{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:01:10Z","timestamp":1793390470189,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018938","name":"Administration of Traditional Chinese Medicine of Jilin Province","doi-asserted-by":"publisher","award":["20222042"],"award-info":[{"award-number":["20222042"]}],"id":[{"id":"10.13039\/100018938","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018938","name":"Administration of Traditional Chinese Medicine of Jilin Province","doi-asserted-by":"publisher","award":["20241074"],"award-info":[{"award-number":["20241074"]}],"id":[{"id":"10.13039\/100018938","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074019"],"award-info":[{"award-number":["82074019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81961128028"],"award-info":[{"award-number":["81961128028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274158"],"award-info":[{"award-number":["82274158"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A04J5398"],"award-info":[{"award-number":["2025A04J5398"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3502800"],"award-info":[{"award-number":["2023YFC3502800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3502803"],"award-info":[{"award-number":["2023YFC3502803"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.phrs.2024.107570","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T19:07:38Z","timestamp":1735672058000},"page":"107570","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Wogonin effects on the efflux transporters BCRP and MRP2, explain its effectiveness in ulcerative colitis: Implications for metabolic and transport interactions"],"prefix":"10.1016","volume":"212","author":[{"given":"Yuanyuan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zerong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangyu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxiong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqiu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2024.107570_bib1","doi-asserted-by":"crossref","first-page":"16389","DOI":"10.3748\/wjg.v20.i44.16389","article-title":"Ulcerative colitis-associated colorectal cancer","volume":"20","author":"Masakazu Yashiro","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phrs.2024.107570_bib2","doi-asserted-by":"crossref","unstructured":"R.\u00a0Voelker,\u00a0What is ulcerative colitis?What is ulcerative colitis? JAMA,\u00a0Jama\u00a0331\u00a0(2024)\u00a0716, doi:10.1001\/jama.2023.23814.","DOI":"10.1001\/jama.2023.23814"},{"key":"10.1016\/j.phrs.2024.107570_bib3","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1053\/j.gastro.2022.01.033","article-title":"Ozanimod for the treatment of ulcerative colitis","volume":"162","author":"Khanna","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phrs.2024.107570_bib4","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1038\/d41586-018-07276-2","article-title":"Ulcerative colitis: towards remission","volume":"563","author":"Eisenstein","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2024.107570_bib5","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1142\/S0192415X21500464","article-title":"Herbal medicine and acupuncture combined treatment attenuates colitis in rats","volume":"49","author":"Lee","year":"2021","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.phrs.2024.107570_bib6","first-page":"540","article-title":"Dapagliflozin reduces left ventricular mass","volume":"17","author":"Lim","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.phrs.2024.107570_bib7","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1111\/1541-4337.12351","article-title":"The bioavailability, transport, and bioactivity of dietary flavonoids: a review from a historical perspective","volume":"17","author":"Williamson","year":"2018","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.1016\/j.phrs.2024.107570_bib8","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1021\/tx049826v","article-title":"Identification of 14 quercetin phase II mono- and mixed conjugates and their formation by rat and human phase II in vitro model systems","volume":"17","author":"Van der Woude","year":"2004","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.phrs.2024.107570_bib9","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/ptr.7677","article-title":"Wogonin regulates colonocyte metabolism via PPARgamma to inhibit Enterobacteriaceae against dextran sulfate sodium-induced colitis in mice","volume":"37","author":"Su","year":"2023","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phrs.2024.107570_bib10","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2023.13115","article-title":"Dracocephalum moldavica L. extract alleviates experimental colitis in rats by modulating gut microbiome and inflammatory pathways","volume":"28","author":"Gang","year":"2023","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phrs.2024.107570_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154658","article-title":"Wumei Wan attenuates angiogenesis and inflammation by modulating RAGE signaling pathway in IBD: network pharmacology analysis and experimental evidence","volume":"111","author":"Duan","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phrs.2024.107570_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.642665","article-title":"Computational model for membrane transporters. Potential implications for cancer","volume":"9","author":"Carusela","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.phrs.2024.107570_bib13","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.pharmthera.2006.04.009","article-title":"Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs","volume":"112","author":"Cascorbi","year":"2006","journal-title":"Pharm. Ther."},{"key":"10.1016\/j.phrs.2024.107570_bib14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1208\/s12248-014-9668-6","article-title":"Role of the breast cancer resistance protein (BCRP\/ABCG2) in drug transport--an update","volume":"17","author":"Mao","year":"2015","journal-title":"AAPS J."},{"key":"10.1016\/j.phrs.2024.107570_bib15","doi-asserted-by":"crossref","first-page":"603","DOI":"10.2174\/138920010792927325","article-title":"Structure and function of the human breast cancer resistance protein (BCRP\/ABCG2)","volume":"11","author":"Ni","year":"2010","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.phrs.2024.107570_bib16","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/bdd.677","article-title":"Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats","volume":"30","author":"Barve","year":"2009","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.phrs.2024.107570_bib17","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1248\/bpb.26.1120","article-title":"Glucurono- and sulfo-conjugation of kaempferol in rat liver subcellular preparations and cultured hepatocytes","volume":"26","author":"Yodogawa","year":"2003","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.phrs.2024.107570_bib18","doi-asserted-by":"crossref","first-page":"11862","DOI":"10.3748\/wjg.v21.i41.11862","article-title":"Novel understanding of ABC transporters ABCB1\/MDR\/P-glycoprotein, ABCC2\/MRP2, and ABCG2\/BCRP in colorectal pathophysiology","volume":"21","author":"Vibeke Andersen","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phrs.2024.107570_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119255","article-title":"High ABCC2 and low ABCG2 gene expression are early events in the colorectal adenoma-carcinoma sequence","volume":"10","author":"Andersen","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2024.107570_bib20","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.3389\/fphar.2018.01115","article-title":"Baicalein enhances the oral bioavailability and hepatoprotective effects of silybin through the inhibition of efflux transporters BCRP and MRP2","volume":"9","author":"Xu","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phrs.2024.107570_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2022.106303","article-title":"Kaempferol suppression of acute colitis is regulated by the efflux transporters BCRP and MRP2","volume":"179","author":"Liu","year":"2022","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.phrs.2024.107570_bib22","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1124\/mol.108.052019","article-title":"Intestinal breast cancer resistance protein (BCRP)\/Bcrp1 and multidrug resistance protein 3 (MRP3)\/Mrp3 are involved in the pharmacokinetics of resveratrol","volume":"75","author":"Van de Wetering","year":"2009","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.phrs.2024.107570_bib23","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1089\/acm.2007.0617","article-title":"Variable isoflavone content of red clover products affects intestinal disposition of biochanin A, formononetin, genistein, and daidzein","volume":"14","author":"Wang","year":"2008","journal-title":"J. Alter. Complement Med."},{"key":"10.1016\/j.phrs.2024.107570_bib24","article-title":"The correlation between endotoxin, D-Lactate, and diamine oxidase with endoscopic activity in inflammatory bowel disease","volume":"2022","author":"Zhang","year":"2022","journal-title":"Dis. Markers"},{"key":"10.1016\/j.phrs.2024.107570_bib25","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cca.2015.04.010","article-title":"Afamin--A pleiotropic glycoprotein involved in various disease states","volume":"446","author":"Dieplinger","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.phrs.2024.107570_bib26","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.3892\/ijo.2014.2320","article-title":"Flavonoid components in Scutellaria baicalensis inhibit nicotine-induced proliferation, metastasis and lung cancer-associated inflammation in vitro","volume":"44","author":"Gong","year":"2014","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.phrs.2024.107570_bib27","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9381513","article-title":"Therapy effects of wogonin on ovarian cancer cells","volume":"2017","author":"Ruibin","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.phrs.2024.107570_bib28","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1007\/s11095-017-2157-8","article-title":"Breast cancer resistance protein and multidrug resistance protein 2 regulate the disposition of acacetin glucuronides","volume":"34","author":"Jiang","year":"2017","journal-title":"Pharm. Res."},{"key":"10.1016\/j.phrs.2024.107570_bib29","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1007\/s11095-007-9502-2","article-title":"On the rate and extent of drug delivery to the brain","volume":"25","author":"Hammarlund-Udenaes","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.phrs.2024.107570_bib30","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0026-895X(24)05652-9","article-title":"Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships","volume":"66","author":"Chen","year":"2004","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.phrs.2024.107570_bib31","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1002\/jps.21057","article-title":"Metabolism and disposition of resveratrol in the isolated perfused rat liver: role of Mrp2 in the biliary excretion of glucuronides","volume":"97","author":"Maier-Salamon","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.phrs.2024.107570_bib32","doi-asserted-by":"crossref","first-page":"976","DOI":"10.3945\/ajcn.2009.28854","article-title":"Disposition of soy isoflavones in normal human breast tissue","volume":"91","author":"Bolca","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.phrs.2024.107570_bib33","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cbi.2008.09.007","article-title":"FDH: an aldehyde dehydrogenase fusion enzyme in folate metabolism","volume":"178","author":"Krupenko","year":"2009","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.phrs.2024.107570_bib34","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/biof.1070","article-title":"\u03b1-Tocopherol binding to human serum albumin","volume":"39","author":"Fanali","year":"2013","journal-title":"Biofactors"},{"key":"10.1016\/j.phrs.2024.107570_bib35","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s13048-024-01511-3","article-title":"Protective effect of afamin protein against oxidative stress related injury in human ovarian granulosa cells","volume":"17","author":"Zhang","year":"2024","journal-title":"J. Ovarian Res."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661824005152?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661824005152?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:43:54Z","timestamp":1778795034000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661824005152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":35,"alternative-id":["S1043661824005152"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2024.107570","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Wogonin effects on the efflux transporters BCRP and MRP2, explain its effectiveness in ulcerative colitis: Implications for metabolic and transport interactions","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2024.107570","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107570"}}