{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:56:14Z","timestamp":1792151774589,"version":"4.4.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.phrs.2025.107820","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T02:45:11Z","timestamp":1749177911000},"page":"107820","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Nicotinamide-N-methyltransferase inhibition improves cardiac function and structure in a heart failure with preserved ejection fraction mouse model"],"prefix":"10.1016","volume":"217","author":[{"given":"Sunhuo","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia G.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash Deep","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia","family":"Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth M.","family":"Schouten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Str\u00f6mstedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"L\u00f6fgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Persson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Fredlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Rohman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Bergstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Akerud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Ericson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Kreisel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meztli Matadamas","family":"Guzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman H.W.","family":"Sillj\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf A.","family":"de Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.G.","family":"Meems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2025.107820_bib1","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1093\/eurheartj\/ehz641","article-title":"How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the heart failure association (HFA) of the european society of cardiology (ESC)","volume":"40","author":"Pieske","year":"2019","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.phrs.2025.107820_bib2","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1093\/cvr\/cvaa256","article-title":"The effects of liraglutide and dapagliflozin on cardiac function and structure in a multi-hit mouse model of heart failure with preserved ejection fraction","volume":"117","author":"Withaar","year":"2021","journal-title":"Cardiovasc Res."},{"key":"10.1016\/j.phrs.2025.107820_bib3","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1161\/CIRCULATIONAHA.121.056589","article-title":"NAD+ metabolism in cardiac health, aging, and disease","volume":"144","author":"Abdellatif","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2025.107820_bib4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jare.2021.08.003","article-title":"Nicotinamide mononucleotide (NMN) as an anti-aging health product \u2013 promises and safety concerns","volume":"37","author":"Nadeeshani","year":"2022","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.phrs.2025.107820_bib5","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1161\/CIRCRESAHA.120.317046","article-title":"NAD+ repletion reverses heart failure with preserved ejection fraction","volume":"128","author":"Tong","year":"2021","journal-title":"Circ. Res"},{"key":"10.1016\/j.phrs.2025.107820_bib6","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/j.celrep.2019.07.043","article-title":"Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome and induces transcriptomic and Anti-inflammatory signatures","volume":"28","author":"Elhassan","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.phrs.2025.107820_bib7","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/ajcn\/nqaa072","article-title":"Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans","volume":"112","author":"Remie","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.phrs.2025.107820_bib8","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.2337\/db14-0667","article-title":"Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans","volume":"64","author":"Van De Weijer","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.phrs.2025.107820_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-46120-z","article-title":"Safety and metabolism of Long-term administration of NIAGEN (Nicotinamide Riboside Chloride) in a randomized, Double-Blind, Placebo-controlled clinical trial of healthy overweight adults","volume":"9","author":"Conze","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2025.107820_bib10","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/ajcn\/nqy132","article-title":"A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects","volume":"108","author":"Dollerup","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.phrs.2025.107820_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186459","article-title":"An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers","volume":"12","author":"Airhart","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2025.107820_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/sciadv.adi4862","article-title":"What is really known about the effects of nicotinamide riboside supplementation in humans","volume":"9","author":"Damgaard","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.phrs.2025.107820_bib13","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.jacbts.2022.06.012","article-title":"Safety and tolerability of nicotinamide riboside in heart failure with reduced ejection fraction","volume":"7","author":"Wang","year":"2022","journal-title":"JACC Basic Transl. Sci."},{"key":"10.1016\/j.phrs.2025.107820_bib14","doi-asserted-by":"crossref","first-page":"6054","DOI":"10.1172\/JCI138538","article-title":"Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure","volume":"130","author":"Zhou","year":"2020","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.phrs.2025.107820_bib15","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.tem.2017.02.004","article-title":"Nicotinamide N-Methyltransferase: more than a vitamin B3 clearance enzyme","volume":"28","author":"Pissios","year":"2017","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2025.107820_bib16","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00125-014-3490-7","article-title":"Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance","volume":"58","author":"Kannt","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.phrs.2025.107820_bib17","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1210\/jc.2015-1732","article-title":"Serum N1-methylnicotinamide is associated with obesity and diabetes in Chinese","volume":"100","author":"Liu","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2025.107820_bib18","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/nature13198","article-title":"Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity","volume":"508","author":"Kraus","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2025.107820_bib19","first-page":"1","article-title":"Serum N1-methylnicotinamide is associated with left ventricular systolic dysfunction in Chinese","volume":"8","author":"Liu","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2025.107820_bib20","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41591-023-02793-8","article-title":"A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk","volume":"30","author":"Ferrell","year":"2024","journal-title":"Nat. Med"},{"key":"10.1016\/j.phrs.2025.107820_bib21","doi-asserted-by":"crossref","first-page":"527","DOI":"10.2337\/db18-0780","article-title":"Genetic nicotinamide N-methyltransferase (NNMT) deficiency in Male mice improves insulin sensitivity in diet-induced obesity but does not affect glucose tolerance","volume":"68","author":"Brachs","year":"2019","journal-title":"Diabetes"},{"key":"10.1016\/j.phrs.2025.107820_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-022-19634-2","article-title":"Novel tricyclic small molecule inhibitors of nicotinamide N-methyltransferase for the treatment of metabolic disorders","volume":"12","author":"Ruf","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2025.107820_bib23","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/nature13198","article-title":"Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity","volume":"508","author":"Kraus","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2025.107820_bib24","doi-asserted-by":"crossref","first-page":"3536","DOI":"10.1093\/cvr\/cvac133","article-title":"Inflammatory pathways in heart failure with preserved left ventricular ejection fraction: implications for future interventions","volume":"118","author":"Pugliese","year":"2023","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.phrs.2025.107820_bib25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3390\/ani4010035","article-title":"Improving bioscience research reporting: the arrive guidelines for reporting animal research","volume":"4","author":"Kilkenny","year":"2013","journal-title":"Animals"},{"key":"10.1016\/j.phrs.2025.107820_bib26","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1093\/cvr\/cvaa256","article-title":"The effects of liraglutide and dapagliflozin on cardiac function and structure in a multi-hit mouse model of heart failure with preserved ejection fraction","volume":"117","author":"Withaar","year":"2021","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.phrs.2025.107820_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23052427","article-title":"Antisense therapy attenuates phospholamban p.(Arg14del) cardiomyopathy in mice and reverses protein aggregation","volume":"23","author":"Eijgenraam","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.phrs.2025.107820_bib28","doi-asserted-by":"crossref","first-page":"5180","DOI":"10.1038\/s41467-021-25439-0","article-title":"Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy","volume":"12","author":"Grote Beverborg","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2025.107820_bib29","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1046\/j.1469-7580.1997.19130417.x","article-title":"Distribution of myocardial macrophages in the normal human heart","volume":"191","author":"Azzawi","year":"1997","journal-title":"J. Anat."},{"key":"10.1016\/j.phrs.2025.107820_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BSR20220200","article-title":"Adipose tissue macrophages and their role in obesity-associated insulin resistance: an overview of the complex dynamics at play","volume":"43","author":"Guria","year":"2023","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.phrs.2025.107820_bib31","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1210\/jc.2009-0925","article-title":"Human adipose tissue macrophages: M1 and M2 cell surface markers in subcutaneous and omental depots and after weight loss","volume":"94","author":"Aron-Wisnewsky","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2025.107820_bib32","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.jacbts.2023.05.012","article-title":"The cardioprotective effects of semaglutide exceed those of dietary weight loss in mice with HFpEF","volume":"8","author":"Withaar","year":"2023","journal-title":"JACC Basic Transl. Sci."},{"key":"10.1016\/j.phrs.2025.107820_bib33","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1093\/eurheartj\/ehaa952","article-title":"Fighting HFpEF in women: taking aim at belly fat","volume":"42","author":"Withaar","year":"2021","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.phrs.2025.107820_bib34","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S1734-1140(09)70009-X","article-title":"Activation of nicotinamide N-methyltrasferase and increased formation of 1-methylnicotinamide (MNA) in atherosclerosis","volume":"61","author":"Mateuszuk","year":"2009","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.phrs.2025.107820_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-023-34916-z","article-title":"Nicotinamide N-methyltransferase (NNMT) regulates the glucocorticoid signaling pathway during the early phase of adipogenesis","volume":"13","author":"Roberti","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2025.107820_bib36","first-page":"1","article-title":"Identification of nicotinamide N-methyltransferase as a promising therapeutic target for sarcopenia","author":"Liang","year":"2024","journal-title":"Aging Cell"},{"key":"10.1016\/j.phrs.2025.107820_bib37","doi-asserted-by":"crossref","first-page":"37509","DOI":"10.1021\/acsomega.2c04286","article-title":"Nicotinamide N-Methyltransferase remodeled cell metabolism and aggravated proinflammatory responses by activating STAT3\/IL1\u03b2\/PGE2Pathway","volume":"7","author":"Yang","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.phrs.2025.107820_bib38","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/s44318-023-00009-w","article-title":"Control of NAD+ homeostasis by autophagic flux modulates mitochondrial and cardiac function","volume":"43","author":"Zhang","year":"2024","journal-title":"EMBO J."},{"key":"10.1016\/j.phrs.2025.107820_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-22081-7","article-title":"A small molecule inhibitor of nicotinamide N-methyltransferase for the treatment of metabolic disorders","volume":"8","author":"Kannt","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2025.107820_bib40","first-page":"141","article-title":"Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice","author":"Finnerty","year":"2019","journal-title":"Biochem Pharm."},{"key":"10.1016\/j.phrs.2025.107820_bib41","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/pro.3307","article-title":"The human protein Atlas: a spatial map of the human proteome","volume":"27","author":"Thul","year":"2018","journal-title":"Protein Sci."},{"key":"10.1016\/j.phrs.2025.107820_bib42","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/nar\/gkac633","article-title":"Construction of a cross-species cell landscape at single-cell level","volume":"51","author":"Wang","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.phrs.2025.107820_bib43","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1016\/j.cmet.2024.05.013","article-title":"Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer","volume":"36","author":"Jiang","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.phrs.2025.107820_bib44","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/CIRCRESAHA.113.301720","article-title":"Remodeling of the mononuclear phagocyte network underlies chronic inflammation and disease progression in heart failure: critical importance of the cardiosplenic axis","volume":"114","author":"Ismahil","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.phrs.2025.107820_bib45","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/cvr\/cvaa217","article-title":"Metabolic inflammation in heart failure with preserved ejection fraction","volume":"117","author":"Schiattarella","year":"2021","journal-title":"Cardiovasc Res."},{"key":"10.1016\/j.phrs.2025.107820_bib46","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1084\/jem.20171274","article-title":"Cardiac macrophages promote diastolic dysfunction","volume":"215","author":"Hulsmans","year":"2018","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.phrs.2025.107820_bib47","doi-asserted-by":"crossref","first-page":"E4661","DOI":"10.1073\/pnas.1720065115","article-title":"Distinct roles of resident and nonresident macrophages in nonischemic cardiomyopathy","volume":"115","author":"Liao","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.phrs.2025.107820_bib48","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1161\/CIRCULATIONAHA.120.050498","article-title":"Myocardial gene expression signatures in human heart failure with preserved ejection fraction","volume":"143","author":"Hahn","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2025.107820_bib49","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.jchf.2020.04.007","article-title":"Endomyocardial biopsy characterization of heart failure with preserved ejection fraction and prevalence of cardiac amyloidosis","volume":"8","author":"Hahn","year":"2020","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.phrs.2025.107820_bib50","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1084\/jem.20171274","article-title":"Cardiac macrophages promote diastolic dysfunction","volume":"215","author":"Hulsmans","year":"2018","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.phrs.2025.107820_bib51","doi-asserted-by":"crossref","first-page":"5272","DOI":"10.1111\/dom.15879","article-title":"Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction","author":"Babula","year":"2024","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.phrs.2025.107820_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jbc.2023.105027","article-title":"Nicotinamide N-methyltransferase mediates lipofibroblast\u2013myofibroblast transition and apoptosis resistance","volume":"299","author":"Rehan","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2025.107820_bib53","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.jhep.2022.03.021","article-title":"Hepatocyte-specific depletion of nnmt protects mice from non-alcoholic steatohepatitis","volume":"77","author":"Li","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phrs.2025.107820_bib54","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.2147\/IJGM.S420706","article-title":"Nicotinamide N-Methyl transferase as a predictive marker of tubular fibrosis in CKD","volume":"16","author":"Ye","year":"2023","journal-title":"Int J. Gen. Med"},{"key":"10.1016\/j.phrs.2025.107820_bib55","doi-asserted-by":"crossref","DOI":"10.1038\/s44161-024-00542-9","article-title":"Cardiac NAD+ depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics","author":"Doan","year":"2024","journal-title":"Nat. Cardiovasc. Res."},{"key":"10.1016\/j.phrs.2025.107820_bib56","first-page":"1","volume":"23","author":"P\u00e9ter Bai1","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.phrs.2025.107820_bib57","doi-asserted-by":"crossref","first-page":"87","DOI":"10.14348\/molcells.2016.2318","article-title":"Sirt1 and the mitochondria","volume":"39","author":"Tang","year":"2016","journal-title":"Mol. Cells"},{"key":"10.1016\/j.phrs.2025.107820_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15252\/emmm.202113943","article-title":"NAD + homeostasis in human health and disease","volume":"13","author":"Zapata-P\u00e9rez","year":"2021","journal-title":"EMBO Mol. Med"},{"key":"10.1016\/j.phrs.2025.107820_bib59","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1161\/CIRCRESAHA.118.312498","article-title":"Sirtuins and NAD+ in the development and treatment of metabolic and cardiovascular diseases","volume":"123","author":"Kane","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.phrs.2025.107820_bib60","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1161\/CIRCULATIONAHA.110.958033","article-title":"Silent information regulator 1 protects the heart from ischemia\/reperfusion","volume":"122","author":"Hsu","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2025.107820_bib61","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1016\/j.ijcard.2016.06.223","article-title":"PARP inhibition and postinfarction myocardial remodeling","volume":"217","author":"Halmosi","year":"2016","journal-title":"Int J. Cardiol."},{"key":"10.1016\/j.phrs.2025.107820_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/toxins8110339","article-title":"N-methyl-2-pyridone-5-carboxamide (2PY) \u2014 major metabolite of nicotinamide: an update on an old uremic toxin","volume":"8","author":"Lenglet","year":"2016","journal-title":"Toxins"},{"key":"10.1016\/j.phrs.2025.107820_bib63","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2390164","article-title":"Time-restricted feeding ameliorates non-alcoholic fatty liver disease through modulating hepatic nicotinamide metabolism via gut microbiota remodeling","volume":"16","author":"Feng","year":"2024","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phrs.2025.107820_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2021.686249","article-title":"Uremic toxins: an alarming danger concerning the cardiovascular system","volume":"12","author":"Falconi","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.phrs.2025.107820_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacc.2024.08.028","article-title":"Inflammation in obesity-related HFpEF","author":"Verma","year":"2024","journal-title":"J. Am. Coll. Cardiol. D."},{"key":"10.1016\/j.phrs.2025.107820_bib66","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1161\/CIRCRESAHA.123.322381","article-title":"Indole-3-Propionic acid protects against heart failure with preserved ejection fraction","volume":"134","author":"Wang","year":"2024","journal-title":"Circ. Res."},{"key":"10.1016\/j.phrs.2025.107820_bib67","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/nchembio.1204","article-title":"NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink","volume":"9","author":"Ulanovskaya","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.phrs.2025.107820_bib68","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-66034-9","article-title":"Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice","volume":"14","author":"Dimet-Wiley","year":"2024","journal-title":"Sci. Rep."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661825002452?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661825002452?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T23:09:24Z","timestamp":1764976164000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661825002452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":68,"alternative-id":["S1043661825002452"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2025.107820","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nicotinamide-N-methyltransferase inhibition improves cardiac function and structure in a heart failure with preserved ejection fraction mouse model","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2025.107820","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107820"}}