{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:19:37Z","timestamp":1793837977010,"version":"4.6.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016350","name":"Sichuan Provincial Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2024MS170"],"award-info":[{"award-number":["2024MS170"]}],"id":[{"id":"10.13039\/501100016350","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","doi-asserted-by":"publisher","award":["ZYYCXTD-D-202209"],"award-info":[{"award-number":["ZYYCXTD-D-202209"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172723"],"award-info":[{"award-number":["82172723"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304887"],"award-info":[{"award-number":["82304887"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFF0720300"],"award-info":[{"award-number":["2023YFF0720300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2024YFFK0156"],"award-info":[{"award-number":["2024YFFK0156"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.phrs.2025.107878","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T15:10:23Z","timestamp":1753369823000},"page":"107878","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Natural small molecule bergapten ameliorates rheumatoid arthritis by targeting STAT3"],"prefix":"10.1016","volume":"219","author":[{"given":"Jun","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingzhou","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengrong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guochen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaifeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanbin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7877-7440","authenticated-orcid":false,"given":"Dong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2025.107878_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212580","article-title":"Takinib inhibits inflammation in human rheumatoid arthritis synovial fibroblasts by targeting the janus kinase-signal transducer and activator of transcription 3 (JAK\/STAT3) Pathway","volume":"22","author":"Panipinto","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.phrs.2025.107878_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110766","article-title":"Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression","volume":"39","author":"Meednu","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.phrs.2025.107878_bib3","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1016\/j.apsb.2023.04.003","article-title":"Bone-derived MSCs encapsulated in alginate hydrogel prevent collagen-induced arthritis in mice through the activation of adenosine A(2A\/2B) receptors in tolerogenic dendritic cells","volume":"13","author":"Shi","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phrs.2025.107878_bib4","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1002\/jbmr.3637","article-title":"Cannabinoid Receptor 2 agonist prevents local and systemic inflammatory bone destruction in rheumatoid arthritis","volume":"34","author":"Zhu","year":"2019","journal-title":"J. Bone Min. Res"},{"key":"10.1016\/j.phrs.2025.107878_bib5","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00296-016-3638-5","article-title":"Mortality in patients with rheumatoid arthritis: a 15-year prospective cohort study","volume":"37","author":"van den Hoek","year":"2017","journal-title":"Rheuma Int"},{"key":"10.1016\/j.phrs.2025.107878_bib6","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1136\/annrheumdis-2019-216243","article-title":"Economic burden of rheumatoid arthritis: a systematic review of literature in biologic era","volume":"79","author":"Hsieh","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.phrs.2025.107878_bib7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1741-7015-12-35","article-title":"Epigenetics in the pathogenesis of rheumatoid arthritis","volume":"12","author":"Glant","year":"2014","journal-title":"BMC Med"},{"key":"10.1016\/j.phrs.2025.107878_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/biom13050766","article-title":"New Targets and Strategies for Rheumatoid Arthritis: From Signal Transduction to Epigenetic Aspect","volume":"13","author":"Zhu","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.phrs.2025.107878_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114426","article-title":"Bergapten alleviates depression-like behavior by inhibiting cyclooxygenase 2 activity and NF-\u03baB\/MAPK signaling pathway in microglia","volume":"365","author":"Yan","year":"2023","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phrs.2025.107878_bib10","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1021\/jf0484632","article-title":"Antioxidant activity of Citrus limonoids, flavonoids, and coumarins","volume":"53","author":"Yu","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phrs.2025.107878_bib11","doi-asserted-by":"crossref","first-page":"15069","DOI":"10.1021\/acsomega.0c00887","article-title":"In Silico Studies and In Vivo MAO(A) inhibitory activity of coumarins isolated from Angelica Archangelica extract: an approach toward antidepressant activity","volume":"5","author":"Kaur","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.phrs.2025.107878_bib12","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.bbrc.2018.01.071","article-title":"Anti-inflammatory and proresolution activities of bergapten isolated from the roots of Ficus hirta in an in vivo zebrafish model","volume":"496","author":"Yang","year":"2018","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.phrs.2025.107878_bib13","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1093\/abbs\/gmab037","article-title":"Novel application of bergapten and quercetin with anti-bacterial, osteogenesis-potentiating, and anti-inflammation tri-effects","volume":"53","author":"Wei","year":"2021","journal-title":"Acta Biochim Biophys. Sin. (Shanghai)"},{"key":"10.1016\/j.phrs.2025.107878_bib14","article-title":"Bergapten attenuates human papillary thyroid cancer cell proliferation by triggering apoptosis and the GSK-3\u03b2, P13K and AKT pathways","author":"Li","year":"2024","journal-title":"Adv. Clin. Exp. Med"},{"key":"10.1016\/j.phrs.2025.107878_bib15","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12943-015-0403-4","article-title":"Bergapten drives autophagy through the up-regulation of PTEN expression in breast cancer cells","volume":"14","author":"De Amicis","year":"2015","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.phrs.2025.107878_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115693","article-title":"Anti-inflammatory and osteoprotective effects of Shi-Wei-Ru-Xiang pills on collagen-induced arthritis in rats via inhibiting MAPK and STAT3 pathways","volume":"300","author":"Xiong","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phrs.2025.107878_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21093230","article-title":"Targeting of phospholipase D1 ameliorates collagen-induced arthritis via modulation of Treg and Th17 cell imbalance and suppression of osteoclastogenesis","volume":"21","author":"Yoo","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.phrs.2025.107878_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109451","article-title":"Glaucocalyxin A suppresses inflammatory responses and induces apoptosis in TNF-a-induced human rheumatoid arthritis via modulation of the STAT3 pathway","volume":"341","author":"Zhang","year":"2021","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.phrs.2025.107878_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.128776","article-title":"From co-delivery to synergistic anti-inflammatory effect: Studies on chitosan-stabilized Janus emulsions having chloroquine phosphate and flavopiridol in Complete Freund's Adjuvant induced arthritis rat model","volume":"258","author":"Pawde","year":"2024","journal-title":"Int J. Biol. Macromol."},{"key":"10.1016\/j.phrs.2025.107878_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152876","article-title":"Kadsura heteroclita stem suppresses the onset and progression of adjuvant-induced arthritis in rats","volume":"58","author":"Yu","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phrs.2025.107878_bib21","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive Integration of Single-Cell Data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2025.107878_bib22","first-page":"1064","article-title":"Exogenous reference gene normalization for real-time reverse transcription-polymerase chain reaction analysis under dynamic endogenous transcription","volume":"7","author":"Johnston","year":"2012","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.phrs.2025.107878_bib23","doi-asserted-by":"crossref","first-page":"14558","DOI":"10.1096\/fj.202000494RR","article-title":"Sennoside A prevents liver fibrosis by binding DNMT1 and suppressing DNMT1-mediated PTEN hypermethylation in HSC activation and proliferation","volume":"34","author":"Zhu","year":"2020","journal-title":"Faseb J."},{"key":"10.1016\/j.phrs.2025.107878_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155031","article-title":"A large-scale transcriptional analysis reveals herb-derived ginsenoside F2 suppressing hepatocellular carcinoma via inhibiting STAT3","volume":"120","author":"Tan","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phrs.2025.107878_bib25","doi-asserted-by":"crossref","first-page":"9623","DOI":"10.1073\/pnas.1121606109","article-title":"Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts","volume":"109","author":"Zhang","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.phrs.2025.107878_bib26","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/art.41958","article-title":"Effect of JAK inhibition on the induction of proinflammatory HLA-DR+CD90+ rheumatoid arthritis synovial fibroblasts by Interferon-\u03b3","volume":"74","author":"Zhao","year":"2022","journal-title":"Arthritis Rheuma"},{"key":"10.1016\/j.phrs.2025.107878_bib27","article-title":"Glucose transporter 1 in rheumatoid arthritis and autoimmunity","volume":"12","author":"Zezina","year":"2020","journal-title":"Wiley Inter. Rev. Syst. Biol. Med"},{"key":"10.1016\/j.phrs.2025.107878_bib28","first-page":"45","article-title":"Similarity and dissimilarity regularized nonnegative matrix factorization for single-cell RNA-seq analysis","volume":"14","author":"Zhu","year":"2022","journal-title":"Inter. Sci."},{"key":"10.1016\/j.phrs.2025.107878_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001143","article-title":"Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes","volume":"19","author":"Ravindra","year":"2021","journal-title":"PLoS Biol."},{"key":"10.1016\/j.phrs.2025.107878_bib30","doi-asserted-by":"crossref","DOI":"10.1186\/ar1899","article-title":"CD147 overexpression on synoviocytes in rheumatoid arthritis enhances matrix metalloproteinase production and invasiveness of synoviocytes","volume":"8","author":"Zhu","year":"2006","journal-title":"Arthritis Res Ther."},{"key":"10.1016\/j.phrs.2025.107878_bib31","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12974-025-03400-y","article-title":"Inhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translation of spinal STAT3 and decreasing downstream C-C Motif Chemokine Ligand 7 synthesis","volume":"22","author":"Chi","year":"2025","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.phrs.2025.107878_bib32","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1158\/0008-5472.CAN-15-2973","article-title":"FAP promotes immunosuppression by cancer-associated fibroblasts in the tumor microenvironment via STAT3-CCL2 Signaling","volume":"76","author":"Yang","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.phrs.2025.107878_bib33","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13046-025-03303-z","article-title":"VSIG4(+) tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1.","volume":"44","author":"Pan","year":"2025","journal-title":"J. Exp. Clin. Cancer Res"},{"key":"10.1016\/j.phrs.2025.107878_bib34","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1007\/s10565-022-09786-2","article-title":"NSD1 promotes esophageal cancer tumorigenesis via HIF1\u03b1 signaling","volume":"39","author":"He","year":"2023","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.phrs.2025.107878_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112217","article-title":"mTOR promotes an inflammatory response through the HIF1 signaling pathway in ulcerative colitis","volume":"134","author":"Wang","year":"2024","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.phrs.2025.107878_bib36","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1002\/art.41182","article-title":"Role of Chondrocytes in the Development of Rheumatoid Arthritis Via Transmembrane Protein 147-Mediated NF-\u03baB Activation","volume":"72","author":"Ota","year":"2020","journal-title":"Arthritis Rheuma"},{"key":"10.1016\/j.phrs.2025.107878_bib37","first-page":"591","article-title":"Global epidemiology of rheumatoid arthritis","volume":"18","author":"Finckh","year":"2022","journal-title":"Nat. Rev. Rheuma"},{"key":"10.1016\/j.phrs.2025.107878_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108442","article-title":"The natural compound notopterol binds and targets JAK2\/3 to ameliorate inflammation and arthritis","volume":"33","author":"Wang","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.phrs.2025.107878_bib39","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1039\/C9LC00394K","article-title":"Remotely controlled nanofluidic implantable platform for tunable drug delivery","volume":"19","author":"Di Trani","year":"2019","journal-title":"Lab Chip"},{"key":"10.1016\/j.phrs.2025.107878_bib40","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.intimp.2017.04.026","article-title":"\"Bergapten prevents lipopolysaccharide-induced inflammation in RAW264.7 cells through suppressing JAK\/STAT activation and ROS production and increases the survival rate of mice after LPS challenge","volume":"48","author":"Zhou","year":"2017","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.phrs.2025.107878_bib41","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41584-020-0413-5","article-title":"Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes","volume":"16","author":"Nygaard","year":"2020","journal-title":"Nat. Rev. Rheuma"},{"key":"10.1016\/j.phrs.2025.107878_bib42","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41584-022-00790-8","article-title":"Synovial tissue macrophages in joint homeostasis, rheumatoid arthritis and disease remission","volume":"18","author":"Kurowska-Stolarska","year":"2022","journal-title":"Nat. Rev. Rheuma"},{"key":"10.1016\/j.phrs.2025.107878_bib43","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41467-018-02890-0","article-title":"IL-6\/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation","volume":"9","author":"Zhao","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2025.107878_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113442","article-title":"Anti-inflammation effect of Qingchang suppository in ulcerative colitis through JAK2\/STAT3 signaling pathway in vitro and in vivo","volume":"266","author":"Yu","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phrs.2025.107878_bib45","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nrd.2017.201","article-title":"JAK inhibition as a therapeutic strategy for immune and inflammatory diseases","volume":"16","author":"Schwartz","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.phrs.2025.107878_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113813","article-title":"The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes","volume":"43","author":"Bhusal","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.phrs.2025.107878_bib47","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/s43018-022-00431-9","article-title":"Ectopic JAK-STAT activation enables the transition to a stem-like and multilineage state conferring AR-targeted therapy resistance","volume":"3","author":"Deng","year":"2022","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.phrs.2025.107878_bib48","article-title":"Bile acid-microbiome interaction promotes gastric carcinogenesis","volume":"9","author":"Wang","year":"2022","journal-title":"Adv. Sci. (Weinh. )"},{"key":"10.1016\/j.phrs.2025.107878_bib49","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.biopha.2018.08.145","article-title":"\"Bergapten inhibits liver carcinogenesis by modulating LXR\/PI3K\/Akt and IDOL\/LDLR pathways","volume":"108","author":"Pattanayak","year":"2018","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.phrs.2025.107878_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111798","article-title":"Bergapten inhibits airway inflammation and MRGPRX2-mediated mast cells activation by targeting NR4A1","volume":"130","author":"Wang","year":"2024","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.phrs.2025.107878_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115697","article-title":"Tadalafil and bergapten mitigate streptozotocin-induced sporadic Alzheimer's disease in mice via modulating neuroinflammation, PI3K\/Akt, Wnt\/\u03b2-catenin, AMPK\/mTOR signaling pathways","volume":"429","author":"Salem","year":"2021","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.phrs.2025.107878_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175242","article-title":"Bergapten attenuates microglia-mediated neuroinflammation and ischemic brain injury by targeting Kv1.3 and Carbonyl reductase 1","volume":"933","author":"Gao","year":"2022","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.phrs.2025.107878_bib53","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1002\/2211-5463.12648","article-title":"Bergapten alleviates osteoarthritis by regulating the ANP32A\/ATM signaling pathway","volume":"9","author":"He","year":"2019","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.phrs.2025.107878_bib54","doi-asserted-by":"crossref","DOI":"10.1007\/s00210-024-03113-8","article-title":"Bergapten enhances mitophagy to regulate intestinal barrier and Th17\/Treg balance in mice with Crohn's disease-like colitis via PPAR\u03b3\/NF-\u03baB signaling pathway","author":"Xu","year":"2024","journal-title":"Naunyn Schmiede Arch. Pharm."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661825003032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661825003032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T06:18:35Z","timestamp":1772777915000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661825003032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":54,"alternative-id":["S1043661825003032"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2025.107878","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Natural small molecule bergapten ameliorates rheumatoid arthritis by targeting STAT3","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2025.107878","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107878"}}