{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:37:10Z","timestamp":1784291830237,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.phrs.2024.107507","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T08:33:42Z","timestamp":1731573222000},"page":"107507","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Formation of CSE-YAP complex drives FOXD3-mediated transition of neurotoxic astrocytes in Parkinson\u2019s disease"],"prefix":"10.1016","volume":"210","author":[{"given":"Rong-Xin","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Han","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2024.107507_bib1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0140-6736(23)01419-8","article-title":"The epidemiology of Parkinson's disease","volume":"403","author":"Ben-Shlomo","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2024.107507_bib2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0140-6736(23)01478-2","article-title":"The pathogenesis of Parkinson's disease","volume":"403","author":"Morris","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2024.107507_bib3","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson's disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2024.107507_bib4","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1212\/WNL.38.8.1285","article-title":"Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains","volume":"38","author":"McGeer","year":"1988","journal-title":"Neurology"},{"key":"10.1016\/j.phrs.2024.107507_bib5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1474-4422(23)00378-2","article-title":"Safety, tolerability, and efficacy of NLY01 in early untreated Parkinson's disease: a randomised, double-blind, placebo-controlled trial","volume":"23","author":"McGarry","year":"2024","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phrs.2024.107507_bib6","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adi7828","article-title":"Neuroinflammation: an astrocyte perspective","volume":"15","author":"Lee","year":"2023","journal-title":"Sci. Transl. Med"},{"key":"10.1016\/j.phrs.2024.107507_bib7","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.it.2020.07.007","article-title":"The role of astrocytes in CNS inflammation","volume":"41","author":"Giovannoni","year":"2020","journal-title":"Trends Immunol."},{"key":"10.1016\/j.phrs.2024.107507_bib8","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41573-022-00390-x","article-title":"Function and therapeutic value of astrocytes in neurological diseases","volume":"21","author":"Lee","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.phrs.2024.107507_bib9","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2024.107507_bib10","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1038\/s42255-023-00887-8","article-title":"Alleviating symptoms of neurodegenerative disorders by astrocyte-specific overexpression of TMEM164 in mice","volume":"5","author":"Zhang","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.phrs.2024.107507_bib11","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/s41586-023-06935-3","article-title":"A molecular switch for neuroprotective astrocyte reactivity","volume":"626","author":"Cameron","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2024.107507_bib12","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/s41591-018-0051-5","article-title":"Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease","volume":"24","author":"Yun","year":"2018","journal-title":"Nat. Med"},{"key":"10.1016\/j.phrs.2024.107507_bib13","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2174\/1874609811306010007","article-title":"Reactive astrocytes are key players in nigrostriatal dopaminergic neurorepair in the MPTP mouse model of Parkinson's disease: focus on endogenous neurorestoration","volume":"6","author":"Episcopo","year":"2013","journal-title":"Curr. Aging Sci."},{"key":"10.1016\/j.phrs.2024.107507_bib14","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1515\/revneuro-2023-0039","article-title":"Transsulfuration pathway: a targeting neuromodulator in Parkinson's disease","volume":"34","author":"Corona-Trejo","year":"2023","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.phrs.2024.107507_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.659402","article-title":"Neuroprotective roles of the reverse transsulfuration pathway in Alzheimer's disease","volume":"13","author":"Paul","year":"2021","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.phrs.2024.107507_bib16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bbi.2017.07.159","article-title":"Impaired CBS-H(2)S signaling axis contributes to MPTP-induced neurodegeneration in a mouse model of Parkinson's disease.","volume":"67","author":"Yuan","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.phrs.2024.107507_bib17","doi-asserted-by":"crossref","DOI":"10.1089\/ars.2022.0174","article-title":"Cystathionine beta-synthase suppresses NLRP3 inflammasome activation via redox regulation in microglia","author":"Mou","year":"2023","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.phrs.2024.107507_bib18","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/febs.15360","article-title":"CRY1-CBS binding regulates circadian clock function and metabolism","volume":"288","author":"Cal-Kayitmazbatir","year":"2021","journal-title":"FEBS J."},{"key":"10.1016\/j.phrs.2024.107507_bib19","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1089\/ars.2010.3517","article-title":"Hydrogen sulfide: neurophysiology and neuropathology","volume":"15","author":"Hu","year":"2011","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.phrs.2024.107507_bib20","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s10522-021-09929-8","article-title":"Exercise renovates H(2)S and Nrf2-related antioxidant pathways to suppress apoptosis in the natural ageing process of male rat cortex.","volume":"22","author":"Lin","year":"2021","journal-title":"Biogerontology"},{"key":"10.1016\/j.phrs.2024.107507_bib21","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/s41419-022-05399-z","article-title":"Mitochondrial glutamine transporter SLC1A5_var, a potential target to suppress astrocyte reactivity in Parkinson's disease","volume":"13","author":"Liu","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phrs.2024.107507_bib22","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1080\/15548627.2023.2196889","article-title":"CircEPS15, as a sponge of MIR24-3p ameliorates neuronal damage in Parkinson disease through boosting PINK1-PRKN-mediated mitophagy","volume":"19","author":"Zhou","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.phrs.2024.107507_bib23","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.apsb.2022.07.021","article-title":"Impeding the combination of astrocytic ASCT2 and NLRP3 by talniflumate alleviates neuroinflammation in experimental models of Parkinson's disease","volume":"13","author":"Liu","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phrs.2024.107507_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102168","article-title":"Kir6.2 is essential to maintain neurite features by modulating PM20D1-reduced mitochondrial ATP generation","volume":"47","author":"Song","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.phrs.2024.107507_bib25","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/s41593-022-01061-1","article-title":"Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson's disease","volume":"25","author":"Kamath","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phrs.2024.107507_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107687","article-title":"Therapeutic potential of sulfur-containing natural products in inflammatory diseases","volume":"216","author":"Cao","year":"2020","journal-title":"Pharm. Ther."},{"key":"10.1016\/j.phrs.2024.107507_bib27","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1474-9726.2009.00543.x","article-title":"Neuroprotective effects of hydrogen sulfide on Parkinson's disease rat models","volume":"9","author":"Hu","year":"2010","journal-title":"Aging Cell"},{"key":"10.1016\/j.phrs.2024.107507_bib28","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40478-023-01526-9","article-title":"Roles of neuropathology-associated reactive astrocytes: a systematic review","volume":"11","author":"Lawrence","year":"2023","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.phrs.2024.107507_bib29","doi-asserted-by":"crossref","first-page":"377","DOI":"10.32604\/or.2022.026085","article-title":"The role of YAP in the control of the metastatic potential of oral cancer","volume":"29","author":"Ahmad","year":"2021","journal-title":"Oncol. Res."},{"key":"10.1016\/j.phrs.2024.107507_bib30","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/s41467-022-28913-5","article-title":"Fusobacterium nucleatum reduces METTL3-mediated m(6)A modification and contributes to colorectal cancer metastasis.","volume":"13","author":"Chen","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2024.107507_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175743","article-title":"Hydrogen sulfide inhibits lipopolysaccharide-based neuroinflammation-induced astrocyte polarization after cerebral ischemia\/reperfusion injury","volume":"949","author":"Li","year":"2023","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.phrs.2024.107507_bib32","article-title":"H(2)S Regulates the Phenotypic Transformation of Astrocytes Following Cerebral Ischemia\/Reperfusion via Inhibiting the RhoA\/ROCK Pathway.","author":"Ding","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phrs.2024.107507_bib33","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1021\/acschemneuro.0c00674","article-title":"CSE-Derived H(2)S Inhibits Reactive Astrocytes Proliferation and Promotes Neural Functional Recovery after Cerebral Ischemia\/Reperfusion Injury in Mice Via Inhibition of RhoA\/ROCK(2) Pathway","volume":"12","author":"Zhang","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.phrs.2024.107507_bib34","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41582-023-00822-1","article-title":"Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration","volume":"19","author":"Patani","year":"2023","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.phrs.2024.107507_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110761","article-title":"Telmisartan inhibits microglia-induced neurotoxic A1 astrocyte conversion via PPARgamma-mediated NF-kappaB\/p65 degradation.","volume":"123","author":"Quan","year":"2023","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.phrs.2024.107507_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115550","article-title":"Complement receptor 3-mediated neurotoxic glial activation contributes to rotenone-induced cognitive decline in mice","volume":"266","author":"Wang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661824004523?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661824004523?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T11:48:16Z","timestamp":1734522496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661824004523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":36,"alternative-id":["S1043661824004523"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2024.107507","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Formation of CSE-YAP complex drives FOXD3-mediated transition of neurotoxic astrocytes in Parkinson\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2024.107507","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107507"}}