{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T23:53:07Z","timestamp":1766188387951,"version":"3.48.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.phrs.2025.108019","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:50:34Z","timestamp":1762275034000},"page":"108019","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A randomized, three-way crossover clinical trial on the efficacy of Mastiha based therapies (Pistacia lentiscus var. Chia) in functional dyspepsia"],"prefix":"10.1016","volume":"222","author":[{"given":"Stamatia-Angeliki","family":"Kleftaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charalampia","family":"Amerikanou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chara","family":"Tzavara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodora","family":"Biagki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demetra","family":"Sigala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Bouziou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stamatiki","family":"Zouboulaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aikaterini","family":"Koutsia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvira-Victoria","family":"Smyrnioudis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiotis","family":"Anapliotis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andriana C.","family":"Kaliora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2025.108019_bib1","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/S0140-6736(20)30469-4","article-title":"Functional dyspepsia","volume":"396","author":"Ford","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2025.108019_bib2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1053\/j.gastro.2020.04.014","article-title":"Worldwide prevalence and burden of functional gastrointestinal disorders, results of Rome Foundation global study","volume":"160","author":"Sperber","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phrs.2025.108019_bib3","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.1038\/s41598-024-54716-3","article-title":"Global prevalence of functional dyspepsia according to Rome criteria, 1990\u20132020: a systematic review and meta-analysis","volume":"14","author":"Lee","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2025.108019_bib4","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1053\/j.gastro.2016.02.011","article-title":"Gastroduodenal disorders","volume":"150","author":"Stanghellini","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phrs.2025.108019_bib5","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.cgh.2021.07.043","article-title":"Clinical and psychological factors predict outcome in patients with functional dyspepsia: a prospective study","volume":"20","author":"Singh","year":"2022","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.phrs.2025.108019_bib6","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00535-019-01550-4","article-title":"Recent understanding of the pathophysiology of functional dyspepsia: role of the duodenum as the pathogenic center","volume":"54","author":"Miwa","year":"2019","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.phrs.2025.108019_bib7","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1080\/13543784.2019.1673365","article-title":"Drugs under development for the treatment of functional dyspepsia and related disorders","volume":"28","author":"Tack","year":"2019","journal-title":"Expert Opin. Investig. Drugs"},{"issue":"5","key":"10.1016\/j.phrs.2025.108019_bib8","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1136\/gutjnl-2021-326158","article-title":"Alterations to the duodenal microbiota are linked to gastric emptying and symptoms in functional dyspepsia","volume":"72","author":"Shanahan","year":"2023","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.phrs.2025.108019_bib9","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.3390\/nu15061544","article-title":"Food, dietary patterns, or is eating behavior to blame? Analyzing the nutritional aspects of functional dyspepsia","volume":"15","author":"Amerikanou","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.phrs.2025.108019_bib10","unstructured":"European Medicines Agency, 2015. European Union herbal monograph on Pistacia lentiscus L., resin (mastix). \u3008http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Herbal_Herbal_monograph\/2015\/07\/WC500190099.pdf\u3009. [Accessed on 24\/10\/2025]."},{"issue":"3","key":"10.1016\/j.phrs.2025.108019_bib11","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3390\/nu14030590","article-title":"Overview of Chios Mastic Gum (Pistacia lentiscus) effects on human health","volume":"14","author":"Soulaidopoulos","year":"2022","journal-title":"Nutrients"},{"issue":"7","key":"10.1016\/j.phrs.2025.108019_bib12","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3390\/antiox8070208","article-title":"Antioxidant and anti-inflammatory properties of mastiha: a review of preclinical and clinical studies","volume":"8","author":"Papada","year":"2019","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.phrs.2025.108019_bib13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jep.2009.11.021","article-title":"Is Chios mastic gum effective in the treatment of functional dyspepsia? A prospective randomised double-blind placebo controlled trial","volume":"127","author":"Dabos","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phrs.2025.108019_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069494","article-title":"Evaluation of the genotoxic and antigenotoxic effects of Chios mastic water by the in vitro micronucleus test on human lymphocytes and the in vivo wing somatic test on Drosophila","volume":"8","author":"Vlastos","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2025.108019_bib15","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.foodchem.2011.05.043","article-title":"Chemical investigation and antimicrobial properties of mastic water and its major constituents","volume":"129","author":"Paraschos","year":"2011","journal-title":"Food Chem."},{"key":"10.1016\/j.phrs.2025.108019_bib16","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3164\/jcbn.20-162","article-title":"Early effects of acotiamide or mosapride intake on gastric emptying: a randomized 3-way crossover study using the 13C breath test","volume":"68","author":"Kaai","year":"2021","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.phrs.2025.108019_bib17","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1111\/apt.13753","article-title":"Validation of the Leuven Postprandial Distress Scale, a questionnaire for symptom assessment in the functional dyspepsia\/postprandial distress syndrome","volume":"44","author":"Carbone","year":"2016","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.phrs.2025.108019_bib18","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1111\/j.1524-4733.2008.00356.x","article-title":"Validity of the EuroQoL (EQ-5D) instrument in a Greek general population","volume":"11","author":"Kontodimopoulos","year":"2008","journal-title":"Value Health"},{"key":"10.1016\/j.phrs.2025.108019_bib19","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1186\/s12884-022-05127-7","article-title":"Validation of the generalized anxiety disorder screener (GAD-7) in Cypriot pregnant and postpartum women","volume":"22","author":"Vogazianos","year":"2022","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.phrs.2025.108019_bib20","article-title":"Chaihushugan powder regulates the gut microbiota to alleviate mitochondrial oxidative stress in the gastric tissues of rats with functional dyspepsia","volume":"16","author":"Liu","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phrs.2025.108019_bib21","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.phymed.2018.08.008","article-title":"Plasma free amino acid profile in quiescent inflammatory bowel disease patients orally administered with Mastiha (Pistacia lentiscus); a randomised clinical trial","volume":"56","author":"Papada","year":"2019","journal-title":"Phytomedicine"},{"issue":"15","key":"10.1016\/j.phrs.2025.108019_bib22","doi-asserted-by":"crossref","first-page":"12038","DOI":"10.3390\/ijms241512038","article-title":"Chios mastic gum: chemical profile and pharmacological properties in inflammatory bowel disease: from the past to the future","volume":"24","author":"Ottria","year":"2023","journal-title":"Int J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.phrs.2025.108019_bib23","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1002\/ptr.7359","article-title":"Antiinflammatory activity of natural triterpenes-an overview from 2006 to 2021","volume":"36","author":"Miranda","year":"2022","journal-title":"Phytother. Res."},{"issue":"8","key":"10.1016\/j.phrs.2025.108019_bib24","doi-asserted-by":"crossref","first-page":"947","DOI":"10.3390\/ma10080947","article-title":"Update on monoterpenes as antimicrobial agents: a particular focus on p-cymene","volume":"10","author":"Marchese","year":"2017","journal-title":"Materials (Basel)"},{"issue":"3","key":"10.1016\/j.phrs.2025.108019_bib25","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3390\/molecules30030467","article-title":"Antioxidant and anti-inflammatory effects of vanillic acid in human plasma, human neutrophils, and non-cellular models in vitro","volume":"30","author":"Magiera","year":"2025","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.phrs.2025.108019_bib26","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3892\/etm.2021.11106","article-title":"p-Coumaric acid suppresses reactive oxygen species-induced senescence in nucleus pulposus cells","volume":"23","author":"Sheng","year":"2022","journal-title":"Exp. Ther. Med."},{"issue":"11","key":"10.1016\/j.phrs.2025.108019_bib27","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.3390\/nu10111779","article-title":"C Antioxidative efficacy of a Pistacia lentiscus supplement and its effect on the plasma amino acid profile in inflammatory bowel disease: a randomised, double-blind, placebo-controlled trial","volume":"10","author":"Papada","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.phrs.2025.108019_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202001178","article-title":"Effect of Mastiha supplementation on NAFLD: The MAST4HEALTH randomised, controlled trial","volume":"65","author":"Amerikanou","year":"2021","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.phrs.2025.108019_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105753","article-title":"Mastiha has efficacy in immune-mediated inflammatory diseases through a microRNA-155 Th17 dependent action","volume":"171","author":"Amerikanou","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.phrs.2025.108019_bib30","doi-asserted-by":"crossref","first-page":"322","DOI":"10.5056\/jnm20026","article-title":"Functional dyspepsia: a narrative review with a focus on sex-gender differences","volume":"26","author":"Kim","year":"2020","journal-title":"J. Neurogastroenterol. Motil."},{"key":"10.1016\/j.phrs.2025.108019_bib31","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.14474","article-title":"Placebo response in pharmacological trials in patients with functional dyspepsia-a systematic review and meta-analysis","volume":"35","author":"Bosman","year":"2023","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.phrs.2025.108019_bib32","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.14527","article-title":"Placebo effects in functional dyspepsia: causes and implications for clinical trials","volume":"35","author":"Jones","year":"2023","journal-title":"Neurogastroenterol. Motil."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104366182500444X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104366182500444X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T23:50:46Z","timestamp":1766188246000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S104366182500444X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":32,"alternative-id":["S104366182500444X"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2025.108019","relation":{},"ISSN":["1043-6618"],"issn-type":[{"type":"print","value":"1043-6618"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A randomized, three-way crossover clinical trial on the efficacy of Mastiha based therapies (Pistacia lentiscus var. Chia) in functional dyspepsia","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2025.108019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108019"}}