{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:13:37Z","timestamp":1792872817483,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009991","name":"Jilin Province Department of Finance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009991","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.phrs.2025.107991","type":"journal-article","created":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T05:31:16Z","timestamp":1760247076000},"page":"107991","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["ALKBH3-AS1 drives SMAD3 stabilization via YTHDF2: Uncovering a pathogenic pathway for Th17 dysregulation in SLE"],"prefix":"10.1016","volume":"221","author":[{"given":"Yanli","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanchuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sensen","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guifeng","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueming","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3785-3691","authenticated-orcid":false,"given":"Huanfa","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.phrs.2025.107991_bib1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/nrrheum.2016.186","article-title":"KE. New insights into the immunopathogenesis of systemic lupus erythematosus","volume":"12","author":"Tsokos","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"issue":"2","key":"10.1016\/j.phrs.2025.107991_bib2","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.0300-9475.2004.01370.x","article-title":"Decreased CD4+CD25+ t cells in peripheral blood of patients with systemic lupus erythematosus","volume":"59","author":"Liu","year":"2004","journal-title":"Scand. J. Immunol."},{"issue":"8","key":"10.1016\/j.phrs.2025.107991_bib3","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nrneph.2017.85","article-title":"Redefining lupus nephritis: clinical implications of pathophysiologic subtypes","volume":"13","author":"Yu","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"issue":"2","key":"10.1016\/j.phrs.2025.107991_bib4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/ni1552","article-title":"Interleukin 17-producing t helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice","volume":"9","author":"Hsu","year":"2008","journal-title":"Nat. Immunol."},{"issue":"12","key":"10.1016\/j.phrs.2025.107991_bib5","doi-asserted-by":"crossref","first-page":"8761","DOI":"10.4049\/jimmunol.181.12.8761","article-title":"Expanded double negative t cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys","volume":"181","author":"Crisp\u00edn","year":"2008","journal-title":"J. immunol."},{"issue":"2","key":"10.1016\/j.phrs.2025.107991_bib6","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41584-019-0356-x","article-title":"T cell metabolism: new insights in systemic lupus erythematosus pathogenesis and therapy","volume":"16","author":"Sharabi","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.phrs.2025.107991_bib7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jaut.2017.12.005","article-title":"Plasticity and heterogeneity of Th17 in immune-mediated kidney diseases","volume":"87","author":"Krebs","year":"2018","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.phrs.2025.107991_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/848790","article-title":"The emerging functions of long noncoding RNA in immune cells: autoimmune diseases","volume":"2015","author":"Sigdel","year":"2015","journal-title":"J. Immunol. Res."},{"issue":"31","key":"10.1016\/j.phrs.2025.107991_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abn9181","article-title":"lncRNA-GM targets Foxo1 to promote t cell-mediated autoimmunity","volume":"8","author":"Chen","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.phrs.2025.107991_bib10","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.molimm.2020.06.027","article-title":"Gm15575 functions as a ceRNA to up-regulate CCL7 expression through sponging miR-686 in Th17 cells","volume":"125","author":"Bian","year":"2020","journal-title":"Mol. Immunol."},{"issue":"12","key":"10.1016\/j.phrs.2025.107991_bib11","doi-asserted-by":"crossref","first-page":"22477","DOI":"10.1002\/jcp.28811","article-title":"Knockdown of lncRNA NEAT1 inhibits Th17\/CD4(+) t cell differentiation through reducing the STAT3 protein level","volume":"234","author":"Shui","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.phrs.2025.107991_bib12","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.cell.2023.12.037","article-title":"Xist ribonucleoproteins promote female sex-biased autoimmunity","volume":"187","author":"Dou","year":"2024","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.phrs.2025.107991_bib13","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12929-023-00969-5","article-title":"Long noncoding RNA SNHG16 regulates TLR4-mediated autophagy and NETosis formation in alveolar hemorrhage associated with systemic lupus erythematosus","volume":"30","author":"Hsieh","year":"2023","journal-title":"J. Biomed. Sci."},{"issue":"1","key":"10.1016\/j.phrs.2025.107991_bib14","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/s41392-021-00779-x","article-title":"Roles and mechanisms of exosomal non-coding RNAs in human health and diseases","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"issue":"8","key":"10.1016\/j.phrs.2025.107991_bib15","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/s41573-021-00219-z","article-title":"Noncoding RNA therapeutics - challenges and potential solutions","volume":"20","author":"Winkle","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"issue":"13","key":"10.1016\/j.phrs.2025.107991_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22136948","article-title":"Targeting Intra-Pulmonary P53-Dependent long Non-Coding RNA expression as a therapeutic intervention for systemic lupus Erythematosus-Associated diffuse alveolar hemorrhage","volume":"22","author":"Chen","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.phrs.2025.107991_bib17","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41577-020-00490-y","article-title":"Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity","volume":"21","author":"Veglia","year":"2021","journal-title":"Nat. Rev. Immunol."},{"issue":"331","key":"10.1016\/j.phrs.2025.107991_bib18","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1126\/scitranslmed.aae0482","article-title":"Arginase-1-dependent promotion of TH17 differentiation and disease progression by MDSCs in systemic lupus erythematosus","volume":"8","author":"Wu","year":"2016","journal-title":"Sci. Transl. Med."},{"issue":"2","key":"10.1016\/j.phrs.2025.107991_bib19","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.ymthe.2022.10.013","article-title":"Polyamines from myeloid-derived suppressor cells promote Th17 polarization and disease progression","volume":"31","author":"Hu","year":"2023","journal-title":"Mole. therapy J. Am. Soc. Gene Therapy"},{"issue":"10","key":"10.1016\/j.phrs.2025.107991_bib20","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1136\/annrheumdis-2020-217162","article-title":"Performance of the 2019 EULAR\/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities","volume":"79","author":"Johnson","year":"2020","journal-title":"Ann. Rheum. Dis."},{"issue":"9","key":"10.1016\/j.phrs.2025.107991_bib21","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.it.2009.06.003","article-title":"Induction of autoimmunity by pristane and other naturally occurring hydrocarbons","volume":"30","author":"Reeves","year":"2009","journal-title":"Trends Immunol."},{"issue":"6","key":"10.1016\/j.phrs.2025.107991_bib22","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.immuni.2016.05.015","article-title":"The MicroRNA-183-96-182 cluster promotes t helper 17 cell pathogenicity by negatively regulating transcription factor Foxo1 expression","volume":"44","author":"Ichiyama","year":"2016","journal-title":"Immunity"},{"issue":"Pt A","key":"10.1016\/j.phrs.2025.107991_bib23","article-title":"Exosomal lncRNA TUG1 derived from BMSC ameliorate collagen-induced arthritis via BLIMP1-mediated Th17\/Treg balance","volume":"142","author":"Ye","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.phrs.2025.107991_bib24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s12016-025-09041-6","article-title":"The role of M(6)A modification in autoimmunity: emerging mechanisms and therapeutic implications","volume":"68","author":"Xu","year":"2025","journal-title":"Clin. Rev. Allergy Immunol."},{"issue":"6","key":"10.1016\/j.phrs.2025.107991_bib25","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1101\/gad.455708","article-title":"A natural antisense transcript regulates Zeb2\/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition","volume":"22","author":"Beltran","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.phrs.2025.107991_bib26","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.gde.2017.07.009","article-title":"Cis- and trans-acting lncRNAs in pluripotency and reprogramming","volume":"46","author":"Yan","year":"2017","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"1","key":"10.1016\/j.phrs.2025.107991_bib27","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.intimp.2014.02.038","article-title":"TGF-\u03b2\/Smad signaling pathway regulates Th17\/Treg balance during echinococcus multilocularis infection","volume":"20","author":"Pang","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phrs.2025.107991_bib28","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.30433","article-title":"LAST, a c-Myc-inducible long noncoding RNA, cooperates with CNBP to promote\u00a0CCND1\u00a0mRNA stability in human cells","volume":"6","author":"Cao","year":"2017","journal-title":"eLife"},{"issue":"10","key":"10.1016\/j.phrs.2025.107991_bib29","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a034728","article-title":"What are 3\u2032 UTRs doing?","volume":"11","author":"Mayr","year":"2019","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"3","key":"10.1016\/j.phrs.2025.107991_bib30","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/nrm.2017.103","article-title":"Functional 5\u2032 UTR mRNA structures in eukaryotic translation regulation and how to find them","volume":"19","author":"Leppek","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.phrs.2025.107991_bib31","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/imr.12056","article-title":"Molecular control of Tfh-cell differentiation by roquin family proteins","volume":"253","author":"Heissmeyer","year":"2013","journal-title":"Immunol. Rev."},{"issue":"1","key":"10.1016\/j.phrs.2025.107991_bib32","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/imr.12051","article-title":"Post-transcriptional regulatory networks in immunity","volume":"253","author":"Ivanov","year":"2013","journal-title":"Immunol. Rev."},{"issue":"1","key":"10.1016\/j.phrs.2025.107991_bib33","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41392-020-00450-x","article-title":"The role of m6A modification in the biological functions and diseases","volume":"6","author":"Jiang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.phrs.2025.107991_bib34","doi-asserted-by":"crossref","first-page":"938","DOI":"10.3389\/fimmu.2020.00938","article-title":"Myeloid Cell-Derived arginase in cancer immune response","volume":"11","author":"Grzywa","year":"2020","journal-title":"Front. Immunol."},{"issue":"15","key":"10.1016\/j.phrs.2025.107991_bib35","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1158\/0008-5472.CAN-16-2634","article-title":"Long noncoding RNA and cancer: a new paradigm","volume":"77","author":"Bhan","year":"2017","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.phrs.2025.107991_bib36","doi-asserted-by":"crossref","DOI":"10.1152\/ajplung.00416.2018","article-title":"Regulation of IL-17A and implications for TGF-\u03b21 comodulation of airway smooth muscle remodeling in severe asthma","volume":"316","author":"Evasovic","year":"2019","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"69","key":"10.1016\/j.phrs.2025.107991_bib37","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abi4613","article-title":"Transforming growth factor-\u03b21 in regulatory t cell biology","volume":"7","author":"Moreau","year":"2022","journal-title":"Sci. Immunol."},{"issue":"2","key":"10.1016\/j.phrs.2025.107991_bib38","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202009045","article-title":"LNCcation: lncRNA localization and function","volume":"220","author":"Bridges","year":"2021","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.phrs.2025.107991_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10982","article-title":"Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer","volume":"7","author":"Du","year":"2016","journal-title":"Nat. Commun."},{"issue":"1-2","key":"10.1016\/j.phrs.2025.107991_bib40","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cell.2015.12.017","article-title":"Noncoding RNA NORAD regulates genomic stability by sequestering PUMILIO proteins","volume":"164","author":"Lee","year":"2016","journal-title":"Cell"},{"issue":"7333","key":"10.1016\/j.phrs.2025.107991_bib41","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/nature09701","article-title":"lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3\u2032 UTRs via alu elements","volume":"470","author":"Gong","year":"2011","journal-title":"Nature"},{"issue":"7424","key":"10.1016\/j.phrs.2025.107991_bib42","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/nature11508","article-title":"Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat","volume":"491","author":"Carrieri","year":"2012","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.phrs.2025.107991_bib43","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/ncb3295","article-title":"The LINK-A lncRNA activates normoxic HIF1\u03b1 signalling in triple-negative breast cancer","volume":"18","author":"Lin","year":"2016","journal-title":"Nat. Cell Biol."},{"issue":"2","key":"10.1016\/j.phrs.2025.107991_bib44","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41590-017-0028-4","article-title":"RNA-binding proteins control gene expression and cell fate in the immune system","volume":"19","author":"Turner","year":"2018","journal-title":"Nat. Immunol."},{"issue":"6","key":"10.1016\/j.phrs.2025.107991_bib45","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.molcel.2011.08.018","article-title":"Molecular mechanisms of long noncoding RNAs","volume":"43","author":"Wang","year":"2011","journal-title":"Mol. Cell"},{"issue":"5","key":"10.1016\/j.phrs.2025.107991_bib46","article-title":"linc-ADAIN, a human adipose lincRNA, regulates adipogenesis by modulating KLF5 and IL-8 mRNA stability","volume":"43","author":"O'Reilly","year":"2024","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.phrs.2025.107991_bib47","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/1878-0261.12676","article-title":"LNCAROD is stabilized by m6A methylation and promotes cancer progression via forming a ternary complex with HSPA1A and YBX1 in head and neck squamous cell carcinoma","volume":"14","author":"Ban","year":"2020","journal-title":"Mol. Oncol."},{"issue":"9","key":"10.1016\/j.phrs.2025.107991_bib48","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s11926-017-0685-1","article-title":"Epigenetics in SLE","volume":"19","author":"Hedrich","year":"2017","journal-title":"Curr. Rheumatol. Rep."},{"issue":"9","key":"10.1016\/j.phrs.2025.107991_bib49","article-title":"The study of METTL14, ALKBH5, and YTHDF2 in peripheral blood mononuclear cells from systemic lupus erythematosus","volume":"8","author":"Luo","year":"2020","journal-title":"Mol. Genet. Genom. Med."},{"issue":"5","key":"10.1016\/j.phrs.2025.107991_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0322989","article-title":"LncRNA NEAT1 protects uremic toxin-induced intestinal epithelial barrier injury by regulating miR-122-5p\/Occludin axis","volume":"20","author":"Han","year":"2025","journal-title":"PloS One"},{"issue":"4","key":"10.1016\/j.phrs.2025.107991_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113995","article-title":"ATF4-SLC7A11-GSH axis mediates the acquisition of immunosuppressive properties by activated CD4(+) t cells in low arginine condition","volume":"43","author":"Zou","year":"2024","journal-title":"Cell Rep."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661825004165?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661825004165?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T04:37:44Z","timestamp":1762490264000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661825004165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":51,"alternative-id":["S1043661825004165"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2025.107991","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ALKBH3-AS1 drives SMAD3 stabilization via YTHDF2: Uncovering a pathogenic pathway for Th17 dysregulation in SLE","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2025.107991","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107991"}}