{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:13:00Z","timestamp":1791825180406,"version":"4.3.4"},"reference-count":152,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008723","name":"Finnish Medical Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018167","name":"Urmas Pekkalan s\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018167","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005633","name":"Syd\u00e4ntutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon Europe","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.phrs.2025.107892","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T15:55:21Z","timestamp":1753977321000},"page":"107892","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Nuclear receptors CAR and PXR as cardiometabolic regulators"],"prefix":"10.1016","volume":"219","author":[{"given":"Janne","family":"Hukkanen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenni","family":"K\u00fcblbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jukka","family":"Hakkola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaana","family":"Rys\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2025.107892_bib1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev-physiol-021909-135917","article-title":"Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics","volume":"72","author":"Huang","year":"2010","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.phrs.2025.107892_bib2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.cell.2014.03.012","article-title":"Nuclear receptors, RXR, and the big bang","volume":"157","author":"Evans","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2025.107892_bib3","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.addr.2010.08.006","article-title":"Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR","volume":"62","author":"Tolson","year":"2010","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.phrs.2025.107892_bib4","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1515\/mr-2022-0032","article-title":"Atypical functions of xenobiotic receptors in lipid and glucose metabolism","volume":"2","author":"Wang","year":"2023","journal-title":"Med. Rev."},{"key":"10.1016\/j.phrs.2025.107892_bib5","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.3390\/cells9112445","article-title":"PXR and 4\u03b2-Hydroxycholesterol axis and the components of metabolic syndrome","volume":"9","author":"Hukkanen","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.phrs.2025.107892_bib6","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.bbagrm.2016.03.012","article-title":"Regulation of hepatic energy metabolism by the nuclear receptor PXR","volume":"1859","author":"Hakkola","year":"2016","journal-title":"Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms"},{"key":"10.1016\/j.phrs.2025.107892_bib7","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.3390\/cells9112395","article-title":"Regulation of CAR and PXR expression in health and disease","volume":"9","author":"Daujat-Chavanieu","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.phrs.2025.107892_bib8","doi-asserted-by":"crossref","first-page":"38379","DOI":"10.1074\/jbc.M404949200","article-title":"The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane x receptor (PXR) and constitutively activated receptor (CAR)","volume":"279","author":"Burk","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2025.107892_bib9","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1124\/dmd.121.000482","article-title":"Searching for constitutive androstane receptor modulators","volume":"50","author":"Honkakoski","year":"2022","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.phrs.2025.107892_bib10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0304-4165(02)00481-6","article-title":"Functional and structural comparison of PXR and CAR","volume":"1619","author":"Moore","year":"2003","journal-title":"Biochim. Et. Biophys. Acta (BBA) Gen. Subj."},{"key":"10.1016\/j.phrs.2025.107892_bib11","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1517\/17425251003598886","article-title":"Activation of xenobiotic receptors: driving into the nucleus","volume":"6","author":"Li","year":"2010","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.phrs.2025.107892_bib12","doi-asserted-by":"crossref","first-page":"7931","DOI":"10.1128\/MCB.24.18.7931-7940.2004","article-title":"Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode Drug-Metabolizing and gluconeogenic enzymes","volume":"24","author":"Kodama","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.phrs.2025.107892_bib13","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/FPC.0b013e3282f706e0","article-title":"Sterol regulatory element binding protein 1 interacts with pregnane x receptor and constitutive androstane receptor and represses their target genes","volume":"18","author":"Roth","year":"2008","journal-title":"Pharm. Genom."},{"key":"10.1016\/j.phrs.2025.107892_bib14","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1124\/mol.107.041012","article-title":"Regulatory Cross-Talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane x receptor increase Insig-1 expression","volume":"73","author":"Roth","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.phrs.2025.107892_bib15","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1053\/j.gastro.2007.11.037","article-title":"Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPAR\u03b3 in promoting steatosis","volume":"134","author":"Zhou","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phrs.2025.107892_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.959902","article-title":"The role of pregnane x receptor (PXR) in substance metabolism","volume":"13","author":"Lv","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.phrs.2025.107892_bib17","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/metabo14010012","article-title":"Lipid metabolism in metabolic-associated steatotic liver disease (MASLD)","volume":"14","author":"Syed-Abdul","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.phrs.2025.107892_bib18","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.phrs.2025.107892_bib19","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1111\/bph.15433","article-title":"Activation of pregnane x receptor induces atherogenic lipids and PCSK9 by a SREBP2-mediated mechanism","volume":"178","author":"Karpale","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2025.107892_bib20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.toxlet.2021.04.016","article-title":"PXR-mediated expression of FABP4 promotes valproate-induced lipid accumulation in HepG2 cells","volume":"346","author":"Yan","year":"2021","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.phrs.2025.107892_bib21","doi-asserted-by":"crossref","unstructured":"D. L\u00fctjohann, C. Hahn, W. Prange, T. Sudhop, M. Axelson, T. Sauerbruch, K.V. Bergmann, C. ReichelInfluence of rifampin on serum markers of cholesterol and bile acid synthesis in men, CP 42 (2004) 307\u2013313. https:\/\/doi.org\/10.5414\/CPP42307..","DOI":"10.5414\/CPP42307"},{"key":"10.1016\/j.phrs.2025.107892_bib22","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1093\/bbb\/zbad004","article-title":"A diet supplemented with cholic acid elevates blood pressure accompanied by albuminuria in rats","volume":"87","author":"Shimoda","year":"2023","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.phrs.2025.107892_bib23","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/toxsci\/kfs211","article-title":"J., chronic exposure to rifaximin causes hepatic steatosis in pregnane x receptor-humanized mice","volume":"129","author":"Cheng","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.phrs.2025.107892_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/FPC.0b013e328333a1dd","article-title":"The nuclear receptor PXR gene variants are associated with liver injury in nonalcoholic fatty liver disease","volume":"20","author":"Sookoian","year":"2010","journal-title":"Pharm. Genom."},{"key":"10.1016\/j.phrs.2025.107892_bib25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.tox.2018.08.007","article-title":"Modulation of xenobiotic nuclear receptors in high-fat diet induced non-alcoholic fatty liver disease","volume":"410","author":"Li","year":"2018","journal-title":"Toxicology"},{"key":"10.1016\/j.phrs.2025.107892_bib26","doi-asserted-by":"crossref","first-page":"E1195","DOI":"10.1152\/ajpendo.00513.2004","article-title":"PPAR\u03b32 regulates lipogenesis and lipid accumulation in steatotic hepatocytes","volume":"288","author":"Schadinger","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2025.107892_bib27","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1016\/j.biocel.2007.03.012","article-title":"CD36: implications in cardiovascular disease","volume":"39","author":"Febbraio","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.phrs.2025.107892_bib28","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.2337\/db12-1039","article-title":"PXR ablation alleviates Diet-Induced and genetic obesity and insulin resistance in mice","volume":"62","author":"He","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.phrs.2025.107892_bib29","doi-asserted-by":"crossref","first-page":"9768","DOI":"10.1074\/jbc.M610072200","article-title":"Nuclear pregnane x receptor Cross-talk with FoxA2 to mediate Drug-induced regulation of lipid metabolism in fasting mouse liver","volume":"282","author":"Nakamura","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2025.107892_bib30","doi-asserted-by":"crossref","first-page":"15013","DOI":"10.1074\/jbc.M511116200","article-title":"A novel pregnane x Receptor-mediated and sterol regulatory Element-binding Protein-independent lipogenic pathway","volume":"281","author":"Zhou","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2025.107892_bib31","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1053\/j.gastro.2007.11.037","article-title":"Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPAR\u03b3 in promoting steatosis","volume":"134","author":"Zhou","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phrs.2025.107892_bib32","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.tips.2012.07.003","article-title":"Targeting xenobiotic receptors PXR and CAR for metabolic diseases","volume":"33","author":"Gao","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.phrs.2025.107892_bib33","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1007\/s00204-019-02445-2","article-title":"Pregnane x receptor mediates steatotic effects of propiconazole and tebuconazole in human liver cell lines","volume":"93","author":"Knebel","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.phrs.2025.107892_bib34","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.cbi.2010.01.008","article-title":"Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile","volume":"184","author":"Moya","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.phrs.2025.107892_bib35","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.bbrc.2011.02.048","article-title":"Acetylation of pregnane x receptor protein determines selective function independent of ligand activation","volume":"406","author":"Biswas","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phrs.2025.107892_bib36","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bbrc.2022.05.055","article-title":"Mice blocking Ser347 phosphorylation of pregnane x receptor develop hepatic fasting-induced steatosis and hypertriglyceridemia","volume":"615","author":"Yokobori","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phrs.2025.107892_bib37","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1042\/cs0500349","article-title":"Effect of phenobarbitone on plasma lipids in normal subjects","volume":"50","author":"Durrington","year":"1976","journal-title":"Clin. Sci."},{"key":"10.1016\/j.phrs.2025.107892_bib38","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1194\/jlr.M800226-JLR200","article-title":"The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress","volume":"50","author":"Maglich","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.phrs.2025.107892_bib39","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1124\/molpharm.120.000103","article-title":"Antiepileptic drug\u2013activated constitutive androstane receptor inhibits peroxisome proliferator\u2013activated receptor \u03b1 and peroxisome proliferator\u2013activated receptor \u03b3 coactivator 1\u03b1\u2013dependent gene expression to increase blood triglyceride levels","volume":"98","author":"Shizu","year":"2020","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.phrs.2025.107892_bib40","doi-asserted-by":"crossref","first-page":"18831","DOI":"10.1073\/pnas.0909731106","article-title":"Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease","volume":"106","author":"Dong","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2025.107892_bib41","doi-asserted-by":"crossref","first-page":"25984","DOI":"10.1074\/jbc.M109.016808","article-title":"The constitutive androstane receptor is an Anti-obesity nuclear receptor that improves insulin sensitivity","volume":"284","author":"Gao","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2025.107892_bib42","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1124\/mol.110.064618","article-title":"A functional Cross-Talk between liver x Receptor-\u03b1 and constitutive androstane receptor links lipogenesis and xenobiotic responses","volume":"78","author":"Zhai","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.phrs.2025.107892_bib43","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1210\/en.2009-1435","article-title":"Hepatic expression of thyroid hormone-responsive spot 14 protein is regulated by constitutive androstane receptor (NR1I3)","volume":"151","author":"Breuker","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.phrs.2025.107892_bib44","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3390\/cells11030313","article-title":"Nuclear receptor PXR in drug-induced hypercholesterolemia","volume":"11","author":"Karpale","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.phrs.2025.107892_bib45","first-page":"49","article-title":"Dyslipidemia related to antiretroviral therapy","volume":"13","author":"Estrada","year":"2011","journal-title":"AIDS Rev."},{"key":"10.1016\/j.phrs.2025.107892_bib46","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2165\/00002018-200124060-00003","article-title":"Drug-Induced lipid changes: a review of the unintended effects of some commonly used drugs on serum lipid levels","volume":"24","author":"Mantel-Teeuwisse","year":"2001","journal-title":"Drug Saf."},{"key":"10.1016\/j.phrs.2025.107892_bib47","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1194\/jlr.M800608-JLR200","article-title":"Activation of PXR induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apoe deficient mice","volume":"50","author":"Zhou","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.phrs.2025.107892_bib48","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.jhep.2018.12.038","article-title":"Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce hypercholesterolemia and hepatic steatosis","volume":"70","author":"Gwag","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phrs.2025.107892_bib49","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.nutres.2023.09.006","article-title":"Resveratrol attenuates efavirenz-induced hepatic steatosis and hypercholesterolemia in mice by inhibiting pregnane x receptor activation and decreasing inflammation","volume":"119","author":"Miao","year":"2023","journal-title":"Nutr. Res."},{"key":"10.1016\/j.phrs.2025.107892_bib50","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nrendo.2017.91","article-title":"SREBP-regulated lipid metabolism: convergent physiology \u2014 divergent pathophysiology","volume":"13","author":"Shimano","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.phrs.2025.107892_bib51","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1007\/s00204-023-03575-4","article-title":"Adverse outcome pathway for pregnane x receptor-induced hypercholesterolemia","volume":"97","author":"Itkonen","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.phrs.2025.107892_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155271","article-title":"Chlorogenic acid regulates the expression of NPC1L1 and HMGCR through PXR and SREBP2 signaling pathways and their interactions with HSP90 to maintain cholesterol homeostasis","volume":"123","author":"Meng","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phrs.2025.107892_bib53","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.125657","article-title":"The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling","volume":"4","author":"Meng","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.phrs.2025.107892_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1398462","article-title":"Cannabidiol promotes intestinal cholesterol uptake mediated by pregnane x receptor","volume":"15","author":"Brown","year":"2024","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.phrs.2025.107892_bib55","doi-asserted-by":"crossref","DOI":"10.1289\/EHP9262","article-title":"Effects of dicyclohexyl phthalate exposure on PXR activation and lipid homeostasis in mice","volume":"129","author":"Sui","year":"2021","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.phrs.2025.107892_bib56","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1007\/s00204-020-02936-7","article-title":"Inhibition and induction of CYP enzymes in humans: an update","volume":"94","author":"Hakkola","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.phrs.2025.107892_bib57","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1194\/jlr.M700374-JLR200","article-title":"Activation of the constitutive androstane receptor decreases HDL in wild-type and human apoA-I transgenic mice","volume":"49","author":"Masson","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.phrs.2025.107892_bib58","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1186\/1471-2164-10-384","article-title":"Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers","volume":"10","author":"Re\u017een","year":"2009","journal-title":"BMC Genom."},{"key":"10.1016\/j.phrs.2025.107892_bib59","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1161\/ATVBAHA.110.222497","article-title":"Constitutive androstane receptor activation decreases plasma apolipoprotein B\u2013Containing lipoproteins and atherosclerosis in Low-Density lipoprotein Receptor\u2013Deficient mice","volume":"31","author":"Sberna","year":"2011","journal-title":"ATVB"},{"key":"10.1016\/j.phrs.2025.107892_bib60","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1194\/jlr.M017376","article-title":"Deficiency of PXR decreases atherosclerosis in apoE-deficient mice","volume":"52","author":"Sui","year":"2011","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.phrs.2025.107892_bib61","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1194\/jlr.RA119000122","article-title":"Myeloid-specific deficiency of pregnane x receptor decreases atherosclerosis in LDL receptor-deficient mice","volume":"61","author":"Sui","year":"2020","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.phrs.2025.107892_bib62","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.3390\/cells11071125","article-title":"Pregnane x receptor mediates atherosclerosis induced by dicyclohexyl phthalate in LDL Receptor-Deficient mice","volume":"11","author":"Liu","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.phrs.2025.107892_bib63","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000492","article-title":"Bisphenol a increases atherosclerosis in pregnane x receptor-humanized ApoE deficient mice","volume":"3","author":"Sui","year":"2014","journal-title":"JAHA"},{"key":"10.1016\/j.phrs.2025.107892_bib64","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1210\/en.2017-03250","article-title":"Perinatal bisphenol a exposure increases atherosclerosis in adult Male PXR-Humanized mice","volume":"159","author":"Sui","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.phrs.2025.107892_bib65","doi-asserted-by":"crossref","first-page":"9267","DOI":"10.3390\/ijms22179267","article-title":"Activation of the constitutive androstane receptor inhibits leukocyte adhesiveness to dysfunctional endothelium","volume":"22","author":"L\u00f3pez-Riera","year":"2021","journal-title":"IJMS"},{"key":"10.1016\/j.phrs.2025.107892_bib66","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1021\/acs.jmedchem.2c01140","article-title":"Discovery of novel human constitutive androstane receptor agonists with the Imidazo[1,2- a]pyridine structure","volume":"66","author":"Mejdrov\u00e1","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.phrs.2025.107892_bib67","doi-asserted-by":"crossref","first-page":"4054","DOI":"10.1038\/s41467-024-48472-1","article-title":"Chemical manipulation of an activation\/inhibition switch in the nuclear receptor PXR","volume":"15","author":"Garcia-Maldonado","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2025.107892_bib68","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/s41467-025-56642-y","article-title":"The hypolipidemic effect of MI-883, the combined CAR agonist\/ PXR antagonist, in diet-induced hypercholesterolemia model","volume":"16","author":"Dusek","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2025.107892_bib69","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/clpt.2013.48","article-title":"Pregnane x receptor agonists impair postprandial glucose tolerance","volume":"93","author":"Rys\u00e4","year":"2013","journal-title":"Clin. Pharm. Ther."},{"key":"10.1016\/j.phrs.2025.107892_bib70","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1002\/cpt.1871","article-title":"Pregnane x receptor activator rifampin increases blood pressure and stimulates plasma renin activity","volume":"108","author":"Hassani-Nezhad-Gashti","year":"2020","journal-title":"Clin. Pharma Ther."},{"key":"10.1016\/j.phrs.2025.107892_bib71","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.023492","article-title":"Pregnane x Receptor-4\u03b2-Hydroxycholesterol axis in the regulation of Overweight- and Obesity-Induced hypertension","volume":"11","author":"Rahunen","year":"2022","journal-title":"JAHA"},{"key":"10.1016\/j.phrs.2025.107892_bib72","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1210\/me.2006-0291","article-title":"Activation of pregnane x receptor disrupts glucocorticoid and mineralocorticoid homeostasis","volume":"21","author":"Zhai","year":"2007","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.phrs.2025.107892_bib73","doi-asserted-by":"crossref","first-page":"F927","DOI":"10.1152\/ajprenal.1992.262.6.F927","article-title":"Corticosterone 6 beta-hydroxylation correlates with blood pressure in spontaneously hypertensive rats","volume":"262","author":"Watlington","year":"1992","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.phrs.2025.107892_bib74","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s13318-024-00923-2","article-title":"Hypertensive nephropathy changes the expression of Drug-Metabolizing enzymes and transporters in spontaneously hypertensive rat liver and kidney","volume":"50","author":"Pan","year":"2025","journal-title":"Eur. J. Drug Metab. Pharm."},{"key":"10.1016\/j.phrs.2025.107892_bib75","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1093\/cvr\/cvr330","article-title":"Pregnane x receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress","volume":"93","author":"Swales","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.phrs.2025.107892_bib76","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1161\/01.HYP.0000253478.51950.27","article-title":"Regulation of vascular tone during pregnancy: a novel role for the pregnane x receptor","volume":"49","author":"Hagedorn","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.phrs.2025.107892_bib77","doi-asserted-by":"crossref","first-page":"E350","DOI":"10.1152\/ajpendo.00572.2018","article-title":"The pregnane x receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation","volume":"317","author":"Pulakazhi Venu","year":"2019","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2025.107892_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103397","article-title":"Activation of nuclear receptor pregnane-X-receptor protects against abdominal aortic aneurysm by inhibiting oxidative stress","volume":"77","author":"Shen","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.phrs.2025.107892_bib79","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1161\/HYPERTENSIONAHA.114.03585","article-title":"Epoxyeicosatrienoic acids, hypertension, and kidney injury","volume":"65","author":"Imig","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.phrs.2025.107892_bib80","doi-asserted-by":"crossref","first-page":"13174","DOI":"10.1073\/pnas.1312065110","article-title":"Shear stress activation of nuclear receptor PXR in endothelial detoxification","volume":"110","author":"Wang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2025.107892_bib81","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1210\/me.2004-0427","article-title":"Evolution of the pregnane x receptor: adaptation to Cross-Species differences in biliary bile salts","volume":"19","author":"Krasowski","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.phrs.2025.107892_bib82","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.toxlet.2016.11.013","article-title":"Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane x (PXR) receptor","volume":"265","author":"Carazo","year":"2017","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.phrs.2025.107892_bib83","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/FPC.0000000000000489","article-title":"Pregnane x receptor gene variant rs7643645 and total mortality in subjects with nonalcoholic fatty liver disease","volume":"33","author":"K\u00e4r\u00e4j\u00e4m\u00e4ki","year":"2023","journal-title":"Pharm. Genom."},{"key":"10.1016\/j.phrs.2025.107892_bib84","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2125.2010.03773.x","article-title":"4\u03b2-hydroxycholesterol, an endogenous marker of CYP3A4\/5 activity in humans","volume":"71","author":"Diczfalusy","year":"2011","journal-title":"Brit J. Clin. Pharma"},{"key":"10.1016\/j.phrs.2025.107892_bib85","doi-asserted-by":"crossref","first-page":"310","DOI":"10.2174\/138920008784220664","article-title":"Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4","volume":"9","author":"Zhou","year":"2008","journal-title":"CDM"},{"key":"10.1016\/j.phrs.2025.107892_bib86","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1210\/er.2001-0038","article-title":"The nuclear pregnane x receptor: a key regulator of xenobiotic metabolism","volume":"23","author":"Kliewer","year":"2002","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.phrs.2025.107892_bib87","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/383728a0","article-title":"An oxysterol signalling pathway mediated by the nuclear receptor LXR\u03b1","volume":"383","author":"Janowski","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2025.107892_bib88","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3389\/fphar.2020.00361","article-title":"4\u03b2-Hydroxycholesterol signals from the liver to regulate peripheral cholesterol transporters","volume":"11","author":"Salonurmi","year":"2020","journal-title":"Front. Pharm."},{"key":"10.1016\/j.phrs.2025.107892_bib89","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00395-015-0520-7","article-title":"Emerging role of liver x receptors in cardiac pathophysiology and heart failure","volume":"111","author":"Cannon","year":"2016","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.phrs.2025.107892_bib90","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.lfs.2018.10.042","article-title":"The effects of LXR agonist GW3965 on vascular reactivity and inflammation in hypertensive rat aorta","volume":"213","author":"Han","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.phrs.2025.107892_bib91","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/FJC.0000000000000693","article-title":"Activation of liver x receptors by GW3965 attenuated deoxycorticosterone Acetate\u2013Salt Hypertension-Induced cardiac functional and structural changes","volume":"74","author":"Bal","year":"2019","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.phrs.2025.107892_bib92","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.031824","article-title":"Liver x receptor agonist 4\u03b2-Hydroxycholesterol as a prognostic factor in coronary artery disease","volume":"13","author":"Rahunen","year":"2024","journal-title":"JAHA"},{"key":"10.1016\/j.phrs.2025.107892_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2021.100051","article-title":"4\u03b2-Hydroxycholesterol is a prolipogenic factor that promotes SREBP1c expression and activity through the liver x receptor","volume":"62","author":"Moldavski","year":"2021","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.phrs.2025.107892_bib94","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00395-012-0323-z","article-title":"Activation of liver x receptors in the heart leads to accumulation of intracellular lipids and attenuation of ischemia\u2013reperfusion injury","volume":"108","author":"Lei","year":"2013","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.phrs.2025.107892_bib95","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.019473","article-title":"Liver x receptor agonist AZ876 induces beneficial endogenous cardiac lipid reprogramming and protects against Isoproterenol-Induced cardiac damage","volume":"10","author":"Ritter","year":"2021","journal-title":"JAHA"},{"key":"10.1016\/j.phrs.2025.107892_bib96","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s00395-018-0699-5","article-title":"LXR\/RXR signaling and neutrophil phenotype following myocardial infarction classify sex differences in remodeling","volume":"113","author":"DeLeon-Pennell","year":"2018","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.phrs.2025.107892_bib97","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.tips.2015.04.002","article-title":"A new model of reverse cholesterol transport: enTICEing strategies to stimulate intestinal cholesterol excretion","volume":"36","author":"Temel","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.phrs.2025.107892_bib98","doi-asserted-by":"crossref","first-page":"38685","DOI":"10.1074\/jbc.M105127200","article-title":"Antiepileptic drugs increase plasma levels of 4\u03b2-Hydroxycholesterolin humans","volume":"276","author":"Bodin","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2025.107892_bib99","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1136\/bmj.2.6130.99","article-title":"Increase of serum high-density lipoprotein in phenytoin users","volume":"2","author":"Nikkila","year":"1978","journal-title":"BMJ"},{"key":"10.1016\/j.phrs.2025.107892_bib100","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1177\/08830738060210011301","article-title":"Effect of antiepileptic drugs on plasma lipids, lipoprotein (a), and liver enzymes","volume":"21","author":"Mujgan Sonmez","year":"2006","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.phrs.2025.107892_bib101","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1600-0404.1982.tb03067.x","article-title":"Serum elevation of high density lipoprotein (HDL) cholesterol in epileptic patients taking carbamazepine or phenytoin","volume":"65","author":"O\u2019Neill","year":"2009","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.phrs.2025.107892_bib102","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1161\/01.ATV.15.12.2151","article-title":"A prospective, randomized trial of phenytoin in nonepileptic subjects with reduced HDL cholesterol","volume":"15","author":"Miller","year":"1995","journal-title":"ATVB"},{"key":"10.1016\/j.phrs.2025.107892_bib103","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/clpt.1987.88","article-title":"Lack of effect of hepatic enzyme induction on metabolic control in patients with type 2 (non-insulin-dependent) diabetes","volume":"41","author":"Korhonen","year":"1987","journal-title":"Clin. Pharm. Ther."},{"key":"10.1016\/j.phrs.2025.107892_bib104","article-title":"Activation of pregnane x receptor by pregnenolone 16 \u03b1-carbonitrile prevents High-Fat Diet-Induced obesity in AKR\/J mice","volume":"7","author":"Ma","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.phrs.2025.107892_bib105","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1074\/jbc.M113.494575","article-title":"Role of pregnane x receptor in obesity and glucose homeostasis in Male mice","volume":"289","author":"Spruiell","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2025.107892_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2023.101779","article-title":"Pregnane x receptor activation remodels glucose metabolism to promote NAFLD development in obese mice","volume":"76","author":"Karpale","year":"2023","journal-title":"Mol. Metab."},{"key":"10.1016\/j.phrs.2025.107892_bib107","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2133\/dmpk.23.8","article-title":"The roles of nuclear receptors CAR and PXR in hepatic energy metabolism","volume":"23","author":"Konno","year":"2008","journal-title":"Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.phrs.2025.107892_bib108","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1042\/BJ20070481","article-title":"Human nuclear pregnane x receptor cross-talk with CREB to repress cAMP activation of the glucose-6-phosphatase gene","volume":"407","author":"Kodama","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.phrs.2025.107892_bib109","doi-asserted-by":"crossref","first-page":"45139","DOI":"10.1074\/jbc.M405423200","article-title":"Ligand-activated pregnane x receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1\u03b1","volume":"279","author":"Bhalla","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2025.107892_bib110","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1124\/jpet.113.209379","article-title":"Serum- and Glucocorticoid-Regulated kinase 2 determines Drug-Activated pregnane x receptor to induce gluconeogenesis in human liver cells","volume":"348","author":"Gotoh","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.phrs.2025.107892_bib111","doi-asserted-by":"crossref","DOI":"10.1038\/srep14076","article-title":"Statin-activated nuclear receptor PXR promotes SGK2 dephosphorylation by scaffolding PP2C to induce hepatic gluconeogenesis","volume":"5","author":"Gotoh","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2025.107892_bib112","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.bcp.2015.11.023","article-title":"Involvement of pregnane x receptor in the impaired glucose utilization induced by atorvastatin in hepatocytes","volume":"100","author":"Ling","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phrs.2025.107892_bib113","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1016\/j.apsb.2021.09.031","article-title":"PXR activation impairs hepatic glucose metabolism partly via inhibiting the HNF4\u03b1\u2013GLUT2 pathway","volume":"12","author":"Liu","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phrs.2025.107892_bib114","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.cellsig.2017.09.003","article-title":"Glucose elicits serine\/threonine kinase VRK1 to phosphorylate nuclear pregnane x receptor as a novel hepatic gluconeogenic signal","volume":"40","author":"Gotoh","year":"2017","journal-title":"Cell. Signal."},{"key":"10.1016\/j.phrs.2025.107892_bib115","first-page":"131","article-title":"Glucose tolerance and insulin response to glucose load before and after enzyme inducing therapy in subjects with glucose intolerance and patients with NIDDM having hyperinsulinemia or relative insulin deficiency","volume":"11","author":"Sotaniemi","year":"1989","journal-title":"Diabetes Res."},{"key":"10.1016\/j.phrs.2025.107892_bib116","doi-asserted-by":"crossref","first-page":"911","DOI":"10.2337\/diab.34.9.911","article-title":"Enzyme inducers improve insulin sensitivity in Non-insulin-dependent diabetic subjects","volume":"34","author":"Lahtela","year":"1985","journal-title":"Diabetes"},{"key":"10.1016\/j.phrs.2025.107892_bib117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/mol.61.1.1","article-title":"Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital","volume":"61","author":"Ueda","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.phrs.2025.107892_bib118","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1124\/jpet.116.232140","article-title":"Phenobarbital and insulin reciprocate activation of the nuclear receptor constitutive androstane receptor through the insulin receptor","volume":"357","author":"Yasujima","year":"2016","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.phrs.2025.107892_bib119","doi-asserted-by":"crossref","DOI":"10.1621\/nrs.13002","article-title":"Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium","volume":"13","author":"Oshida","year":"2015","journal-title":"Nucl. Recept Signal"},{"key":"10.1016\/j.phrs.2025.107892_bib120","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.bbagrm.2015.10.001","article-title":"Evodia alkaloids suppress gluconeogenesis and lipogenesis by activating the constitutive androstane receptor","volume":"1859","author":"Yu","year":"2016","journal-title":"Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms"},{"key":"10.1016\/j.phrs.2025.107892_bib121","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2174\/1389200219666180918152241","article-title":"The role of xenobiotic receptors on hepatic glycolipid metabolism","volume":"20","author":"Chen","year":"2019","journal-title":"CDM"},{"key":"10.1016\/j.phrs.2025.107892_bib122","doi-asserted-by":"crossref","first-page":"30169","DOI":"10.1074\/jbc.M004898200","article-title":"Regulation of phosphoenolpyruvate carboxykinase and Insulin-like growth Factor-binding Protein-1 gene expression by insulin","volume":"275","author":"Hall","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2025.107892_bib123","doi-asserted-by":"crossref","first-page":"36324","DOI":"10.1074\/jbc.M003616200","article-title":"Regulation of Glucose-6-phosphatase gene expression by protein kinase B\u03b1 and the forkhead transcription factor FKHR","volume":"275","author":"Schmoll","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2025.107892_bib124","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1111\/bph.12090","article-title":"The constitutive androstane receptor activator 4-[( 4R, 6R)-4,6-diphenyl-1,3-dioxan-2-yl]- N, N -dimethylaniline inhibits the gluconeogenic genes PEPCK and G6Pase through the suppression of HNF4 \u03b1 and FOXO1 transcriptional activity","volume":"168","author":"Yarushkin","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2025.107892_bib125","doi-asserted-by":"crossref","first-page":"14537","DOI":"10.1074\/jbc.M510713200","article-title":"Functional inhibitory Cross-talk between constitutive androstane receptor and hepatic nuclear Factor-4 in hepatic Lipid\/Glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1\u03b1","volume":"281","author":"Miao","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2025.107892_bib126","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1210\/me.2015-1145","article-title":"CAR suppresses hepatic gluconeogenesis by facilitating the ubiquitination and degradation of PGC1\u03b1","volume":"29","author":"Gao","year":"2015","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.phrs.2025.107892_bib127","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1210\/me.2015-1292","article-title":"Irisin is regulated by CAR in liver and is a mediator of hepatic glucose and lipid metabolism","volume":"30","author":"Mo","year":"2016","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.phrs.2025.107892_bib128","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10616-020-00384-w","article-title":"Genome-wide expression profiling reveals increased stability and mitochondrial energy metabolism of the human liver cell line HepaRG-CAR","volume":"72","author":"Adam","year":"2020","journal-title":"Cytotechnology"},{"key":"10.1016\/j.phrs.2025.107892_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115055","article-title":"Overexpression of the constitutive androstane receptor and shaken 3D-culturing increase biotransformation and oxidative phosphorylation and sensitivity to mitochondrial amiodarone toxicity of HepaRG cells","volume":"399","author":"Van Der Mark","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phrs.2025.107892_bib130","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.bbagrm.2016.03.007","article-title":"Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPAR\u03b1 in primary human hepatocytes","volume":"1859","author":"Kandel","year":"2016","journal-title":"Biochim. et Biophys. Acta (BBA) Gene Regul. Mechan."},{"key":"10.1016\/j.phrs.2025.107892_bib131","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.apsb.2020.08.015","article-title":"Gadd45b is required in part for the anti-obesity effect of constitutive androstane receptor (CAR)","volume":"11","author":"Cai","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phrs.2025.107892_bib132","doi-asserted-by":"crossref","first-page":"8791","DOI":"10.3390\/ijms24108791","article-title":"Comparative transcriptomic analysis of three common liver cell lines","volume":"24","author":"Arzumanian","year":"2023","journal-title":"IJMS"},{"key":"10.1016\/j.phrs.2025.107892_bib133","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1080\/03602532.2022.2039688","article-title":"Through a glass, darkly? Heparg and HepG2 cells as models of human phase I drug metabolism","volume":"54","author":"Stanley","year":"2022","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.phrs.2025.107892_bib134","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1124\/jpet.117.247296","article-title":"Establishing transcriptional signatures to differentiate PXR-, CAR-, and AhR-mediated regulation of drug metabolism and transport genes in cryopreserved human hepatocytes","volume":"365","author":"Moscovitz","year":"2018","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.phrs.2025.107892_bib135","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/toxsci\/kfv136","article-title":"Comparative proteomic characterization of 4 human Liver-Derived single cell culture models reveals significant variation in the capacity for drug disposition, bioactivation, and detoxication","volume":"147","author":"Sison-Young","year":"2015","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.phrs.2025.107892_bib136","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.3390\/cells12192368","article-title":"Improvements in maturity and stability of 3D iPSC-Derived Hepatocyte-like cell cultures","volume":"12","author":"Suominen","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.phrs.2025.107892_bib137","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/sj.bjp.0707601","article-title":"Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells","volume":"153","author":"Martin","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2025.107892_bib138","doi-asserted-by":"crossref","first-page":"17277","DOI":"10.1074\/jbc.M300138200","article-title":"Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes","volume":"278","author":"Maglich","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2025.107892_bib139","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1093\/toxsci\/kfr191","article-title":"Multi-species analyses of direct activators of the constitutive androstane receptor","volume":"123","author":"Omiecinski","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.phrs.2025.107892_bib140","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1101\/gad.846800","article-title":"Reciprocal activation of xenobiotic response genes by nuclear receptors SXR\/PXR and CAR","volume":"14","author":"Xie","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.phrs.2025.107892_bib141","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.tox.2010.11.008","article-title":"Comparative study of human and mouse pregnane x receptor agonistic activity in 200 pesticides using in vitro reporter gene assays","volume":"280","author":"Kojima","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.phrs.2025.107892_bib142","doi-asserted-by":"crossref","first-page":"8385","DOI":"10.1093\/nar\/gky692","article-title":"In vivo genome-wide binding interactions of mouse and human constitutive androstane receptors reveal novel gene targets","volume":"46","author":"Niu","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phrs.2025.107892_bib143","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2174\/187569209788654005","article-title":"Activation of CAR and PXR by dietary, environmental and occupational chemicals alters drug metabolism, intermediary metabolism, and cell proliferation","volume":"7","author":"Hernandez","year":"2009","journal-title":"CPPM"},{"key":"10.1016\/j.phrs.2025.107892_bib144","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.taap.2014.05.009","article-title":"Activation of the constitutive androstane receptor inhibits gluconeogenesis without affecting lipogenesis or fatty acid synthesis in human hepatocytes","volume":"279","author":"Lynch","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phrs.2025.107892_bib145","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-56570-0","article-title":"Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor","volume":"9","author":"Lukowicz","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2025.107892_bib146","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1210\/mend.16.5.0828","article-title":"Pregnane x receptor (PXR), constitutive androstane receptor (CAR), and benzoate x receptor (BXR) define three pharmacologically distinct classes of nuclear receptors","volume":"16","author":"Moore","year":"2002","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.phrs.2025.107892_bib147","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1124\/pr.55.4.2","article-title":"Induction of drug metabolism: the role of nuclear receptors","volume":"55","author":"Handschin","year":"2003","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.phrs.2025.107892_bib148","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00018-017-2693-8","article-title":"Mouse models for human intestinal microbiota research: a critical evaluation","volume":"75","author":"Hugenholtz","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.phrs.2025.107892_bib149","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/dmm.017400","article-title":"How informative is the mouse for human gut microbiota research?","volume":"8","author":"Nguyen","year":"2015","journal-title":"Dis. Models Mech."},{"key":"10.1016\/j.phrs.2025.107892_bib150","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s40495-019-00200-w","article-title":"Microbiome is a functional modifier of P450 drug metabolism","volume":"5","author":"Dempsey","year":"2019","journal-title":"Curr. Pharm. Rep."},{"key":"10.1016\/j.phrs.2025.107892_bib151","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1124\/dmd.121.000415","article-title":"Pregnane x receptor and the Gut-Liver axis: a recent update","volume":"50","author":"Dutta","year":"2022","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.phrs.2025.107892_bib152","article-title":"Bile acid-mediated gut-liver axis crosstalk: the role of nuclear receptor signaling in dynamic regulation of inflammatory networks","volume":"16","author":"Yan","year":"2025","journal-title":"Front. Immunol."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661825003172?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661825003172?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T10:45:54Z","timestamp":1772880354000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661825003172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":152,"alternative-id":["S1043661825003172"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2025.107892","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nuclear receptors CAR and PXR as cardiometabolic regulators","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2025.107892","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107892"}}