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Sci."},{"issue":"5","key":"10.1016\/j.phrs.2024.107551_bib184","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1159\/000447902","article-title":"Luteolin attenuates foam cell formation and apoptosis in ox-LDL-stimulated macrophages by enhancing autophagy","volume":"39","author":"Zhang","year":"2016","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.phrs.2024.107551_bib185","article-title":"J. Nut Formononetin alleviates hepatic steatosis by facilitating TFEB-mediated lysosome biogenesis and lipophagy r","volume":"73","author":"Wang","year":"2019","journal-title":"Biochem"},{"issue":"7","key":"10.1016\/j.phrs.2024.107551_bib186","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1002\/ptr.7797","article-title":"Homoplantaginin attenuates high glucose-induced vascular endothelial cell apoptosis through promoting autophagy via the AMPK\/TFEB pathway","volume":"37","author":"Fan","year":"2023","journal-title":"Phytother. 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Ethnopharmacol."},{"key":"10.1016\/j.phrs.2024.107551_bib189","doi-asserted-by":"crossref","first-page":"512","DOI":"10.3389\/fphar.2020.00512","article-title":"Quercetin attenuates atherosclerosis via modulating oxidized LDL-induced endothelial cellular senescence","volume":"11","author":"Jiang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phrs.2024.107551_bib190","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2023.109314","article-title":"Quercetin alleviates atherosclerosis by suppressing oxidized LDL-induced senescence in plaque macrophage via inhibiting the p38MAPK\/p16 pathway","volume":"116","author":"Luo","year":"2023","journal-title":"J. Nutr. 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Food Chem."},{"issue":"6","key":"10.1016\/j.phrs.2024.107551_bib193","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1111\/jam.14441","article-title":"Quercetin reduces atherosclerotic lesions by altering the gut microbiota and reducing atherogenic lipid metabolites","volume":"127","author":"Nie","year":"2019","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.phrs.2024.107551_bib194","doi-asserted-by":"crossref","first-page":"2547588","DOI":"10.1155\/2023\/2547588","article-title":"Dihydromyricetin inhibits M1 macrophage polarization in atherosclerosis by modulating miR-9-mediated SIRT1\/NF-kappaB signaling pathway","volume":"2023","author":"Yang","year":"2023","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.phrs.2024.107551_bib195","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.hjc.2023.08.004","article-title":"Impact of quercetin in patients with myocardial infarction. 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Res."},{"issue":"8","key":"10.1016\/j.phrs.2024.107551_bib197","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1039\/C7FO00342K","article-title":"Soybean isoflavones ameliorate ischemic cardiomyopathy by activating Nrf2-mediated antioxidant responses","volume":"8","author":"Li","year":"2017","journal-title":"Food Funct."},{"issue":"4","key":"10.1016\/j.phrs.2024.107551_bib198","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1136\/svn-2017-000104","article-title":"Ginkgo biloba extract improved cognitive and neurological functions of acute ischaemic stroke: a randomised controlled trial","volume":"2","author":"Li","year":"2017","journal-title":"Stroke Vasc. Neurol."},{"issue":"5","key":"10.1016\/j.phrs.2024.107551_bib199","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1067\/mhj.2002.121463","article-title":"Efficacy and safety of crataegus extract WS 1442 in comparison with placebo in patients with chronic stable New York heart association class-III heart failure","volume":"143","author":"Tauchert","year":"2002","journal-title":"Am. 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