{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:14:52Z","timestamp":1790612092193,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2020B1515130005"],"award-info":[{"award-number":["2020B1515130005"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82230119"],"award-info":[{"award-number":["82230119"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.phrs.2025.107686","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T21:08:34Z","timestamp":1741900114000},"page":"107686","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["A sinomenine derivative alleviates bone destruction in collagen-induced arthritis mice by suppressing mitochondrial dysfunction and oxidative stress via the NRF2\/HO-1\/NQO1 signaling pathway"],"prefix":"10.1016","volume":"215","author":[{"given":"Wan-Yi","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Min","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Feng","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Lian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Yi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Kang","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Nan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-Hai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Zi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Ning","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Man","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Qi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He-Quan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu-Dan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.phrs.2025.107686_bib1","first-page":"284","article-title":"Overview of rheumatoid arthritis and scientific understanding of the disease","volume":"34","author":"Jahid","year":"2023","journal-title":"Mediterr. J. Rheuma"},{"issue":"2","key":"10.1016\/j.phrs.2025.107686_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23020905","article-title":"Rheumatoid arthritis: pathogenic roles of diverse immune cells","volume":"23","author":"Jang","year":"2022","journal-title":"Int J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.phrs.2025.107686_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/biom11010048","article-title":"Rheumatoid arthritis in the view of osteoimmunology","volume":"11","author":"Aureal","year":"2020","journal-title":"Biomolecules"},{"issue":"4","key":"10.1016\/j.phrs.2025.107686_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/cells9040880","article-title":"Update on the pathomechanism, diagnosis, and treatment options for rheumatoid arthritis","volume":"9","author":"Lin","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.phrs.2025.107686_bib5","doi-asserted-by":"crossref","first-page":"1107670","DOI":"10.3389\/fimmu.2023.1107670","article-title":"Role of reactive oxygen species and mitochondrial damage in rheumatoid arthritis and targeted drugs","volume":"14","author":"Jing","year":"2023","journal-title":"Front Immunol."},{"key":"10.1016\/j.phrs.2025.107686_bib6","article-title":"The role of reactive oxygen species in bone cell physiology and pathophysiology","volume":"19","author":"Marques-Carvalho","year":"2023","journal-title":"Bone Rep."},{"issue":"6","key":"10.1016\/j.phrs.2025.107686_bib7","article-title":"An update on mitochondrial reactive oxygen species production","volume":"9","author":"Mailloux","year":"2020","journal-title":"Antioxidants (Basel)"},{"issue":"6","key":"10.1016\/j.phrs.2025.107686_bib8","article-title":"The role of reactive oxygen species in the rheumatoid arthritis-associated synovial microenvironment","volume":"11","author":"Wang","year":"2022","journal-title":"Antioxidants (Basel)"},{"issue":"9","key":"10.1016\/j.phrs.2025.107686_bib9","doi-asserted-by":"crossref","first-page":"10049","DOI":"10.1021\/acsomega.4c00163","article-title":"An overview of therapeutic targeting of Nrf2 signaling pathway in rheumatoid arthritis","volume":"9","author":"Saha","year":"2024","journal-title":"ACS Omega"},{"issue":"7","key":"10.1016\/j.phrs.2025.107686_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23368","article-title":"Eriodictyol regulated ferroptosis, mitochondrial dysfunction, and cell viability via Nrf2\/HO-1\/NQO1 signaling pathway in ovarian cancer cells","volume":"37","author":"Wang","year":"2023","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.phrs.2025.107686_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111382","article-title":"Artesunate attenuates bone erosion in rheumatoid arthritis by suppressing reactive oxygen species via activating p62\/Nrf2 signaling","volume":"137","author":"Su","year":"2021","journal-title":"Biomed. Pharm."},{"issue":"1","key":"10.1016\/j.phrs.2025.107686_bib12","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1186\/s13018-024-05221-w","article-title":"Mechanism of action of Nrf2 and its related natural regulators in rheumatoid arthritis","volume":"19","author":"Ma","year":"2024","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.phrs.2025.107686_bib13","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.freeradbiomed.2022.08.012","article-title":"Pros and cons of NRF2 activation as adjunctive therapy in rheumatoid arthritis","volume":"190","author":"Manda","year":"2022","journal-title":"Free Radic. Biol. Med."},{"issue":"12","key":"10.1016\/j.phrs.2025.107686_bib14","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1038\/s41401-023-01124-4","article-title":"Sinomenine ameliorates collagen-induced arthritis in mice by targeting GBP5 and regulating the P2X7 receptor to suppress NLRP3-related signaling pathways","volume":"44","author":"Li","year":"2023","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.phrs.2025.107686_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111195","article-title":"Sinomenine protects bone from destruction to ameliorate arthritis via activating p62(Thr269\/Ser272)-Keap1-Nrf2 feedback loop","volume":"135","author":"Liao","year":"2021","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.phrs.2025.107686_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105715","article-title":"Sinomenine contributes to the inhibition of the inflammatory response and the improvement of osteoarthritis in mouse-cartilage cells by acting on the Nrf2\/HO-1 and NF-kappaB signaling pathways","volume":"75","author":"Wu","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.phrs.2025.107686_bib17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12906-023-03864-6","article-title":"Benefit-risk assessment of traditional Chinese medicine preparations of sinomenine using multicriteria decision analysis (MCDA) for patients with rheumatoid arthritis","volume":"23","author":"Xiang","year":"2023","journal-title":"BMC Complement Med. Ther."},{"key":"10.1016\/j.phrs.2025.107686_bib18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.eng.2021.04.014","article-title":"The correlation between decreased ornithine level and alleviation of rheumatoid arthritis patients assessed by a randomized, placebo-controlled, double-blind clinical trial of sinomenine","volume":"16","author":"Shi","year":"2022","journal-title":"Engineering"},{"key":"10.1016\/j.phrs.2025.107686_bib19","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.phymed.2018.12.030","article-title":"Comparison of combination therapy with methotrexate and sinomenine or leflunomide for active rheumatoid arthritis: a randomized controlled clinical trial","volume":"57","author":"Huang","year":"2019","journal-title":"Phytomedicine"},{"issue":"12","key":"10.1016\/j.phrs.2025.107686_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14122820","article-title":"Recent advancements in drug delivery of sinomenine, a disease-modifying anti-rheumatic drug","volume":"14","author":"Chen","year":"2022","journal-title":"Pharmaceutics"},{"issue":"24","key":"10.1016\/j.phrs.2025.107686_bib21","article-title":"Towards better sinomenine-type drugs to treat rheumatoid arthritis: molecular mechanisms and structural modification","volume":"27","author":"Zhang","year":"2022","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.phrs.2025.107686_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/molecules29020540","article-title":"Bioactivities and mechanisms of action of sinomenine and its derivatives: a comprehensive review","volume":"29","author":"Hou","year":"2024","journal-title":"Molecules"},{"issue":"11","key":"10.1016\/j.phrs.2025.107686_bib23","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1016\/j.apsb.2021.05.027","article-title":"Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K\/AKT\/mTOR and AMPK\/mTOR pathway","volume":"11","author":"Zheng","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"12","key":"10.1016\/j.phrs.2025.107686_bib24","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.1836","article-title":"Pit assay to measure the bone resorptive activity of bone marrow-derived osteoclasts","volume":"6","author":"Vesprey","year":"2016","journal-title":"Bio Protoc."},{"key":"10.1016\/j.phrs.2025.107686_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.817281","article-title":"Modulation of differentiation and bone resorbing activity of human (Pre-) osteoclasts after X-ray exposure","volume":"13","author":"Eckert","year":"2022","journal-title":"Front Immunol."},{"issue":"6","key":"10.1016\/j.phrs.2025.107686_bib26","first-page":"328","article-title":"Comparative characterization of osteoclasts derived from murine bone marrow macrophages and RAW 264.7 cells using quantitative proteomics","volume":"2","author":"Ng","year":"2018","journal-title":"JBMR"},{"issue":"6937","key":"10.1016\/j.phrs.2025.107686_bib27","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2025.107686_bib28","doi-asserted-by":"crossref","first-page":"1043975","DOI":"10.3389\/fphar.2022.1043975","article-title":"Receptor activator of nuclear factor-kappaB ligand-mediated osteoclastogenesis signaling pathway and related therapeutic natural compounds","volume":"13","author":"Qu","year":"2022","journal-title":"Front Pharm."},{"issue":"11","key":"10.1016\/j.phrs.2025.107686_bib29","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1136\/annrheumdis-2019-215920","article-title":"Global, regional and national burden of rheumatoid arthritis 1990-2017: a systematic analysis of the Global Burden of Disease study 2017","volume":"78","author":"Safiri","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.phrs.2025.107686_bib30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41413-018-0016-9","article-title":"Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies","volume":"6","author":"Guo","year":"2018","journal-title":"Bone Res"},{"issue":"5","key":"10.1016\/j.phrs.2025.107686_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25052688","article-title":"Osteoimmunology: the crosstalk between T cells, B cells, and osteoclasts in rheumatoid arthritis","volume":"25","author":"Yang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2025.107686_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155114","article-title":"Pharmacological mechanisms of sinomenine in anti-inflammatory immunity and osteoprotection in rheumatoid arthritis: a systematic review","volume":"121","author":"Li","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phrs.2025.107686_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154751","article-title":"Sinomenine hydrochloride bidirectionally inhibits progression of tumor and autoimmune diseases by regulating AMPK pathway","volume":"114","author":"Li","year":"2023","journal-title":"Phytomedicine"},{"issue":"14","key":"10.1016\/j.phrs.2025.107686_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25147676","article-title":"Antioxidant activity and the therapeutic effect of sinomenine hydrochloride-loaded liposomes-in-hydrogel on atopic dermatitis","volume":"25","author":"Chen","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2025.107686_bib35","doi-asserted-by":"crossref","first-page":"1041006","DOI":"10.3389\/fcell.2022.1041006","article-title":"Sinomenine regulates immune cell subsets: potential neuro-immune intervene for precise treatment of chronic pain","volume":"10","author":"Lai","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.phrs.2025.107686_bib36","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jconrel.2022.05.016","article-title":"Multifunctional nanoparticles of sinomenine hydrochloride for treat-to-target therapy of rheumatoid arthritis via modulation of proinflammatory cytokines","volume":"348","author":"Lin","year":"2022","journal-title":"J. Control Release"},{"issue":"1","key":"10.1016\/j.phrs.2025.107686_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20010070","article-title":"Research advances and prospects on mechanism of sinomenin on histamine release and the binding to histamine receptors","volume":"20","author":"Zhang","year":"2018","journal-title":"Int J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.phrs.2025.107686_bib38","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1007\/s00204-022-03368-1","article-title":"Sex-related differences in safety profiles, pharmacokinetics and tissue distribution of sinomenine hydrochloride in rats","volume":"96","author":"Huang","year":"2022","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.phrs.2025.107686_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.998554","article-title":"The monocyte-to-osteoclast transition in rheumatoid arthritis: recent findings","volume":"13","author":"Iwamoto","year":"2022","journal-title":"Front Immunol."},{"key":"10.1016\/j.phrs.2025.107686_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.778078","article-title":"Macrophage-osteoclast associations: origin, polarization, and subgroups","volume":"12","author":"Sun","year":"2021","journal-title":"Front Immunol."},{"key":"10.1016\/j.phrs.2025.107686_bib41","doi-asserted-by":"crossref","first-page":"1034050","DOI":"10.3389\/fimmu.2022.1034050","article-title":"Regulation of differentiation and generation of osteoclasts in rheumatoid arthritis","volume":"13","author":"Niu","year":"2022","journal-title":"Front Immunol."},{"issue":"1","key":"10.1016\/j.phrs.2025.107686_bib42","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41413-023-00257-w","article-title":"New insights into inflammatory osteoclast precursors as therapeutic targets for rheumatoid arthritis and periodontitis","volume":"11","author":"Hascoet","year":"2023","journal-title":"Bone Res."},{"issue":"14","key":"10.1016\/j.phrs.2025.107686_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20143576","article-title":"Reactive oxygen species in osteoclast differentiation and possible pharmaceutical targets of ROS-mediated osteoclast diseases","volume":"20","author":"Agidigbi","year":"2019","journal-title":"Int J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.phrs.2025.107686_bib44","article-title":"Mitochondrial dysfunction and oxidative stress in rheumatoid arthritis","volume":"11","author":"Lopez-Armada","year":"2022","journal-title":"Antioxidants- (Basel)"},{"issue":"9","key":"10.1016\/j.phrs.2025.107686_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/biom12091216","article-title":"Mitochondrial dysfunction in rheumatoid arthritis","volume":"12","author":"Ma","year":"2022","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.phrs.2025.107686_bib46","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41594-018-0172-z","article-title":"Structure of yeast cytochrome c oxidase in a supercomplex with cytochrome bc(1)","volume":"26","author":"Hartley","year":"2019","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"13","key":"10.1016\/j.phrs.2025.107686_bib47","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2021385118","article-title":"Mitochondrial metabolism is essential for invariant natural killer T cell development and function","volume":"118","author":"Weng","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.phrs.2025.107686_bib48","first-page":"3","article-title":"Mitochondrial electron transport chain, ROS generation and uncoupling (Review)","author":"Zhao","year":"2019","journal-title":"Int. J. Mol. Med 44(1)"},{"key":"10.1016\/j.phrs.2025.107686_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108557","article-title":"7-deacetyl-gedunin suppresses proliferation of Human rheumatoid arthritis synovial fibroblast through activation of Nrf2\/ARE signaling","volume":"107","author":"Chen","year":"2022","journal-title":"Int. Immunopharmacol."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661825001112?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661825001112?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T14:45:44Z","timestamp":1762353944000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661825001112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":49,"alternative-id":["S1043661825001112"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2025.107686","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A sinomenine derivative alleviates bone destruction in collagen-induced arthritis mice by suppressing mitochondrial dysfunction and oxidative stress via the NRF2\/HO-1\/NQO1 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2025.107686","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107686"}}