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Biol."},{"key":"10.1016\/j.phrs.2025.107924_bib83","doi-asserted-by":"crossref","first-page":"7626","DOI":"10.1158\/0008-5472.CAN-09-0493","article-title":"Nitrosative-stress induced S-glutathionylation of PDI leads to activation of the unfolded protein response","volume":"69","author":"Townsend","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.phrs.2025.107924_bib84","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/273549","article-title":"S-glutathionylation of protein disulfide isomerase regulates estrogen receptor \u03b1 stability and function","volume":"2012","author":"Xiong","year":"2012","journal-title":"Int. J. Cell Biol."},{"key":"10.1016\/j.phrs.2025.107924_bib85","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jsbmb.2008.09.005","article-title":"Protein disulfide isomerase is a multifunctional regulator of estrogenic status in target cells","volume":"112","author":"Fu","year":"2008","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.phrs.2025.107924_bib86","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1158\/0008-5472.CAN-06-2583","article-title":"Tumor-induced oxidative stress perturbs nuclear Factor-\u03baB Activity-Augmenting tumor necrosis Factor-\u03b1\u2013Mediated T-Cell death: protection by curcumin","volume":"67","author":"Bhattacharyya","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.phrs.2025.107924_bib87","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3390\/antiox8090382","article-title":"Side effects of curcumin: epigenetic and antiproliferative implications for normal dermal fibroblast and breast cancer cells","volume":"8","author":"Cianfruglia","year":"2019","journal-title":"Antioxidants"},{"key":"10.1016\/j.phrs.2025.107924_bib88","first-page":"1266","article-title":"Curcumin inhibits proliferation and promotes apoptosis of breast cancer cells","volume":"16","author":"Hu","year":"2018","journal-title":"Exp. Ther. 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Biol. Chem."},{"key":"10.1016\/j.phrs.2025.107924_bib104","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.MCHD-0044-2016","article-title":"Glutathione and glutathione transferase omega 1 as key posttranslational regulators in macrophages","volume":"5","author":"Hughes","year":"2017","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.phrs.2025.107924_bib105","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217113","article-title":"Immunomodulatory molecules in colorectal cancer liver metastasis","volume":"598","author":"Kong","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phrs.2025.107924_bib106","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.bbrc.2017.11.018","article-title":"Protein S-glutathionylation induced by hypoxia increases hypoxia-inducible factor-1\u03b1 in human colon cancer cells","volume":"495","author":"Jeon","year":"2018","journal-title":"Biochem. Biophys. Res. 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A."},{"key":"10.1016\/j.phrs.2025.107924_bib110","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.3390\/cancers12113336","article-title":"The role of oxidative stress and its counteractive utility in colorectal cancer (CRC)","volume":"12","author":"Basak","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.phrs.2025.107924_bib111","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.bbadis.2016.11.010","article-title":"Mitochondrial dysfunction and oxidative stress in metabolic disorders - a step towards mitochondria based therapeutic strategies","volume":"1863","author":"Bhatti","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phrs.2025.107924_bib112","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.3390\/ijms25021007","article-title":"A prognostic activity of glutaredoxin 1 protein (Grx1) in colon cancer","volume":"25","author":"Brzozowa-Zasada","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2025.107924_bib113","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.3390\/ijms25021060","article-title":"Glutaredoxin 2 protein (Grx2) as an independent prognostic factor associated with the survival of colon adenocarcinoma patients","volume":"25","author":"Brzozowa-Zasada","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2025.107924_bib114","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1089\/ars.2020.8074","article-title":"Reactive oxygen species induced p53 activation: DNA damage, redox signaling, or both?","volume":"33","author":"Shi","year":"2020","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.phrs.2025.107924_bib115","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nm0797-730","article-title":"Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell","volume":"3","author":"Bonnet","year":"1997","journal-title":"Nat. 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