{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T14:32:55Z","timestamp":1793716375760,"version":"4.6.1"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474308"],"award-info":[{"award-number":["82474308"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374308"],"award-info":[{"award-number":["82374308"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2022YFC2010104"],"award-info":[{"award-number":["2022YFC2010104"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.phrs.2025.107617","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T11:17:26Z","timestamp":1737199046000},"page":"107617","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["AlphaFold-based AI docking reveals AMPK\/SIRT1-TFEB pathway modulation by traditional Chinese medicine in metabolic-associated fatty liver disease"],"prefix":"10.1016","volume":"212","author":[{"given":"Lulu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyan","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yini","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shipeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingru","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2025.107617_bib1","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nrgastro.2013.171","article-title":"The global NAFLD epidemic","volume":"10","author":"Loomba","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phrs.2025.107617_bib2","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1053\/j.gastro.2019.11.312","article-title":"International consensus Panel, MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease","volume":"158","author":"Eslam","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phrs.2025.107617_bib3","doi-asserted-by":"crossref","first-page":"329","DOI":"10.14218\/JCTH.2021.00178","article-title":"Metabolic-associated fatty liver disease (MAFLD): a multi-systemic disease beyond the liver","volume":"10","author":"Kaya","year":"2022","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.phrs.2025.107617_bib4","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1210\/clinem\/dgac321","article-title":"Global prevalence and clinical characteristics of metabolic-associated fatty liver disease: a meta-analysis and systematic review of 10 739 607 individuals","volume":"107","author":"Chan","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2025.107617_bib5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1210\/clinem\/dgab578","article-title":"The emerging role of glucagon-like peptide-1 receptor agonists for the management of NAFLD","volume":"107","author":"Patel Chavez","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2025.107617_bib6","article-title":"Advancements in the treatment of non-alcoholic fatty liver disease (NAFLD)","volume":"13","author":"Rong","year":"2022","journal-title":"Front Endocrinol."},{"key":"10.1016\/j.phrs.2025.107617_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1302227","article-title":"Methylsulfonylmethane ameliorates metabolic-associated fatty liver disease by restoring autophagy flux via AMPK\/mTOR\/ULK1 signaling pathway","volume":"14","author":"Han","year":"2023","journal-title":"Front Pharm."},{"key":"10.1016\/j.phrs.2025.107617_bib8","doi-asserted-by":"crossref","first-page":"10055","DOI":"10.3390\/ijms231710055","article-title":"Autophagy dysregulation in metabolic associated fatty liver disease: a new therapeutic target","volume":"23","author":"Chen","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.phrs.2025.107617_bib9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/978-981-10-8684-7_10","article-title":"Autophagy, NAFLD and NAFLD-related HCC","volume":"1061","author":"Wu","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.phrs.2025.107617_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2021.100973","article-title":"Autophagy in liver diseases: a review","volume":"82","author":"Qian","year":"2021","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.phrs.2025.107617_bib11","doi-asserted-by":"crossref","first-page":"672","DOI":"10.3390\/biom12050672","article-title":"Role of TFEB in Autophagy and the Pathogenesis of Liver Diseases","volume":"12","author":"Yan","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.phrs.2025.107617_bib12","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1083\/jcb.201501002","article-title":"MiT\/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5","volume":"210","author":"Nezich","year":"2015","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.phrs.2025.107617_bib13","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.4161\/15384047.2014.955719","article-title":"Autophagy and lysosomal related protein expression patterns in human glioblastoma","volume":"15","author":"Giatromanolaki","year":"2014","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.phrs.2025.107617_bib14","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1128\/MCB.01091-14","article-title":"Regulation of the transcription factor EB-PGC1\u03b1 axis by beclin-1 controls mitochondrial quality and cardiomyocyte death under stress","volume":"35","author":"Ma","year":"2015","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.phrs.2025.107617_bib15","doi-asserted-by":"crossref","first-page":"439","DOI":"10.7150\/ijms.88134","article-title":"Deficiency of diacylglycerol Kinase \u03b6 promotes Beclin1-mediated autophagy via the mTOR\/TFEB signaling pathway: relevance to maladaptive cardiac hypertrophy","volume":"21","author":"Liu","year":"2024","journal-title":"Int J. Med Sci."},{"key":"10.1016\/j.phrs.2025.107617_bib16","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1080\/15548627.2018.1482147","article-title":"Revisiting LAMP1 as a marker for degradative autophagy-lysosomal organelles in the nervous system","volume":"14","author":"Cheng","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.phrs.2025.107617_bib17","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.3389\/fimmu.2017.01161","article-title":"Lysosomal Ca2+\u2009signaling regulates high glucose-mediated interleukin-1\u03b2 secretion via transcription factor EB in human monocytic cells","volume":"8","author":"Tseng","year":"2017","journal-title":"Front Immunol."},{"key":"10.1016\/j.phrs.2025.107617_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2023.155516","article-title":"Metformin-induced TTP mediates communication between Kupffer cells and hepatocytes to alleviate hepatic steatosis by regulating lipophagy and necroptosis","volume":"141","author":"Park","year":"2023","journal-title":"Metabolism"},{"key":"10.1016\/j.phrs.2025.107617_bib19","doi-asserted-by":"crossref","first-page":"E751","DOI":"10.1152\/ajpendo.00745.2009","article-title":"AMPK and SIRT1: a long-standing partnership?","volume":"298","author":"Ruderman","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2025.107617_bib20","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.biochi.2021.11.008","article-title":"Role of AMPK mediated pathways in autophagy and aging","volume":"195","author":"Ge","year":"2022","journal-title":"Biochimie"},{"key":"10.1016\/j.phrs.2025.107617_bib21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3892\/mmr.2022.12922","article-title":"Role of the AMPK\/SIRT1 pathway in non\u2011alcoholic fatty liver disease (Review)","volume":"27","author":"Anggreini","year":"2023","journal-title":"Mol. Med Rep."},{"key":"10.1016\/j.phrs.2025.107617_bib22","doi-asserted-by":"crossref","first-page":"7096","DOI":"10.18632\/aging.202566","article-title":"Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages","volume":"13","author":"Zheng","year":"2021","journal-title":"Aging"},{"key":"10.1016\/j.phrs.2025.107617_bib23","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.3390\/biom12081079","article-title":"Progress in nonalcoholic fatty liver disease: SIRT family regulates mitochondrial biogenesis","volume":"12","author":"Zeng","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.phrs.2025.107617_bib24","doi-asserted-by":"crossref","first-page":"E730","DOI":"10.1152\/ajpendo.00225.2016","article-title":"Treatment of nonalcoholic fatty liver disease: role of AMPK","volume":"311","author":"Smith","year":"2016","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2025.107617_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.970292","article-title":"The AMPK pathway in fatty liver disease","volume":"13","author":"Fang","year":"2022","journal-title":"Front Physiol."},{"key":"10.1016\/j.phrs.2025.107617_bib26","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1080\/13880209.2023.2188549","article-title":"JianPi-QingHua formula attenuates nonalcoholic fatty liver disease by regulating the AMPK\/SIRT1\/NF-\u03baB pathway in high-fat-diet-fed C57BL\/6 mice","volume":"61","author":"Tian","year":"2023","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phrs.2025.107617_bib27","doi-asserted-by":"crossref","first-page":"494","DOI":"10.3389\/fphys.2019.00494","article-title":"Tangshen formula alleviates hepatic steatosis by inducing autophagy through the AMPK\/SIRT1 pathway","volume":"10","author":"Wang","year":"2019","journal-title":"Front Physiol."},{"key":"10.1016\/j.phrs.2025.107617_bib28","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13020-021-00469-4","article-title":"Traditional Chinese Medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives","volume":"16","author":"Dai","year":"2021","journal-title":"Chin. Med"},{"key":"10.1016\/j.phrs.2025.107617_bib29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13020-024-00894-1","article-title":"Integrated traditional Chinese and Western medicine in the prevention and treatment of non-alcoholic fatty liver disease: future directions and strategies","volume":"19","author":"Ding","year":"2024","journal-title":"Chin. Med"},{"key":"10.1016\/j.phrs.2025.107617_bib30","first-page":"3","article-title":"Lecture 23 Discussion on medical cases of fatty liver","volume":"14","author":"Yingshuai","year":"2015","journal-title":"Tradit. Chin. Med. J."},{"key":"10.1016\/j.phrs.2025.107617_bib31","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.3390\/ijms20081904","article-title":"The effects of astragalus membranaceus active extracts on autophagy-related diseases","volume":"20","author":"Shan","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2025.107617_bib32","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.yjmcc.2016.10.017","article-title":"Cinnamaldehyde ameliorates LPS-induced cardiac dysfunction via TLR4-NOX4 pathway: the regulation of autophagy and ROS production","volume":"101","author":"Zhao","year":"2016","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.phrs.2025.107617_bib33","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cbi.2018.06.005","article-title":"Alisol A 24-acetate ameliorates nonalcoholic steatohepatitis by inhibiting oxidative stress and stimulating autophagy through the AMPK\/mTOR pathway","volume":"291","author":"Wu","year":"2018","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.phrs.2025.107617_bib34","first-page":"421","article-title":"Cassiae Semen improves non-alcoholic fatty liver disease through autophagy-related pathway","volume":"15","author":"Ding","year":"2023","journal-title":"Chin. Herb. Med"},{"key":"10.1016\/j.phrs.2025.107617_bib35","article-title":"Aurantio-obtusin attenuates non-alcoholic fatty liver disease through AMPK-mediated autophagy and fatty acid oxidation pathways","volume":"12","author":"Zhou","year":"2021","journal-title":"Front Pharm."},{"key":"10.1016\/j.phrs.2025.107617_bib36","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/apm.12185","article-title":"Inhibitory effect of co-administration of atorvastatin and endothelin-1 receptor antagonist on the progression of atherosclerosis in rabbit","volume":"122","author":"Sun","year":"2014","journal-title":"APMIS"},{"key":"10.1016\/j.phrs.2025.107617_bib37","first-page":"221","article-title":"Body surface area of the golden Syrian hamster","volume":"41","author":"Ohwada","year":"1992","journal-title":"Jikken Dobutsu"},{"key":"10.1016\/j.phrs.2025.107617_bib38","doi-asserted-by":"crossref","first-page":"D1110","DOI":"10.1093\/nar\/gky1021","article-title":"SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping","volume":"47","author":"Wu","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phrs.2025.107617_bib39","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0168-9525(97)01103-7","article-title":"GeneCards: integrating information about genes, proteins and diseases","volume":"13","author":"Rebhan","year":"1997","journal-title":"Trends Genet"},{"key":"10.1016\/j.phrs.2025.107617_bib40","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phrs.2025.107617_bib41","doi-asserted-by":"crossref","unstructured":"UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2023, Nucleic Acids Res 51 (2023) D523\u2013D531. https:\/\/doi.org\/10.1093\/nar\/gkac1052.","DOI":"10.1093\/nar\/gkac1052"},{"key":"10.1016\/j.phrs.2025.107617_bib42","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2025.107617_bib43","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/bioinformatics\/btq066","article-title":"How significant is a protein structure similarity with TM-score =\u20090.5?","volume":"26","author":"Xu","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.phrs.2025.107617_bib44","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/prot.20264","article-title":"Scoring function for automated assessment of protein structure template quality","volume":"57","author":"Zhang","year":"2004","journal-title":"Proteins"},{"key":"10.1016\/j.phrs.2025.107617_bib45","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1080\/15548627.2021.1898748","article-title":"AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3","volume":"17","author":"Paquette","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.phrs.2025.107617_bib46","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.cmet.2013.08.019","article-title":"AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation","volume":"18","author":"Gowans","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.phrs.2025.107617_bib47","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1463-1326.2005.00561.x","article-title":"AMP-activated protein kinase: role in metabolism and therapeutic implications","volume":"8","author":"Schimmack","year":"2006","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.phrs.2025.107617_bib48","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.3390\/molecules26123766","article-title":"Rutin and quercetin decrease cholesterol in HepG2 cells but not plasma cholesterol in hamsters by oral administration","volume":"26","author":"Liang","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.phrs.2025.107617_bib49","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.21915","article-title":"Naringin abates adverse effects of cadmium-mediated hepatotoxicity: an experimental study using HepG2 cells","volume":"31","author":"Rathi","year":"2017","journal-title":"J. Biochem Mol. Toxicol."},{"key":"10.1016\/j.phrs.2025.107617_bib50","doi-asserted-by":"crossref","first-page":"32539","DOI":"10.1074\/jbc.M706543200","article-title":"Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family","volume":"282","author":"Sanders","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2025.107617_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1291501","article-title":"Metabolic-associated fatty liver disease: a selective review of pathogenesis, diagnostic approaches, and therapeutic strategies","volume":"11","author":"Habibullah","year":"2024","journal-title":"Front Med."},{"key":"10.1016\/j.phrs.2025.107617_bib52","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/CM9.0000000000002089","article-title":"From MAFLD to hepatocellular carcinoma and everything in between","volume":"135","author":"Bae","year":"2022","journal-title":"Chin. Med J."},{"key":"10.1016\/j.phrs.2025.107617_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1120621","article-title":"Liver fibrosis and MAFLD: the exploration of multi-drug combination therapy strategies","volume":"10","author":"Dong","year":"2023","journal-title":"Front Med."},{"key":"10.1016\/j.phrs.2025.107617_bib54","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1016\/j.cgh.2021.12.002","article-title":"2019 global NAFLD prevalence: a systematic review and meta-analysis","volume":"20","author":"Le","year":"2022","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phrs.2025.107617_bib55","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3390\/biomedicines10020274","article-title":"Pharmacotherapy for non-alcoholic fatty liver disease: emerging targets and drug candidates","volume":"10","author":"Prikhodko","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.phrs.2025.107617_bib56","doi-asserted-by":"crossref","first-page":"824","DOI":"10.3390\/biom12060824","article-title":"NAFLD: mechanisms, treatments, and biomarkers","volume":"12","author":"Nassir","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.phrs.2025.107617_bib57","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1016\/j.apsb.2022.05.001","article-title":"Therapeutic potential of traditional Chinese medicine for the treatment of NAFLD: a promising drug Potentilla discolor Bunge","volume":"12","author":"Ji","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phrs.2025.107617_bib58","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13020-020-00422-x","article-title":"Efficacy and safety of traditional Chinese medicines for non-alcoholic fatty liver disease: a systematic literature review of randomized controlled trials","volume":"16","author":"Liang","year":"2021","journal-title":"Chin. Med."},{"key":"10.1016\/j.phrs.2025.107617_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155209","article-title":"Si-Ni-San inhibits hepatic Fasn expression and lipid accumulation in MAFLD mice through AMPK\/p300\/SREBP-1c axis","volume":"123","author":"Lan","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phrs.2025.107617_bib60","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.mam.2006.08.005","article-title":"Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy","volume":"27","author":"Eskelinen","year":"2006","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.phrs.2025.107617_bib61","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/cdd.2010.191","article-title":"The Beclin 1 network regulates autophagy and apoptosis","volume":"18","author":"Kang","year":"2011","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.phrs.2025.107617_bib62","article-title":"Binding Features and Functions of ATG3","volume":"9","author":"F. D","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.phrs.2025.107617_bib63","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3390\/ijms17030332","article-title":"Crosstalk between autophagy and apoptosis: potential and emerging therapeutic targets for cardiac diseases","volume":"17","author":"Li","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2025.107617_bib64","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/15548627.2022.2062112","article-title":"Acetylation in the regulation of autophagy","volume":"19","author":"Xu","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.phrs.2025.107617_bib65","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.celrep.2019.06.070","article-title":"Upregulation of the autophagy adaptor p62\/SQSTM1 prolongs health and lifespan in middle-aged drosophila","volume":"28","author":"Aparicio","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.phrs.2025.107617_bib66","doi-asserted-by":"crossref","first-page":"7338","DOI":"10.1038\/s41467-023-42829-8","article-title":"Local membrane source gathering by p62 body drives autophagosome formation","volume":"14","author":"Feng","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2025.107617_bib67","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.3390\/cells11193153","article-title":"TFEB; beyond its role as an autophagy and lysosomes regulator","volume":"11","author":"Franco-Ju\u00e1rez","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.phrs.2025.107617_bib68","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phrs.2025.107617_bib69","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1111\/jgh.16272","article-title":"AMPK\/mTOR pathway significance in healthy liver and non-alcoholic fatty liver disease and its progression","volume":"38","author":"Marcondes-de-Castro","year":"2023","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phrs.2025.107617_bib70","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.3168\/jds.2023-24000","article-title":"Evaluation of hepatic AMPK, mTORC1, and autophagy-lysosomal pathway in cows with mild or moderate fatty liver","volume":"107","author":"Du","year":"2024","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.phrs.2025.107617_bib71","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2016.16","article-title":"AMPK activators: mechanisms of action and physiological activities","volume":"48","author":"Kim","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.phrs.2025.107617_bib72","article-title":"Chinese medicine in the treatment of non-alcoholic fatty liver disease based on network pharmacology: a review","volume":"15","author":"Z. S","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phrs.2025.107617_bib73","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S2095-4964(15)60187-X","article-title":"Autophagy in cerebral ischemia and the effects of traditional Chinese medicine","volume":"13","author":"Huang","year":"2015","journal-title":"J. Integr. Med."}],"updated-by":[{"DOI":"10.1016\/j.phrs.2025.107689","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000}}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661825000428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661825000428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:52:33Z","timestamp":1791471153000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661825000428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":73,"alternative-id":["S1043661825000428"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2025.107617","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AlphaFold-based AI docking reveals AMPK\/SIRT1-TFEB pathway modulation by traditional Chinese medicine in metabolic-associated fatty liver disease","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2025.107617","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107617"}}