{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:21:22Z","timestamp":1793118082108,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003711"],"award-info":[{"award-number":["82003711"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903306"],"award-info":[{"award-number":["81903306"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["19YF1459400"],"award-info":[{"award-number":["19YF1459400"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["24YF2758300"],"award-info":[{"award-number":["24YF2758300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["23ZR1477600"],"award-info":[{"award-number":["23ZR1477600"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["19ZR1469700"],"award-info":[{"award-number":["19ZR1469700"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010097","name":"China Association for Science and Technology","doi-asserted-by":"publisher","award":["2022QNRC001"],"award-info":[{"award-number":["2022QNRC001"]}],"id":[{"id":"10.13039\/100010097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["2024GKQ26"],"award-info":[{"award-number":["2024GKQ26"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["21MC1930500"],"award-info":[{"award-number":["21MC1930500"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010574","name":"China Academy of Space Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010574","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.phrs.2025.107728","type":"journal-article","created":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T06:17:30Z","timestamp":1743920250000},"page":"107728","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Breaking the synergism of iron overload and miR-122 to rescue lipid accumulation and peroxidation in MASLD"],"prefix":"10.1016","volume":"215","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7576-8928","authenticated-orcid":false,"given":"Yuxiao","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengpu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiwen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.phrs.2025.107728_bib1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.jhep.2024.08.024","article-title":"Frailty and risk of metabolic dysfunction-associated steatotic liver disease and other chronic liver diseases","volume":"82","author":"Zhong","year":"2025","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phrs.2025.107728_bib2","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.12659\/MSM.896494","article-title":"The role of iron and iron overload in chronic liver disease","volume":"22","author":"Milic","year":"2016","journal-title":"Med. Sci. Monit."},{"issue":"11","key":"10.1016\/j.phrs.2025.107728_bib3","first-page":"695","article-title":"Iron overload in patients with chronic liver disease","volume":"12","author":"Kowdley","year":"2016","journal-title":"Gastroenterol. Hepatol. (N. Y)"},{"issue":"10","key":"10.1016\/j.phrs.2025.107728_bib4","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1016\/j.cmet.2024.07.013","article-title":"Integrative clinical and preclinical studies identify FerroTerminator1 as a potent therapeutic drug for MASH","volume":"36","author":"Tao","year":"2024","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.phrs.2025.107728_bib5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000343856","article-title":"Hepatic iron overload and hepatocellular carcinoma","volume":"3","author":"Kew","year":"2014","journal-title":"Liver Cancer"},{"issue":"4","key":"10.1016\/j.phrs.2025.107728_bib6","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.3945\/ajcn.111.015743","article-title":"Hepatic iron stores are increased as assessed by magnetic resonance imaging in a Chinese population with altered glucose homeostasis","volume":"94","author":"Zheng","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"issue":"5","key":"10.1016\/j.phrs.2025.107728_bib7","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.2337\/db13-1195","article-title":"Hepcidin is directly regulated by insulin and plays an important role in iron overload in streptozotocin-induced diabetic rats","volume":"63","author":"Wang","year":"2014","journal-title":"Diabetes"},{"issue":"10","key":"10.1016\/j.phrs.2025.107728_bib8","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1111\/jgh.15971","article-title":"A critical evaluation of the role of iron overload in fatty liver disease","volume":"37","author":"Fernandez","year":"2022","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.phrs.2025.107728_bib9","doi-asserted-by":"crossref","first-page":"G117","DOI":"10.1152\/ajpgi.00246.2015","article-title":"Iron overload results in hepatic oxidative stress, immune cell activation, and hepatocellular ballooning injury, leading to nonalcoholic steatohepatitis in genetically obese mice","volume":"310","author":"Handa","year":"2016","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.phrs.2025.107728_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102131","article-title":"Fibroblast growth factor 21 attenuates iron overload-induced liver injury and fibrosis by inhibiting ferroptosis","volume":"46","author":"Wu","year":"2021","journal-title":"Redox Biol."},{"issue":"43","key":"10.1016\/j.phrs.2025.107728_bib11","article-title":"Association between dietary iron intake and the prevalence of nonalcoholic fatty liver disease: a cross-sectional study","volume":"98","author":"Yang","year":"2019","journal-title":"Med. (Baltim. )"},{"issue":"1","key":"10.1016\/j.phrs.2025.107728_bib12","doi-asserted-by":"crossref","first-page":"4069","DOI":"10.1038\/s41598-019-40449-1","article-title":"Independent and combined effects of dietary iron composition and selected risk factors on the risk of NAFLD in a Chinese population","volume":"9","author":"Peng","year":"2019","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.phrs.2025.107728_bib13","doi-asserted-by":"crossref","first-page":"5653","DOI":"10.1039\/D2FO04082D","article-title":"Association of iron status with non-alcoholic fatty liver disease and liver fibrosis in US adults: a cross-sectional study from NHANES 2017-2018","volume":"14","author":"Tan","year":"2023","journal-title":"Food Funct."},{"issue":"11","key":"10.1016\/j.phrs.2025.107728_bib14","doi-asserted-by":"crossref","first-page":"7544","DOI":"10.1002\/jcp.30391","article-title":"Rapid responses of adipocytes to iron overload increase serum TG level by decreasing adiponectin","volume":"236","author":"Tang","year":"2021","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.phrs.2025.107728_bib15","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.freeradbiomed.2020.10.013","article-title":"Mild iron overload induces TRIP12-mediated degradation of YY1 to trigger hepatic inflammation","volume":"161","author":"Tang","year":"2020","journal-title":"Free Radic. Biol. Med"},{"issue":"8","key":"10.1016\/j.phrs.2025.107728_bib16","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1182\/blood-2016-12-755967","article-title":"The hepatocyte-specific HNF4\u03b1\/miR-122 pathway contributes to iron overload-mediated hepatic inflammation","volume":"130","author":"Li","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.phrs.2025.107728_bib17","article-title":"HIF1alpha\/miR-146alpha\/TRAF6\/NF-kappaB axis modulates hepatic iron overload-induced inflammation","volume":"125","author":"Mo","year":"2023","journal-title":"J. Nutr. Biochem"},{"issue":"3","key":"10.1016\/j.phrs.2025.107728_bib18","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1053\/jhep.2001.22506","article-title":"Increased cancer risk in a cohort of 230 patients with hereditary hemochromatosis in comparison to matched control patients with non-iron-related chronic liver disease","volume":"33","author":"Fracanzani","year":"2001","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.phrs.2025.107728_bib19","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1053\/j.gastro.2003.09.035","article-title":"Cancer risk in patients with hereditary hemochromatosis and in their first-degree relatives","volume":"125","author":"Elmberg","year":"2003","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.phrs.2025.107728_bib20","first-page":"273","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism","volume":"171","author":"Stockwell","year":"2017","journal-title":"Redox Biol., Dis., Cell"},{"issue":"6","key":"10.1016\/j.phrs.2025.107728_bib21","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.phrs.2025.107728_bib22","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.jhep.2008.01.019","article-title":"miR-122, a paradigm for the role of microRNAs in the liver","volume":"48","author":"Girard","year":"2008","journal-title":"J. Hepatol."},{"issue":"9","key":"10.1016\/j.phrs.2025.107728_bib23","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0960-9822(02)00809-6","article-title":"Identification of tissue-specific microRNAs from mouse","volume":"12","author":"Lagos-Quintana","year":"2002","journal-title":"Curr. Biol."},{"issue":"8","key":"10.1016\/j.phrs.2025.107728_bib24","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1172\/JCI63539","article-title":"Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver","volume":"122","author":"Hsu","year":"2012","journal-title":"J. Clin. Investig."},{"issue":"8","key":"10.1016\/j.phrs.2025.107728_bib25","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1172\/JCI63455","article-title":"MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis","volume":"122","author":"Tsai","year":"2012","journal-title":"J. Clin. Investig."},{"issue":"6","key":"10.1016\/j.phrs.2025.107728_bib26","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1002\/hep.22569","article-title":"Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression","volume":"48","author":"Cheung","year":"2008","journal-title":"Hepatology"},{"issue":"40","key":"10.1016\/j.phrs.2025.107728_bib27","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.1038\/onc.2009.211","article-title":"Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties","volume":"28","author":"Coulouarn","year":"2009","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.phrs.2025.107728_bib28","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1182\/blood-2016-12-755967","article-title":"The hepatocyte-specific HNF4a\/miR-122 pathway contributes to iron overload-mediated hepatic inflammation","volume":"130","author":"Li","year":"2017","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.phrs.2025.107728_bib29","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/nar\/gkt1011","article-title":"Resveratrol and EGCG bind directly and distinctively to miR-33a and miR-122 and modulate divergently their levels in hepatic cells","volume":"42","author":"Baselga-Escudero","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.phrs.2025.107728_bib30","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.phrs.2012.02.007","article-title":"Effect of quercetin on inflammatory gene expression in mice liver in vivo - role of redox factor 1, miRNA-122 and miRNA-125b","volume":"65","author":"Boesch-Saadatmandi","year":"2012","journal-title":"Pharm. Res."},{"issue":"4","key":"10.1016\/j.phrs.2025.107728_bib31","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.jcmgh.2022.12.008","article-title":"Hepatocyte smoothened activity controls susceptibility to insulin resistance and nonalcoholic fatty liver disease","volume":"15","author":"Chen","year":"2023","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"issue":"10","key":"10.1016\/j.phrs.2025.107728_bib32","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1002\/hep4.2031","article-title":"Loss of SLC46A1 decreases tumor iron content in hepatocellular carcinoma","volume":"6","author":"Wang","year":"2022","journal-title":"Hepatol. Commun."},{"issue":"9","key":"10.1016\/j.phrs.2025.107728_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0074471","article-title":"Relationship between differential hepatic microRNA expression and decreased hepatic cytochrome P450 3A activity in cirrhosis","volume":"8","author":"Vuppalanchi","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.phrs.2025.107728_bib34","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.ymgme.2012.08.017","article-title":"Acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, is controlled by SREBP-2 and affects serum cholesterol levels","volume":"107","author":"Hasegawa","year":"2012","journal-title":"Mol. Genet Metab."},{"issue":"5","key":"10.1016\/j.phrs.2025.107728_bib35","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.chembiol.2021.07.022","article-title":"FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication","volume":"29","author":"Yamane","year":"2022","journal-title":"Cell Chem. Biol."},{"issue":"5","key":"10.1016\/j.phrs.2025.107728_bib36","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1074\/jbc.TM118.004144","article-title":"Cytochrome P450 research and The Journal of Biological Chemistry","volume":"294","author":"Guengerich","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.phrs.2025.107728_bib37","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/s41589-020-0472-6","article-title":"Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis","volume":"16","author":"Zou","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.phrs.2025.107728_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2020.154306","article-title":"SLC46A1 contributes to hepatic iron metabolism by importing heme in hepatocytes","volume":"110","author":"Li","year":"2020","journal-title":"Metabolism"},{"issue":"14","key":"10.1016\/j.phrs.2025.107728_bib39","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.phrs.2025.107728_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/nu14010029","article-title":"Nutrient intake and status in adults consuming plant-based diets compared to meat-eaters: a systematic review","volume":"14","author":"Neufingerl","year":"2021","journal-title":"Nutrients"},{"issue":"12","key":"10.1016\/j.phrs.2025.107728_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0209340","article-title":"Measurement of liver iron by magnetic resonance imaging in the UK Biobank population","volume":"13","author":"McKay","year":"2018","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.phrs.2025.107728_bib42","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1017\/S0007114516003639","article-title":"Association between predominantly plant-based diets and iron status in Chinese adults: a cross-sectional analysis","volume":"116","author":"He","year":"2016","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.phrs.2025.107728_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.155953","article-title":"Targeting the regulation of iron homeostasis as a potential therapeutic strategy for nonalcoholic fatty liver disease","volume":"157","author":"Sui","year":"2024","journal-title":"Metabolism"},{"issue":"34","key":"10.1016\/j.phrs.2025.107728_bib44","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.3748\/wjg.v18.i34.4651","article-title":"Interactions between hepatic iron and lipid metabolism with possible relevance to steatohepatitis","volume":"18","author":"Ahmed","year":"2012","journal-title":"World J. Gastroenterol."},{"issue":"4","key":"10.1016\/j.phrs.2025.107728_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101156","article-title":"Iron loading induces cholesterol synthesis and sensitizes endothelial cells to TNFalpha-mediated apoptosis","volume":"297","author":"Fisher","year":"2021","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.phrs.2025.107728_bib46","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.celrep.2015.12.023","article-title":"Reciprocal Regulation between SIRT6 and miR-122 Controls Liver Metabolism and Predicts Hepatocarcinoma Prognosis","volume":"14","author":"Elhanati","year":"2016","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.phrs.2025.107728_bib47","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/oby.23365","article-title":"Exosomal miR-122 promotes adipogenesis and aggravates obesity through the VDR\/SREBF1 axis","volume":"30","author":"Huang","year":"2022","journal-title":"Obes. (Silver Spring)"},{"issue":"4","key":"10.1016\/j.phrs.2025.107728_bib48","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1172\/JCI44883","article-title":"The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice","volume":"121","author":"Castoldi","year":"2011","journal-title":"J. Clin. Invest"},{"issue":"5","key":"10.1016\/j.phrs.2025.107728_bib49","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.2337\/db07-1552","article-title":"Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action","volume":"57","author":"Turner","year":"2008","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.phrs.2025.107728_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/nu14010124","article-title":"Absorption kinetics of berberine and dihydroberberine and their impact on glycemia: a randomized, controlled, crossover pilot trial","volume":"14","author":"Moon","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.phrs.2025.107728_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113301","article-title":"Toxicological assessment of dihydroberberine","volume":"168","author":"Lewis","year":"2022","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.phrs.2025.107728_bib52","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.ymthe.2021.09.012","article-title":"Sphingosine-1-phosphate transporter spinster homolog 2 is essential for iron-regulated metastasis of hepatocellular carcinoma","volume":"30","author":"Li","year":"2022","journal-title":"Mol. Ther."},{"issue":"4","key":"10.1016\/j.phrs.2025.107728_bib53","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1007\/s12011-022-03296-2","article-title":"Iron deficiency increases phosphorylation of SP1 to upregulate SPNS2 expression in hepatocellular carcinoma","volume":"201","author":"Wang","year":"2023","journal-title":"Biol. Trace Elem. Res"},{"issue":"8","key":"10.1016\/j.phrs.2025.107728_bib54","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1039\/D2MO00025C","article-title":"A multi-omics study of the anti-cancer effect of a ferulic acid derivative FA-30","volume":"18","author":"Wang","year":"2022","journal-title":"Mol. Omics"},{"issue":"9","key":"10.1016\/j.phrs.2025.107728_bib55","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.5417","article-title":"Investigation of the apoptosis-inducing effect of docetaxel by comprehensive LC-MS-based metabolomics and network pharmacology approaches","volume":"36","author":"Wang","year":"2022","journal-title":"Biomed. Chromatogr.: BMC"},{"issue":"2","key":"10.1016\/j.phrs.2025.107728_bib56","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.ymthe.2021.09.012","article-title":"Sphingosine-1-phosphate transporter spinster homolog 2 is essential for iron-regulated metastasis of hepatocellular carcinoma","volume":"30","author":"Li","year":"2022","journal-title":"Mol. Ther. J. Am. Soc. Gene Ther."},{"issue":"6472","key":"10.1016\/j.phrs.2025.107728_bib57","doi-asserted-by":"crossref","DOI":"10.1126\/science.aav1741","article-title":"The biochemical basis of microRNA targeting efficacy","volume":"366","author":"McGeary","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.phrs.2025.107728_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2023.109357","article-title":"Iron deficiency downregulates ENPEP to promote angiogenesis in liver tumors","volume":"117","author":"Wu","year":"2023","journal-title":"J. Nutr. Biochem"},{"key":"10.1016\/j.phrs.2025.107728_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114750","article-title":"Iron deficiency in hepatocellular carcinoma cells induced sorafenib resistance by upregulating HIF-1alpha to inhibit apoptosis","volume":"163","author":"Gao","year":"2023","journal-title":"Biomed. Pharmacother."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661825001537?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661825001537?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T14:41:39Z","timestamp":1762353699000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661825001537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":59,"alternative-id":["S1043661825001537"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2025.107728","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Breaking the synergism of iron overload and miR-122 to rescue lipid accumulation and peroxidation in MASLD","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2025.107728","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107728"}}