{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:55:34Z","timestamp":1791899734889,"version":"4.3.4"},"reference-count":260,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274027"],"award-info":[{"award-number":["82274027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32330098"],"award-info":[{"award-number":["32330098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474014"],"award-info":[{"award-number":["82474014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32472943"],"award-info":[{"award-number":["32472943"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2023ZD040430103"],"award-info":[{"award-number":["2023ZD040430103"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2025JJ20087"],"award-info":[{"award-number":["2025JJ20087"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025T021HN"],"award-info":[{"award-number":["2025T021HN"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.phrs.2025.108031","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T02:52:24Z","timestamp":1762829544000},"page":"108031","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Diet, gut-brain axis, and metabolism-epigenome-immunity networks: A triad in neurological disease management"],"prefix":"10.1016","volume":"222","author":[{"given":"Yishu","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5724-1516","authenticated-orcid":false,"given":"Zhaoqian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8011-2405","authenticated-orcid":false,"given":"Weilin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5149-1204","authenticated-orcid":false,"given":"Xiaoyuan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2025.108031_bib1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.tins.2024.05.007","article-title":"Unravelling consciousness and brain function through the lens of time, space, and information","volume":"47","author":"Luppi","year":"2024","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.phrs.2025.108031_bib2","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.tins.2023.04.001","article-title":"Why is everyone talking about brain state?","volume":"46","author":"Greene","year":"2023","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.phrs.2025.108031_bib3","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1007\/s11427-021-2103-5","article-title":"Interactions between central nervous system and peripheral metabolic organs","volume":"65","author":"Zeng","year":"2022","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.phrs.2025.108031_bib4","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.tcm.2023.07.003","article-title":"Vagus nerve stimulation for cardiovascular diseases: Is there light at the end of the tunnel?","volume":"34","author":"Zafeiropoulos","year":"2024","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.phrs.2025.108031_bib5","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nrgastro.2016.76","article-title":"Vagal neurocircuitry and its influence on gastric motility","volume":"13","author":"Travagli","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phrs.2025.108031_bib6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00401-024-02790-2","article-title":"Inflammatory aspects of Alzheimer's disease","volume":"148","author":"Botella Lucena","year":"2024","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.phrs.2025.108031_bib7","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/s41583-024-00805-1","article-title":"mTOR and neuroinflammation in epilepsy: implications for disease progression and treatment","volume":"25","author":"Ravizza","year":"2024","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.phrs.2025.108031_bib8","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1177\/0271678X18800589","article-title":"The importance of comorbidities in ischemic stroke: Impact of hypertension on the cerebral circulation","volume":"38","author":"Cipolla","year":"2018","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.phrs.2025.108031_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241210069","article-title":"Effects of diabetes mellitus-related dysglycemia on the functions of blood-brain barrier and the risk of dementia","volume":"24","author":"W\u0105troba","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2025.108031_bib10","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.tem.2023.08.014","article-title":"Brain-body communication in metabolic control","volume":"34","author":"Furlan","year":"2023","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2025.108031_bib11","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1093\/brain\/awaa238","article-title":"Brain-first versus body-first Parkinson's disease: a multimodal imaging case-control study","volume":"143","author":"Horsager","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.phrs.2025.108031_bib12","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson's disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.phrs.2025.108031_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.791213","article-title":"To the gut microbiome and beyond: the brain-first or body-first hypothesis in Parkinson's disease","volume":"13","author":"Nuzum","year":"2022","journal-title":"Front Microbiol"},{"key":"10.1016\/j.phrs.2025.108031_bib14","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1126\/science.abi6087","article-title":"Signaling inflammation across the gut-brain axis","volume":"374","author":"Agirman","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.phrs.2025.108031_bib15","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1093\/cvr\/cvae185","article-title":"Heart-brain axis in health and disease: role of innate and adaptive immunity","volume":"120","author":"Simats","year":"2025","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.phrs.2025.108031_bib16","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/s41586-022-04427-4","article-title":"The lung microbiome regulates brain autoimmunity","volume":"603","author":"Hosang","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2025.108031_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102341","article-title":"Research progress in Alzheimer's disease and bone-brain axis","volume":"98","author":"Zhang","year":"2024","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.phrs.2025.108031_bib18","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41392-024-01743-1","article-title":"Microbiota-gut-brain axis and its therapeutic applications in neurodegenerative diseases","volume":"9","author":"Loh","year":"2024","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.phrs.2025.108031_bib19","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The microbiota-gut-brain axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phrs.2025.108031_bib20","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1093\/advances\/nmaa181","article-title":"Diet and the microbiota-gut-brain axis: sowing the seeds of good mental health","volume":"12","author":"Berding","year":"2021","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.phrs.2025.108031_bib21","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70253","article-title":"Berberine alleviates kainic acid-induced acute epileptic seizures in mice via reshaping gut microbiota-associated lipid metabolism","volume":"31","author":"Dai","year":"2025","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.phrs.2025.108031_bib22","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The microbiota-gut-brain axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phrs.2025.108031_bib23","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1038\/s42255-024-01108-6","article-title":"Feeding gut microbes to nourish the brain: unravelling the diet-microbiota-gut-brain axis","volume":"6","author":"Schneider","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.phrs.2025.108031_bib24","doi-asserted-by":"crossref","DOI":"10.1172\/JCI189519","article-title":"Zombie neurons in epilepsy: a burgeoning role for senescence in drug-resistant epilepsy","volume":"135","author":"Carvill","year":"2025","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.phrs.2025.108031_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107861","article-title":"Dietary nutrition for neurological disease therapy: current status and future directions","volume":"226","author":"Mao","year":"2021","journal-title":"Pharm. Ther."},{"key":"10.1016\/j.phrs.2025.108031_bib26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S1474-4422(21)00330-6","article-title":"The neuropsychiatry of Parkinson's disease: advances and challenges","volume":"21","author":"Weintraub","year":"2022","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phrs.2025.108031_bib27","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1001\/jama.2020.26858","article-title":"Diagnosis and treatment of multiple sclerosis: a review","volume":"325","author":"McGinley","year":"2021","journal-title":"Jama"},{"key":"10.1016\/j.phrs.2025.108031_bib28","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0140-6736(23)01473-3","article-title":"Multiple sclerosis","volume":"403","author":"Jakimovski","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2025.108031_bib29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41593-022-01207-1","article-title":"An RNA-targeting CRISPR-Cas13d system alleviates disease-related phenotypes in Huntington's disease models","volume":"26","author":"Morelli","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phrs.2025.108031_bib30","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/S1474-4422(22)00309-X","article-title":"Traumatic brain injury: progress and challenges in prevention, clinical care, and research","volume":"21","author":"Maas","year":"2022","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phrs.2025.108031_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2023.1102147","article-title":"m6A methylation: critical roles in aging and neurological diseases","volume":"16","author":"Fan","year":"2023","journal-title":"Front Mol. Neurosci."},{"key":"10.1016\/j.phrs.2025.108031_bib32","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1001\/jama.2022.1420","article-title":"What Is Acute Ischemic Stroke?","volume":"327","author":"Walter","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.phrs.2025.108031_bib33","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1016\/S0140-6736(24)00642-1","article-title":"Stroke","volume":"403","author":"Hilkens","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2025.108031_bib34","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S1474-4422(17)30158-8","article-title":"Gadolinium deposition in the brain: summary of evidence and recommendations","volume":"16","author":"Gulani","year":"2017","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phrs.2025.108031_bib35","doi-asserted-by":"crossref","DOI":"10.1172\/JCI164199","article-title":"TIMP2 ameliorates blood-brain barrier disruption in traumatic brain injury by inhibiting Src-dependent VE-cadherin internalization","volume":"134","author":"Tang","year":"2023","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.phrs.2025.108031_bib36","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1038\/s41380-023-02018-x","article-title":"Probing neural circuit mechanisms in Alzheimer's disease using novel technologies","volume":"28","author":"Grieco","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.phrs.2025.108031_bib37","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.neuron.2019.03.004","article-title":"Circuit mechanisms of Parkinson's disease","volume":"101","author":"McGregor","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2025.108031_bib38","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nn.3950","article-title":"Microcircuits and their interactions in epilepsy: is the focus out of focus?","volume":"18","author":"Paz","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phrs.2025.108031_bib39","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.neuron.2009.05.015","article-title":"Neurons that fire together also conspire together: is normal sleep circuitry hijacked to generate epilepsy?","volume":"62","author":"Beenhakker","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2025.108031_bib40","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.1016\/j.neuron.2022.06.023","article-title":"Microglia in multiple sclerosis: protectors turn destroyers","volume":"110","author":"Yong","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2025.108031_bib41","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20202715","article-title":"Functional immune cell-astrocyte interactions","volume":"218","author":"Sanmarco","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.phrs.2025.108031_bib42","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41573-022-00391-w","article-title":"The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics","volume":"21","author":"Karran","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.phrs.2025.108031_bib43","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.ijbiomac.2020.07.327","article-title":"Role of tau protein in Alzheimer's disease: the prime pathological player","volume":"163","author":"Muralidar","year":"2020","journal-title":"Int J. Biol. Macromol."},{"key":"10.1016\/j.phrs.2025.108031_bib44","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1038\/s41380-022-01565-z","article-title":"The synapse as a treatment avenue for Alzheimer's disease","volume":"27","author":"Peng","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.phrs.2025.108031_bib45","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntington's disease","volume":"369","author":"Walker","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2025.108031_bib46","doi-asserted-by":"crossref","first-page":"13S","DOI":"10.2967\/jnumed.121.263195","article-title":"The role of amyloid PET in imaging neurodegenerative disorders: a review","volume":"63","author":"Chapleau","year":"2022","journal-title":"J. Nucl. Med"},{"key":"10.1016\/j.phrs.2025.108031_bib47","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s11910-018-0890-y","article-title":"Novel imaging biomarkers for Huntington's disease and other hereditary choreas","volume":"18","author":"Fazio","year":"2018","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.phrs.2025.108031_bib48","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adg4122","article-title":"A protein panel in cerebrospinal fluid for diagnostic and predictive assessment of Alzheimer's disease","volume":"15","author":"Haque","year":"2023","journal-title":"Sci. Transl. Med"},{"key":"10.1016\/j.phrs.2025.108031_bib49","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-46470-8","article-title":"Peripheral expression of mutant huntingtin is a critical determinant of weight loss and metabolic disturbances in Huntington's disease","volume":"9","author":"Lakra","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2025.108031_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24054477","article-title":"What the gut tells the brain-is there a link between microbiota and Huntington's disease?","volume":"24","author":"Wronka","year":"2023","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.phrs.2025.108031_bib51","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41586-018-0255-3","article-title":"Structure of a human synaptic GABA(A) receptor","volume":"559","author":"Zhu","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2025.108031_bib52","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1124\/pharmrev.122.000618","article-title":"Dopamine, immunity, and disease","volume":"75","author":"Channer","year":"2023","journal-title":"Pharm. Rev."},{"key":"10.1016\/j.phrs.2025.108031_bib53","doi-asserted-by":"crossref","DOI":"10.1021\/acs.accounts.3c00617","article-title":"Acetylcholinesterase: a versatile template to coin potent modulators of multiple therapeutic targets","author":"Luque","year":"2024","journal-title":"Acc. Chem. Res 57 450467"},{"key":"10.1016\/j.phrs.2025.108031_bib54","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1038\/s41380-022-01589-5","article-title":"Bioactive human Alzheimer brain soluble A\u03b2: pathophysiology and therapeutic opportunities","volume":"27","author":"Li","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.phrs.2025.108031_bib55","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/physrev.00002.2020","article-title":"Developmental origins of metabolic diseases","volume":"101","author":"Hoffman","year":"2021","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phrs.2025.108031_bib56","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1017\/S0007114515002470","article-title":"Maternal folate status as a risk factor for autism spectrum disorders: a review of existing evidence","volume":"114","author":"DeVilbiss","year":"2015","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.phrs.2025.108031_bib57","doi-asserted-by":"crossref","DOI":"10.3390\/nu13103530","article-title":"Maternal nutrition and neurodevelopment: a scoping review","volume":"13","author":"Cort\u00e9s-Albornoz","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.phrs.2025.108031_bib58","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jaac.2019.11.021","article-title":"Maternal Vitamin D Levels and the risk of offspring attention-deficit\/hyperactivity disorder","volume":"60","author":"Sucksdorff","year":"2021","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.phrs.2025.108031_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113911","article-title":"Impaired social cognition caused by perinatal protein malnutrition evokes neurodevelopmental disorder symptoms and is intergenerationally transmitted","volume":"347","author":"Fesser","year":"2022","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phrs.2025.108031_bib60","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.it.2022.01.007","article-title":"Maternal inflammation and its ramifications on fetal neurodevelopment","volume":"43","author":"Kwon","year":"2022","journal-title":"Trends Immunol."},{"key":"10.1016\/j.phrs.2025.108031_bib61","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022111192","article-title":"Maternal immune activation leads to defective brain-blood vessels and intracerebral hemorrhages in male offspring","volume":"41","author":"Rasile","year":"2022","journal-title":"EMBO J."},{"key":"10.1016\/j.phrs.2025.108031_bib62","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1176\/appi.ajp.21111176","article-title":"Maternal perinatal stress trajectories and negative affect and amygdala development in offspring","volume":"180","author":"Marr","year":"2023","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.phrs.2025.108031_bib63","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.biopsych.2018.08.018","article-title":"Inflammation: a proposed intermediary between maternal stress and offspring neuropsychiatric risk","volume":"85","author":"Hantsoo","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2025.108031_bib64","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S2215-0366(16)30148-1","article-title":"Maternal depression and mental health in early childhood: an examination of underlying mechanisms in low-income and middle-income countries","volume":"3","author":"Herba","year":"2016","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.phrs.2025.108031_bib65","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41392-024-01743-1","article-title":"Microbiota-gut-brain axis and its therapeutic applications in neurodegenerative diseases","volume":"9","author":"Loh","year":"2024","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.phrs.2025.108031_bib66","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41392-023-01673-4","article-title":"Gut liver brain axis in diseases: the implications for therapeutic interventions","volume":"8","author":"Yan","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.phrs.2025.108031_bib67","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/s41569-025-01140-3","article-title":"The brain-heart axis: integrative cooperation of neural, mechanical and biochemical pathways","volume":"22","author":"Valenza","year":"2025","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.phrs.2025.108031_bib68","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41581-018-0018-2","article-title":"The gut microbiota and the brain-gut-kidney axis in hypertension and chronic kidney disease","volume":"14","author":"Yang","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.phrs.2025.108031_bib69","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12264-022-00934-6","article-title":"Parkinson's disease: a multisystem disorder","volume":"39","author":"Costa","year":"2023","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.phrs.2025.108031_bib70","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s10571-021-01066-7","article-title":"The gut-brain axis: two ways signaling in Parkinson's disease","volume":"42","author":"Dogra","year":"2022","journal-title":"Cell Mol. Neurobiol."},{"key":"10.1016\/j.phrs.2025.108031_bib71","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1212\/WNL.0000000000003961","article-title":"Vagotomy and Parkinson disease: a Swedish register-based matched-cohort study","volume":"88","author":"Liu","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.phrs.2025.108031_bib72","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/ana.24448","article-title":"Vagotomy and subsequent risk of Parkinson's disease","volume":"78","author":"Svensson","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.phrs.2025.108031_bib73","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/j.jhep.2020.07.013","article-title":"Hepatic encephalopathy: novel insights into classification, pathophysiology and therapy","volume":"73","author":"Rose","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phrs.2025.108031_bib74","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1161\/CIRCULATIONAHA.117.029127","article-title":"Higher risk of vascular dementia in myocardial infarction survivors","volume":"137","author":"Sundb\u00f8ll","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2025.108031_bib75","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1161\/CIRCULATIONAHA.121.055018","article-title":"Atrial fibrillation and dementia: a report from the AF-SCREEN international collaboration","volume":"145","author":"Rivard","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2025.108031_bib76","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.kint.2021.09.025","article-title":"Uremic encephalopathy","volume":"101","author":"Rosner","year":"2022","journal-title":"Kidney Int"},{"key":"10.1016\/j.phrs.2025.108031_bib77","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41577-022-00684-6","article-title":"Inflammation and immune dysfunction in Parkinson disease","volume":"22","author":"Tansey","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phrs.2025.108031_bib78","doi-asserted-by":"crossref","first-page":"696","DOI":"10.2174\/156652411797536660","article-title":"Gastrointestinal immune system and brain dialogue implicated in neuroinflammatory and neurodegenerative diseases","volume":"11","author":"Deretzi","year":"2011","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.phrs.2025.108031_bib79","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S1474-4422(14)70305-9","article-title":"Role of the innate and adaptive immune responses in the course of multiple sclerosis","volume":"14","author":"Hemmer","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phrs.2025.108031_bib80","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22094395","article-title":"Links between immune cells from the periphery and the brain in the pathogenesis of epilepsy: a narrative review","volume":"22","author":"Yamanaka","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2025.108031_bib81","article-title":"Autoreactive lymphocytes in multiple sclerosis: Pathogenesis and treatment target","volume":"13","author":"Liu","year":"2022","journal-title":"Front Immunol."},{"key":"10.1016\/j.phrs.2025.108031_bib82","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s13311-019-00750-3","article-title":"Autoimmune epilepsy","volume":"16","author":"Husari","year":"2019","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.phrs.2025.108031_bib83","doi-asserted-by":"crossref","DOI":"10.4028\/b-wjQRP6","article-title":"Th1\/Th2 imbalance in peripheral blood echoes microglia state dynamics in CNS during TLE progression","volume":"11","author":"Wang","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.phrs.2025.108031_bib84","doi-asserted-by":"crossref","DOI":"10.3390\/cells12040657","article-title":"Mechanisms of blood-brain barrier protection by microbiota-derived short-chain fatty acids","volume":"12","author":"Fock","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.phrs.2025.108031_bib85","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1186\/s12974-016-0765-6","article-title":"The histone deacetylase inhibitor, sodium butyrate, exhibits neuroprotective effects for ischemic stroke in middle-aged female rats","volume":"13","author":"Park","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.phrs.2025.108031_bib86","doi-asserted-by":"crossref","first-page":"6391","DOI":"10.1007\/s12035-016-0149-z","article-title":"HDAC inhibitor sodium butyrate-mediated epigenetic regulation enhances neuroprotective function of microglia during ischemic stroke","volume":"54","author":"Patnala","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phrs.2025.108031_bib87","article-title":"The impact of systemic inflammation on Alzheimer's Disease Pathology","volume":"12","author":"Xie","year":"2021","journal-title":"Front Immunol."},{"key":"10.1016\/j.phrs.2025.108031_bib88","doi-asserted-by":"crossref","first-page":"5877","DOI":"10.1016\/j.cell.2024.08.050","article-title":"Brain-body physiology: local, reflex, and central communication","volume":"187","author":"Sammons","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2025.108031_bib89","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1093\/brain\/awaa238","article-title":"Brain-first versus body-first Parkinson's disease: a multimodal imaging case-control study","volume":"143","author":"Horsager","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.phrs.2025.108031_bib90","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13024-024-00766-0","article-title":"Gut-first Parkinson's disease is encoded by gut dysbiome","volume":"19","author":"Munoz-Pinto","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.phrs.2025.108031_bib91","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41531-023-00511-2","article-title":"Gastrointestinal disorders in Parkinson's disease and other Lewy body diseases","volume":"9","author":"Hirayama","year":"2023","journal-title":"NPJ Park. Dis."},{"key":"10.1016\/j.phrs.2025.108031_bib92","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fneur.2017.00037","article-title":"Exploring Braak's Hypothesis of Parkinson's Disease","volume":"8","author":"Rietdijk","year":"2017","journal-title":"Front Neurol."},{"key":"10.1016\/j.phrs.2025.108031_bib93","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1212\/WNL.0000000000002035","article-title":"A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease","volume":"85","author":"Turner","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.phrs.2025.108031_bib94","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.exger.2016.10.004","article-title":"Examining the impact of grape consumption on brain metabolism and cognitive function in patients with mild decline in cognition: a double-blinded placebo controlled pilot study","volume":"87","author":"Lee","year":"2017","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.phrs.2025.108031_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155094","volume":"121","author":"Hajiluian","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phrs.2025.108031_bib96","doi-asserted-by":"crossref","first-page":"249","DOI":"10.14283\/jpad.2021.22","article-title":"Effects of folic acid and vitamin B12 supplementation on cognitive impairment and inflammation in patients with Alzheimer's disease: a randomized, single-blinded, placebo-controlled trial","volume":"8","author":"Chen","year":"2021","journal-title":"J. Prev. Alzheimers Dis."},{"key":"10.1016\/j.phrs.2025.108031_bib97","doi-asserted-by":"crossref","DOI":"10.1136\/jnnp-2018-320199","article-title":"Effects of vitamin D supplementation on cognitive function and blood A\u03b2-related biomarkers in older adults with Alzheimer's disease: a randomised, double-blind, placebo-controlled trial","author":"Jia","year":"2019","journal-title":"J. Neurol. Neurosurg. Psychiatry 90 13471352"},{"key":"10.1016\/j.phrs.2025.108031_bib98","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0891-5849(01)00595-0","article-title":"Influence of vitamin E and C supplementation on lipoprotein oxidation in patients with Alzheimer's disease","volume":"31","author":"Kontush","year":"2001","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.phrs.2025.108031_bib99","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/papr.12902","article-title":"Reduction in migraine and headache frequency and intensity with combined antioxidant prophylaxis (N-acetylcysteine, Vitamin E, and Vitamin C): a randomized sham-controlled pilot study","volume":"20","author":"Visser","year":"2020","journal-title":"Pain. Pr."},{"key":"10.1016\/j.phrs.2025.108031_bib100","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/biof.5520240131","article-title":"Effects of vitamin C and aspirin in ischemic stroke-related lipid peroxidation: results of the AVASAS (Aspirin Versus Ascorbic acid plus Aspirin in Stroke) Study","volume":"24","author":"Polidori","year":"2005","journal-title":"Biofactors"},{"key":"10.1016\/j.phrs.2025.108031_bib101","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1093\/brain\/awae041","article-title":"L-serine treatment in patients with GRIN-related encephalopathy: a phase 2A, non-randomized study","volume":"147","author":"Juli\u00e1-Palacios","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.phrs.2025.108031_bib102","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1089\/neu.2023.0433","article-title":"Head Injury treatment with healthy and advanced dietary supplements: a pilot randomized controlled trial of the tolerability, safety, and efficacy of branched chain amino acids in the treatment of concussion in adolescents and young adults","volume":"41","author":"Corwin","year":"2024","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.phrs.2025.108031_bib103","doi-asserted-by":"crossref","DOI":"10.3390\/nu11081810","article-title":"Supplementation with synbiotics and\/or branched chain amino acids in hepatic encephalopathy: a pilot randomised placebo-controlled clinical study","volume":"11","author":"Vidot","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.phrs.2025.108031_bib104","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13195-015-0134-1","article-title":"Effects of Souvenaid on plasma micronutrient levels and fatty acid profiles in mild and mild-to-moderate Alzheimer's disease","volume":"7","author":"Rijpma","year":"2015","journal-title":"Alzheimers Res Ther."},{"key":"10.1016\/j.phrs.2025.108031_bib105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-121828","article-title":"Effects on transthyretin in plasma and cerebrospinal fluid by DHA-rich n - 3 fatty acid supplementation in patients with Alzheimer's disease: the OmegAD study","volume":"36","author":"Fax\u00e9n-Irving","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.phrs.2025.108031_bib106","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1002\/alz.12154","article-title":"Dietary fatty acids and risk of Alzheimer's disease and related dementias: Observations from the Washington Heights-Hamilton Heights-Inwood Columbia Aging Project (WHICAP)","volume":"16","author":"Gustafson","year":"2020","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.phrs.2025.108031_bib107","doi-asserted-by":"crossref","first-page":"n1448","DOI":"10.1136\/bmj.n1448","article-title":"Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: randomized controlled trial","volume":"374","author":"Ramsden","year":"2021","journal-title":"Bmj"},{"key":"10.1016\/j.phrs.2025.108031_bib108","article-title":"The efficacy of alpha-lipoic acid in improving oxidative, inflammatory, and mood status in women with episodic migraine in a randomised, double-blind, placebo-controlled clinical trial","volume":"75","author":"Rezaei Kelishadi","year":"2021","journal-title":"Int J. Clin. Pr."},{"key":"10.1016\/j.phrs.2025.108031_bib109","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41598-021-04397-z","article-title":"The beneficial effect of Alpha-lipoic acid supplementation as a potential adjunct treatment in episodic migraines","volume":"12","author":"Kelishadi","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2025.108031_bib110","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1526-4610.2006.00626.x","article-title":"A randomized double-blind placebo-controlled trial of thioctic acid in migraine prophylaxis","volume":"47","author":"Magis","year":"2007","journal-title":"Headache"},{"key":"10.1016\/j.phrs.2025.108031_bib111","first-page":"36","article-title":"The blood glutathione system in cerebral vascular diseases and its treatment with alpha-lipoic acid]","volume":"108","author":"Kolesnichenko","year":"2008","journal-title":"Zh Nevrol. Psikhiatr Im. S S Korsakova"},{"key":"10.1016\/j.phrs.2025.108031_bib112","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105668","article-title":"Effect of synbiotic supplementation on migraine characteristics and inflammatory biomarkers in women with migraine: Results of a randomized controlled trial","volume":"169","author":"Ghavami","year":"2021","journal-title":"Pharm. Res"},{"key":"10.1016\/j.phrs.2025.108031_bib113","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/MEG.0b013e328330a8d3","article-title":"Bifidobacterium combined with fructo-oligosaccharide versus lactulose in the treatment of patients with hepatic encephalopathy","volume":"22","author":"Malaguarnera","year":"2010","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phrs.2025.108031_bib114","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/2638703","article-title":"Oxidative Stress and Dementia in Alzheimer's Patients: Effects of Synbiotic Supplementation","volume":"2020","author":"Ton","year":"2020","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.phrs.2025.108031_bib115","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.gpb.2021.08.009","article-title":"Effects of Resistant Starch on Symptoms, Fecal Markers, and Gut Microbiota in Parkinson's Disease - The RESISTA-PD Trial","volume":"20","author":"Becker","year":"2022","journal-title":"Genom. Proteom. Bioinforma."},{"key":"10.1016\/j.phrs.2025.108031_bib116","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-74400-w","article-title":"Synbiotic supplementation may globally improve non-motor symptoms in patients with stable Parkinson's disease: results from an open label single-arm study","volume":"14","author":"Andreozzi","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2025.108031_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105400","article-title":"Association between seizure reduction during ketogenic diet treatment of epilepsy and changes in circulatory metabolites and gut microbiota composition","volume":"109","author":"Dahlin","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.phrs.2025.108031_bib118","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1186\/s12967-023-04561-1","article-title":"Very-low-calorie ketogenic diet vs hypocaloric balanced diet in the prevention of high-frequency episodic migraine: the EMIKETO randomized, controlled trial","volume":"21","author":"Caprio","year":"2023","journal-title":"J. Transl. Med"},{"key":"10.1016\/j.phrs.2025.108031_bib119","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctim.2020.102366","article-title":"The effect of the Mediterranean diet on cognitive function in patients with Parkinson's disease: A randomized clinical controlled trial","volume":"50","author":"Paknahad","year":"2020","journal-title":"Complement Ther. Med"},{"key":"10.1016\/j.phrs.2025.108031_bib120","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/1028415X.2020.1751509","article-title":"The effects of Mediterranean diet on severity of disease and serum Total Antioxidant Capacity (TAC) in patients with Parkinson's disease: a single center, randomized controlled trial","volume":"25","author":"Paknahad","year":"2022","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.phrs.2025.108031_bib121","first-page":"46","article-title":"Effects of Mediterranean Diet or Mindfulness-Based Stress Reduction during Pregnancy on Fetal Brain Development Detected by Neurosonography: A Secondary Analysis of a Randomized Clinical Trial (IMPACT BCN)","volume":"52","author":"Nakaki","year":"2025","journal-title":"Fetal Diagn. Ther."},{"key":"10.1016\/j.phrs.2025.108031_bib122","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.30255","article-title":"Effect of a Mediterranean Diet or Mindfulness-Based Stress Reduction During Pregnancy on Child Neurodevelopment: A Prespecified Analysis of the IMPACT BCN Randomized Clinical Trial","volume":"6","author":"Crovetto","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.phrs.2025.108031_bib123","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/alz.12421","article-title":"Mediterranean and Western diet effects on Alzheimer's disease biomarkers, cerebral perfusion, and cognition in mid-life: A randomized trial","volume":"18","author":"Hoscheidt","year":"2022","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.phrs.2025.108031_bib124","doi-asserted-by":"crossref","DOI":"10.3390\/ijms251810009","article-title":"MIND Diet Impact on Multiple Sclerosis Patients: Biochemical Changes after Nutritional Intervention","volume":"25","author":"Navarrete-P\u00e9rez","year":"2024","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.phrs.2025.108031_bib125","doi-asserted-by":"crossref","first-page":"5996","DOI":"10.1002\/alz.14062","article-title":"The MIND diet, brain transcriptomic alterations, and dementia","volume":"20","author":"Li","year":"2024","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.phrs.2025.108031_bib126","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1080\/1028415X.2021.1954294","article-title":"The effects of the dietary approaches to stop hypertension (DASH) diet on oxidative stress and clinical indices of migraine patients: a randomized controlled trial","volume":"25","author":"Arab","year":"2022","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.phrs.2025.108031_bib127","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1161\/STROKEAHA.116.015019","article-title":"Adherence to a Healthy Nordic Diet and Risk of Stroke: A Danish Cohort Study","volume":"48","author":"Hansen","year":"2017","journal-title":"Stroke"},{"key":"10.1016\/j.phrs.2025.108031_bib128","doi-asserted-by":"crossref","DOI":"10.3390\/nu17020336","article-title":"Dietary Intake, Mediterranean and Nordic Diet Adherence in Alzheimer's Disease and Dementia: A Systematic Review","volume":"17","author":"Christodoulou","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.phrs.2025.108031_bib129","doi-asserted-by":"crossref","first-page":"751","DOI":"10.17219\/acem\/43585","article-title":"Celiac Disease and Epilepsy: The Effect of Gluten-Free Diet on Seizure Control","volume":"25","author":"Bashiri","year":"2016","journal-title":"Adv. Clin. Exp. Med"},{"key":"10.1016\/j.phrs.2025.108031_bib130","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.schres.2024.05.001","article-title":"Pilot study indicates that a gluten-free diet lowers oxidative stress for gluten-sensitive persons with schizophrenia","volume":"269","author":"Kim","year":"2024","journal-title":"Schizophr. Res"},{"key":"10.1016\/j.phrs.2025.108031_bib131","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.cmet.2018.05.006","article-title":"Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota","volume":"27","author":"Cignarella","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.phrs.2025.108031_bib132","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1016\/j.cmet.2024.05.017","article-title":"Brain responses to intermittent fasting and the healthy living diet in older adults","volume":"36","author":"Kapogiannis","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.phrs.2025.108031_bib133","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.1016\/j.cell.2021.05.045","article-title":"Metabolic modeling of single Th17 cells reveals regulators of autoimmunity","volume":"184","author":"Wagner","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2025.108031_bib134","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107861","article-title":"Dietary nutrition for neurological disease therapy: Current status and future directions","volume":"226","author":"Mao","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phrs.2025.108031_bib135","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41586-018-0023-4","article-title":"Innate immune memory in the brain shapes neurological disease hallmarks","volume":"556","author":"Wendeln","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2025.108031_bib136","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13073-023-01155-w","article-title":"The neuroimmune axis of Alzheimer's disease","volume":"15","author":"Jorfi","year":"2023","journal-title":"Genome Med"},{"key":"10.1016\/j.phrs.2025.108031_bib137","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41582-022-00651-8","article-title":"The metabolic basis of epilepsy","volume":"18","author":"Rho","year":"2022","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.phrs.2025.108031_bib138","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.tins.2022.12.001","article-title":"Mitochondrial signalling and homeostasis: from cell biology to neurological disease","volume":"46","author":"Collier","year":"2023","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.phrs.2025.108031_bib139","article-title":"Potential Intersections between lncRNA, Vascular Cognitive Impairment, and Immunization Strategies: Insights and Future Directions","volume":"12","author":"Fan","year":"2024","journal-title":"Vaccin. (Basel)"},{"key":"10.1016\/j.phrs.2025.108031_bib140","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.immuni.2020.10.011","article-title":"The intersection of epigenetics and metabolism in trained immunity","volume":"54","author":"Fanucchi","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.phrs.2025.108031_bib141","doi-asserted-by":"crossref","first-page":"10237","DOI":"10.1073\/pnas.172399499","article-title":"Appraising the brain's energy budget","volume":"99","author":"Raichle","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.phrs.2025.108031_bib142","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.freeradbiomed.2022.09.032","article-title":"Altered glucose metabolism in Alzheimer's disease: Role of mitochondrial dysfunction and oxidative stress","volume":"193","author":"Dewanjee","year":"2022","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.phrs.2025.108031_bib143","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev-pathmechdis-031521-034145","article-title":"Genetics and Pathogenesis of Parkinson's Syndrome","volume":"18","author":"Ye","year":"2023","journal-title":"Annu Rev. Pathol."},{"key":"10.1016\/j.phrs.2025.108031_bib144","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.seizure.2021.06.028","article-title":"Brain concentrations of glutamate and GABA in human epilepsy: A review","volume":"91","author":"Sarlo","year":"2021","journal-title":"Seizure"},{"key":"10.1016\/j.phrs.2025.108031_bib145","doi-asserted-by":"crossref","DOI":"10.3390\/cells13080719","article-title":"Epigenetic Changes in Alzheimer's Disease: DNA Methylation and Histone Modification","volume":"13","author":"De Plano","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.phrs.2025.108031_bib146","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1177\/1073858417705840","article-title":"The Epigenetics of Epilepsy and Its Progression","volume":"24","author":"Hauser","year":"2018","journal-title":"Neuroscientist"},{"key":"10.1016\/j.phrs.2025.108031_bib147","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?","volume":"17","author":"Leng","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.phrs.2025.108031_bib148","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41582-019-0217-x","article-title":"Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy","volume":"15","author":"Vezzani","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.phrs.2025.108031_bib149","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41586-020-03160-0","article-title":"Restoring metabolism of myeloid cells reverses cognitive decline in ageing","volume":"590","author":"Minhas","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2025.108031_bib150","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.cmet.2022.02.013","article-title":"Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer's disease","volume":"34","author":"Pan","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.phrs.2025.108031_bib151","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41392-022-01078-9","article-title":"The role of histone modifications: from neurodevelopment to neurodiseases","volume":"7","author":"Park","year":"2022","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.phrs.2025.108031_bib152","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103150","article-title":"S-Adenosyl-l-methionine restores brain mitochondrial membrane fluidity and GSH content improving Niemann-Pick type C disease","volume":"72","author":"Goicoechea","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.phrs.2025.108031_bib153","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105074","article-title":"Epigenetic regulation in Huntington's disease","volume":"148","author":"Hyeon","year":"2021","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.phrs.2025.108031_bib154","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13024-023-00676-7","article-title":"Mitochondrial dysfunction in Parkinson's disease - a key disease hallmark with therapeutic potential","volume":"18","author":"Henrich","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.phrs.2025.108031_bib155","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.neuron.2021.12.034","article-title":"Epigenomic priming of immune genes implicates oligodendroglia in multiple sclerosis susceptibility","volume":"110","author":"Meijer","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2025.108031_bib156","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S1474-4422(21)00063-6","article-title":"Cellular immunology of relapsing multiple sclerosis: interactions, checks, and balances","volume":"20","author":"Bar-Or","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phrs.2025.108031_bib157","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S1474-4422(19)30078-X","article-title":"Global brain inflammation in stroke","volume":"18","author":"Shi","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phrs.2025.108031_bib158","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1152\/physrev.00041.2021","article-title":"Mitochondrial quality control in health and in Parkinson's disease","volume":"102","author":"Eldeeb","year":"2022","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phrs.2025.108031_bib159","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41582-021-00530-8","article-title":"Maternal immune activation and neuroinflammation in human neurodevelopmental disorders","volume":"17","author":"Han","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.phrs.2025.108031_bib160","doi-asserted-by":"crossref","first-page":"4594","DOI":"10.3390\/ijms22094594","article-title":"Mitochondrial DNA methylation and human diseases","volume":"22","author":"Stoccoro","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2025.108031_bib161","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s12974-022-02463-5","article-title":"Epigenetic regulation of innate immune memory in microglia","volume":"19","author":"Zhang","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.phrs.2025.108031_bib162","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.cmet.2018.12.008","article-title":"Obesity-induced cellular senescence drives anxiety and impairs neurogenesis","volume":"29","author":"Ogrodnik","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.phrs.2025.108031_bib163","doi-asserted-by":"crossref","first-page":"6133","DOI":"10.1038\/s41467-020-19861-z","article-title":"Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain","volume":"11","author":"Madore","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2025.108031_bib164","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jnutbio.2016.12.006","article-title":"Contributions of polyunsaturated fatty acids (PUFA) on cerebral neurobiology: an integrated omics approach with epigenomic focus","volume":"42","author":"Chakraborty","year":"2017","journal-title":"J. Nutr. Biochem"},{"key":"10.1016\/j.phrs.2025.108031_bib165","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12974-023-02705-0","article-title":"Microglia\/macrophages require vitamin D signaling to restrain neuroinflammation and brain injury in a murine ischemic stroke model","volume":"20","author":"Cui","year":"2023","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.phrs.2025.108031_bib166","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.freeradbiomed.2022.09.001","article-title":"Quercetin alleviates kainic acid-induced seizure by inhibiting the Nrf2-mediated ferroptosis pathway","volume":"191","author":"Xie","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phrs.2025.108031_bib167","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1002\/ptr.8219","article-title":"Pomegranate polyphenol punicalin ameliorates lipopolysaccharide-induced memory impairment, behavioral disorders, oxidative stress, and neuroinflammation via inhibition of TLR4-NF-\u043aB pathway","volume":"38","author":"Chen","year":"2024","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phrs.2025.108031_bib168","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/s41430-021-01060-8","article-title":"Ketogenic diet for epilepsy: an overview of systematic review and meta-analysis","volume":"76","author":"Ruan","year":"2022","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.phrs.2025.108031_bib169","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s42003-024-05860-z","article-title":"Ketogenic diet and BHB rescue the fall of long-term potentiation in an Alzheimer's mouse model and stimulates synaptic plasticity pathway enzymes","volume":"7","author":"Di Lucente","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.phrs.2025.108031_bib170","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.bbi.2024.04.016","article-title":"Mediterranean diet protects against a neuroinflammatory cortical transcriptome: Associations with brain volumetrics, peripheral inflammation, social isolation, and anxiety in nonhuman primates (Macaca fascicularis)","volume":"119","author":"Frye","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.phrs.2025.108031_bib171","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40035-024-00406-z","article-title":"Dietary fasting and time-restricted eating in Huntington's disease: therapeutic potential and underlying mechanisms","volume":"13","author":"Wells","year":"2024","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.phrs.2025.108031_bib172","doi-asserted-by":"crossref","DOI":"10.3390\/nu12102946","article-title":"Dietary intake, mediterranean diet adherence and caloric intake in Huntington's Disease: A Review","volume":"12","author":"Christodoulou","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.phrs.2025.108031_bib173","doi-asserted-by":"crossref","first-page":"8190","DOI":"10.1021\/acsnano.2c01872","article-title":"Polystyrene nanoplastics toxicity to zebrafish: dysregulation of the brain-intestine-microbiota axis","volume":"16","author":"Teng","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.phrs.2025.108031_bib174","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1001\/jamapsychiatry.2022.4974","article-title":"Role of the gut-brain axis in the shared genetic etiology between gastrointestinal tract diseases and psychiatric disorders: a genome-wide pleiotropic analysis","volume":"80","author":"Gong","year":"2023","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.phrs.2025.108031_bib175","doi-asserted-by":"crossref","first-page":"16050","DOI":"10.1073\/pnas.1102999108","article-title":"Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve","volume":"108","author":"Bravo","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.phrs.2025.108031_bib176","doi-asserted-by":"crossref","DOI":"10.3390\/nu16040546","article-title":"The anti-inflammatory and curative exponent of probiotics: a comprehensive and authentic ingredient for the sustained functioning of major human organs","volume":"16","author":"Virk","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.phrs.2025.108031_bib177","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01651-22","article-title":"Probiotics (Lactobacillus plantarum HNU082) supplementation relieves ulcerative colitis by affecting intestinal barrier functions, immunity-related gene expression, gut microbiota, and metabolic pathways in mice","volume":"10","author":"Wu","year":"2022","journal-title":"Microbiol Spectr."},{"key":"10.1016\/j.phrs.2025.108031_bib178","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms10112268","article-title":"Role of probiotics and diet in the management of neurological diseases and mood states: a review","volume":"10","author":"Thangaleela","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.phrs.2025.108031_bib179","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20174121","article-title":"Probiotics for Parkinson's Disease","volume":"20","author":"Gazerani","year":"2019","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.phrs.2025.108031_bib180","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13893","article-title":"Investigation of nerve pathways mediating colorectal dysfunction in Parkinson's disease model produced by lesion of nigrostriatal dopaminergic neurons","volume":"32","author":"Chai","year":"2020","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.phrs.2025.108031_bib181","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41593-020-0589-7","article-title":"Gut-seeded \u03b1-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice","volume":"23","author":"Challis","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phrs.2025.108031_bib182","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1176\/jnp.14.2.223","article-title":"An essay on the shaking palsy","volume":"14","author":"Parkinson","year":"2002","journal-title":"1817. J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.phrs.2025.108031_bib183","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/ana.24448","article-title":"Vagotomy and subsequent risk of Parkinson's disease","volume":"78","author":"Svensson","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.phrs.2025.108031_bib184","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2016.11.018","article-title":"Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease","volume":"167","author":"Sampson","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2025.108031_bib185","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/mds.26069","article-title":"Gut microbiota are related to Parkinson's disease and clinical phenotype","volume":"30","author":"Scheperjans","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.phrs.2025.108031_bib186","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.53111","article-title":"A gut bacterial amyloid promotes \u03b1-synuclein aggregation and motor impairment in mice","volume":"9","author":"Sampson","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.phrs.2025.108031_bib187","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1038\/s41467-023-38248-4","article-title":"Gut microbiome dysbiosis across early Parkinson's disease, REM sleep behavior disorder and their first-degree relatives","volume":"14","author":"Huang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2025.108031_bib188","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.parkreldis.2016.08.019","article-title":"Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls","volume":"32","author":"Unger","year":"2016","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.phrs.2025.108031_bib189","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6323","article-title":"Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism","volume":"364","author":"Maini Rekdal","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.phrs.2025.108031_bib190","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.celrep.2017.07.031","article-title":"Human gut-derived commensal bacteria suppress CNS inflammatory and demyelinating disease","volume":"20","author":"Mangalam","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.phrs.2025.108031_bib191","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2126272","article-title":"Periodontitis-related salivary microbiota aggravates Alzheimer's disease via gut-brain axis crosstalk","volume":"14","author":"Lu","year":"2022","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phrs.2025.108031_bib192","article-title":"Gut microbiota composition is related to AD pathology","volume":"12","author":"Verhaar","year":"2021","journal-title":"Front Immunol."},{"issue":"1","key":"10.1016\/j.phrs.2025.108031_bib193","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1073\/pnas.1000082107","article-title":"Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis","volume":"108","author":"Lee","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.phrs.2025.108031_bib194","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00338-20","article-title":"A comprehensive review on the role of the gut microbiome in human neurological disorders","volume":"35","author":"Sorboni","year":"2022","journal-title":"Clin. Microbiol Rev."},{"key":"10.1016\/j.phrs.2025.108031_bib195","doi-asserted-by":"crossref","unstructured":"Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course. Cell 185, 3467-3486.e3416 (2022). https:\/\/doi.org\/10.1016\/j.cell.2022.08.021.","DOI":"10.1016\/j.cell.2022.08.021"},{"key":"10.1016\/j.phrs.2025.108031_bib196","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/s41582-022-00697-8","article-title":"The role of the gut microbiota in multiple sclerosis","volume":"18","author":"Correale","year":"2022","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.phrs.2025.108031_bib197","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2020.1869501","article-title":"Involvement of the microbiota-gut-brain axis in chronic restraint stress: disturbances of the kynurenine metabolic pathway in both the gut and brain","volume":"13","author":"Deng","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phrs.2025.108031_bib198","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1038\/s41380-022-01569-9","article-title":"Multi-omics analyses of serum metabolome, gut microbiome and brain function reveal dysregulated microbiota-gut-brain axis in bipolar depression","volume":"27","author":"Li","year":"2022","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"10.1016\/j.phrs.2025.108031_bib199","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1542\/peds.2009-1878C","article-title":"Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report","volume":"125","author":"Buie","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.phrs.2025.108031_bib200","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/s41579-020-00460-0","article-title":"The gut microbiota-brain axis in behaviour and brain disorders","volume":"19","author":"Morais","year":"2021","journal-title":"Nat. Rev. Microbiol"},{"key":"10.1016\/j.phrs.2025.108031_bib201","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2019.05.004","article-title":"Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice","volume":"177","author":"Sharon","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2025.108031_bib202","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40168-016-0225-7","article-title":"Microbiota transfer therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study","volume":"5","author":"Kang","year":"2017","journal-title":"Microbiome"},{"key":"10.1016\/j.phrs.2025.108031_bib203","doi-asserted-by":"crossref","first-page":"5821","DOI":"10.1038\/s41598-019-42183-0","article-title":"Long-term benefit of Microbiota Transfer Therapy on autism symptoms and gut microbiota","volume":"9","author":"Kang","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2025.108031_bib204","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/s41593-023-01361-0","article-title":"Multi-level analysis of the gut-brain axis shows autism spectrum disorder-associated molecular and microbial profiles","volume":"26","author":"Morton","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phrs.2025.108031_bib205","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s12974-022-02472-4","article-title":"A crosstalk between gut and brain in sepsis-induced cognitive decline","volume":"19","author":"Giridharan","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.phrs.2025.108031_bib206","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1080\/15548627.2022.2102309","article-title":"Microglial mitophagy integrates the microbiota-gut-brain axis to restrain neuroinflammation during neurotropic herpesvirus infection","volume":"19","author":"Li","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.phrs.2025.108031_bib207","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1016\/j.neuron.2023.07.010","article-title":"A novel immune modulator IM33 mediates a glia-gut-neuronal axis that controls lifespan","volume":"111","author":"Xu","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2025.108031_bib208","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1001\/jamaneurol.2013.396","article-title":"Effect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides: randomized clinical trial","volume":"70","author":"Hanson","year":"2013","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.phrs.2025.108031_bib209","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/cns.13779","article-title":"Ketogenic diet ameliorates cognitive impairment and neuroinflammation in a mouse model of Alzheimer's disease","volume":"28","author":"Xu","year":"2022","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.phrs.2025.108031_bib210","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S1474-4422(20)30231-3","article-title":"Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches","volume":"19","author":"Kellar","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phrs.2025.108031_bib211","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105314","article-title":"The impact of the microbiota-gut-brain axis on Alzheimer's disease pathophysiology","volume":"164","author":"Doifode","year":"2021","journal-title":"Pharm. Res"},{"key":"10.1016\/j.phrs.2025.108031_bib212","first-page":"S21","article-title":"The role of diet in Parkinson's disease","volume":"14","author":"Tosefsky","year":"2024","journal-title":"J. Park. Dis."},{"key":"10.1016\/j.phrs.2025.108031_bib213","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2271613","article-title":"Gut microbiome-targeted therapies for Alzheimer's disease","volume":"15","author":"Zhang","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phrs.2025.108031_bib214","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40035-024-00404-1","article-title":"Therapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedside","volume":"13","author":"Ma","year":"2024","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.phrs.2025.108031_bib215","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2274126","article-title":"Targeting gut microbiota: new therapeutic opportunities in multiple sclerosis","volume":"15","author":"Kujawa","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phrs.2025.108031_bib216","article-title":"The gut microbiota-brain axis in neurological disorders","volume":"5","author":"You","year":"2024","journal-title":"MedComm (2020)"},{"key":"10.1016\/j.phrs.2025.108031_bib217","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70593","article-title":"The microbiota-gut-brain connection: a new horizon in neurological and neuropsychiatric disorders","volume":"31","author":"Faysal","year":"2025","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.phrs.2025.108031_bib218","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1126\/science.abo4220","article-title":"Modulating brain function with microbiota","volume":"376","author":"Foster","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.phrs.2025.108031_bib219","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/s41586-022-05525-z","article-title":"A microbiome-dependent gut-brain pathway regulates motivation for exercise","volume":"612","author":"Dohnalov\u00e1","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2025.108031_bib220","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/s41467-023-36497-x","article-title":"An open label, non-randomized study assessing a prebiotic fiber intervention in a small cohort of Parkinson's disease participants","volume":"14","author":"Hall","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2025.108031_bib221","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.81453","article-title":"A prebiotic diet modulates microglial states and motor deficits in \u03b1-synuclein overexpressing mice","volume":"11","author":"Abdel-Haq","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.phrs.2025.108031_bib222","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bbi.2018.02.005","article-title":"Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson's disease mice: gut microbiota, glial reaction and TLR4\/TNF-\u03b1 signaling pathway","volume":"70","author":"Sun","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.phrs.2025.108031_bib223","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1016\/j.apsb.2021.03.020","article-title":"Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4\/MyD88\/NF-\u03baB pathway through microbiota-gut-brain axis","volume":"11","author":"Zhao","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phrs.2025.108031_bib224","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.bbi.2023.12.023","article-title":"Dietary fibre confers therapeutic effects in a preclinical model of Huntington's disease","volume":"116","author":"Gubert","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.phrs.2025.108031_bib225","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114308","article-title":"Butyrate ameliorates chronic alcoholic central nervous damage by suppressing microglia-mediated neuroinflammation and modulating the microbiome-gut-brain axis","volume":"160","author":"Wei","year":"2023","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.phrs.2025.108031_bib226","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/s43587-023-00516-9","article-title":"Chiral nanoparticle-remodeled gut microbiota alleviates neurodegeneration via the gut-brain axis","volume":"3","author":"Guo","year":"2023","journal-title":"Nat. Aging"},{"key":"10.1016\/j.phrs.2025.108031_bib227","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1987779","article-title":"Depression and anxiety in patients with active ulcerative colitis: crosstalk of gut microbiota, metabolomics and proteomics","volume":"13","author":"Yuan","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phrs.2025.108031_bib228","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1016\/j.clnu.2022.09.012","article-title":"The gut microbiome, mild cognitive impairment, and probiotics: a randomized clinical trial in middle-aged and older adults","volume":"41","author":"Aljumaah","year":"2022","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.phrs.2025.108031_bib229","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.bbi.2023.11.016","article-title":"Probiotic Clostridium butyricum ameliorates cognitive impairment in obesity via the microbiota-gut-brain axis","volume":"115","author":"Zheng","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.phrs.2025.108031_bib230","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.bbi.2020.10.014","article-title":"Probiotic Clostridium butyricum ameliorated motor deficits in a mouse model of Parkinson's disease via gut microbiota-GLP-1 pathway","volume":"91","author":"Sun","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.phrs.2025.108031_bib231","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.cmet.2024.03.010","article-title":"Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity","volume":"36","author":"Zhao","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.phrs.2025.108031_bib232","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1136\/gutjnl-2018-317431","article-title":"Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer's disease animal model","volume":"69","author":"Kim","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.phrs.2025.108031_bib233","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41586-022-05637-6","article-title":"Insulin-regulated serine and lipid metabolism drive peripheral neuropathy","volume":"614","author":"Handzlik","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2025.108031_bib234","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.cell.2018.04.027","article-title":"The gut microbiota mediates the anti-seizure effects of the ketogenic diet","volume":"173","author":"Olson","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2025.108031_bib235","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/alz.12206","article-title":"A ketogenic drink improves cognition in mild cognitive impairment: results of a 6-month RCT","volume":"17","author":"Fortier","year":"2021","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.phrs.2025.108031_bib236","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.cell.2018.09.004","article-title":"Dysregulated microbial fermentation of soluble fiber induces cholestatic liver cancer","volume":"175","author":"Singh","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2025.108031_bib237","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s40168-022-01255-6","article-title":"The microbiota-gut-brain axis participates in chronic cerebral hypoperfusion by disrupting the metabolism of short-chain fatty acids","volume":"10","author":"Xiao","year":"2022","journal-title":"Microbiome"},{"key":"10.1016\/j.phrs.2025.108031_bib238","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/s41586-023-06409-6","article-title":"Lactate limits CNS autoimmunity by stabilizing HIF-1\u03b1 in dendritic cells","volume":"620","author":"Sanmarco","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2025.108031_bib239","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1016\/j.neuron.2023.06.013","article-title":"2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer's resilience","volume":"111","author":"Kumar","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2025.108031_bib240","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.114195","article-title":"The effect of probiotics on immune responses and their therapeutic application: A new treatment option for multiple sclerosis","volume":"159","author":"Hashemi","year":"2023","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.phrs.2025.108031_bib241","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1007\/s11427-023-2346-1","article-title":"Gut microbiota bridges dietary nutrients and host immunity","volume":"66","author":"Fan","year":"2023","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.phrs.2025.108031_bib242","doi-asserted-by":"crossref","DOI":"10.3390\/genes12081181","article-title":"Host genetics and gut microbiome: perspectives for multiple sclerosis","volume":"12","author":"Maglione","year":"2021","journal-title":"Genes"},{"key":"10.1016\/j.phrs.2025.108031_bib243","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1007\/s12264-021-00715-7","article-title":"Simultaneous 3D visualization of the microvascular and neural network in mouse spinal cord using synchrotron radiation micro-computed tomography","volume":"37","author":"Jiang","year":"2021","journal-title":"Neurosci. Bull."},{"issue":"1","key":"10.1016\/j.phrs.2025.108031_bib244","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-016-0779-0","article-title":"Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease","volume":"14","author":"Moussa","year":"2017","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.phrs.2025.108031_bib245","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2216932120","article-title":"Dietary flavanols restore hippocampal-dependent memory in older adults with lower diet quality and lower habitual flavanol consumption","volume":"120","author":"Brickman","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.phrs.2025.108031_bib246","doi-asserted-by":"crossref","first-page":"874","DOI":"10.2174\/1871530319666190212170140","article-title":"The neuromodulatory effects of \u03c9-3 fatty acids and nano-curcumin on the COX-2\/ iNOS network in migraines: a clinical trial study from gene expression to clinical symptoms","volume":"19","author":"Abdolahi","year":"2019","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"10.1016\/j.phrs.2025.108031_bib247","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.1002\/ptr.7179","article-title":"Effects of curcuminoids on inflammatory and oxidative stress biomarkers and clinical outcomes in critically ill patients: a randomized double-blind placebo-controlled trial","volume":"35","author":"Zahedi","year":"2021","journal-title":"Phytother. Res"},{"key":"10.1016\/j.phrs.2025.108031_bib248","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3390\/nu8030150","article-title":"Clinical evaluation of effects of chronic resveratrol supplementation on cerebrovascular function, cognition, mood, physical function and general well-being in postmenopausal women-rationale and study design","volume":"8","author":"Evans","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.phrs.2025.108031_bib249","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s13195-022-01097-2","article-title":"Genistein effect on cognition in prodromal Alzheimer's disease patients. The GENIAL clinical trial","volume":"14","author":"Vi\u00f1a","year":"2022","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.phrs.2025.108031_bib250","first-page":"3877","article-title":"Aterofisiol(\u00ae) in carotid plaque evolution","author":"Amato","year":"2015","journal-title":"Drug Des. Devel Ther. 9"},{"key":"10.1016\/j.phrs.2025.108031_bib251","doi-asserted-by":"crossref","DOI":"10.3390\/nu10030329","article-title":"Resveratrol in patients with minimal hepatic encephalopathy","volume":"10","author":"Malaguarnera","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.phrs.2025.108031_bib252","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jns.2016.05.056","article-title":"Biochemical and clinical effects of Whey protein supplementation in Parkinson's disease: a pilot study","volume":"367","author":"Tosukhowong","year":"2016","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.phrs.2025.108031_bib253","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s12028-010-9461-z","article-title":"Metabolic and clinical effects of the supplementation of a functional mixture of amino acids in cerebral hemorrhage","volume":"14","author":"Laviano","year":"2011","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.phrs.2025.108031_bib254","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1161\/STROKEAHA.114.008022","article-title":"Dietary cysteine and other amino acids and stroke incidence in women","volume":"46","author":"Larsson","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.phrs.2025.108031_bib255","first-page":"189","article-title":"Alpha-lipoic acid as a new treatment option for Alzheimer's disease--a 48 months follow-up analysis","author":"Hager","year":"2007","journal-title":"J. Neural Transm. Suppl."},{"key":"10.1016\/j.phrs.2025.108031_bib256","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1136\/jnnp-2012-304792","article-title":"Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial","volume":"84","author":"Mart\u00ednez-Lapiscina","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.phrs.2025.108031_bib257","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1001\/jamapediatrics.2020.2282","article-title":"Efficacy of ketogenic diet, modified Atkins diet, and low glycemic index therapy diet among children with drug-resistant epilepsy: a randomized clinical trial","volume":"174","author":"Sondhi","year":"2020","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.phrs.2025.108031_bib258","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3233\/JAD-2011-110080","article-title":"Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression","volume":"26","author":"Govindarajan","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.phrs.2025.108031_bib259","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s40168-021-01107-9","article-title":"Fecal microbiota transplantation protects rotenone-induced Parkinson's disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis","volume":"9","author":"Zhao","year":"2021","journal-title":"Microbiome"},{"key":"10.1016\/j.phrs.2025.108031_bib260","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s13311-019-00719-2","article-title":"Neuroprotection of fasting mimicking diet on MPTP-induced Parkinson's disease mice via gut microbiota and metabolites","volume":"16","author":"Zhou","year":"2019","journal-title":"Neurotherapeutics"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661825004566?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661825004566?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:40:58Z","timestamp":1773322858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661825004566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":260,"alternative-id":["S1043661825004566"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2025.108031","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diet, gut-brain axis, and metabolism-epigenome-immunity networks: A triad in neurological disease management","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2025.108031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108031"}}