{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:47:56Z","timestamp":1788922076001,"version":"build-2803163510"},"reference-count":138,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016658","name":"National Plan on Drugs","doi-asserted-by":"publisher","award":["PNSD 2022\/020"],"award-info":[{"award-number":["PNSD 2022\/020"]}],"id":[{"id":"10.13039\/100016658","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023731","name":"Regional Government of Andalusia Ministry of Health and Consumer Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["CUP J53D23012440006"],"award-info":[{"award-number":["CUP J53D23012440006"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["PRIN 2022SZ2FMK"],"award-info":[{"award-number":["PRIN 2022SZ2FMK"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["PRIN2022LHMF43"],"award-info":[{"award-number":["PRIN2022LHMF43"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["CUP J53D23012220001"],"award-info":[{"award-number":["CUP J53D23012220001"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["RD21\/0009\/0003"],"award-info":[{"award-number":["RD21\/0009\/0003"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["FORT23\/00013"],"award-info":[{"award-number":["FORT23\/00013"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI22\/00427"],"award-info":[{"award-number":["PI22\/00427"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI20\/01399"],"award-info":[{"award-number":["PI20\/01399"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI22\/01833"],"award-info":[{"award-number":["PI22\/01833"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.phrs.2025.108005","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T01:34:01Z","timestamp":1761356041000},"page":"108005","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Targeting the endocannabinoid\/paracannabinoid systems in binge eating behavior: Efficacy of dual ligands in a preclinical model"],"prefix":"10.1016","volume":"222","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4256-7702","authenticated-orcid":false,"given":"Marialuisa","family":"de Ceglia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Botticelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8484-7513","authenticated-orcid":false,"given":"Emanuela","family":"Micioni Di Bonaventura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Vargas Fuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8044-1206","authenticated-orcid":false,"given":"Maria Vittoria","family":"Micioni Di Bonaventura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rodriguez de Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Cifani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2025.108005_bib1","series-title":"Diagnostic and statistical manual of mental disorders (5th edition","author":"Association","year":"2013"},{"key":"10.1016\/j.phrs.2025.108005_bib2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12888-015-0445-6","article-title":"\"Binge-eating disorder diagnosis and treatment: a recap in front of DSM-5","volume":"15","author":"Amianto","year":"2015","journal-title":"BMC Psychiatry"},{"issue":"1","key":"10.1016\/j.phrs.2025.108005_bib3","article-title":"\"Binge eating disorder","volume":"8","author":"Giel","year":"2022","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"9","key":"10.1016\/j.phrs.2025.108005_bib4","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s40263-024-01111-1","article-title":"\"Pharmacological treatment of binge eating disorder and frequent comorbid diseases","volume":"38","author":"Himmerich","year":"2024","journal-title":"CNS Drugs"},{"key":"10.1016\/j.phrs.2025.108005_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.104857","article-title":"\"Treatment of eating disorders: a systematic meta-review of meta-analyses and network meta-analyses","volume":"142","author":"Monteleone","year":"2022","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.phrs.2025.108005_bib6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.neubiorev.2016.01.013","article-title":"\"The neurobiological basis of binge-eating disorder","volume":"63","author":"Kessler","year":"2016","journal-title":"Neurosci. Biobehav Rev."},{"issue":"11","key":"10.1016\/j.phrs.2025.108005_bib7","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1007\/s11920-024-01534-z","article-title":"\"Reward and inhibitory control as mechanisms and treatment targets for binge eating disorder","volume":"26","author":"Pasquale","year":"2024","journal-title":"Curr. Psychiatry Rep."},{"issue":"2","key":"10.1016\/j.phrs.2025.108005_bib8","doi-asserted-by":"crossref","first-page":"e874","DOI":"10.1210\/clinem\/dgab661","article-title":"\"Insulin action to inhibit food intake: is it all in your head?","volume":"107","author":"Schur","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"7","key":"10.1016\/j.phrs.2025.108005_bib9","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1007\/s00018-016-2133-1","article-title":"\"Leptin signalling pathways in hypothalamic neurons","volume":"73","author":"Kwon","year":"2016","journal-title":"Cell Mol. Life Sci."},{"issue":"11","key":"10.1016\/j.phrs.2025.108005_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/nu12113502","article-title":"\"The melanocortin system behind the dysfunctional eating behaviors","volume":"12","author":"Micioni Di Bonaventura","year":"2020","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.phrs.2025.108005_bib11","doi-asserted-by":"crossref","first-page":"229","DOI":"10.5483\/BMBRep.2015.48.4.272","article-title":"\"Network of hypothalamic neurons that control appetite","volume":"48","author":"Sohn","year":"2015","journal-title":"BMB Rep."},{"key":"10.1016\/j.phrs.2025.108005_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105847","article-title":"\"Assessing the role of ghrelin and the enzyme ghrelin O-acyltransferase (GOAT) system in food reward, food motivation, and binge eating behavior","volume":"172","author":"Micioni Di Bonaventura","year":"2021","journal-title":"Pharm. Res"},{"issue":"1","key":"10.1016\/j.phrs.2025.108005_bib13","doi-asserted-by":"crossref","first-page":"R87","DOI":"10.1152\/ajpregu.00604.2003","article-title":"\"Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size","volume":"287","author":"Blevins","year":"2004","journal-title":"Eng. ) Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"6","key":"10.1016\/j.phrs.2025.108005_bib14","doi-asserted-by":"crossref","first-page":"E1230","DOI":"10.1152\/ajpendo.90927.2008","article-title":"\"Integration of hormonal and nutrient signals that regulate leptin synthesis and secretion","volume":"296","author":"Lee","year":"2009","journal-title":"Eng. ) Am. J. Physiol. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.phrs.2025.108005_bib15","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.numecd.2007.06.004","article-title":"\"Neuroendocrine control of food intake","volume":"18","author":"Valassi","year":"2008","journal-title":"Nutr. Metab. Cardiovasc Dis."},{"issue":"1","key":"10.1016\/j.phrs.2025.108005_bib16","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1210\/mend.13.1.0223","article-title":"\"Characterization of Agouti-related protein binding to melanocortin receptors","volume":"13","author":"Yang","year":"1999","journal-title":"Mol. Endocrinol."},{"issue":"6","key":"10.1016\/j.phrs.2025.108005_bib17","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0149-7634(02)00041-6","article-title":"\"Opioid peptides and the control of human ingestive behaviour","volume":"26","author":"Yeomans","year":"2002","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"2","key":"10.1016\/j.phrs.2025.108005_bib18","doi-asserted-by":"crossref","first-page":"S77","DOI":"10.1038\/sj.ijo.0801284","article-title":"\"Glucocorticoids and neuroendocrine function","volume":"24","author":"Cavagnini","year":"2000","journal-title":"Int J. Obes. Relat. Metab. Disord."},{"issue":"8","key":"10.1016\/j.phrs.2025.108005_bib19","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.2174\/1570159X15666171128143158","article-title":"\"Oxytocin and eating disorders: a narrative review on emerging findings and perspectives","volume":"16","author":"Giel","year":"2018","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.phrs.2025.108005_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2023.106030","article-title":"\"Neuroendocrinological factors in binge eating disorder: a narrative review","volume":"150","author":"Baenas","year":"2023","journal-title":"Psychoneuroendocrinology"},{"issue":"7","key":"10.1016\/j.phrs.2025.108005_bib21","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1002\/eat.24181","article-title":"\"Evaluating the efficacy of the selective orexin 1 receptor antagonist nivasorexant in an animal model of binge-eating disorder","volume":"57","author":"Steiner","year":"2024","journal-title":"Int J. Eat. Disord."},{"key":"10.1016\/j.phrs.2025.108005_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106521","article-title":"\"Investigating the role of the central melanocortin system in stress and stress-related disorders","volume":"185","author":"Micioni Di Bonaventura","year":"2022","journal-title":"Pharm. Res"},{"issue":"1","key":"10.1016\/j.phrs.2025.108005_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22010398","article-title":"\"On the role of central Type-1 cannabinoid receptor gene regulation in food intake and eating behaviors","volume":"22","author":"Pucci","year":"2021","journal-title":"Int J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.phrs.2025.108005_bib24","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/eat.22989","article-title":"\"Transcriptional regulation of the endocannabinoid system in a rat model of binge-eating behavior reveals a selective modulation of the hypothalamic fatty acid amide hydrolase gene","volume":"52","author":"Pucci","year":"2019","journal-title":"Int. J. Eat. Disord."},{"key":"10.1016\/j.phrs.2025.108005_bib25","series-title":"in Handbook of the Biology and Pathology of Mental Disorders","first-page":"1","article-title":"\"Eating disorders and the endocannabinoid system","author":"de Ceglia","year":"2025"},{"issue":"10","key":"10.1016\/j.phrs.2025.108005_bib26","article-title":"\"Obesity as a condition determined by food addiction: should brain endocannabinoid system alterations be the cause and its modulation the solution?","volume":"14","author":"de Ceglia","year":"2021","journal-title":"Pharm. (Basel)"},{"key":"10.1016\/j.phrs.2025.108005_bib27","article-title":"\"Cafeteria diet abstinence induces depressive behavior and disrupts endocannabinoid signaling in dopaminergic areas: a preclinical study","author":"de Ceglia","year":"2024","journal-title":"Curr. Neuropharmacol."},{"issue":"11","key":"10.1016\/j.phrs.2025.108005_bib28","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1038\/s41386-020-0686-z","article-title":"\"Oleoylethanolamide decreases frustration stress-induced binge-like eating in female rats: a novel potential treatment for binge eating disorder","volume":"45","author":"Romano","year":"2020","journal-title":"Neuropsychopharmacology"},{"issue":"21","key":"10.1016\/j.phrs.2025.108005_bib29","doi-asserted-by":"crossref","first-page":"9612","DOI":"10.1523\/JNEUROSCI.22-21-09612.2002","article-title":"\"A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding","volume":"22","author":"G\u00f3mez","year":"2002","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.phrs.2025.108005_bib30","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.neuropharm.2007.03.007","article-title":"\"The cannabinoid CB1 receptor antagonist SR141716A (Rimonabant) enhances the metabolic benefits of long-term treatment with oleoylethanolamide in zucker rats","volume":"54","author":"Serrano","year":"2008","journal-title":"Neuropharmacology"},{"issue":"16","key":"10.1016\/j.phrs.2025.108005_bib31","doi-asserted-by":"crossref","first-page":"6639","DOI":"10.1021\/acs.jmedchem.5b00849","article-title":"\"Novel Oxazolidinone-Based peroxisome proliferator activated receptor agonists: molecular modeling, synthesis, and biological evaluation","volume":"58","author":"Fresno","year":"2015","journal-title":"J. Med Chem."},{"key":"10.1016\/j.phrs.2025.108005_bib32","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.bcp.2018.09.008","article-title":"\"PPAR\u03b1\/CB1 receptor dual ligands as a novel therapy for alcohol use disorder: evaluation of a novel oleic acid conjugate in preclinical rat models","volume":"157","author":"Alen","year":"2018","journal-title":"Biochem Pharm."},{"issue":"10","key":"10.1016\/j.phrs.2025.108005_bib33","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1242\/dmm.019919","article-title":"Treatment with a novel oleic-acid\u2013dihydroxyamphetamine conjugation ameliorates non-alcoholic fatty liver disease in obese zucker rats","volume":"8","author":"Decara","year":"2015","journal-title":"Dis. Models amp Mech."},{"issue":"2","key":"10.1016\/j.phrs.2025.108005_bib34","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1021\/jm0601102","article-title":"\"Novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and PPARalpha activation","volume":"50","author":"Cano","year":"2007","journal-title":"J. Med Chem."},{"issue":"10","key":"10.1016\/j.phrs.2025.108005_bib35","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1002\/eat.22767","article-title":"\"Hypothalamic CRF1 receptor mechanisms are not sufficient to account for binge-like palatable food consumption in female rats","volume":"50","author":"Micioni Di Bonaventura","year":"2017","journal-title":"Int J. Eat. Disord."},{"issue":"19","key":"10.1016\/j.phrs.2025.108005_bib36","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1021\/acschemneuro.0c00456","article-title":"\"Novel highly potent and selective Sigma1 receptor antagonists effectively block the binge eating episode in female rats","volume":"11","author":"Cifani","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.phrs.2025.108005_bib37","series-title":"in Animal Models of Eating Disorders","first-page":"239","article-title":"\"Impact of a history of caloric restriction and a frustration stress manipulation on Binge-Like eating behavior in female rats: preclinical results","author":"Micioni Di Bonaventura","year":"2021"},{"issue":"23","key":"10.1016\/j.phrs.2025.108005_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232315228","article-title":"\"Endocannabinoid system regulation in female rats with recurrent episodes of binge eating","volume":"23","author":"Pucci","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.phrs.2025.108005_bib39","article-title":"\"Acute intrahippocampal administration of melanin-concentrating hormone impairs memory consolidation and decreases the expression of MCHR-1 and TrkB receptors","volume":"123","author":"Ruiz-Viroga","year":"2022","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2025.108005_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112994","article-title":"\"Dietary administration of D-chiro-inositol attenuates sex-specific metabolic imbalances in the 5xFAD mouse model of alzheimer's disease","volume":"150","author":"L\u00f3pez-Gambero","year":"2022","journal-title":"Biomed. Pharm."},{"issue":"5","key":"10.1016\/j.phrs.2025.108005_bib41","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1021\/acsptsci.4c00105","article-title":"\"Hydroxytyrosol linoleoyl ether ameliorates Metabolic-Associated fatty liver disease symptoms in obese zucker rats","volume":"7","author":"Tovar","year":"2024","journal-title":"ACS Pharm. Transl. Sci."},{"key":"10.1016\/j.phrs.2025.108005_bib42","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.physbeh.2016.01.029","article-title":"\"Behavioral and hormonal responses to stress in binge-like eating prone female rats","volume":"157","author":"Calvez","year":"2016","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.phrs.2025.108005_bib43","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pbb.2018.04.003","article-title":"\"Piracetam attenuates binge eating disorder related symptoms in rats","volume":"169","author":"Hussain","year":"2018","journal-title":"Pharm. Biochem Behav."},{"key":"10.1016\/j.phrs.2025.108005_bib44","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neuroscience.2024.09.028","article-title":"\"Intermittent access to sugary drinks associated with fasting induces overeating and depressive-like behavior in female C57BL\/6J mice","volume":"560","author":"Paim","year":"2024","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2025.108005_bib45","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fnins.2018.00040","article-title":"\"Limited access to a high fat diet alters endocannabinoid tone in female rats","volume":"12","author":"Satta","year":"2018","journal-title":"Front Neurosci."},{"issue":"5","key":"10.1016\/j.phrs.2025.108005_bib46","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.physbeh.2010.09.006","article-title":"\"Effect of salidroside, active principle of rhodiola rosea extract, on binge eating","volume":"101","author":"Cifani","year":"2010","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.phrs.2025.108005_bib47","doi-asserted-by":"crossref","unstructured":"M.V. Micioni Di Bonaventura, G. Vitale, M. Massi, and C. Cifani, \"Effect of Hypericum perforatum Extract in an Experimental Model of Binge Eating in Female Rats,\" (in eng), J Obes, vol. 2012, p. 956137, 2012, doi: 10.1155\/2012\/956137.","DOI":"10.1155\/2012\/956137"},{"issue":"1","key":"10.1016\/j.phrs.2025.108005_bib48","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00213-008-1442-y","article-title":"\"A preclinical model of binge eating elicited by yo-yo dieting and stressful exposure to food: effect of sibutramine, fluoxetine, topiramate, and midazolam","volume":"204","author":"Cifani","year":"2009","journal-title":"Psychopharmacol. (Berl. )"},{"issue":"9","key":"10.1016\/j.phrs.2025.108005_bib49","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.molmet.2017.04.011","article-title":"\"The glucoregulatory actions of leptin","volume":"6","author":"D'Souza A","year":"2017","journal-title":"\" ( Eng. ) Mol. Metab."},{"issue":"4","key":"10.1016\/j.phrs.2025.108005_bib50","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1210\/endrev\/bnae008","article-title":"\"The glucocorticoid receptor: isoforms, functions, and contribution to glucocorticoid sensitivity","volume":"45","author":"Lockett","year":"2024","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.phrs.2025.108005_bib51","doi-asserted-by":"crossref","first-page":"1256093","DOI":"10.3389\/fendo.2023.1256093","article-title":"\"The role of C-peptide in diabetes and its complications: an updated review","volume":"14","author":"Chen","year":"2023","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.phrs.2025.108005_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2018.10.005","article-title":"\"The metabolic underpinning of eating disorders: a systematic review and meta-analysis of insulin sensitivity","volume":"497","author":"Ilyas","year":"2019","journal-title":"Mol. Cell Endocrinol."},{"issue":"4","key":"10.1016\/j.phrs.2025.108005_bib53","first-page":"40","article-title":"\"Association of eating disorders with glycaemic control and insulin resistance in patients of type 2 diabetes mellitus","volume":"14","author":"Kumar","year":"2023","journal-title":"Int J. Biochem Mol. Biol."},{"issue":"52","key":"10.1016\/j.phrs.2025.108005_bib54","article-title":"\"Obese patients with a binge eating disorder have an unfavorable metabolic and inflammatory profile","volume":"94","author":"Succurro","year":"2015","journal-title":"Med. (Baltim. )"},{"key":"10.1016\/j.phrs.2025.108005_bib55","doi-asserted-by":"crossref","unstructured":"Y.E. Dean et al., \"Association Between Type 1 Diabetes Mellitus and Eating Disorders: A Systematic Review and Meta-Analysis,\" (in eng), Endocrinol Diabetes Metab, vol. 7, no. 3, p. e473, May 2024, doi: 10.1002\/edm2.473.","DOI":"10.1002\/edm2.473"},{"issue":"12","key":"10.1016\/j.phrs.2025.108005_bib56","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.2337\/db14-0340","article-title":"\"Insulin regulates brain function, but how does it get there?","volume":"63","author":"Gray","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.phrs.2025.108005_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2020.113071","article-title":"\"Reward and psychopathological correlates of eating disorders: the explanatory role of leptin","volume":"290","author":"Cassioli","year":"2020","journal-title":"Psychiatry Res"},{"issue":"7","key":"10.1016\/j.phrs.2025.108005_bib58","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11920-016-0701-6","article-title":"\"Hormonal factors and disturbances in eating disorders","volume":"18","author":"Culbert","year":"2016","journal-title":"Curr. Psychiatry Rep."},{"issue":"1","key":"10.1016\/j.phrs.2025.108005_bib59","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41593-022-01208-0","article-title":"\"Early adversity promotes binge-like eating habits by remodeling a leptin-responsive lateral hypothalamus-brainstem pathway","volume":"26","author":"Shin","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phrs.2025.108005_bib60","doi-asserted-by":"crossref","unstructured":"J. Wauman and J. Tavernier, \"Leptin receptor signaling: pathways to leptin resistance,\" (in eng), Front Biosci (Landmark Ed), vol. 16, no. 7, pp. 2771-93, Jun 1 2011, doi: 10.2741\/3885.","DOI":"10.2741\/3885"},{"issue":"3","key":"10.1016\/j.phrs.2025.108005_bib61","doi-asserted-by":"crossref","first-page":"536","DOI":"10.2337\/db08-0822","article-title":"\"Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin","volume":"58","author":"Rahmouni","year":"2009","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.phrs.2025.108005_bib62","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1515\/mr-2022-0017","article-title":"\"Leptin signaling and leptin resistance","volume":"2","author":"Liu","year":"2022","journal-title":"Med Rev. (2021)"},{"issue":"11","key":"10.1016\/j.phrs.2025.108005_bib63","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1210\/en.2011-0178","article-title":"\"Cellular leptin resistance impairs the leptin-mediated suppression of neuropeptide y secretion in hypothalamic neurons","volume":"152","author":"Dhillon","year":"2011","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.phrs.2025.108005_bib64","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.cmet.2013.12.015","article-title":"\"Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain","volume":"19","author":"Balland","year":"2014","journal-title":"Cell Metab."},{"issue":"42","key":"10.1016\/j.phrs.2025.108005_bib65","doi-asserted-by":"crossref","first-page":"28066","DOI":"10.1074\/jbc.M805545200","article-title":"\"Leptin stimulates both JAK2-dependent and JAK2-independent signaling pathways","volume":"283","author":"Jiang","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.phrs.2025.108005_bib66","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s11684-013-0263-5","article-title":"\"Leptin signaling and leptin resistance","volume":"7","author":"Zhou","year":"2013","journal-title":"Front Med"},{"key":"10.1016\/j.phrs.2025.108005_bib67","doi-asserted-by":"crossref","unstructured":"S.M. Schultze, B.A. Hemmings, M. Niessen, and O. Tschopp, \"PI3K\/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis,\" Expert Reviews in Molecular Medicine, vol. 14, p. e1, 2012, Art no. e1, doi: 10.1017\/S1462399411002109.","DOI":"10.1017\/S1462399411002109"},{"issue":"5","key":"10.1016\/j.phrs.2025.108005_bib68","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.2337\/db13-0670","article-title":"\"Effects of AMPK activation on insulin sensitivity and metabolism in Leptin-Deficient Ob\/Ob mice","volume":"63","author":"Zachariah Tom","year":"2014","journal-title":"Diabetes"},{"issue":"7","key":"10.1016\/j.phrs.2025.108005_bib69","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1172\/JCI67227","article-title":"\"AMPK, insulin resistance, and the metabolic syndrome","volume":"123","author":"Ruderman","year":"2013","journal-title":"J. Clin. Investig."},{"issue":"6","key":"10.1016\/j.phrs.2025.108005_bib70","doi-asserted-by":"crossref","first-page":"E1247","DOI":"10.1152\/ajpendo.00274.2009","article-title":"\"Recent advances in understanding leptin signaling and leptin resistance","volume":"297","author":"Morris","year":"2009","journal-title":"Eng. ) Am. J. Physiol. Endocrinol. Metab."},{"issue":"7","key":"10.1016\/j.phrs.2025.108005_bib71","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1007\/s00125-016-3963-y","article-title":"\"Inactivation of class II PI3K-C2\u03b1 induces leptin resistance, age-dependent insulin resistance and obesity in Male mice","volume":"59","author":"Alliouachene","year":"2016","journal-title":"Diabetologia"},{"issue":"4","key":"10.1016\/j.phrs.2025.108005_bib72","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cmet.2009.08.013","article-title":"\"MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity","volume":"10","author":"Kleinridders","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.phrs.2025.108005_bib73","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1159\/000452908","article-title":"\"Leptin, neuroinflammation and obesity","volume":"48","author":"Dragano","year":"2017","journal-title":"Front Horm. Res"},{"issue":"1","key":"10.1016\/j.phrs.2025.108005_bib74","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0006-8993(97)01388-7","article-title":"\"Localization of leptin receptor immunoreactivity in the lean and obese zucker rat brain","volume":"785","author":"Yarnell","year":"1998","journal-title":"Brain Res"},{"issue":"4","key":"10.1016\/j.phrs.2025.108005_bib75","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1159\/000054718","article-title":"\"Leptin immunoreactivity is localized to neurons in rat brain","volume":"75","author":"Ur","year":"2002","journal-title":"Neuroendocrinology"},{"issue":"3","key":"10.1016\/j.phrs.2025.108005_bib76","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0059625","article-title":"\"Leptin activates oxytocin neurons of the hypothalamic paraventricular nucleus in both control and diet-induced obese rodents","volume":"8","author":"Perello","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2025.108005_bib77","doi-asserted-by":"crossref","first-page":"8237","DOI":"10.1038\/ncomms9237","article-title":"\"Hypothalamic PKA regulates leptin sensitivity and adiposity","volume":"6","author":"Yang","year":"2015","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.phrs.2025.108005_bib78","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nn885","article-title":"\"A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding","volume":"5","author":"Zhao","year":"2002","journal-title":"Nat. Neurosci."},{"issue":"2","key":"10.1016\/j.phrs.2025.108005_bib79","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1210\/en.2011-1635","article-title":"\"Overexpression of FoxO1 in the hypothalamus and pancreas causes obesity and glucose intolerance","volume":"153","author":"Kim","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.phrs.2025.108005_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2023.101833","article-title":"\"AgRP neuron activity promotes associations between sensory and nutritive signals to guide flavor preference","volume":"78","author":"Nyema","year":"2023","journal-title":"Mol. Metab."},{"key":"10.1016\/j.phrs.2025.108005_bib81","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/7854_2010_79","article-title":"\"The genetics of eating disorders","volume":"6","author":"Helder","year":"2011","journal-title":"Curr. Top. Behav. Neurosci."},{"issue":"4","key":"10.1016\/j.phrs.2025.108005_bib82","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1601-183X.2009.00493.x","article-title":"\"Deletion of agouti-related protein blunts ethanol self-administration and binge-like drinking in mice","volume":"8","author":"Navarro","year":"2009","journal-title":"Genes Brain Behav."},{"issue":"1","key":"10.1016\/j.phrs.2025.108005_bib83","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.eatbeh.2010.09.008","article-title":"\"Eating disorders in adolescents: correlations between symptoms and central control of eating behavior","volume":"12","author":"Lofrano-Prado","year":"2011","journal-title":"Eat. Behav."},{"issue":"4","key":"10.1016\/j.phrs.2025.108005_bib84","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2174\/1871530318666171212092725","article-title":"\"Neuroendocrine and metabolic disorders in bulimia nervosa","volume":"18","author":"Milano","year":"2018","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"issue":"8","key":"10.1016\/j.phrs.2025.108005_bib85","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1007\/s40519-021-01117-4","article-title":"\"Altered regional grey matter volume and appetite-related hormone levels in adolescent obesity with or without binge-eating disorder","volume":"26","author":"Turan","year":"2021","journal-title":"Eat. Weight Disord."},{"issue":"23","key":"10.1016\/j.phrs.2025.108005_bib86","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.2174\/0929867324666170316120836","article-title":"\"Targeting NPY, CRF\/UCNs and NPS neuropeptide systems to treat alcohol use disorder (AUD)","volume":"24","author":"Rodriguez","year":"2017","journal-title":"Curr. Med Chem."},{"key":"10.1016\/j.phrs.2025.108005_bib87","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/bs.irn.2015.09.003","article-title":"\"Endocannabinoid regulation of neuroendocrine systems","volume":"125","author":"Tasker","year":"2015","journal-title":"Int Rev. Neurobiol."},{"issue":"6","key":"10.1016\/j.phrs.2025.108005_bib88","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1210\/en.2005-0983","article-title":"\"Neuromedin u partially mediates leptin-induced hypothalamo-pituitary adrenal (HPA) stimulation and has a physiological role in the regulation of the HPA axis in the rat","volume":"147","author":"Jethwa","year":"2006","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.phrs.2025.108005_bib89","article-title":"\"Effects of sub-chronic CRH administration into the hypothalamic paraventricular and central amygdala nuclei in Male rats with a focus on food intake biomarkers","volume":"95","author":"Rayatpour","year":"2023","journal-title":"Acad. Bras. Cienc."},{"issue":"3","key":"10.1016\/j.phrs.2025.108005_bib90","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1210\/jcem-68-3-517","article-title":"\"Alterations of the adrenocorticotropin-cortisol axis in normal weight bulimic women: evidence for a central mechanism","volume":"68","author":"Mortola","year":"1989","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.phrs.2025.108005_bib91","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.appet.2005.11.007","article-title":"\"Bulimia nervosa--a primary defect in the hypothalamic-pituitary-adrenal axis?,\" (in eng)","volume":"46","author":"Birketvedt","year":"2006","journal-title":"Appetite"},{"issue":"4","key":"10.1016\/j.phrs.2025.108005_bib92","first-page":"235","article-title":"\"Corticotropin-releasing hormone: possible role in eating disorders","volume":"7","author":"Krahn","year":"1989","journal-title":"Psychiatr. Med"},{"issue":"2","key":"10.1016\/j.phrs.2025.108005_bib93","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0278-5846(95)00306-1","article-title":"\"Neurobiological and psychopharmacological basis in the therapy of bulimia and anorexia","volume":"20","author":"Mauri","year":"1996","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.phrs.2025.108005_bib94","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1517\/13543784.6.4.427","article-title":"\"Investigational drugs for eating disorders","volume":"6","author":"Crow","year":"1997","journal-title":"Expert Opin. Invest. Drugs"},{"issue":"47","key":"10.1016\/j.phrs.2025.108005_bib95","doi-asserted-by":"crossref","first-page":"20016","DOI":"10.1073\/pnas.0908789106","article-title":"\"CRF system recruitment mediates dark side of compulsive eating","volume":"106","author":"Cottone","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"12","key":"10.1016\/j.phrs.2025.108005_bib96","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1038\/npp.2013.147","article-title":"\"CRF-CRF1 receptor system in the central and basolateral nuclei of the amygdala differentially mediates excessive eating of palatable food","volume":"38","author":"Iemolo","year":"2013","journal-title":"Neuropsychopharmacology"},{"issue":"34","key":"10.1016\/j.phrs.2025.108005_bib97","doi-asserted-by":"crossref","first-page":"11316","DOI":"10.1523\/JNEUROSCI.1854-14.2014","article-title":"\"Role of bed nucleus of the stria terminalis corticotrophin-releasing factor receptors in frustration stress-induced binge-like palatable food consumption in female rats with a history of food restriction","volume":"34","author":"Micioni Di Bonaventura","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2025.108005_bib98","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1477-7827-7-74","article-title":"\"MyD88 and TRIF mediate the cyclic adenosine monophosphate (cAMP) induced corticotropin releasing hormone (CRH) expression in JEG3 choriocarcinoma cell line","volume":"7","author":"Uh","year":"2009","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"4","key":"10.1016\/j.phrs.2025.108005_bib99","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1159\/000443093","article-title":"\"Induction of microglial activation by mediators released from mast cells","volume":"38","author":"Zhang","year":"2016","journal-title":"Cell Physiol. Biochem"},{"key":"10.1016\/j.phrs.2025.108005_bib100","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.brainresbull.2017.01.026","article-title":"\"Activation of ATP-sensitive potassium channel by iptakalim normalizes stress-induced HPA axis disorder and depressive behaviour by alleviating inflammation and oxidative stress in mouse hypothalamus","volume":"130","author":"Zhao","year":"2017","journal-title":"Brain Res Bull."},{"issue":"12","key":"10.1016\/j.phrs.2025.108005_bib101","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1111\/j.1365-2826.2011.02220.x","article-title":"\"Tonic, but not phasic corticosterone, constrains stress activatedextracellular-regulated-kinase 1\/ 2 immunoreactivity within the hypothalamic paraventricular nucleus","volume":"23","author":"Osterlund","year":"2011","journal-title":"J. Neuroendocr."},{"issue":"1","key":"10.1016\/j.phrs.2025.108005_bib102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/JOE-13-0365","article-title":"\"Absence of glucocorticoids augments stress-induced Mkp1 mRNA expression within the hypothalamic-pituitary-adrenal axis","volume":"220","author":"Osterlund","year":"2014","journal-title":"J. Endocrinol."},{"issue":"4","key":"10.1016\/j.phrs.2025.108005_bib103","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1369-1600.2009.00152.x","article-title":"\"Pre-exposure to environmental cues predictive of food availability elicits hypothalamic-pituitary-adrenal axis activation and increases operant responding for food in female rats,\" (in eng)","volume":"14","author":"Cifani","year":"2009","journal-title":"Addict. Biol."},{"issue":"3","key":"10.1016\/j.phrs.2025.108005_bib104","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1111\/ejn.14110","article-title":"\"Systematic review of the effects of acute stress in binge eating disorder","volume":"50","author":"Naish","year":"2019","journal-title":"Eur. J. Neurosci."},{"issue":"4","key":"10.1016\/j.phrs.2025.108005_bib105","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrm3311","article-title":"\"AMPK: a nutrient and energy sensor that maintains energy homeostasis","volume":"13","author":"Hardie","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phrs.2025.108005_bib106","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.appet.2018.04.011","article-title":"\"The effects of scheduled running wheel access on binge-like eating behavior and its consequences","volume":"126","author":"Albertz","year":"2018","journal-title":"Appetite"},{"key":"10.1016\/j.phrs.2025.108005_bib107","doi-asserted-by":"crossref","unstructured":"I.A. Mendez, S.B. Ostlund, N.T. Maidment, and N.P. Murphy, \"Involvement of Endogenous Enkephalins and \u03b2-Endorphin in Feeding and Diet-Induced Obesity,\" Neuropsychopharmacology, vol. 40, no. 9, pp. 2103-2112, 2015\/08\/01 2015, doi: 10.1038\/npp.2015.67.","DOI":"10.1038\/npp.2015.67"},{"issue":"2","key":"10.1016\/j.phrs.2025.108005_bib108","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3390\/brainsci13020212","article-title":"The role of Beta-Endorphin in food Deprivation-Mediated increases in food intake and Binge-Eating","volume":"13","author":"Tolentino","year":"2023","journal-title":"Brain Sci."},{"issue":"1","key":"10.1016\/j.phrs.2025.108005_bib109","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1017\/S0033291700002531","article-title":"\"Plasma immunoreactive beta-endorphin in bulimics","volume":"16","author":"Fullerton","year":"1986","journal-title":"Psychol. Med"},{"issue":"2","key":"10.1016\/j.phrs.2025.108005_bib110","doi-asserted-by":"crossref","first-page":"41","DOI":"10.14740\/jocmr4066","article-title":"\"The opioid system and food intake: use of opiate antagonists in treatment of binge eating disorder and abnormal eating behavior","volume":"12","author":"Valbrun","year":"2020","journal-title":"J. Clin. Med Res"},{"issue":"1","key":"10.1016\/j.phrs.2025.108005_bib111","doi-asserted-by":"crossref","first-page":"6875","DOI":"10.1038\/s41467-023-42623-6","article-title":"\"Lateral hypothalamic proenkephalin neurons drive threat-induced overeating associated with a negative emotional state","volume":"14","author":"You","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.phrs.2025.108005_bib112","doi-asserted-by":"crossref","first-page":"R99","DOI":"10.1152\/ajpregu.00675.2006","article-title":"\"Paraventricular opioids alter intake of high-fat but not high-sucrose diet depending on diet preference in a binge model of feeding","volume":"293","author":"Naleid","year":"2007","journal-title":"Eng. ) Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"7","key":"10.1016\/j.phrs.2025.108005_bib113","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.3390\/ijms22073779","article-title":"Endogenous opioid peptides and alternatively spliced mu opioid receptor seven transmembrane Carboxyl-Terminal variants","volume":"22","author":"Abrimian","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.phrs.2025.108005_bib114","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1124\/mol.120.119388","article-title":"\"Five decades of research on opioid peptides: current knowledge and unanswered questions","volume":"98","author":"Fricker","year":"2020","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.phrs.2025.108005_bib115","doi-asserted-by":"crossref","DOI":"10.3389\/fnsys.2022.932546","article-title":"\"The role of enkephalinergic systems in substance use disorders","volume":"16","author":"Rysztak","year":"2022","journal-title":"Front Syst. Neurosci."},{"issue":"7","key":"10.1016\/j.phrs.2025.108005_bib116","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1038\/npp.2013.28","article-title":"\"Hypothalamic \u03ba-Opioid receptor modulates the orexigenic effect of ghrelin","volume":"38","author":"Romero-Pic\u00f3","year":"2013","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/j.phrs.2025.108005_bib117","doi-asserted-by":"crossref","first-page":"R1105","DOI":"10.1152\/ajpregu.00076.2011","article-title":"\"Involvement of the opioid system in the orexigenic and hedonic effects of melanin-concentrating hormone","volume":"301","author":"Lopez","year":"2011","journal-title":"Eng. ) Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"3","key":"10.1016\/j.phrs.2025.108005_bib118","doi-asserted-by":"crossref","first-page":"R814","DOI":"10.1152\/ajpregu.2001.280.3.R814","article-title":"\"Opioid receptor involvement in the effect of AgRP- (83-132) on food intake and food selection","volume":"280","author":"Hagan","year":"2001","journal-title":"Eng. ) Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.phrs.2025.108005_bib119","doi-asserted-by":"crossref","DOI":"10.1016\/j.appet.2024.107504","article-title":"\"Control of motivation for sucrose in the paraventricular hypothalamic nucleus by dynorphin peptides and the kappa opioid receptor","volume":"200","author":"Sandoval-Caballero","year":"2024","journal-title":"Appetite"},{"issue":"10","key":"10.1016\/j.phrs.2025.108005_bib120","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113305","article-title":"\"High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via \u03ba-opioid signaling","volume":"42","author":"Gruber","year":"2023","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.phrs.2025.108005_bib121","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/sj.npp.1300695","article-title":"\"Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in Binge-Eating disorder, but not in bulimia nervosa","volume":"30","author":"Monteleone","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2025.108005_bib122","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.neuropharm.2017.05.033","article-title":"\"Endocannabinoid modulation of homeostatic and non-homeostatic feeding circuits","volume":"124","author":"Lau","year":"2017","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.phrs.2025.108005_bib123","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1463-1326.2011.01515.x","article-title":"\"The atypical cannabinoid O-1602 stimulates food intake and adiposity in rats","volume":"14","author":"D\u00edaz-Arteaga","year":"2012","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.phrs.2025.108005_bib124","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pharmthera.2014.06.007","article-title":"\"GPR55: from orphan to metabolic regulator?","volume":"145","author":"Liu","year":"2015","journal-title":"Pharm. Ther."},{"issue":"6","key":"10.1016\/j.phrs.2025.108005_bib125","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1002\/eat.23917","article-title":"\"Anxiety associated with palatable food withdrawal is reversed by the selective FAAH inhibitor PF-3845: a regional analysis of the contribution of endocannabinoid signaling machinery","volume":"56","author":"de Ceglia","year":"2023","journal-title":"Int. J. Eat. Disord."},{"issue":"1","key":"10.1016\/j.phrs.2025.108005_bib126","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12974-023-02701-4","article-title":"\"Inhibition of 2-arachidonoylglycerol degradation enhances glial immunity by single-cell transcriptomic analysis","volume":"20","author":"Zhu","year":"2023","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.phrs.2025.108005_bib127","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.bbr.2016.10.044","article-title":"\"Hypothalamic expression of inflammatory mediators in an animal model of binge eating","volume":"320","author":"Alboni","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.phrs.2025.108005_bib128","doi-asserted-by":"crossref","first-page":"1030639","DOI":"10.3389\/fnmol.2022.1030639","article-title":"\"Focusing on cyclin-dependent kinases 5: a potential target for neurological disorders","volume":"15","author":"Tian","year":"2022","journal-title":"Front Mol. Neurosci."},{"issue":"2","key":"10.1016\/j.phrs.2025.108005_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109800","article-title":"\"Functional heterogeneity of POMC neurons relies on mTORC1 signaling","volume":"37","author":"Saucisse","year":"2021","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.phrs.2025.108005_bib130","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.pharep.2018.01.010","article-title":"\"Effects of central RVD-hemopressin(\u03b1) administration on anxiety, feeding behavior and hypothalamic neuromodulators in the rat","volume":"70","author":"Recinella","year":"2018","journal-title":"Pharm. Rep."},{"issue":"5","key":"10.1016\/j.phrs.2025.108005_bib131","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nrd2553","article-title":"\"Targeting the endocannabinoid system: to enhance or reduce?","volume":"7","author":"Di Marzo","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.phrs.2025.108005_bib132","article-title":"\"Feeding regulation by oleoylethanolamide synthesized from dietary oleic acid","volume":"165","author":"Igarashi","year":"2021","journal-title":"Prostaglandins Leukot. Ess. Fat. Acids"},{"key":"10.1016\/j.phrs.2025.108005_bib133","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bbr.2017.11.015","article-title":"\"Diabetes mellitus and Alzheimer\u2019s disease: GSK-3\u03b2 as a potential link","volume":"339","author":"Zhang","year":"2018","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.phrs.2025.108005_bib134","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112308","volume":"135","author":"Hassan","year":"2024","journal-title":"Int Immunopharmacol."},{"issue":"5","key":"10.1016\/j.phrs.2025.108005_bib135","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.cmet.2019.07.013","article-title":"\"Glucose-Dependent insulinotropic polypeptide Receptor-Expressing cells in the hypothalamus regulate food intake","volume":"30","author":"Adriaenssens","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.phrs.2025.108005_bib136","article-title":"\"Oleoylethanolamide facilitates PPARa and TFEB signaling and attenuates ab pathology in a mouse model of alzheimer's disease","author":"Comerota","year":"2023","journal-title":"Res Sq."},{"key":"10.1016\/j.phrs.2025.108005_bib137","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104770","article-title":"\"Oleoylethanolamide supplementation in obese patients newly diagnosed with non-alcoholic fatty liver disease: effects on metabolic parameters, anthropometric indices, and expression of PPAR-\u03b1, UCP1, and UCP2 genes","volume":"156","author":"Tutunchi","year":"2020","journal-title":"Pharm. Res"},{"key":"10.1016\/j.phrs.2025.108005_bib138","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1054-3589(05)52008-8","article-title":"\"Inhibition of glucagon secretion","volume":"52","author":"Young","year":"2005","journal-title":"Eng. ) Adv. Pharm."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104366182500430X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104366182500430X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:12:27Z","timestamp":1773270747000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S104366182500430X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":138,"alternative-id":["S104366182500430X"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2025.108005","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting the endocannabinoid\/paracannabinoid systems in binge eating behavior: Efficacy of dual ligands in a preclinical model","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2025.108005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108005"}}