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Immunol."},{"issue":"6","key":"10.1016\/j.phrs.2025.107589_bib75","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.ccell.2022.04.018","article-title":"Tumor-induced erythroid precursor-differentiated myeloid cells mediate immunosuppression and curtail anti-PD-1\/PD-L1 treatment efficacy [J]","volume":"40","author":"Long","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.phrs.2025.107589_bib76","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.semcdb.2017.05.023","article-title":"ROS signalling in the biology of cancer [J]","volume":"80","author":"Moloney","year":"2018","journal-title":"Semin Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.phrs.2025.107589_bib77","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.stemcr.2020.07.004","article-title":"A single radioprotective dose of prostaglandin E(2) blocks irradiation-induced apoptotic signaling and early cycling of hematopoietic stem cells [J]","volume":"15","author":"Patterson","year":"2020","journal-title":"Stem Cell Rep."},{"issue":"1","key":"10.1016\/j.phrs.2025.107589_bib78","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2024.5455","article-title":"Protective effect of ginseng extract and total ginsenosides on hematopoietic stem cell damage by inhibiting cell apoptosis and regulating the intestinal microflora [J]","volume":"55","author":"Liang","year":"2025","journal-title":"Int J. Mol. Med"},{"issue":"6","key":"10.1016\/j.phrs.2025.107589_bib79","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17060849","article-title":"Protective effect of ginsenoside Rg1 on hematopoietic stem\/progenitor cells through attenuating oxidative stress and the Wnt\/\u03b2-catenin signaling pathway in a mouse model of d-galactose-induced aging [J]","volume":"17","author":"Li","year":"2016","journal-title":"Int J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.phrs.2025.107589_bib80","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/aps.2013.136","article-title":"Ginsenoside Rg1 enhances the resistance of hematopoietic stem\/progenitor cells to radiation-induced aging in mice [J]","volume":"35","author":"Chen","year":"2014","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.phrs.2025.107589_bib81","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.biopha.2017.10.148","article-title":"Alleviation of ginsenoside Rg1 on hematopoietic homeostasis defects caused by lead-acetate [J]","volume":"97","author":"Cai","year":"2018","journal-title":"Biomed. Pharm."},{"issue":"4","key":"10.1016\/j.phrs.2025.107589_bib82","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/ptr.6027","article-title":"Radioprotective effects of dammarane sapogenins against (60) Co-induced myelosuppression in mice [J]","volume":"32","author":"Dong","year":"2018","journal-title":"Phytother. Res"},{"key":"10.1016\/j.phrs.2025.107589_bib83","doi-asserted-by":"crossref","first-page":"616","DOI":"10.3389\/fphar.2018.00616","article-title":"Transcriptome profiling analysis reveals the potential mechanisms of three bioactive ingredients of Fufang E\u2032jiao Jiang during chemotherapy-induced myelosuppression in mice [J]","volume":"9","author":"Li","year":"2018","journal-title":"Front Pharm."},{"key":"10.1016\/j.phrs.2025.107589_bib84","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.630921","article-title":"Astragaloside IV and saponins of rhizoma polygonati cure cyclophosphamide-induced myelosuppression in lung adenocarcinoma via down-regulating miR-142-3p [J]","volume":"11","author":"Gu","year":"2021","journal-title":"Front Oncol."},{"key":"10.1016\/j.phrs.2025.107589_bib85","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.2147\/IJN.S399568","article-title":"Gold Nanoparticles Coated with SH-PEG-NH(2) and Loaded with Ziyuglycoside I for promoting autophagy in hematopoietic stem cells [J]","volume":"18","author":"Xiong","year":"2023","journal-title":"Int J. Nanomed."},{"key":"10.1016\/j.phrs.2025.107589_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110862","article-title":"Ziyuglycoside II alleviates cyclophosphamide-induced leukopenia in mice via regulation of HSPC proliferation and differentiation [J]","volume":"132","author":"Fang","year":"2020","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.phrs.2025.107589_bib87","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.freeradbiomed.2012.10.530","article-title":"Resveratrol ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice [J]","volume":"54","author":"Zhang","year":"2013","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.phrs.2025.107589_bib88","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/j.ijbiomac.2021.05.120","article-title":"Radix astragali polysaccharide RAP directly protects hematopoietic stem cells from chemotherapy-induced myelosuppression by increasing FOS expression [J]","volume":"183","author":"Bao","year":"2021","journal-title":"Int J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.phrs.2025.107589_bib89","article-title":"Astragalus polysaccharide has a protective effect on hematopoiesis in an irradiated mouse model and decreases apoptosis in megakaryocytes [J]","volume":"23","author":"Li","year":"2021","journal-title":"Mol. Med Rep."},{"issue":"3","key":"10.1016\/j.phrs.2025.107589_bib90","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032987","article-title":"STS1 and STS2 phosphatase inhibitor baicalein enhances the expansion of hematopoietic and progenitor stem cells and alleviates 5-fluorouracil-induced myelosuppression [J]","volume":"24","author":"Li","year":"2023","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.phrs.2025.107589_bib91","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.freeradbiomed.2017.09.014","article-title":"Theaflavin ameliorates ionizing radiation-induced hematopoietic injury via the NRF2 pathway [J]","volume":"113","author":"Han","year":"2017","journal-title":"Free Radic. Biol. 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Rep."},{"key":"10.1016\/j.phrs.2025.107589_bib94","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.826716","article-title":"Sporoderm-broken spores of ganoderma lucidum sensitizes ovarian cancer to cisplatin by ROS\/ERK signaling and attenuates chemotherapy-related toxicity [J]","volume":"13","author":"Cen","year":"2022","journal-title":"Front Pharm."},{"issue":"4","key":"10.1016\/j.phrs.2025.107589_bib95","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1142\/S0192415X16500440","article-title":"Anti-aging effect of siraitia grosuenorii by enhancement of hematopoietic stem cell function [J]","volume":"44","author":"Bai","year":"2016","journal-title":"Am. J. Chin. Med"},{"key":"10.1016\/j.phrs.2025.107589_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110934","article-title":"Elucidation of the molecular mechanism of Sanguisorba officinalis L. against leukopenia based on network pharmacology [J]","volume":"132","author":"Wang","year":"2020","journal-title":"Biomed. Pharm."},{"issue":"11","key":"10.1016\/j.phrs.2025.107589_bib97","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s11655-020-3098-3","article-title":"Guilu erxian glue inhibits chemotherapy-induced bone marrow hematopoietic stem cell senescence in mice may via p16(INK4a)-Rb signaling pathway [J]","volume":"26","author":"Wang","year":"2020","journal-title":"Chin. J. Integr. Med"},{"issue":"9","key":"10.1016\/j.phrs.2025.107589_bib98","doi-asserted-by":"crossref","DOI":"10.3390\/biom14091147","article-title":"Sheng xue ning as a novel agent that promotes SCF-driven hematopoietic stem\/progenitor cell proliferation to promote erythropoiesis [J]","volume":"14","author":"Zeng","year":"2024","journal-title":"Biomolecules"},{"issue":"2","key":"10.1016\/j.phrs.2025.107589_bib99","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.3892\/etm.2020.8810","article-title":"Ginsenoside Rg1 protects against Sca-1(+) HSC\/HPC cell aging by regulating the SIRT1-FOXO3 and SIRT3-SOD2 signaling pathways in a \u03b3-ray irradiation-induced aging mice model [J]","volume":"20","author":"Tang","year":"2020","journal-title":"Exp. Ther. Med"},{"issue":"16","key":"10.1016\/j.phrs.2025.107589_bib100","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28166118","article-title":"Pharmacological effects of astragaloside iv: a review [J]","volume":"28","author":"Liang","year":"2023","journal-title":"Molecules"},{"issue":"20","key":"10.1016\/j.phrs.2025.107589_bib101","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1182\/blood-2013-07-515619","article-title":"Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner [J]","volume":"123","author":"Shao","year":"2014","journal-title":"Blood"},{"issue":"37","key":"10.1016\/j.phrs.2025.107589_bib102","doi-asserted-by":"crossref","first-page":"62154","DOI":"10.18632\/oncotarget.19129","article-title":"Shuanghuang Shengbai granule cures myelosuppression and suppresses lung cancer progression: mechanism and therapeutic targets from the aspect of microRNAs [J]","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.phrs.2025.107589_bib103","first-page":"130","article-title":"Saponins from sanguisorba officinalis improve hematopoiesis by promoting survival through FAK and Erk1\/2 activation and modulating cytokine production in bone marrow [J]","volume":"8","author":"Chen","year":"2017","journal-title":"Front Pharm."},{"issue":"10","key":"10.1016\/j.phrs.2025.107589_bib104","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21103449","article-title":"Selective autophagy maintains the Aryl hydrocarbon receptor levels in HeLa cells: a mechanism that is dependent on the p23 Co-chaperone [J]","volume":"21","author":"Yang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.phrs.2025.107589_bib105","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s12272-022-01397-z","article-title":"Latest research progress on anticancer effect of baicalin and its aglycone baicalein [J]","volume":"45","author":"Wang","year":"2022","journal-title":"Arch. Pharm. Res"},{"issue":"4","key":"10.1016\/j.phrs.2025.107589_bib106","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.stemcr.2015.08.006","article-title":"The Phosphatases STS1 and STS2 regulate hematopoietic stem and progenitor cell fitness [J]","volume":"5","author":"Zhang","year":"2015","journal-title":"Stem Cell Rep."},{"issue":"1","key":"10.1016\/j.phrs.2025.107589_bib107","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jep.2009.04.007","article-title":"An herbal decoction of Radix astragali and Radix angelicae sinensis promotes hematopoiesis and thrombopoiesis [J]","volume":"124","author":"Yang","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phrs.2025.107589_bib108","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.molimm.2024.05.008","article-title":"Investigating the protective effects of Astragalus polysaccharides on cyclophosphamide-induced bone marrow suppression in mice and bone mesenchymal stem cells [J]","volume":"171","author":"Wang","year":"2024","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.phrs.2025.107589_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115599","article-title":"Angelica sinensis polysaccharides ameliorated 5-Fluorouracil-induced damage of early B cell progenitors by alleviating oxidative stress of IL-7 producing mesenchymal stem and progenitor cells [J]","volume":"167","author":"Xiao","year":"2023","journal-title":"Biomed. Pharm."},{"issue":"4","key":"10.1016\/j.phrs.2025.107589_bib110","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.lfs.2004.10.080","article-title":"A novel polysaccharide of black soybean promotes myelopoiesis and reconstitutes bone marrow after 5-flurouracil- and irradiation-induced myelosuppression [J]","volume":"77","author":"Liao","year":"2005","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.phrs.2025.107589_bib111","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202100681","article-title":"Structural characterization of polysaccharides isolated from panax notoginseng medicinal residue and its protective effect on myelosuppression induced by cyclophosphamide [J]","volume":"19","author":"Liu","year":"2022","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.phrs.2025.107589_bib112","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12906-015-0642-3","article-title":"The positive effects of Ginsenoside Rg1 upon the hematopoietic microenvironment in a D-Galactose-induced aged rat model [J]","volume":"15","author":"Hu","year":"2015","journal-title":"BMC Complement Alter. Med"},{"issue":"4","key":"10.1016\/j.phrs.2025.107589_bib113","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.jgr.2018.07.009","article-title":"Studies of the effects and mechanisms of ginsenoside Re and Rk(3) on myelosuppression induced by cyclophosphamide [J]","volume":"43","author":"Han","year":"2019","journal-title":"J. Ginseng Res"},{"issue":"5","key":"10.1016\/j.phrs.2025.107589_bib114","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1021\/acs.jafc.8b06073","article-title":"Study of the effects and mechanisms of ginsenoside compound K on myelosuppression [J]","volume":"67","author":"Han","year":"2019","journal-title":"J. Agric. Food Chem."},{"issue":"10","key":"10.1016\/j.phrs.2025.107589_bib115","doi-asserted-by":"crossref","first-page":"5125","DOI":"10.1021\/acs.molpharmaceut.3c00409","article-title":"Human serum albumin nanoparticles as a carrier of 20(S)-protopanaxadiol via intramuscular injection to alleviate cyclophosphamide-induced myelosuppression [J]","volume":"20","author":"Liu","year":"2023","journal-title":"Mol. Pharm."},{"issue":"8","key":"10.1016\/j.phrs.2025.107589_bib116","first-page":"599","article-title":"Protective effects of paeoniflorin and albiflorin on chemotherapy-induced myelosuppression in mice [J]","volume":"14","author":"Zhu","year":"2016","journal-title":"Chin. J. Nat. Med"},{"issue":"2","key":"10.1016\/j.phrs.2025.107589_bib117","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23641","article-title":"Asperuloside alleviates cyclophosphamide-induced myelosuppression by promoting AMPK\/mTOR pathway-mediated autophagy [J]","volume":"38","author":"Che","year":"2024","journal-title":"J. Biochem Mol. Toxicol."},{"issue":"1","key":"10.1016\/j.phrs.2025.107589_bib118","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-16436-9","article-title":"Curcumin activates DNA repair pathway in bone marrow to improve carboplatin-induced myelosuppression [J]","volume":"7","author":"Chen","year":"2017","journal-title":"Sci. Rep."},{"issue":"13","key":"10.1016\/j.phrs.2025.107589_bib119","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.2174\/1386207326666230228120608","article-title":"Effect and mechanism of specnuezhenide on chemotherapy-induced myelosuppression [J]","volume":"26","author":"Han","year":"2023","journal-title":"Comb. Chem. High. Throughput Screen"},{"key":"10.1016\/j.phrs.2025.107589_bib120","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.2147\/DDDT.S458953","article-title":"Exploration of the active component and mechanisms of shengyu decoction against myelosuppression using network pharmacology and in vitro experimental validation [J]","volume":"18","author":"Ma","year":"2024","journal-title":"Drug Des. Devel Ther."},{"key":"10.1016\/j.phrs.2025.107589_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2022.109149","article-title":"Quercetin supplementation attenuates cisplatin induced myelosuppression in mice through regulation of hematopoietic growth factors and hematopoietic inhibitory factors [J]","volume":"110","author":"Chuang","year":"2022","journal-title":"J. Nutr. Biochem"},{"issue":"15","key":"10.1016\/j.phrs.2025.107589_bib122","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/j.scib.2023.07.018","article-title":"Martynoside rescues 5-fluorouracil-impaired ribosome biogenesis by stabilizing RPL27A [J]","volume":"68","author":"Hong","year":"2023","journal-title":"Sci. Bull. (Beijing)"},{"key":"10.1016\/j.phrs.2025.107589_bib123","article-title":"Blood-supplementing effect of low molecular weight peptides of E-Jiao on chemotherapy-induced myelosuppression: evaluation of pharmacological activity and identification of bioactive peptides released in vivo [J]","volume":"15","author":"Zhang","year":"2024","journal-title":"Front Pharm."},{"issue":"2","key":"10.1016\/j.phrs.2025.107589_bib124","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1081\/IPH-120003761","article-title":"Modulation by Acanthospermum australe extracts of the tumor induced hematopoietic changes in mice [J]","volume":"24","author":"Mirandola","year":"2002","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"2","key":"10.1016\/j.phrs.2025.107589_bib125","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jgr.2019.01.001","article-title":"Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis [J]","volume":"44","author":"Han","year":"2020","journal-title":"J. Ginseng Res"},{"issue":"18","key":"10.1016\/j.phrs.2025.107589_bib126","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1016\/j.bmc.2019.07.054","article-title":"Effect of Panax ginseng combined with Angelica sinensis on the dissolution of ginsenosides and in chemotherapy mice hematopoietic function [J]","volume":"27","author":"Zheng","year":"2019","journal-title":"Bioorg. Med Chem."},{"issue":"1","key":"10.1016\/j.phrs.2025.107589_bib127","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s13020-022-00678-5","article-title":"Carbohydrates and ginsenosides in shenmai injection jointly improve hematopoietic function during chemotherapy-induced myelosuppression in mice [J]","volume":"17","author":"Zhang","year":"2022","journal-title":"Chin. Med"},{"issue":"Pt 2","key":"10.1016\/j.phrs.2025.107589_bib128","article-title":"Mechanism of herb pair containing Astragali Radix and Spatholobi Caulis in the treatment of myelosuppression based on network pharmacology and experimental investigation [J]","volume":"319","author":"Peng","year":"2024","journal-title":"J. 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Biol."},{"key":"10.1016\/j.phrs.2025.107589_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113965","article-title":"Danggui buxue decoction enhances the anticancer activity of gemcitabine and alleviates gemcitabine-induced myelosuppression [J]","volume":"273","author":"Liu","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phrs.2025.107589_bib132","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112035","article-title":"Dangguibuxue decoction abolishes abnormal accumulation of erythroid progenitor cells induced by melanoma [J]","volume":"242","author":"Li","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phrs.2025.107589_bib133","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114397","article-title":"Cytoprotective effects of spleen-invigorating pill against 5-fluorouracil injury to mouse bone marrow stromal cells [J]","volume":"280","author":"Zhang","year":"2021","journal-title":"J. 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(Tokyo)"},{"issue":"5","key":"10.1016\/j.phrs.2025.107589_bib147","first-page":"986","article-title":"Effect of lulong zaisheng decoction ii on chemotherapy-induced bone marrow suppression and its mechanism [J]","volume":"39","author":"Cui","year":"2023","journal-title":"Chin. Pharmacol. Bull."},{"key":"10.1016\/j.phrs.2025.107589_bib148","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113160","article-title":"Siwu Paste protects bone marrow hematopoietic function in rats with blood deficiency syndrome by regulating TLR4\/NF-\u03baB\/NLRP3 signaling pathway [J]","volume":"262","author":"Du","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"11","key":"10.1016\/j.phrs.2025.107589_bib149","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.stem.2023.09.013","article-title":"Hematopoietic stem cells through the ages: a lifetime of adaptation to organismal demands [J]","volume":"30","author":"Kasbekar","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.phrs.2025.107589_bib150","doi-asserted-by":"crossref","DOI":"10.1016\/j.jare.2024.04.027","article-title":"Tetrahydroxy stilbene glucoside rejuvenates aging hematopoietic stem cells with predilection for lymphoid differentiation via AMPK and Tet2 [J]","author":"Gao","year":"2024","journal-title":"J. Adv. Res"},{"issue":"1","key":"10.1016\/j.phrs.2025.107589_bib151","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13921","article-title":"Rutin is a potent senomorphic agent to target senescent cells and can improve chemotherapeutic efficacy [J]","volume":"23","author":"Liu","year":"2024","journal-title":"Aging Cell"},{"issue":"9","key":"10.1016\/j.phrs.2025.107589_bib152","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/s43587-023-00473-3","article-title":"Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems [J]","volume":"3","author":"Girotra","year":"2023","journal-title":"Nat. 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Med."},{"key":"10.1016\/j.phrs.2025.107589_bib157","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111338","article-title":"Polysaccharide-rich extract from Polygonatum sibiricum protects hematopoiesis in bone marrow suppressed by triple negative breast cancer [J]","volume":"137","author":"Xie","year":"2021","journal-title":"Biomed. Pharm."},{"issue":"Pt 2","key":"10.1016\/j.phrs.2025.107589_bib158","article-title":"Anti-aging activities of neutral and acidic polysaccharides from Polygonum multiflorum Thunb in Caenorhabditis elegans [J]","volume":"257","author":"Fan","year":"2024","journal-title":"Int J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.phrs.2025.107589_bib159","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1021\/mp400514t","article-title":"Chitosan-g-TPGS nanoparticles for anticancer drug delivery and overcoming multidrug resistance [J","volume":"11","author":"Guo","year":"2014","journal-title":"Mol. Pharm."},{"issue":"1","key":"10.1016\/j.phrs.2025.107589_bib160","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s11671-023-03947-w","article-title":"Flash nanoprecipitation allows easy fabrication of pH-responsive acetalated dextran nanoparticles for intracellular release of payloads [J]","volume":"19","author":"Hughes","year":"2024","journal-title":"Discov. Nano"},{"key":"10.1016\/j.phrs.2025.107589_bib161","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.2147\/IJN.S326629","article-title":"TPGS-modified long-circulating liposomes loading ziyuglycoside i for enhanced therapy of myelosuppression [J]","volume":"16","author":"Song","year":"2021","journal-title":"Int J. Nanomed."},{"issue":"21","key":"10.1016\/j.phrs.2025.107589_bib162","doi-asserted-by":"crossref","first-page":"13342","DOI":"10.1021\/acs.chemrev.1c00422","article-title":"Gold Nanorods: the most versatile plasmonic nanoparticles [J]","volume":"121","author":"Zheng","year":"2021","journal-title":"Chem. Rev."},{"issue":"48","key":"10.1016\/j.phrs.2025.107589_bib163","doi-asserted-by":"crossref","first-page":"8127","DOI":"10.1039\/C8TB02390E","article-title":"Gold nanoparticles impair autophagy flux through shape-dependent endocytosis and lysosomal dysfunction [J]","volume":"6","author":"Zhou","year":"2018","journal-title":"J. Mater. Chem. B"},{"issue":"6","key":"10.1016\/j.phrs.2025.107589_bib164","first-page":"2651","article-title":"Anti myelosuppressant and hematopoietic activities of ethanolic fraction obtained from seeds of Carica papaya L [J]","volume":"33","author":"Ishaque","year":"2020","journal-title":"Pak. J. Pharm. Sci."},{"key":"10.1016\/j.phrs.2025.107589_bib165","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1016\/j.csbj.2021.05.049","article-title":"Profiling of host genetic alterations and intra-tumor microbiomes in colorectal cancer [J]","volume":"19","author":"Okuda","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.phrs.2025.107589_bib166","article-title":"Nano formulation approaches for curcumin delivery- a review [J]","volume":"82","author":"Gayathri","year":"2023","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"1","key":"10.1016\/j.phrs.2025.107589_bib167","doi-asserted-by":"crossref","DOI":"10.1080\/10717544.2023.2174206","article-title":"Recent progress in nanotechnology-based drug carriers for resveratrol delivery [J]","volume":"30","author":"Li","year":"2023","journal-title":"Drug Deliv."},{"issue":"2","key":"10.1016\/j.phrs.2025.107589_bib168","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11655-016-2503-4","article-title":"Clinical observation of Shuanghuang Shengbai Granule on prevention and treatment of myelosuppression caused by chemotherapy in cancer patients [J]","volume":"23","author":"Wang","year":"2017","journal-title":"Chin. J. Integr. 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Chem."},{"issue":"6","key":"10.1016\/j.phrs.2025.107589_bib172","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/ptr.6054","article-title":"Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: review [J]","volume":"32","author":"Soleimani","year":"2018","journal-title":"Phytother. Res"},{"issue":"34","key":"10.1016\/j.phrs.2025.107589_bib173","doi-asserted-by":"crossref","first-page":"6064","DOI":"10.2174\/13816128113199990407","article-title":"Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence [J]","volume":"19","author":"Tom\u00e9-Carneiro","year":"2013","journal-title":"Curr. Pharm. Des."},{"issue":"1","key":"10.1016\/j.phrs.2025.107589_bib174","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/mnfr.201200589","article-title":"Review of recent data on the metabolism, biological effects, and toxicity of resveratrol in humans [J]","volume":"58","author":"Cottart","year":"2014","journal-title":"Mol. Nutr. Food Res"},{"issue":"8005","key":"10.1016\/j.phrs.2025.107589_bib175","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/s41586-024-07186-6","article-title":"Resilient anatomy and local plasticity of naive and stress haematopoiesis [J]","volume":"627","author":"Wu","year":"2024","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.phrs.2025.107589_bib176","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41556-019-0439-6","article-title":"Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization [J]","volume":"22","author":"Baccin","year":"2020","journal-title":"Nat. Cell Biol."},{"issue":"4","key":"10.1016\/j.phrs.2025.107589_bib177","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/s41551-019-0495-z","article-title":"On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology [J]","volume":"4","author":"Chou","year":"2020","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.phrs.2025.107589_bib178","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.855777","article-title":"Bone marrow microenvironment-on-chip for culture of functional hematopoietic stem cells [J]","volume":"10","author":"Sharipol","year":"2022","journal-title":"Front Bioeng. 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