{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:45:24Z","timestamp":1787316324843,"version":"build-2736575974"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T00:00:00Z","timestamp":1738454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010229","name":"Natural Science Foundation of Tianjin Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["23JCYBJC00490"],"award-info":[{"award-number":["23JCYBJC00490"]}],"id":[{"id":"10.13039\/501100010229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0905600"],"award-info":[{"award-number":["2019YFA0905600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32201015"],"award-info":[{"award-number":["32201015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273580"],"award-info":[{"award-number":["82273580"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171239"],"award-info":[{"award-number":["32171239"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.phrs.2025.107642","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T19:08:13Z","timestamp":1738609693000},"page":"107642","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Butyrate-engineered yeast activates Nppa and Sgcg genes and reduces radiation-induced heart damage via the gut-heart axis"],"prefix":"10.1016","volume":"213","author":[{"given":"Jiahao","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaihua","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangbo","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manman","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jigang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxue","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3008-4869","authenticated-orcid":false,"given":"He","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2025.107642_bib1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/nrclinonc.2015.120","article-title":"Opportunities and challenges of radiotherapy for treating cancer","volume":"12","author":"Schaue","year":"2015","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.phrs.2025.107642_bib2","article-title":"T cell-derived apoptotic extracellular vesicles hydrolyze cGAMP to alleviate radiation enteritis via surface enzyme ENPP1","volume":"11","author":"Zhou","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.phrs.2025.107642_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.586392","article-title":"The impact of gut microbiota on radiation-induced enteritis","volume":"11","author":"Jian","year":"2021","journal-title":"Front. Cell Infect. Microbiol"},{"key":"10.1016\/j.phrs.2025.107642_bib4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/advances\/nmx009","article-title":"Butyrate: a double-edged sword for health?","volume":"9","author":"Liu","year":"2018","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.phrs.2025.107642_bib5","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41577-024-01014-8","article-title":"Short-chain fatty acids: linking diet, the microbiome and immunity","volume":"24","author":"Mann","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phrs.2025.107642_bib6","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1053\/j.gastro.2024.05.014","article-title":"Gut microbiota-derived butyrate induces epigenetic and metabolic reprogramming in myeloid-derived suppressor cells to alleviate primary biliary cholangitis","volume":"167","author":"Wang","year":"2024","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phrs.2025.107642_bib7","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41392-021-00507-5","article-title":"Pyroptosis: mechanisms and diseases","volume":"6","author":"Yu","year":"2021","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.phrs.2025.107642_bib8","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13976","article-title":"Nicotinamide riboside intervention alleviates hematopoietic system injury of ionizing radiation-induced premature aging mice","volume":"22","author":"Li","year":"2023","journal-title":"Aging Cell"},{"key":"10.1016\/j.phrs.2025.107642_bib9","doi-asserted-by":"crossref","first-page":"882","DOI":"10.3109\/0284186X.2015.1010693","article-title":"Pudendal nerve injury in men with fecal incontinence after radiotherapy for prostate cancer","volume":"54","author":"Loganathan","year":"2015","journal-title":"Acta Oncol."},{"key":"10.1016\/j.phrs.2025.107642_bib10","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jtho.2020.11.002","article-title":"Cardiac toxicity of thoracic radiotherapy: existing evidence and future directions","volume":"16","author":"Banfill","year":"2021","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.phrs.2025.107642_bib11","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1038\/s41591-023-02591-2","article-title":"Thymus alterations and susceptibility to immune checkpoint inhibitor myocarditis","volume":"29","author":"Fenioux","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.phrs.2025.107642_bib12","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1186\/s13287-019-1417-4","article-title":"Radio-detoxified LPS alters bone marrow-derived extracellular vesicles and endothelial progenitor cells","volume":"10","author":"Hegyesi","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.phrs.2025.107642_bib13","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1007\/s00330-021-08260-7","article-title":"Myocardial injury detected by T1 and T2 mapping on CMR predicts subsequent cancer therapy-related cardiac dysfunction in patients with breast cancer treated by epirubicin-based chemotherapy or left-sided RT","volume":"32","author":"Tahir","year":"2022","journal-title":"Eur. Radio;."},{"key":"10.1016\/j.phrs.2025.107642_bib14","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s40257-016-0186-4","article-title":"Radiodermatitis: a review of our current understanding","volume":"17","author":"Singh","year":"2016","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.phrs.2025.107642_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-42171-z","article-title":"A human lung alveolus-on-a-chip model of acute radiation-induced lung injury","volume":"14","author":"Dasgupta","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2025.107642_bib16","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1136\/gutjnl-2017-314050","article-title":"Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit","volume":"67","author":"Li","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.phrs.2025.107642_bib17","article-title":"Gut butyrate-producers confer post-infarction cardiac protection","volume":"14","author":"Chen","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2025.107642_bib18","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1161\/HYPERTENSIONAHA.116.07910","article-title":"Increased systolic and diastolic blood pressure is associated with altered gut microbiota composition and butyrate production in early pregnancy","volume":"68","author":"Gomez-Arango","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.phrs.2025.107642_bib19","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.01987-23","article-title":"Butyrate protects against MRSA pneumonia via regulating gut-lung microbiota and alveolar macrophage M2 polarization","volume":"14","author":"Zhao","year":"2023","journal-title":"mBio"},{"key":"10.1016\/j.phrs.2025.107642_bib20","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.aninu.2017.08.010","article-title":"Implications of butyrate and its derivatives for gut health and animal production","volume":"4","author":"Bedford","year":"2018","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.phrs.2025.107642_bib21","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2316575","article-title":"A tailored series of engineered yeasts for the cell-dependent treatment of inflammatory bowel disease by rational butyrate supplementation","volume":"16","author":"Wu","year":"2024","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phrs.2025.107642_bib22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature11450","article-title":"A metagenome-wide association study of gut microbiota in type 2 diabetes","volume":"490","author":"Qin","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2025.107642_bib23","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2025.107642_bib24","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1136\/gutjnl-2015-309990","article-title":"The gut microbiota and host health: a new clinical frontier","volume":"65","author":"Marchesi","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.phrs.2025.107642_bib25","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1053\/j.gastro.2014.02.009","article-title":"The microbiome in inflammatory bowel disease: current status and the future ahead","volume":"146","author":"Kostic","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phrs.2025.107642_bib26","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s40778-017-0103-7","article-title":"The role of intestinal stem cells in epithelial regeneration following radiation-induced gut injury","volume":"3","author":"Kim","year":"2017","journal-title":"Curr. Stem Cell Rep."},{"key":"10.1016\/j.phrs.2025.107642_bib27","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2293312","article-title":"Akkermansia muciniphila protects the intestine from irradiation-induced injury by secretion of propionic acid","volume":"15","author":"He","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phrs.2025.107642_bib28","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/s41401-021-00615-6","article-title":"Exosomes are involved in total body irradiation-induced intestinal injury in mice","volume":"42","author":"Li","year":"2021","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.phrs.2025.107642_bib29","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1080\/19490976.2019.1709387","article-title":"Gut commensal derived-valeric acid protects against radiation injuries","volume":"11","author":"Li","year":"2020","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phrs.2025.107642_bib30","doi-asserted-by":"crossref","DOI":"10.1126\/science.aay9097","article-title":"Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites","volume":"370","author":"Guo","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.phrs.2025.107642_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202309972","article-title":"A gas therapy strategy for intestinal flora regulation and colitis treatment by nanogel-based multistage NO delivery microcapsules","volume":"36","author":"Fu","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.phrs.2025.107642_bib32","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/s41575-022-00631-9","article-title":"Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms","volume":"19","author":"Cani","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phrs.2025.107642_bib33","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/nm.3914","article-title":"The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment","volume":"21","author":"Zhang","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.phrs.2025.107642_bib34","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nm.4102","article-title":"CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands","volume":"22","author":"Lamas","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.phrs.2025.107642_bib35","article-title":"Dubosiella newyorkensis modulates immune tolerance in colitis via the L-lysine-activated AhR-IDO1-Kyn pathway","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2025.107642_bib36","article-title":"Danggui Shaoyao San: comprehensive modulation of the microbiota-gut-brain axis for attenuating Alzheimer's disease-related pathology","volume":"14","author":"He","year":"2023","journal-title":"Front. Pharm."},{"key":"10.1016\/j.phrs.2025.107642_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.129981","article-title":"Egg white peptides ameliorate dextran sulfate sodium-induced acute colitis symptoms by inhibiting the production of pro-inflammatory cytokines and modulation of gut microbiota composition","volume":"360","author":"Ge","year":"2021","journal-title":"Food Chem."},{"key":"10.1016\/j.phrs.2025.107642_bib38","doi-asserted-by":"crossref","first-page":"7299","DOI":"10.1021\/acs.jafc.2c08564","article-title":"Partially acid-hydrolyzed porphyran improved dextran sulfate sodium-induced acute colitis by modulation of gut microbiota and enhancing the mucosal barrier","volume":"71","author":"Yu","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phrs.2025.107642_bib39","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002699","article-title":"Dysbiosis of gut microbiota with reduced trimethylamine-N-oxide level in patients with large-artery atherosclerotic stroke or transient ischemic attack","volume":"4","author":"Yin","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.phrs.2025.107642_bib40","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1136\/gutjnl-2014-307720","article-title":"Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants","volume":"64","author":"Jaeggi","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.phrs.2025.107642_bib41","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbi.2013.12.005","article-title":"Altered gut microbiota and activity in a murine model of autism spectrum disorders","volume":"37","author":"de Theije","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.phrs.2025.107642_bib42","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S1473-3099(17)30753-3","article-title":"Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis","volume":"18","author":"Tacconelli","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.phrs.2025.107642_bib43","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-27112-y","article-title":"Dysbiosis of human gut microbiome in young-onset colorectal cancer","volume":"12","author":"Yang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2025.107642_bib44","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2057778","article-title":"A dietary carbohydrate - gut Parasutterella - human fatty acid biosynthesis metabolic axis in obesity and type 2 diabetes","volume":"14","author":"Henneke","year":"2022","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phrs.2025.107642_bib45","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1136\/gutjnl-2019-319664","article-title":"Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites","volume":"70","author":"Zhang","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.phrs.2025.107642_bib46","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/nmeth.3508","article-title":"ARM-seq: AlkB-facilitated RNA methylation sequencing reveals a complex landscape of modified tRNA fragments","volume":"12","author":"Cozen","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.phrs.2025.107642_bib47","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00726-020-02823-6","article-title":"Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health","volume":"52","author":"Wu","year":"2020","journal-title":"Amino Acids"},{"key":"10.1016\/j.phrs.2025.107642_bib48","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/j.cell.2015.10.048","article-title":"Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling","volume":"163","author":"Levy","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2025.107642_bib49","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00726-012-1361-4","article-title":"Taurine and inflammatory diseases","volume":"46","author":"Marcinkiewicz","year":"2014","journal-title":"Amino Acids"},{"key":"10.1016\/j.phrs.2025.107642_bib50","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1080\/19490976.2020.1730149","article-title":"Dietary cellulose prevents gut inflammation by modulating lipid metabolism and gut microbiota","volume":"11","author":"Kim","year":"2020","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phrs.2025.107642_bib51","doi-asserted-by":"crossref","first-page":"358","DOI":"10.3389\/fonc.2020.00358","article-title":"NAMPT and NAPRT: two metabolic enzymes with key roles in inflammation","volume":"10","author":"Audrito","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.phrs.2025.107642_bib52","first-page":"3574","article-title":"Differential effects of anthracycline drugs on rat heart and liver microsomal reduced nicotinamide adenine dinucleotide phosphate-dependent lipid peroxidation","volume":"42","author":"Mimnaugh","year":"1982","journal-title":"Cancer Res."},{"key":"10.1016\/j.phrs.2025.107642_bib53","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/abbi.2000.1703","article-title":"Redistribution of cyclic GMP in response to sodium butyrate in colon cells","volume":"376","author":"Crane","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.phrs.2025.107642_bib54","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1017\/S0007114520003736","article-title":"Casein glycomacropeptide is well tolerated in healthy adults and changes neither high-sensitive C-reactive protein, gut microbiota nor faecal butyrate: a restricted randomised trial","volume":"125","author":"Wernlund","year":"2021","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.phrs.2025.107642_bib55","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/s41569-020-0381-0","article-title":"Cardiac natriuretic peptides","volume":"17","author":"Goetze","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.phrs.2025.107642_bib56","article-title":"Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2025.107642_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132013","article-title":"Sodium butyrate alleviates deoxynivalenol-induced porcine intestinal barrier disruption by promoting mitochondrial homeostasis via PCK2 signaling","volume":"459","author":"Xue","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.phrs.2025.107642_bib58","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1152\/physrev.00041.2018","article-title":"Free fatty acid receptors in health and disease","volume":"100","author":"Kimura","year":"2020","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phrs.2025.107642_bib59","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1968257","article-title":"Microbiota metabolite butyrate constrains neutrophil functions and ameliorates mucosal inflammation in inflammatory bowel disease","volume":"13","author":"Li","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phrs.2025.107642_bib60","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1161\/CIRCULATIONAHA.119.037661","article-title":"Reevaluating the genetic contribution of monogenic dilated cardiomyopathy","volume":"141","author":"Mazzarotto","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2025.107642_bib61","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1161\/CIRCULATIONAHA.120.053033","article-title":"Evidence-based assessment of genes in dilated cardiomyopathy","volume":"144","author":"Jordan","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2025.107642_bib62","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1002\/1878-0261.12750","article-title":"Prevention and treatment of radiotherapy-induced side effects","volume":"14","author":"Barazzuol","year":"2020","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.phrs.2025.107642_bib63","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nrgastro.2016.165","article-title":"Diet, microorganisms and their metabolites, and colon cancer","volume":"13","author":"O'Keefe","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phrs.2025.107642_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104947","article-title":"Microbiota-derived butyrate regulates intestinal inflammation: focus on inflammatory bowel disease","volume":"159","author":"Couto","year":"2020","journal-title":"Pharm. Res"},{"key":"10.1016\/j.phrs.2025.107642_bib65","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1136\/gutjnl-2023-330291","article-title":"Roseburia intestinalis generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8(+) T cells","volume":"72","author":"Kang","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.phrs.2025.107642_bib66","doi-asserted-by":"crossref","first-page":"4342","DOI":"10.1021\/jf500355p","article-title":"Metabolic engineering of Escherichia coli for production of butyric acid","volume":"62","author":"Saini","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phrs.2025.107642_bib67","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2017.282","article-title":"Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions","volume":"50","author":"Chelakkot","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.phrs.2025.107642_bib68","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/cns.13610","article-title":"Taurine and oxidative stress in retinal health and disease","volume":"27","author":"Castelli","year":"2021","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.phrs.2025.107642_bib69","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1042\/bj2560251","article-title":"The antioxidant action of taurine, hypotaurine and their metabolic precursors","volume":"256","author":"Aruoma","year":"1988","journal-title":"Biochem. J."},{"key":"10.1016\/j.phrs.2025.107642_bib70","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1038\/s12276-023-01041-w","article-title":"Nicotinamide enhances osteoblast differentiation through activation of the mitochondrial antioxidant defense system","volume":"55","author":"Yoon","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.phrs.2025.107642_bib71","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1016\/j.cmet.2024.05.013","article-title":"Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer","volume":"36","author":"Jiang","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.phrs.2025.107642_bib72","doi-asserted-by":"crossref","DOI":"10.1186\/1423-0127-17-S1-S2","article-title":"Physiological roles of taurine in heart and muscle","volume":"17","author":"Schaffer","year":"2010","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.phrs.2025.107642_bib73","doi-asserted-by":"crossref","DOI":"10.1126\/science.abn9257","article-title":"Taurine deficiency as a driver of aging","volume":"380","author":"Singh","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.phrs.2025.107642_bib74","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1186\/s13287-021-02373-y","article-title":"The stromal vascular fraction mitigates radiation-induced gastrointestinal syndrome in mice","volume":"12","author":"Bensemmane","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.phrs.2025.107642_bib75","doi-asserted-by":"crossref","first-page":"448","DOI":"10.15252\/emmm.201606932","article-title":"Faecal microbiota transplantation protects against radiation-induced toxicity","volume":"9","author":"Cui","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.phrs.2025.107642_bib76","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-40794-w","article-title":"A ferroptosis-targeting ceria anchored halloysite as orally drug delivery system for radiation colitis therapy","volume":"14","author":"Feng","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2025.107642_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153424","article-title":"Ghrelin reverts intestinal stem cell loss associated with radiation-induced enteropathy by activating Notch signaling","volume":"81","author":"Kwak","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phrs.2025.107642_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103377","article-title":"Corrigendum to \"NCOA4-mediated ferritinophagy is involved in ionizing radiation-induced ferroptosis of intestinal epithelial cells\" [Redox Biol. 55 (2022) 102413]","volume":"77","author":"Zhou","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.phrs.2025.107642_bib79","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.2217\/fon-2019-0416","article-title":"Radiation-induced intestinal damage: latest molecular and clinical developments","volume":"15","author":"Lu","year":"2019","journal-title":"Future Oncol."},{"key":"10.1016\/j.phrs.2025.107642_bib80","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.freeradbiomed.2011.04.016","article-title":"Mn(III) meso-tetrakis-(N-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression","volume":"51","author":"Li","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phrs.2025.107642_bib81","first-page":"22","article-title":"Endpoint refinement for total body irradiation of C57BL\/6 mice","volume":"63","author":"Nunamaker","year":"2013","journal-title":"Comp. Med."},{"key":"10.1016\/j.phrs.2025.107642_bib82","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.freeradbiomed.2016.09.007","article-title":"3,3\u2032-diindolylmethane mitigates total body irradiation-induced hematopoietic injury in mice","volume":"99","author":"Lu","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phrs.2025.107642_bib83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jrr\/rrw056","article-title":"The Yiqi and Yangyin Formula ameliorates injury to the hematopoietic system induced by total body irradiation","volume":"58","author":"Zhang","year":"2017","journal-title":"J. Radiat. Res."},{"key":"10.1016\/j.phrs.2025.107642_bib84","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/8241678","article-title":"Hydrogen-rich water ameliorates total body irradiation-induced hematopoietic stem cell injury by reducing hydroxyl radical","volume":"2017","author":"Zhang","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.phrs.2025.107642_bib85","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1186\/s12864-015-2168-y","article-title":"Gene expression profiling in non-human primate jejunum, ileum and colon after total-body irradiation: a comparative study of segment-specific molecular and cellular responses","volume":"16","author":"Zheng","year":"2015","journal-title":"BMC Genom."},{"key":"10.1016\/j.phrs.2025.107642_bib86","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.jphotobiol.2016.08.002","article-title":"Radio-protective effect of some new curcumin analogues","volume":"162","author":"El-Gazzar","year":"2016","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.phrs.2025.107642_bib87","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.acthis.2009.07.003","article-title":"Acidic polysaccharide of Panax ginseng as a defense against small intestinal damage by whole-body gamma irradiation of mice","volume":"113","author":"Park","year":"2011","journal-title":"Acta Histochem."},{"key":"10.1016\/j.phrs.2025.107642_bib88","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1269\/jrr.45.549","article-title":"Modulation of haematopoetic system and antioxidant enzymes by Emblica officinalis gaertn and its protective role against gamma-radiation induced damages in mice","volume":"45","author":"Hari Kumar","year":"2004","journal-title":"J. Radiat. Res."},{"key":"10.1016\/j.phrs.2025.107642_bib89","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.777665","article-title":"Lactic acid-producing probiotic Saccharomyces cerevisiae attenuates ulcerative colitis via suppressing macrophage pyroptosis and modulating gut microbiota","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Immunol."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661825000672?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661825000672?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T14:45:19Z","timestamp":1762353919000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661825000672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":89,"alternative-id":["S1043661825000672"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2025.107642","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Butyrate-engineered yeast activates Nppa and Sgcg genes and reduces radiation-induced heart damage via the gut-heart axis","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2025.107642","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107642"}}