{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T22:40:44Z","timestamp":1776292844507,"version":"3.50.1"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016934","name":"Troms\u00f8 Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016934","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.phrs.2025.108065","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T16:21:24Z","timestamp":1765556484000},"page":"108065","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Rapid 64Cu radiolabeling and in vivo evaluation of DSPE\u2013NODAGA liposomes in a murine mammary tumor model"],"prefix":"10.1016","volume":"223","author":[{"given":"Elena","family":"Markova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Kranz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"Karlsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Wolowczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Moldes-Anaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nata\u0161a","family":"\u0160kalko-Basnet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rune","family":"Sundset","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandros Marios","family":"Sofias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Berzaghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Martin-Armas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sjoerd","family":"Hak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2025.108065_bib1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.addr.2012.09.037","article-title":"Liposomal drug delivery systems: from concept to clinical applications","volume":"65","author":"Allen","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.phrs.2025.108065_bib2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jconrel.2012.03.020","article-title":"Doxil\u00ae \u2014 The first FDA-approved nano-drug: lessons learned","volume":"160","author":"Barenholz","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.phrs.2025.108065_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2015.00286","article-title":"Advances and challenges of liposome assisted drug delivery","volume":"6","author":"Sercombe","year":"2015","journal-title":"Front Pharm."},{"key":"10.1016\/j.phrs.2025.108065_bib4","doi-asserted-by":"crossref","first-page":"22796","DOI":"10.1021\/acsami.5b04612","article-title":"Remote loading of 64Cu2+ into liposomes without the use of ion transport enhancers","volume":"7","author":"Henriksen","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.phrs.2025.108065_bib5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2967\/jnumed.114.150318","article-title":"Combined PET\/MR: a technology becomes mature","volume":"56","author":"Wehrl","year":"2015","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.phrs.2025.108065_bib6","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3390\/jcm9010089","article-title":"Radiolabeled PET\/MRI nanoparticles for tumor imaging","volume":"9","author":"Forte","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.phrs.2025.108065_bib7","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/028418600430789","article-title":"High intratumoral accumulation of stealth Liposomal Doxorubicin in sarcomas: rationale for combination with radiotherapy","volume":"39","author":"Koukourakis","year":"2000","journal-title":"Acta Oncol."},{"key":"10.1016\/j.phrs.2025.108065_bib8","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1158\/1078-0432.CCR-16-3193","article-title":"64Cu-MM-302 positron emission tomography quantifies variability of enhanced permeability and retention of nanoparticles in relation to treatment response in patients with metastatic breast cancer","volume":"23","author":"Lee","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.phrs.2025.108065_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202201043","article-title":"PET-CT imaging of polymeric nanoparticle tumor accumulation in patients","volume":"34","author":"Miedema","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.phrs.2025.108065_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11838","article-title":"Nanoreporter PET predicts the efficacy of anti-cancer nanotherapy","volume":"7","author":"P\u00e9rez-Medina","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2025.108065_bib11","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s11307-018-1255-2","article-title":"Imaging nanomedicine-based drug delivery: a review of clinical studies","volume":"20","author":"Man","year":"2018","journal-title":"Mol. Imaging Biol."},{"key":"10.1016\/j.phrs.2025.108065_bib12","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jconrel.2014.03.057","article-title":"EPR: Evidence and fallacy","volume":"190","author":"Nichols","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.phrs.2025.108065_bib13","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/s44222-024-00203-3","article-title":"Nanoparticle delivery to tumours: from EPR and ATR mechanisms to clinical impact","volume":"2","author":"Dasgupta","year":"2024","journal-title":"Nat. Rev. Bioeng."},{"key":"10.1016\/j.phrs.2025.108065_bib14","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s44222-024-00154-9","article-title":"The mechanisms of nanoparticle delivery to solid tumours","volume":"2","author":"Nguyen","year":"2024","journal-title":"Nat. Rev. Bioeng."},{"key":"10.1016\/j.phrs.2025.108065_bib15","doi-asserted-by":"crossref","first-page":"7832","DOI":"10.1021\/acsnano.9b08693","article-title":"Tumor Targeting by \u03b1v\u03b23-integrin-specific lipid nanoparticles occurs via phagocyte hitchhiking","volume":"14","author":"Sofias","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.phrs.2025.108065_bib16","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s41563-019-0566-2","article-title":"The entry of nanoparticles into solid tumours","volume":"19","author":"Sindhwani","year":"2020","journal-title":"Nat. Mater."},{"key":"10.1016\/j.phrs.2025.108065_bib17","doi-asserted-by":"crossref","first-page":"6080","DOI":"10.1021\/acsnano.1c11578","article-title":"Macrophages actively transport nanoparticles in tumors after extravasation","volume":"16","author":"Lin","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.phrs.2025.108065_bib18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0378-5173(02)00703-2","article-title":"Circulation and biodistribution profiles of long-circulating PEG-liposomes of various sizes in rabbits","volume":"253","author":"Awasthi","year":"2003","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.phrs.2025.108065_bib19","doi-asserted-by":"crossref","first-page":"419","DOI":"10.2165\/00003088-200342050-00002","article-title":"Pharmacokinetics of pegylated liposomal doxorubicin","volume":"42","author":"Gabizon","year":"2003","journal-title":"Clin. Pharm."},{"key":"10.1016\/j.phrs.2025.108065_bib20","doi-asserted-by":"crossref","first-page":"4893","DOI":"10.1039\/b705989b","article-title":"Cu-ATSM: a radiopharmaceutical for the PET imaging of hypoxia","author":"V\u0101vere","year":"2007","journal-title":"Dalton Trans."},{"key":"10.1016\/j.phrs.2025.108065_bib21","unstructured":"J.P. Holland, J.S. Lewis, F. DehdashtiAssessing tumor hypoxia by positron emission tomography with Cu-ATSM., The Quarterly Journal of Nuclear Medicine and Molecular Imaging: Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society Of\u2026 53 (2009) 193\u20132002009, 193200."},{"key":"10.1016\/j.phrs.2025.108065_bib22","doi-asserted-by":"crossref","DOI":"10.1186\/s13550-019-0586-6","article-title":"64Cu-ATSM\/64Cu-Cl2 and their relationship to hypoxia in glioblastoma: a preclinical study","volume":"9","author":"P\u00e9r\u00e8s","year":"2019","journal-title":"EJNMMI Res"},{"key":"10.1016\/j.phrs.2025.108065_bib23","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13550-020-00621-5","article-title":"Hypoxia imaging and theranostic potential of [64Cu][Cu(ATSM)] and ionic Cu(II) salts: a review of current evidence and discussion of the retention mechanisms","volume":"10","author":"Liu","year":"2020","journal-title":"EJNMMI Res."},{"key":"10.1016\/j.phrs.2025.108065_bib24","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1021\/acs.inorgchem.7b02929","article-title":"NOTA complexes with Copper(II) and divalent metal ions: kinetic and thermodynamic studies","volume":"57","author":"Kub\u00ed\u010dek","year":"2018","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.phrs.2025.108065_bib25","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.nucmedbio.2014.09.009","article-title":"Comparison of DOTA and NODAGA as chelators for 64Cu-labeled immunoconjugates","volume":"42","author":"Ghosh","year":"2015","journal-title":"Nucl. Med Biol."},{"key":"10.1016\/j.phrs.2025.108065_bib26","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.2967\/jnumed.111.087999","article-title":"PET of Somatostatin Receptor\u2013Positive Tumors Using 64 Cu- and 68 Ga-Somatostatin Antagonists: The Chelate Makes the Difference","volume":"52","author":"Fani","year":"2011","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.phrs.2025.108065_bib27","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.jconrel.2020.09.018","article-title":"Quantitative determination of 64Cu-liposome accumulation at inflammatory and infectious sites: Potential for future theranostic system","volume":"327","author":"Clausen","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.phrs.2025.108065_bib28","doi-asserted-by":"crossref","first-page":"6985","DOI":"10.1021\/acsnano.5b01324","article-title":"Positron Emission Tomography Based Elucidation of the Enhanced Permeability and Retention Effect in Dogs with Cancer Using Copper-64 Liposomes","volume":"9","author":"Hansen","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.phrs.2025.108065_bib29","doi-asserted-by":"crossref","first-page":"12482","DOI":"10.1021\/acsnano.7b06578","article-title":"Intrabilayer 64Cu Labeling of Photoactivatable, Doxorubicin-Loaded Stealth Liposomes","volume":"11","author":"Luo","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.phrs.2025.108065_bib30","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jconrel.2017.11.006","article-title":"Remote-loading of liposomes with manganese-52 and in vivo evaluation of the stabilities of 52Mn-DOTA and 64Cu-DOTA using radiolabelled liposomes and PET imaging","volume":"269","author":"Jensen","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.phrs.2025.108065_bib31","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1021\/bc8002937","article-title":"A novel method to label preformed liposomes with Cu-64 for Positron Emission Tomography (PET) imaging","volume":"19","author":"Seo","year":"2008","journal-title":"Bioconjug Chem."},{"key":"10.1016\/j.phrs.2025.108065_bib32","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1021\/bc100018n","article-title":"Liposomal Cu-64 labeling method using bifunctional chelators: Poly(ethylene glycol) spacer and chelator effects","volume":"21","author":"Seo","year":"2010","journal-title":"Bioconjug Chem."},{"key":"10.1016\/j.phrs.2025.108065_bib33","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.nucmedbio.2016.08.011","article-title":"Copper-64 labeled liposomes for imaging bone marrow","volume":"43","author":"Lee","year":"2016","journal-title":"Nucl. Med Biol."},{"key":"10.1016\/j.phrs.2025.108065_bib34","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s00280-012-2042-4","article-title":"Marqibo\u00ae (vincristine sulfate liposome injection) improves the pharmacokinetics and pharmacodynamics of vincristine","volume":"71","author":"Silverman","year":"2013","journal-title":"Cancer Chemother. Pharm."},{"key":"10.1016\/j.phrs.2025.108065_bib35","unstructured":"International Atomic Energy Agency, Copper-64 Radiopharmaceuticals: Production, Quality Control and Clinical Applications, 2022. \u3008www.iaea.org\/Publications\/index.html\u3009."},{"key":"10.1016\/j.phrs.2025.108065_bib36","doi-asserted-by":"crossref","unstructured":"W.T. Phillips, Delivery of gamma-imaging agents by liposomes, 1999.","DOI":"10.1016\/S0169-409X(98)00108-2"},{"key":"10.1016\/j.phrs.2025.108065_bib37","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1016\/j.biomaterials.2010.11.059","article-title":"64Cu loaded liposomes as positron emission tomography imaging agents","volume":"32","author":"Petersen","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.phrs.2025.108065_bib38","doi-asserted-by":"crossref","first-page":"128","DOI":"10.2967\/jnumed.113.119917","article-title":"A comparison of the behavior of (64)Cu-acetate and (64)Cu-ATSM in vitro and in vivo","volume":"55","author":"Hueting","year":"2014","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.phrs.2025.108065_bib39","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.nucmedbio.2009.11.004","article-title":"Some thoughts on the mechanism of cellular trapping of Cu(II)-ATSM","volume":"37","author":"Dearling","year":"2010","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.phrs.2025.108065_bib40","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cpet.2009.05.009","article-title":"Positron emission tomography imaging of hypoxia","volume":"4","author":"Lapi","year":"2009","journal-title":"PET Clin."},{"key":"10.1016\/j.phrs.2025.108065_bib41","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1053\/j.semnuclmed.2014.10.003","article-title":"Evaluation of hypoxia with copper-labeled diacetyl-bis(N-methylthiosemicarbazone)","volume":"45","author":"Lapi","year":"2015","journal-title":"Semin Nucl. Med."},{"key":"10.1016\/j.phrs.2025.108065_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2016.01.020","article-title":"Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SODG93A mice co-expressing the Copper-Chaperone-for-SOD","volume":"89","author":"Williams","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.phrs.2025.108065_bib43","doi-asserted-by":"crossref","first-page":"12278","DOI":"10.1021\/acsomega.9b01748","article-title":"Does the ATSM-Cu(II) Biomarker Integrate into the Human Cellular Copper Cycle?","volume":"4","author":"Walke","year":"2019","journal-title":"ACS Omega"},{"key":"10.1016\/j.phrs.2025.108065_bib44","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.tranon.2019.05.017","article-title":"Preclinical Pharmacokinetic and Safety Studies of Copper-Diacetyl-Bis(N4-Methylthiosemicarbazone) (Cu-ATSM): Translational Studies for Internal Radiotherapy","volume":"12","author":"Matsumoto","year":"2019","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.phrs.2025.108065_bib45","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s11307-020-01537-1","article-title":"Development and Preclinical Evaluation of 99mTc- and 186Re-Labeled NOTA and NODAGA Bioconjugates Demonstrating Matched Pair Targeting of GRPR-Expressing Tumors","volume":"23","author":"Makris","year":"2021","journal-title":"Mol. Imaging Biol."},{"key":"10.1016\/j.phrs.2025.108065_bib46","doi-asserted-by":"crossref","first-page":"3930","DOI":"10.1021\/mp500283k","article-title":"PET and SPECT Imaging of a Radiolabeled Minigastrin Analogue Conjugated with DOTA, NOTA, and NODAGA and Labeled with 64 Cu, 68 Ga, and 111 In","volume":"11","author":"Roosenburg","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.phrs.2025.108065_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/8565802","article-title":"Comparative evaluation of Anti-HER2 affibody molecules labeled with 64 Cu Using NOTA and NODAGA","volume":"2017","author":"Tolmachev","year":"2017","journal-title":"Contrast Media Mol. Imaging"},{"key":"10.1016\/j.phrs.2025.108065_bib48","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1021\/acs.molpharmaceut.6b00794","article-title":"Liposomes for PET and MR imaging and for dual targeting (magnetic field\/glucose moiety): synthesis, properties, and in vivo studies","volume":"14","author":"Malinge","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.phrs.2025.108065_bib49","doi-asserted-by":"crossref","first-page":"10958","DOI":"10.1021\/acsomega.3c10346","article-title":"Long-term stable liposome modified by PEG-lipid in natural seawater","volume":"9","author":"Izumi","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.phrs.2025.108065_bib50","doi-asserted-by":"crossref","first-page":"7788","DOI":"10.1021\/la200003n","article-title":"Study of PEGylated lipid layers as a model for PEGylated LIposome Surfaces: Molecular Dynamics Simulation and Langmuir Monolayer Studies","volume":"27","author":"Stepniewski","year":"2011","journal-title":"Langmuir"},{"key":"10.1016\/j.phrs.2025.108065_bib51","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.addr.2019.05.012","article-title":"Nuclear imaging of liposomal drug delivery systems: a critical review of radiolabelling methods and applications in nanomedicine","volume":"143","author":"Man","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.phrs.2025.108065_bib52","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.carres.2018.06.008","article-title":"Synthesis of cholesterol-based neoglycoconjugates and their use in the preparation of liposomes for active liver targeting","volume":"465","author":"Silva","year":"2018","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.phrs.2025.108065_bib53","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ijpharm.2007.05.024","article-title":"Doubly radiolabeled liposomes for pretargeted radioimmunotherapy","volume":"344","author":"Mougin-Degraef","year":"2007","journal-title":"Int J. Pharm."},{"key":"10.1016\/j.phrs.2025.108065_bib54","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1021\/mp800049w","article-title":"Pharmacokinetics and Biodistribution of Nanoparticles","volume":"5","author":"Li","year":"2008","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.phrs.2025.108065_bib55","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0360-3016(01)01508-5","article-title":"The effect of irradiation on the biodistribution of radiolabeled pegylated liposomes","volume":"50","author":"Harrington","year":"2001","journal-title":"Int. J. Radiat. Oncol. *Biol. *Phys."},{"key":"10.1016\/j.phrs.2025.108065_bib56","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jconrel.2010.02.021","article-title":"Gemcitabine-loaded PEGylated unilamellar liposomes vs GEMZAR\u00ae: Biodistribution, pharmacokinetic features and in vivo antitumor activity","volume":"144","author":"Paolino","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.phrs.2025.108065_bib57","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0969-8051(97)00169-8","article-title":"Biodistribution of [64Cu]Cu2 and Variance of Metallothionein during Tumor Treatment by Copper","volume":"25","author":"Yu","year":"1998","journal-title":"Nucl. Med Biol."},{"key":"10.1016\/j.phrs.2025.108065_bib58","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13550-017-0346-4","article-title":"Biodistribution and radiation dosimetry of [64Cu]copper dichloride: first-in-human study in healthy volunteers","volume":"7","author":"Avila-Rodriguez","year":"2017","journal-title":"EJNMMI Res"},{"key":"10.1016\/j.phrs.2025.108065_bib59","doi-asserted-by":"crossref","first-page":"4869","DOI":"10.3390\/molecules27154869","article-title":"64CuCl2 PET Imaging of 4T1-Related Allograft of Triple-Negative Breast Cancer in Mice","volume":"27","author":"Latg\u00e9","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.phrs.2025.108065_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1203\/00006450-199307000-00001","article-title":"Targeting zinc protoporphyrin liposomes to the spleen using reticuloendothelial blockade with blank liposomes","volume":"34","author":"Hamori","year":"1993","journal-title":"Pedia Res"},{"key":"10.1016\/j.phrs.2025.108065_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/379807","article-title":"64Cu-NODAGA-c(RGDyK) is a promising new angiogenesis PET tracer: correlation between tumor uptake and integrin expression in human neuroendocrine tumor xenografts","volume":"2012","author":"Oxboel","year":"2012","journal-title":"Int J. Mol. Imaging"},{"key":"10.1016\/j.phrs.2025.108065_bib62","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jconrel.2011.12.038","article-title":"Positron emission tomography evaluation of somatostatin receptor targeted 64Cu-TATE-liposomes in a human neuroendocrine carcinoma mouse model","volume":"160","author":"Petersen","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.phrs.2025.108065_bib63","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.nucmedbio.2013.08.003","article-title":"64Cu-Labeled tetraiodothyroacetic acid-conjugated liposomes for PET imaging of tumor angiogenesis","volume":"40","author":"Kang","year":"2013","journal-title":"Nucl. Med Biol."},{"key":"10.1016\/j.phrs.2025.108065_bib64","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1158\/1078-0432.CCR-16-3193","article-title":"64Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer","volume":"23","author":"Lee","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.phrs.2025.108065_bib65","doi-asserted-by":"crossref","first-page":"14080","DOI":"10.1021\/acsnano.1c04510","article-title":"Specific Endothelial Cells Govern Nanoparticle Entry into Solid Tumors","volume":"15","author":"Kingston","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.phrs.2025.108065_bib66","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/s41563-023-01630-0","article-title":"The exit of nanoparticles from solid tumours","volume":"22","author":"Nguyen","year":"2023","journal-title":"Nat. Mater."},{"key":"10.1016\/j.phrs.2025.108065_bib67","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1021\/acsbiomaterials.3c00510","article-title":"Engineered Liposomes in Interventional Theranostics of Solid Tumors","volume":"9","author":"Kommineni","year":"2023","journal-title":"ACS Biomater. Sci. Eng."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661825004906?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661825004906?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T10:14:50Z","timestamp":1768385690000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661825004906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":67,"alternative-id":["S1043661825004906"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2025.108065","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rapid 64Cu radiolabeling and in vivo evaluation of DSPE\u2013NODAGA liposomes in a murine mammary tumor model","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2025.108065","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108065"}}