":"Mayo","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2024.107156_bib31","doi-asserted-by":"crossref","first-page":"9920","DOI":"10.1074\/jbc.M111305200","volume":"277","author":"Reddy","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2024.107156_bib32","article-title":"Cyclic AMP response element-binding protein (CREB) transcription factor in astrocytic synaptic communication","volume":"14","author":"Kim","year":"2022","journal-title":"Front Synaptic Neurosci."},{"key":"10.1016\/j.phrs.2024.107156_bib33","doi-asserted-by":"crossref","DOI":"10.1158\/2326-6074.TUMIMM18-A10","article-title":"Abstract A10: The dual A2aR\/A2bR antagonist AB928 reverses adenosine-mediated immune suppression and inhibits tumor growth in vivo","volume":"8","author":"DiRenzo","year":"2020","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.phrs.2024.107156_bib34","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41572-019-0106-z","article-title":"Atherosclerosis","volume":"5","author":"Libby","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.phrs.2024.107156_bib35","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s40265-013-0066-7","article-title":"Istradefylline: first global approval","volume":"73","author":"Dungo","year":"2013","journal-title":"Drugs"},{"key":"10.1016\/j.phrs.2024.107156_bib36","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S1474-4422(11)70012-6","article-title":"Preladenant in patients with Parkinson's disease and motor fluctuations: a phase 2, double-blind, randomised trial","volume":"10","author":"Hauser","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phrs.2024.107156_bib37","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.parkreldis.2008.12.006","article-title":"Adenosine, adenosine A 2A antagonists, and Parkinson's disease","volume":"15","author":"Jenner","year":"2009","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.phrs.2024.107156_bib38","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1146\/annurev.immunol.22.012703.104731","article-title":"Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors","volume":"22","author":"Sitkovsky","year":"2004","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.phrs.2024.107156_bib39","doi-asserted-by":"crossref","first-page":"899","DOI":"10.5665\/sleep.1942","article-title":"No thanks, coffee keeps me awake\": individual caffeine sensitivity depends on ADORA2A genotype","volume":"35","author":"Landolt","year":"2012","journal-title":"Sleep"},{"key":"10.1016\/j.phrs.2024.107156_bib40","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0002-9149(97)00256-7","article-title":"Adenosine and adenosine receptors in the cardiovascular system: biochemistry, physiology, and pharmacology","volume":"79","author":"Shryock","year":"1997","journal-title":"Am. J. Cardiol."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661824001002?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661824001002?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T10:34:41Z","timestamp":1778582081000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661824001002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":40,"alternative-id":["S1043661824001002"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2024.107156","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blockade of endothelial adenosine receptor 2\u202fA suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2024.107156","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107156"}}