{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:21:40Z","timestamp":1790727700644,"version":"4.1.0"},"reference-count":129,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017538","name":"Zhejiang Provincial Ten Thousand Plan for Young Top Talents","doi-asserted-by":"publisher","award":["2021R52013"],"award-info":[{"award-number":["2021R52013"]}],"id":[{"id":"10.13039\/501100017538","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274003"],"award-info":[{"award-number":["82274003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973390"],"award-info":[{"award-number":["81973390"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.phrs.2024.107332","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T12:18:12Z","timestamp":1722341892000},"page":"107332","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Regulation mechanism of endoplasmic reticulum stress on metabolic enzymes in liver diseases"],"prefix":"10.1016","volume":"207","author":[{"given":"Shaojun","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiwen","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuchen","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lushan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.phrs.2024.107332_bib1","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1042\/BCJ20170920","article-title":"Emerging roles of endoplasmic reticulum-resident selenoproteins in the regulation of cellular stress responses and the implications for metabolic disease","volume":"475","author":"Addinsall","year":"2018","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.phrs.2024.107332_bib2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/hep.32562","article-title":"Endoplasmic reticulum stress in liver diseases","volume":"77","author":"Ajoolabady","year":"2023","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.phrs.2024.107332_bib3","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41569-021-00511-w","article-title":"Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases","volume":"18","author":"Ren","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"issue":"11","key":"10.1016\/j.phrs.2024.107332_bib4","doi-asserted-by":"crossref","first-page":"4110","DOI":"10.1074\/jbc.RA117.001294","article-title":"The luminal domain of the ER stress sensor protein PERK binds misfolded proteins and thereby triggers PERK oligomerization","volume":"293","author":"Wang","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.phrs.2024.107332_bib5","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/s41419-022-05444-x","article-title":"Endoplasmic reticulum stress-mediated cell death in liver injury","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.phrs.2024.107332_bib6","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201904048","article-title":"IRE1\u03b2 negatively regulates IRE1\u03b1 signaling in response to endoplasmic reticulum stress","volume":"219","author":"Grey","year":"2020","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.phrs.2024.107332_bib7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41568-020-00312-2","article-title":"Endoplasmic reticulum stress signals in the tumour and its microenvironment","volume":"21","author":"Chen","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.phrs.2024.107332_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2019.107401","article-title":"The unfolded protein response and hepatic lipid metabolism in non alcoholic fatty liver disease","volume":"203","author":"Song","year":"2019","journal-title":"Pharmacol. Ther."},{"issue":"24","key":"10.1016\/j.phrs.2024.107332_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242417321","article-title":"The PPP1R15 Family of eIF2-alpha Phosphatase Targeting Subunits (GADD34 and CReP)","volume":"24","author":"Hicks","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.phrs.2024.107332_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-92529-w","article-title":"The ATF6\u03b2-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity","volume":"11","author":"Nguyen","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.phrs.2024.107332_bib11","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.livres.2019.01.002","article-title":"Endoplasmic reticulum stress and liver diseases","volume":"3","author":"Liu","year":"2019","journal-title":"Liver Res."},{"issue":"9","key":"10.1016\/j.phrs.2024.107332_bib12","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.2174\/1389450118666180516122517","article-title":"Endoplasmic reticulum stress related molecular mechanisms in nonalcoholic fatty liver disease (NAFLD)","volume":"19","author":"Wang","year":"2018","journal-title":"Curr. Drug Targets"},{"issue":"3","key":"10.1016\/j.phrs.2024.107332_bib13","article-title":"GPAT3 deficiency attenuates corticosterone-caused hepatic steatosis and oxidative stress through GSK3\u03b2\/Nrf2 signals","volume":"1870","author":"Fan","year":"2024","journal-title":"Biochim. Et. Biophys. Acta Mol. basis Dis."},{"issue":"3","key":"10.1016\/j.phrs.2024.107332_bib14","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/s41419-023-05741-z","article-title":"GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway","volume":"14","author":"Fan","year":"2023","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.phrs.2024.107332_bib15","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.cmet.2022.05.004","article-title":"Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia","volume":"34","author":"Morrow","year":"2022","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.phrs.2024.107332_bib16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/hep.31000","article-title":"Fatty acid synthase inhibitor TVB-2640 reduces hepatic de novo lipogenesis in males with metabolic abnormalities","volume":"72","author":"Syed-Abdul","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.phrs.2024.107332_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217006","article-title":"CPT1A loss disrupts BCAA metabolism to confer therapeutic vulnerability in TP53-mutated liver cancer","volume":"595","author":"Liu","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phrs.2024.107332_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111474","article-title":"Inhibition of Sirt3 activates the cGAS-STING pathway to aggravate hepatocyte damage in hepatic ischemia-reperfusion injury mice","volume":"128","author":"Kong","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.phrs.2024.107332_bib19","doi-asserted-by":"crossref","first-page":"505","DOI":"10.7150\/ijms.77955","article-title":"Activating SIRT1 deacetylates NF-\u03baB p65 to alleviate liver inflammation and fibrosis via inhibiting NLRP3 pathway in macrophages","volume":"20","author":"He","year":"2023","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.phrs.2024.107332_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110294","article-title":"NAMPT inhibition reduces macrophage inflammation through the NAD+\/PARP1 pathway to attenuate liver ischemia-reperfusion injury","volume":"369","author":"Lu","year":"2023","journal-title":"Chem. Biol. Interact."},{"issue":"4","key":"10.1016\/j.phrs.2024.107332_bib21","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1053\/j.gastro.2018.11.019","article-title":"NADPH oxidase 1 in liver macrophages promotes inflammation and tumor development in mice","volume":"156","author":"Liang","year":"2019","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.phrs.2024.107332_bib22","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1042\/CS20201091","article-title":"DUSP12 acts as a novel endogenous protective signal against hepatic ischemia-reperfusion damage by inhibiting ASK1 pathway","volume":"135","author":"Boldorini","year":"2021","journal-title":"Clin. Sci. (Lond. )"},{"issue":"12","key":"10.1016\/j.phrs.2024.107332_bib23","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.3724\/abbs.2022183","article-title":"DUSP9 alleviates hepatic ischemia\/reperfusion injury by restraining both mitogen-activated protein kinase and IKK in an apoptosis signal-regulating kinase 1-dependent manner","volume":"54","author":"Li","year":"2022","journal-title":"Acta Biochim. Et. Biophys. Sin."},{"key":"10.1016\/j.phrs.2024.107332_bib24","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.freeradbiomed.2023.11.040","article-title":"Sentrin-specific protease 1 maintains mitochondrial homeostasis through targeting the deSUMOylation of sirtuin-3 to alleviate oxidative damage induced by hepatic ischemia\/reperfusion","volume":"210","author":"Xia","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phrs.2024.107332_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2023.109701","article-title":"CYP2E1 triggered GRP78\/ATF6\/CHOP signaling axis inhibit apoptosis and promotes progression of hepatocellular carcinoma","volume":"745","author":"Ishteyaque","year":"2023","journal-title":"Arch. Biochem. Biophys."},{"issue":"7","key":"10.1016\/j.phrs.2024.107332_bib26","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/aps.2016.175","article-title":"Astragaloside IV attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes via AMPK activation","volume":"38","author":"Zhou","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"issue":"19","key":"10.1016\/j.phrs.2024.107332_bib27","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.4103\/0366-6999.241799","article-title":"Role of X-box binding protein-1 in fructose-induced de novo lipogenesis in HepG2 cells","volume":"131","author":"Yu","year":"2018","journal-title":"Chin. Med. J. (Engl. )"},{"issue":"4","key":"10.1016\/j.phrs.2024.107332_bib28","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.cmet.2012.09.003","article-title":"IRE1\u03b1-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis","volume":"16","author":"Wang","year":"2012","journal-title":"Cell Metab."},{"issue":"530","key":"10.1016\/j.phrs.2024.107332_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aao4617","article-title":"IRE1\u03b1 prevents hepatic steatosis by processing and promoting the degradation of select microRNAs","volume":"11","author":"Wang","year":"2018","journal-title":"Sci. Signal."},{"issue":"51","key":"10.1016\/j.phrs.2024.107332_bib30","doi-asserted-by":"crossref","first-page":"30366","DOI":"10.1074\/jbc.M115.664169","article-title":"Endoplasmic Reticulum (ER) Stress Induces Sirtuin 1 (SIRT1) Expression via the PI3K-Akt-GSK3\u03b2 Signaling Pathway and Promotes Hepatocellular Injury","volume":"290","author":"Koga","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2024.107332_bib31","article-title":"EMC10 modulates hepatic ER stress and steatosis in an isoform-specific manner","author":"Chen","year":"2024","journal-title":"J. Hepatol."},{"issue":"35","key":"10.1016\/j.phrs.2024.107332_bib32","doi-asserted-by":"crossref","first-page":"25350","DOI":"10.1074\/jbc.M113.470526","article-title":"ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice","volume":"288","author":"Xiao","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.phrs.2024.107332_bib33","first-page":"1649","article-title":"Impact of activating transcription factor 4 signaling on lipogenesis in HepG2 cells","volume":"14","author":"Ren","year":"2016","journal-title":"Mol. Med Rep."},{"issue":"2","key":"10.1016\/j.phrs.2024.107332_bib34","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1042\/BJ20110263","article-title":"ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosis","volume":"438","author":"Li","year":"2011","journal-title":"Biochem. J."},{"issue":"7","key":"10.1016\/j.phrs.2024.107332_bib35","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.2337\/db15-1637","article-title":"Hepatic ATF6 increases fatty acid oxidation to attenuate hepatic steatosis in mice through peroxisome proliferator-activated receptor \u03b1","volume":"65","author":"Chen","year":"2016","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.phrs.2024.107332_bib36","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1053\/j.gastro.2020.06.031","article-title":"IRE1A stimulates hepatocyte-derived extracellular vesicles that promote inflammation in mice with steatohepatitis","volume":"159","author":"Dasgupta","year":"2020","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.phrs.2024.107332_bib37","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s12276-022-00766-4","article-title":"Upregulation of the serine palmitoyltransferase subunit SPTLC2 by endoplasmic reticulum stress inhibits the hepatic insulin response","volume":"54","author":"Kim","year":"2022","journal-title":"Exp. Mol. Med."},{"issue":"6","key":"10.1016\/j.phrs.2024.107332_bib38","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/hepr.12587","article-title":"Patatin-like phospholipase domain-containing protein 3 is involved in hepatic fatty acid and triglyceride metabolism through X-box binding protein 1 and modulation of endoplasmic reticulum stress in mice","volume":"46","author":"Ochi","year":"2016","journal-title":"Hepatol. Res."},{"issue":"3","key":"10.1016\/j.phrs.2024.107332_bib39","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1002\/jcp.22833","article-title":"Free fatty acids induce transglutaminase 2-dependent apoptosis in hepatocytes via ER stress-stimulated PERK pathways","volume":"227","author":"Kuo","year":"2012","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.phrs.2024.107332_bib40","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jhep.2020.04.038","article-title":"ER stress-induced upregulation of NNMT contributes to alcohol-related fatty liver development","volume":"73","author":"Song","year":"2020","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.phrs.2024.107332_bib41","doi-asserted-by":"crossref","first-page":"C585","DOI":"10.1152\/ajpcell.00195.2021","article-title":"Nicotinamide N-methyltransferase upregulation via the mTORC1-ATF4 pathway activation contributes to palmitate-induced lipotoxicity in hepatocytes","volume":"321","author":"Griffiths","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"35","key":"10.1016\/j.phrs.2024.107332_bib42","doi-asserted-by":"crossref","first-page":"18536","DOI":"10.1074\/jbc.M116.726836","article-title":"Liver-specific gene inactivation of the transcription factor ATF4 alleviates alcoholic liver steatosis in mice","volume":"291","author":"Li","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.phrs.2024.107332_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004335","article-title":"Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish","volume":"10","author":"Howarth","year":"2014","journal-title":"PLoS Genet"},{"key":"10.1016\/j.phrs.2024.107332_bib44","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.freeradbiomed.2014.08.030","article-title":"Binge alcohol promotes hypoxic liver injury through a CYP2E1-HIF-1\u03b1-dependent apoptosis pathway in mice and humans","volume":"77","author":"Yun","year":"2014","journal-title":"Free Radic. Biol. Med."},{"issue":"7","key":"10.1016\/j.phrs.2024.107332_bib45","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/hep4.1066","article-title":"Increased ethanol-inducible cytochrome P450-2E1 and cytochrome P450 isoforms in exosomes of alcohol-exposed rodents and patients with alcoholism through oxidative and endoplasmic reticulum stress","volume":"1","author":"Cho","year":"2017","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.phrs.2024.107332_bib46","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.taap.2015.12.025","article-title":"The role of heme oxygenase-1 in drug metabolizing dysfunction in the alcoholic fatty liver exposed to ischemic injury","volume":"292","author":"Park","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phrs.2024.107332_bib47","doi-asserted-by":"crossref","DOI":"10.1111\/jvh.13952","article-title":"Peer support for people living with hepatitis B virus-A foundation for treatment expansion","author":"Downs","year":"2024","journal-title":"J. Viral Hepat."},{"key":"10.1016\/j.phrs.2024.107332_bib48","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.virol.2015.02.031","article-title":"Molecular biology of hepatitis B virus infection","volume":"479-480","author":"Seeger","year":"2015","journal-title":"Virology"},{"issue":"6","key":"10.1016\/j.phrs.2024.107332_bib49","first-page":"8432","article-title":"HBx promotes the proliferative ability of HL\u20117702 cells via the COX\u20112\/Wnt\/\u03b2\u2011catenin pathway","volume":"17","author":"Zheng","year":"2018","journal-title":"Mol. Med Rep."},{"issue":"2","key":"10.1016\/j.phrs.2024.107332_bib50","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1042\/BJ20102071","article-title":"Endoplasmic reticulum stress induced by hepatitis B virus X protein enhances cyclo-oxygenase 2 expression via activating transcription factor 4","volume":"435","author":"Cho","year":"2011","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.phrs.2024.107332_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2023.113721","article-title":"HBx induced upregulation of FATP2 promotes the development of hepatic lipid accumulation","volume":"430","author":"Lu","year":"2023","journal-title":"Exp. Cell Res."},{"issue":"56","key":"10.1016\/j.phrs.2024.107332_bib52","doi-asserted-by":"crossref","first-page":"96027","DOI":"10.18632\/oncotarget.21630","article-title":"Hepatitis B virus X protein inhibits apoptosis by modulating endoplasmic reticulum stress response","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"issue":"45","key":"10.1016\/j.phrs.2024.107332_bib53","doi-asserted-by":"crossref","first-page":"46384","DOI":"10.1074\/jbc.M403568200","article-title":"Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase","volume":"279","author":"Hung","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.phrs.2024.107332_bib54","doi-asserted-by":"crossref","first-page":"12442","DOI":"10.3390\/ijms150712442","article-title":"Induction of apurinic endonuclease 1 overexpression by endoplasmic reticulum stress in hepatoma cells","volume":"15","author":"Cheng","year":"2014","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.phrs.2024.107332_bib55","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1128\/JVI.02363-14","article-title":"Activation of ATP citrate lyase by mTOR signal induces disturbed lipid metabolism in hepatitis B virus pre-S2 mutant tumorigenesis","volume":"89","author":"Teng","year":"2015","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.phrs.2024.107332_bib56","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/jmv.24643","article-title":"Hepatitis B virus X protein impairs \u03b1-interferon signaling via up-regulation of suppressor of cytokine signaling 3 and protein phosphatase 2A","volume":"89","author":"Tsunematsu","year":"2017","journal-title":"J. Med. Virol."},{"issue":"4","key":"10.1016\/j.phrs.2024.107332_bib57","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.molcel.2016.06.024","article-title":"A conserved motif provides binding specificity to the PP2A-B56 phosphatase","volume":"63","author":"Hertz","year":"2016","journal-title":"Mol. Cell"},{"issue":"7","key":"10.1016\/j.phrs.2024.107332_bib58","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/s41419-018-0787-3","article-title":"ER stress regulating protein phosphatase 2A-B56\u03b3, targeted by hepatitis B virus X protein, induces cell cycle arrest and apoptosis of hepatocytes","volume":"9","author":"He","year":"2018","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.phrs.2024.107332_bib59","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nm.4451","article-title":"An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-reperfusion injury","volume":"24","author":"Zhang","year":"2018","journal-title":"Nat. Med."},{"issue":"10","key":"10.1016\/j.phrs.2024.107332_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/cells8101131","article-title":"Inflammasome-Mediated Inflammation in Liver Ischemia-Reperfusion Injury","volume":"8","author":"Jim\u00e9nez-Castro","year":"2019","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.phrs.2024.107332_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101532","article-title":"The ER stress sensor inositol-requiring enzyme 1\u03b1 in Kupffer cells promotes hepatic ischemia-reperfusion injury","volume":"298","author":"Cai","year":"2022","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.phrs.2024.107332_bib62","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.cell.2018.12.012","article-title":"Environmental control of astrocyte pathogenic activities in CNS inflammation","volume":"176","author":"Wheeler","year":"2019","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.phrs.2024.107332_bib63","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1016\/j.cellsig.2010.07.006","article-title":"XBP1U inhibits the XBP1S-mediated upregulation of the iNOS gene expression in mammalian ER stress response","volume":"22","author":"Guo","year":"2010","journal-title":"Cell. Signal."},{"issue":"11","key":"10.1016\/j.phrs.2024.107332_bib64","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1016\/j.cellsig.2012.07.018","article-title":"Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase expression by endoplasmic reticulum stress","volume":"24","author":"Ho","year":"2012","journal-title":"Cell. Signal."},{"issue":"10","key":"10.1016\/j.phrs.2024.107332_bib65","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1097\/LVT.0000000000000210","article-title":"Inhibition of SK2 and ER stress ameliorated inflammation and apoptosis in liver ischemia-reperfusion injury","volume":"29","author":"Jiang","year":"2023","journal-title":"Liver Transpl."},{"issue":"1","key":"10.1016\/j.phrs.2024.107332_bib66","doi-asserted-by":"crossref","first-page":"9232","DOI":"10.1038\/s41598-018-27686-6","article-title":"In vitro inhibition of hepatic stellate cell activation by the autophagy-related lipid droplet protein ATG2A","volume":"8","author":"Hong","year":"2018","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.phrs.2024.107332_bib67","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1055\/s-0039-1681032","article-title":"Endoplasmic reticulum stress in metabolic liver diseases and hepatic fibrosis","volume":"39","author":"Maiers","year":"2019","journal-title":"Semin. Liver Dis."},{"issue":"2","key":"10.1016\/j.phrs.2024.107332_bib68","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1002\/jcp.29952","article-title":"IRE1\u03b1\/NOX4 signaling pathway mediates ROS-dependent activation of hepatic stellate cells in NaAsO(2) -induced liver fibrosis","volume":"236","author":"Tao","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.phrs.2024.107332_bib69","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.biochi.2019.04.006","article-title":"Long non-coding RNA H19, a negative regulator of microRNA-148b-3p, participates in hypoxia stress in human hepatic sinusoidal endothelial cells via NOX4 and eNOS\/NO signaling","volume":"163","author":"Zhu","year":"2019","journal-title":"Biochimie"},{"issue":"1","key":"10.1016\/j.phrs.2024.107332_bib70","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1053\/j.gastro.2015.09.039","article-title":"Endoplasmic reticulum stress in hepatic stellate cells promotes liver fibrosis via PERK-mediated degradation of HNRNPA1 and up-regulation of SMAD2","volume":"150","author":"Koo","year":"2016","journal-title":"Gastroenterology"},{"issue":"18","key":"10.1016\/j.phrs.2024.107332_bib71","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184369","article-title":"Endoplasmic reticulum stress increases DUSP5 expression via PERK-CHOP pathway, leading to hepatocyte death","volume":"20","author":"Jo","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.phrs.2024.107332_bib72","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41572-020-00240-3","article-title":"Hepatocellular carcinoma","volume":"7","author":"Llovet","year":"2021","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"2","key":"10.1016\/j.phrs.2024.107332_bib73","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/hep.29871","article-title":"Dual role for inositol-requiring enzyme 1\u03b1 in promoting the development of hepatocellular carcinoma during diet-induced obesity in mice","volume":"68","author":"Wu","year":"2018","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.phrs.2024.107332_bib74","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s13046-023-02656-7","article-title":"Activation of ACLY by SEC63 deploys metabolic reprogramming to facilitate hepatocellular carcinoma metastasis upon endoplasmic reticulum stress","volume":"42","author":"Hu","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.phrs.2024.107332_bib75","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s12072-014-9582-0","article-title":"Vlierberghe, Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy","volume":"9","author":"Vandewynckel","year":"2015","journal-title":"Hepatol. Int."},{"issue":"1","key":"10.1016\/j.phrs.2024.107332_bib76","doi-asserted-by":"crossref","first-page":"7926","DOI":"10.1038\/s41598-021-86592-6","article-title":"The long noncoding RNA of RMRP is downregulated by PERK, which induces apoptosis in hepatocellular carcinoma cells","volume":"11","author":"Yukimoto","year":"2021","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.phrs.2024.107332_bib77","doi-asserted-by":"crossref","first-page":"986","DOI":"10.3748\/wjg.v23.i6.986","article-title":"Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation","volume":"23","author":"Bu","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phrs.2024.107332_bib78","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.omtn.2021.09.014","article-title":"Endoplasmic reticulum stress promotes sorafenib resistance via miR-188-5p\/hnRNPA2B1-mediated upregulation of PKM2 in hepatocellular carcinoma","volume":"26","author":"Zhou","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"4","key":"10.1016\/j.phrs.2024.107332_bib79","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3350\/cmh.2020.0137","article-title":"Beneficial effect of anti-diabetic drugs for nonalcoholic fatty liver disease","volume":"26","author":"Kim","year":"2020","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.phrs.2024.107332_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115953","article-title":"Protective effects of empagliflozin on methotrexate induced hepatotoxicity in rats","volume":"170","author":"Kalantari","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phrs.2024.107332_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118483","article-title":"The regulation of GSH\/GPX4-mediated lipid accumulation confirms that schisandra polysaccharides should be valued equally as lignans","volume":"333","author":"Xue","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phrs.2024.107332_bib82","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ejphar.2015.11.043","article-title":"Betaine prevented fructose-induced NAFLD by regulating LXR\u03b1\/PPAR\u03b1 pathway and alleviating ER stress in rats","volume":"770","author":"Ge","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2024.107332_bib83","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bbrc.2022.12.014","article-title":"The natural flavone acacetin protects against high-fat diet-induced lipid accumulation in the liver via the endoplasmic reticulum stress\/ferroptosis pathway","volume":"640","author":"Jiang","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"41","key":"10.1016\/j.phrs.2024.107332_bib84","doi-asserted-by":"crossref","first-page":"11428","DOI":"10.1021\/acs.jafc.9b05131","article-title":"Diosgenyl saponin inducing endoplasmic reticulum stress and mitochondria-mediated apoptotic pathways in liver cancer cells","volume":"67","author":"Meng","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phrs.2024.107332_bib85","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bbrc.2023.06.086","article-title":"Saikosaponin A triggers cell ferroptosis in hepatocellular carcinoma by inducing endoplasmic reticulum stress-stimulated ATF3 expression","volume":"674","author":"Lan","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phrs.2024.107332_bib86","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.13376","article-title":"Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1\/NICD pathway","volume":"10","author":"Sun","year":"2022","journal-title":"PeerJ"},{"issue":"3","key":"10.1016\/j.phrs.2024.107332_bib87","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1007\/s10787-024-01447-6","article-title":"Curcumol: a review of its pharmacology, pharmacokinetics, drug delivery systems, structure-activity relationships, and potential applications","volume":"32","author":"Zhai","year":"2024","journal-title":"Inflammopharmacology"},{"issue":"9","key":"10.1016\/j.phrs.2024.107332_bib88","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1136\/gutjnl-2021-325065","article-title":"Targeting ER protein TXNDC5 in hepatic stellate cell mitigates liver fibrosis by repressing non-canonical TGF\u03b2 signalling","volume":"71","author":"Hung","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.phrs.2024.107332_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111504","article-title":"4-Acetylantroquinonol B ameliorates nonalcoholic steatohepatitis by suppression of ER stress and NLRP3 inflammasome activation","volume":"138","author":"Yen","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.phrs.2024.107332_bib90","doi-asserted-by":"crossref","DOI":"10.3390\/nu9040346","article-title":"Homocysteine induces hepatic steatosis involving ER stress response in high methionine diet-fed mice","volume":"9","author":"Ai","year":"2017","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.phrs.2024.107332_bib91","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1111\/jcmm.14275","article-title":"PI3-kinase\/Akt pathway-regulated membrane transportation of acid-sensing ion channel 1a\/Calcium ion influx\/endoplasmic reticulum stress activation on PDGF-induced HSC Activation","volume":"23","author":"Zuo","year":"2019","journal-title":"J. Cell. Mol. Med."},{"issue":"3","key":"10.1016\/j.phrs.2024.107332_bib92","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/bph.14095","article-title":"Tauroursodeoxycholic acid inhibits intestinal inflammation and barrier disruption in mice with non-alcoholic fatty liver disease","volume":"175","author":"Wang","year":"2018","journal-title":"Br. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.phrs.2024.107332_bib93","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1111\/cas.12743","article-title":"Histidine-rich calcium binding protein promotes growth of hepatocellular carcinoma in vitro and in vivo","volume":"106","author":"Liu","year":"2015","journal-title":"Cancer Sci."},{"key":"10.1016\/j.phrs.2024.107332_bib94","doi-asserted-by":"crossref","first-page":"4202","DOI":"10.1038\/ncomms5202","article-title":"Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors","volume":"5","author":"Sanches","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2024.107332_bib95","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.3389\/fphar.2018.01344","article-title":"Inositol-Requiring Enzyme 1 Alpha Endoribonuclease Specific Inhibitor STF-083010 Alleviates Carbon Tetrachloride Induced Liver Injury and Liver Fibrosis in Mice","volume":"9","author":"Chen","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phrs.2024.107332_bib96","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.55865","article-title":"Inhibiting IRE1\u03b1-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma","volume":"9","author":"Pavlovi\u0107","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.phrs.2024.107332_bib97","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.bbrc.2022.09.098","article-title":"KIRA8 attenuates non-alcoholic steatohepatitis through inhibition of the IRE1\u03b1\/XBP1 signalling pathway","volume":"632","author":"Zhao","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"17","key":"10.1016\/j.phrs.2024.107332_bib98","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1038\/s41388-024-02988-4","article-title":"Targeting the IRE1\u03b1-XBP1s axis confers selective vulnerability in hepatocellular carcinoma with activated Wnt signaling","volume":"43","author":"Zhang","year":"2024","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.phrs.2024.107332_bib99","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/s41419-020-03264-5","article-title":"Phosphorylation of eIF2\u03b1 signaling pathway attenuates obesity-induced non-alcoholic fatty liver disease in an ER stress and autophagy-dependent manner","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.phrs.2024.107332_bib100","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-70689-5","article-title":"Administration of small-molecule guanabenz acetate attenuates fatty liver and hyperglycemia associated with obesity","volume":"10","author":"Yoshino","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2024.107332_bib101","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.molmet.2017.12.008","article-title":"Hepatic regulation of VLDL receptor by PPAR\u03b2\/\u03b4 and FGF21 modulates non-alcoholic fatty liver disease","volume":"8","author":"Zarei","year":"2018","journal-title":"Mol. Metab."},{"issue":"6","key":"10.1016\/j.phrs.2024.107332_bib102","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1002\/cpt.3046","article-title":"Population pharmacokinetics and pharmacodynamics of pegozafermin in patients with nonalcoholic steatohepatitis","volume":"114","author":"Tseng","year":"2023","journal-title":"Clin. Pharmacol. Ther."},{"issue":"12","key":"10.1016\/j.phrs.2024.107332_bib103","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.7150\/ijbs.85883","article-title":"Melatonin ameliorates hepatic ferroptosis in NAFLD by inhibiting ER stress via the MT2\/cAMP\/PKA\/IRE1 signaling pathway","volume":"19","author":"Guan","year":"2023","journal-title":"Int. J. Biol. Sci."},{"issue":"19","key":"10.1016\/j.phrs.2024.107332_bib104","article-title":"Inflammation-responsive cell membrane-camouflaged nanoparticles against liver fibrosis via regulating endoplasmic reticulum stress and oxidative stress","volume":"36","author":"Bai","year":"2024","journal-title":"Adv. Mater. (Deerfield Beach, Fla. )"},{"issue":"2","key":"10.1016\/j.phrs.2024.107332_bib105","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22020818","article-title":"Empagliflozin attenuates non-alcoholic fatty liver disease (NAFLD) in high fat diet fed ApoE((-\/-)) mice by activating autophagy and reducing ER stress and apoptosis","volume":"22","author":"Nasiri-Ansari","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2024.107332_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112927","article-title":"Ginsenoside Mc1 improves liver steatosis and insulin resistance by attenuating ER stress","volume":"259","author":"Roh","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phrs.2024.107332_bib107","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jep.2016.03.021","article-title":"Schisandra chinensis extract ameliorates nonalcoholic fatty liver via inhibition of endoplasmic reticulum stress","volume":"185","author":"Jang","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.phrs.2024.107332_bib108","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9010026","article-title":"Endoplasmic reticulum stress-induced resistance to doxorubicin is reversed by mulberry leaf polyphenol extract in hepatocellular carcinoma through inhibition of COX-2","volume":"9","author":"Yang","year":"2019","journal-title":"Antioxidants"},{"issue":"6","key":"10.1016\/j.phrs.2024.107332_bib109","first-page":"5046","article-title":"Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells","volume":"15","author":"Jin","year":"2018","journal-title":"Exp. Ther. Med."},{"issue":"4","key":"10.1016\/j.phrs.2024.107332_bib110","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.bbrc.2018.01.111","article-title":"Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress","volume":"496","author":"Lv","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.phrs.2024.107332_bib111","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10010062","article-title":"Antioxidant and anti-inflammatory effects of korean black ginseng extract through ER stress pathway","volume":"10","author":"An","year":"2021","journal-title":"Antioxidants"},{"issue":"4","key":"10.1016\/j.phrs.2024.107332_bib112","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12040826","article-title":"NAFLD in the 21st century: current knowledge regarding its pathogenesis, diagnosis and therapeutics","volume":"12","author":"Kounatidis","year":"2024","journal-title":"Biomedicines"},{"issue":"2","key":"10.1016\/j.phrs.2024.107332_bib113","doi-asserted-by":"crossref","first-page":"669","DOI":"10.7150\/jca.61622","article-title":"PERK regulates the sensitivity of hepatocellular carcinoma cells to high-LET carbon ions via either apoptosis or ferroptosis","volume":"13","author":"Zheng","year":"2022","journal-title":"J. Cancer"},{"key":"10.1016\/j.phrs.2024.107332_bib114","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.103007","article-title":"Inhibiting the compensatory elevation of xCT collaborates with disulfiram\/copper-induced GSH consumption for cascade ferroptosis and cuproptosis","volume":"69","author":"Zhang","year":"2024","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.phrs.2024.107332_bib115","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.7150\/thno.67722","article-title":"G\u03b1(12) overexpression in hepatocytes by ER stress exacerbates acute liver injury via ROCK1-mediated miR-15a and ALOX12 dysregulation","volume":"12","author":"Tak","year":"2022","journal-title":"Theranostics"},{"issue":"5","key":"10.1016\/j.phrs.2024.107332_bib116","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.7150\/thno.89703","article-title":"Dual regulation of NEMO by Nrf2 and miR-125a inhibits ferroptosis and protects liver from endoplasmic reticulum stress-induced injury","volume":"14","author":"Tak","year":"2024","journal-title":"Theranostics"},{"issue":"6586","key":"10.1016\/j.phrs.2024.107332_bib117","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.phrs.2024.107332_bib118","doi-asserted-by":"crossref","first-page":"1365294","DOI":"10.3389\/fphar.2024.1365294","article-title":"The gut-liver axis in fatty liver disease: role played by natural products","volume":"15","author":"Ming","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.phrs.2024.107332_bib119","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.jhep.2013.12.019","article-title":"Altered profile of human gut microbiome is associated with cirrhosis and its complications","volume":"60","author":"Bajaj","year":"2014","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.phrs.2024.107332_bib120","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/s13059-021-02496-8","article-title":"Gut bacterial metabolites modulate endoplasmic reticulum stress","volume":"22","author":"Ke","year":"2021","journal-title":"Genome Biol."},{"issue":"15","key":"10.1016\/j.phrs.2024.107332_bib121","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21155214","article-title":"Gut Microbiota Metabolites in NAFLD Pathogenesis and Therapeutic Implications","volume":"21","author":"Chen","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"20","key":"10.1016\/j.phrs.2024.107332_bib122","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.3748\/wjg.v25.i20.2450","article-title":"Trimethylamine N-oxide attenuates high-fat high-cholesterol diet-induced steatohepatitis by reducing hepatic cholesterol overload in rats","volume":"25","author":"Zhao","year":"2019","journal-title":"World J. Gastroenterol."},{"issue":"40","key":"10.1016\/j.phrs.2024.107332_bib123","doi-asserted-by":"crossref","first-page":"6141","DOI":"10.3748\/wjg.v26.i40.6141","article-title":"Role of gut microbiota via the gut-liver-brain axis in digestive diseases","volume":"26","author":"Ding","year":"2020","journal-title":"World J. Gastroenterol."},{"issue":"14","key":"10.1016\/j.phrs.2024.107332_bib124","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1042\/CS20210198","article-title":"Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress","volume":"135","author":"Cheng","year":"2021","journal-title":"Clin. Sci. (Lond. )"},{"issue":"7","key":"10.1016\/j.phrs.2024.107332_bib125","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.1002\/jcp.30199","article-title":"Endogenous metabolite, kynurenic acid, attenuates nonalcoholic fatty liver disease via AMPK\/autophagy- and AMPK\/ORP150-mediated signaling","volume":"236","author":"Pyun","year":"2021","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"10.1016\/j.phrs.2024.107332_bib126","doi-asserted-by":"crossref","DOI":"10.3390\/nu15061490","article-title":"Natural product skatole ameliorates lipotoxicity-induced multiple hepatic damage under hyperlipidemic conditions in hepatocytes","volume":"15","author":"Hong","year":"2023","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.phrs.2024.107332_bib127","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2356270","article-title":"The transplantation of the gut microbiome of fat-1 mice protects against colonic mucus layer disruption and endoplasmic reticulum stress induced by high fat diet","volume":"16","author":"Bourragat","year":"2024","journal-title":"Gut Microbes"},{"issue":"4","key":"10.1016\/j.phrs.2024.107332_bib128","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41575-018-0099-1","article-title":"Alcohol, liver disease and the gut microbiota","volume":"16","author":"Bajaj","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phrs.2024.107332_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2023.155740","article-title":"Gut-derived ammonia contributes to alcohol-related fatty liver development via facilitating ethanol metabolism and provoking ATF4-dependent de novo lipogenesis activation","volume":"151","author":"Song","year":"2024","journal-title":"Metabolism"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661824002779?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661824002779?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:43:04Z","timestamp":1778794984000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661824002779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":129,"alternative-id":["S1043661824002779"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2024.107332","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation mechanism of endoplasmic reticulum stress on metabolic enzymes in liver diseases","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2024.107332","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107332"}}