{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:34:04Z","timestamp":1792427644434,"version":"4.5.0"},"reference-count":129,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2025ZD1801400"],"award-info":[{"award-number":["2025ZD1801400"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374476"],"award-info":[{"award-number":["82374476"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474540"],"award-info":[{"award-number":["82474540"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC3507401"],"award-info":[{"award-number":["2024YFC3507401"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.phrs.2025.108074","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T05:02:08Z","timestamp":1766120528000},"page":"108074","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Multi-target neuroprotective effects of notoginsenoside R1 in neurodegenerative diseases: From pharmacokinetics to translational prospects"],"prefix":"10.1016","volume":"224","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6060-7036","authenticated-orcid":false,"given":"Hao-wen","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-pian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-xin","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-xuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi-meng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-jun","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2025.108074_bib1","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1016\/S0140-6736(24)00642-1","article-title":"Stroke","volume":"403","author":"Hilkens","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2025.108074_bib2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/ene.13439","article-title":"Alzheimer\u2019s disease","volume":"25","author":"Lane","year":"2018","journal-title":"Eur. J. Neurol."},{"issue":"8","key":"10.1016\/j.phrs.2025.108074_bib3","first-page":"e475","article-title":"Biomarkers of neurodegeneration across the Global South","volume":"5","author":"McGlinchey","year":"2024","journal-title":"Lancet Healthy Longev."},{"key":"10.1016\/j.phrs.2025.108074_bib4","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S1474-4422(24)00038-3","article-title":"Global, regional, and national burden of disorders affecting the nervous system, 1990\u20132021: a systematic analysis for the Global Burden of Disease Study 2021","volume":"23","author":"GBD 2021 Nervous System Disorders Collaborators","year":"2024","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phrs.2025.108074_bib5","doi-asserted-by":"crossref","DOI":"10.7189\/jogh.13.04160","article-title":"Global, regional, and national burden of neurological disorders in 204 countries and territories worldwide","volume":"13","author":"Huang","year":"2023","journal-title":"J. Glob. Health"},{"key":"10.1016\/j.phrs.2025.108074_bib6","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.3390\/ijms25073995","article-title":"Neuroinflammation in neurodegenerative disorders: current knowledge and therapeutic implications","volume":"25","author":"Giri","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2025.108074_bib7","doi-asserted-by":"crossref","first-page":"6518","DOI":"10.3390\/ijms24076518","article-title":"Inflammatory processes in Alzheimer\u2019s disease\u2014pathomechanism, diagnosis and treatment: a review","volume":"24","author":"Twarowski","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2025.108074_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2024.1415905","article-title":"Enduring effects of psychotherapy, antidepressants and their combination for depression: a systematic review and meta-analysis","volume":"15","author":"Voderholzer","year":"2024","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.phrs.2025.108074_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2024.108751","article-title":"The potential therapeutic strategy in combating neurodegenerative diseases: focusing on natural products","volume":"264","author":"Gao","year":"2024","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phrs.2025.108074_bib10","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1142\/S0192415X25500090","article-title":"Pharmacokinetics and biological activities of notoginsenoside R1: a systematical review","volume":"53","author":"Wen","year":"2025","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.phrs.2025.108074_bib11","article-title":"Mechanisms with network pharmacology approach of ginsenosides in Alzheimer\u2019s disease","volume":"10","author":"He","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.phrs.2025.108074_bib12","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1002\/iub.2862","article-title":"Neuroprotection and mechanisms of ginsenosides in nervous system diseases: progress and perspectives","volume":"76","author":"Zhou","year":"2024","journal-title":"IUBMB Life"},{"key":"10.1016\/j.phrs.2025.108074_bib13","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1038\/s41467-024-48734-y","article-title":"Lipidome atlas of the adult human brain","volume":"15","author":"Osetrova","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2025.108074_bib14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cjtee.2022.06.008","article-title":"Pharmacological properties and mechanisms of notoginsenoside R1 in ischemia\u2013reperfusion injury","volume":"26","author":"Zhu","year":"2023","journal-title":"Chin. J. Trauma."},{"key":"10.1016\/j.phrs.2025.108074_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111693","article-title":"Notoginsenoside R1 activates the NAMPT\u2013NAD+\u2013SIRT1 cascade to promote postischemic angiogenesis by modulating Notch signaling","volume":"140","author":"Zhu","year":"2021","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.phrs.2025.108074_bib16","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1002\/ptr.7450","article-title":"Notoginsenoside R1 ameliorates mitochondrial dysfunction to circumvent neuronal energy failure in acute phase of focal cerebral ischemia","volume":"36","author":"Liu","year":"2022","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phrs.2025.108074_bib17","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1248\/bpb.30.847","article-title":"Pharmacokinetic and absolute bioavailability study of total Panax notoginsenoside","volume":"30","author":"Li","year":"2007","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.phrs.2025.108074_bib18","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.2147\/IJN.S72555","article-title":"Enhanced local bioavailability of single or compound drugs to the inner ear via PLGA nanoparticles through round window administration","author":"Cai","year":"2014","journal-title":"Int. J. Nanomed. 9"},{"key":"10.1016\/j.phrs.2025.108074_bib19","doi-asserted-by":"crossref","first-page":"551","DOI":"10.2147\/DDDT.S240511","article-title":"Focus on notoginsenoside R1 in metabolism and prevention against human diseases","volume":"14","author":"Liu","year":"2020","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.phrs.2025.108074_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154261","article-title":"Global analysis of qualitative and quantitative metabolism of notoginsenoside R1 in rat liver-brain-gut axis based on LC-IT-TOF\/MS combining MMDF strategy","volume":"104","author":"Hu","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phrs.2025.108074_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.4670","article-title":"Dose-dependent exposure profile and metabolic characterization of notoginsenoside R1 in rat plasma by UPLC-ESI-MS\/MS","volume":"33","author":"Zhang","year":"2019","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.phrs.2025.108074_bib22","article-title":"The penetration of therapeutics across the blood\u2013brain barrier: classic case studies and clinical implications","volume":"5","author":"Banks","year":"2024","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.phrs.2025.108074_bib23","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1021\/acsnano.3c10674","article-title":"Functionalized nanomaterials capable of crossing the blood\u2013brain barrier","volume":"18","author":"Zha","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.phrs.2025.108074_bib24","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jchromb.2014.08.034","article-title":"Brain distribution pharmacokinetics and integrated pharmacokinetics of notoginsenoside R1, ginsenosides Rg1, Rb1, Re and Rd in rats after intranasal administration of Panax notoginseng saponins assessed by UPLC\/MS\/MS","volume":"969","author":"Guo","year":"2014","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.phrs.2025.108074_bib25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jep.2014.08.041","article-title":"In vivo distribution and pharmacokinetics of multiple active components from Danshen and Sanqi and their combination via inner ear administration","volume":"156","author":"Long","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phrs.2025.108074_bib26","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.ijpharm.2018.10.005","article-title":"Improved oral bioavailability of notoginsenoside R1 with sodium glycocholate-mediated liposomes prepared by supercritical fluid technology: in vitro and in vivo evaluation","volume":"552","author":"Fan","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.phrs.2025.108074_bib27","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/706723","article-title":"Effects of borneol on pharmacokinetics and tissue distribution of notoginsenoside R1 and ginsenosides Rg1 and Re from Panax notoginseng in rabbits","volume":"2013","author":"Wang","year":"2013","journal-title":"J. Anal. Methods Chem."},{"key":"10.1016\/j.phrs.2025.108074_bib28","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.intimp.2014.06.018","article-title":"Notoginsenoside R1 attenuates amyloid-\u03b2-induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation","volume":"22","author":"Ma","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phrs.2025.108074_bib29","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3892\/mmr.2023.13139","article-title":"Notoginsenoside R1 ameliorates the inflammation induced by amyloid-\u03b2 by suppressing SPHK1-mediated NF-\u03baB activation in PC12 cells","volume":"29","author":"Wang","year":"2024","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phrs.2025.108074_bib30","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3389\/fncel.2020.00280","article-title":"Notoginsenoside R1-induced neuronal repair in models of Alzheimer disease is associated with an alteration in neuronal hyperexcitability regulated by NaV channels","volume":"14","author":"Hu","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.phrs.2025.108074_bib31","doi-asserted-by":"crossref","first-page":"823","DOI":"10.3109\/10715762.2014.911853","article-title":"Suppression of NADPH oxidase- and mitochondrion-derived superoxide by notoginsenoside R1 protects against cerebral ischemia\u2013reperfusion injury through estrogen receptor-dependent activation of Akt\/Nrf2 pathways","volume":"48","author":"Meng","year":"2014","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.phrs.2025.108074_bib32","first-page":"3691","article-title":"Protective effects of notoginsenoside R1 on cerebral ischemia\u2013reperfusion injury in rats","volume":"14","author":"Zou","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.phrs.2025.108074_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110470","article-title":"Anti-ischemia\/reperfusion injury effects of notoginsenoside R1 on small-molecule metabolism in rat brain after ischemic stroke visualized by MALDI-MS imaging","volume":"129","author":"Zhu","year":"2020","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.phrs.2025.108074_bib34","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1515\/med-2022-0461","article-title":"Notoginsenoside R1 alleviates spinal cord injury through the miR-301a\/KLF7 axis to activate Wnt\/\u03b2-catenin pathway","volume":"17","author":"Tang","year":"2022","journal-title":"Open Med"},{"key":"10.1016\/j.phrs.2025.108074_bib35","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/WNR.0000000000001803","article-title":"Notoginsenoside R1 alleviates spinal cord injury by inhibiting oxidative stress, neuronal apoptosis, and inflammation via activating the Nrf2\/HO-1 signaling pathway","volume":"33","author":"Luo","year":"2022","journal-title":"NeuroReport"},{"key":"10.1016\/j.phrs.2025.108074_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0295903","article-title":"Notoginsenoside R1 attenuates brain injury in rats with traumatic brain injury: possible mediation of apoptosis via ERK1\/2 signaling pathway","volume":"18","author":"Pei","year":"2023","journal-title":"PLoS ONE"},{"key":"10.1016\/j.phrs.2025.108074_bib37","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.2147\/DDDT.S451565","article-title":"Notoginsenoside R1 ameliorates high-fat-diet and vitamin D3-induced atherosclerosis via alleviating inflammatory response, inhibiting endothelial dysfunction, and regulating gut microbiota","volume":"18","author":"Ma","year":"2024","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.phrs.2025.108074_bib38","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S1474-4422(24)00369-7","article-title":"Global, regional, and national burden of stroke and its risk factors, 1990\u20132021: a systematic analysis for the Global Burden of Disease Study 2021","volume":"23","author":"GBD 2021 Stroke Risk Factor Collaborators","year":"2024","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phrs.2025.108074_bib39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.apsb.2024.10.004","article-title":"Oxidative stress and inflammation in the pathogenesis of neurological disorders: mechanisms and implications","volume":"15","author":"Dash","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phrs.2025.108074_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113518","article-title":"Emerging neuroprotective strategies for the treatment of ischemic stroke: an overview of clinical and preclinical studies","volume":"335","author":"Paul","year":"2021","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phrs.2025.108074_bib41","article-title":"Cerebral ischemia\u2013reperfusion injury: mechanisms and promising therapies","volume":"16","author":"Yang","year":"2025","journal-title":"Front. Pharm."},{"key":"10.1016\/j.phrs.2025.108074_bib42","doi-asserted-by":"crossref","first-page":"402","DOI":"10.4103\/0973-1296.141765","article-title":"Effects of astragaloside IV combined with the active components of Panax notoginseng on oxidative stress injury and Nrf2\/HO-1 signaling after cerebral ischemia\u2013reperfusion in mice","volume":"10","author":"Deng","year":"2014","journal-title":"Phcog. Mag."},{"issue":"7","key":"10.1016\/j.phrs.2025.108074_bib43","first-page":"1940","article-title":"Protective effect of notoginsenoside R1 on cerebral ischemia\/reperfusion injury in rats","volume":"35","author":"Dong","year":"2015","journal-title":"Chin. J. Gerontol."},{"key":"10.1016\/j.phrs.2025.108074_bib44","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1142\/S0192415X15500809","article-title":"Effects of the combination of the main active components of Astragalus and Panax notoginseng on inflammation and apoptosis of nerve cells after cerebral ischemia\u2013reperfusion","volume":"43","author":"Huang","year":"2015","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.phrs.2025.108074_bib45","doi-asserted-by":"crossref","first-page":"732","DOI":"10.4103\/0973-1296.165572","article-title":"Effects of the main active components combinations of Astragalus and Panax notoginseng on energy metabolism in brain tissues after cerebral ischemia\u2013reperfusion in mice","volume":"11","author":"Huang","year":"2015","journal-title":"Phcog. Mag."},{"key":"10.1016\/j.phrs.2025.108074_bib46","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1124\/jpet.115.230359","article-title":"Notoginsenoside R1 protects against neonatal hypoxic\u2013ischemic brain injury through estrogen receptor-dependent activation of endoplasmic reticulum stress pathways","volume":"357","author":"Wang","year":"2016","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.phrs.2025.108074_bib47","first-page":"13","article-title":"Effect of notoginsenoside R1 on TNF-\u03b1 mRNA after cerebral ischemia\u2013reperfusion injury in rats","volume":"22","author":"Zhao","year":"2017","journal-title":"Zhejiang J. Trauma. Surg."},{"key":"10.1016\/j.phrs.2025.108074_bib48","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1007\/s11064-018-2538-3","article-title":"Protective effects of notoginsenoside R1 via regulation of the PI3K-Akt-mTOR\/JNK pathway in neonatal hypoxic\u2013ischemic brain injury","volume":"43","author":"Tu","year":"2018","journal-title":"Neurochem. Res."},{"issue":"10","key":"10.1016\/j.phrs.2025.108074_bib49","first-page":"2131","article-title":"Effects of different compatibility proportions of salvianolic acid B and notoginsenoside R1 on cerebral ischemia\u2013reperfusion injury in rats","volume":"40","author":"Zhao","year":"2018","journal-title":"Chin. Tradit. Pat. Med."},{"key":"10.1016\/j.phrs.2025.108074_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153660","article-title":"Notoginsenoside R1 intervenes degradation and redistribution of tight junctions to ameliorate blood\u2013brain barrier permeability via Caveolin-1\/MMP-2\/9 pathway after acute ischemic stroke","volume":"90","author":"Liu","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phrs.2025.108074_bib51","article-title":"Notoginsenoside R1 improves cerebral ischemia\/reperfusion injury by promoting neurogenesis via the BDNF\/Akt\/CREB pathway","volume":"12","author":"Zhu","year":"2021","journal-title":"Front. Pharm."},{"key":"10.1016\/j.phrs.2025.108074_bib52","first-page":"15","article-title":"Effect of notoginsenoside R1 on pyroptosis induced by cerebral ischemia\u2013reperfusion, Chin","volume":"30","author":"An","year":"2024","journal-title":"J. Tradit. Chin. Med. Guide"},{"key":"10.1016\/j.phrs.2025.108074_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155530","article-title":"Notoginsenoside R1 alleviates cerebral ischemia\/reperfusion injury by inhibiting the TLR4\/MyD88\/NF-\u03baB signaling pathway through microbiota-gut-brain axis","volume":"128","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phrs.2025.108074_bib54","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.3390\/cells14151205","article-title":"Purified cornel iridoid glycosides attenuated oxidative stress induced by cerebral ischemia\u2013reperfusion injury via morroniside and loganin targeting Nrf2\/NQO-1\/HO-1 signaling pathway","volume":"14","author":"Wang","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.phrs.2025.108074_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/CM9.0000000000002814","article-title":"Fixed-effect and random-effects models in meta-analysis","volume":"137","author":"Zhai","year":"2024","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.phrs.2025.108074_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.imr.2023.101014","article-title":"How to understand and report heterogeneity in a meta-analysis: the difference between I-squared and prediction intervals","volume":"12","author":"Borenstein","year":"2023","journal-title":"Integr. Med. Res."},{"key":"10.1016\/j.phrs.2025.108074_bib57","doi-asserted-by":"crossref","first-page":"973","DOI":"10.3390\/biology14080973","article-title":"Methodological standards for conducting high-quality systematic reviews","volume":"14","author":"De Cassai","year":"2025","journal-title":"Biology"},{"key":"10.1016\/j.phrs.2025.108074_bib58","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/s42003-025-08636-1","article-title":"Microglia are prominent producers of inflammatory cytokines during the hyperacute phase of ischemic stroke","volume":"8","author":"Bourne","year":"2025","journal-title":"Commun. Biol."},{"key":"10.1016\/j.phrs.2025.108074_bib59","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12974-025-03448-w","article-title":"Gut microbiota deficiency reduces neutrophil activation and is protective after ischemic stroke","volume":"22","author":"Tuz","year":"2025","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.phrs.2025.108074_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurot.2024.e00516","article-title":"Blood\u2013brain barrier breakdown in brain ischemia: Insights from MRI perfusion imaging","volume":"22","author":"Sasannia","year":"2025","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.phrs.2025.108074_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115059","article-title":"Corrigendum to \u201cNotoginsenoside R1 activates the NAMPT\u2013NAD+\u2013SIRT1 cascade to promote postischemic angiogenesis by modulating Notch signaling","volume":"165","author":"Zhu","year":"2023","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.phrs.2025.108074_bib62","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1186\/s12916-025-04169-w","article-title":"Trend analysis and future predictions of global burden of Alzheimer\u2019s disease and other dementias: a study based on the Global Burden of Disease database from 1990 to 2021","volume":"23","author":"Hao","year":"2025","journal-title":"BMC Med"},{"key":"10.1016\/j.phrs.2025.108074_bib63","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S1474-4422(25)00274-1","article-title":"Plasma phosphorylated tau for Alzheimer\u2019s disease diagnosis","volume":"24","author":"Keshavan","year":"2025","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phrs.2025.108074_bib64","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/procel\/pwae026","article-title":"Alzheimer\u2019s disease: insights into pathology, molecular mechanisms, and therapy","volume":"16","author":"Zheng","year":"2025","journal-title":"Protein Cell"},{"key":"10.1016\/j.phrs.2025.108074_bib65","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1136\/jnnp-2024-333468","article-title":"Eligibility for anti-amyloid treatment: preparing for disease-modifying therapies for Alzheimer\u2019s disease","volume":"95","author":"Dobson","year":"2024","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.phrs.2025.108074_bib66","doi-asserted-by":"crossref","first-page":"6352","DOI":"10.1038\/srep06352","article-title":"Notoginsenoside R1 increases neuronal excitability and ameliorates synaptic and memory dysfunction following amyloid elevation","volume":"4","author":"Yan","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2025.108074_bib67","doi-asserted-by":"crossref","first-page":"360","DOI":"10.2174\/1871527314666150225141521","article-title":"Protective effect of notoginsenoside R1 on an APP\/PS1 mouse model of Alzheimer\u2019s disease by up-regulating insulin-degrading enzyme and inhibiting A\u03b2 accumulation","volume":"14","author":"Li","year":"2015","journal-title":"CNS Neurol. Disord. Drug Targets"},{"issue":"31","key":"10.1016\/j.phrs.2025.108074_bib68","first-page":"4336","article-title":"Effect of notoginsenoside R1 on learning and memory ability and antioxidation stress in dementia mice induced by D-galactose","volume":"26","author":"Huang","year":"2015","journal-title":"China Pharm."},{"key":"10.1016\/j.phrs.2025.108074_bib69","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1021\/acschemneuro.3c00486","article-title":"Oxidative stress occurs prior to amyloid A\u03b2 plaque formation and tau phosphorylation in Alzheimer\u2019s disease: role of glutathione and metal ions","volume":"14","author":"Roy","year":"2023","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.phrs.2025.108074_bib70","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13024-025-00867-4","article-title":"Biomarkers and therapeutic strategies targeting microglia in neurodegenerative diseases: current status and future directions","volume":"20","author":"Noh","year":"2025","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.phrs.2025.108074_bib71","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.3390\/biom13101492","article-title":"The insulin-degrading enzyme from structure to allosteric modulation: new perspectives for drug design","volume":"13","author":"Tundo","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.phrs.2025.108074_bib72","doi-asserted-by":"crossref","first-page":"6693","DOI":"10.3390\/ijms26146693","article-title":"Understanding the insulin-degrading enzyme: a new look at Alzheimer\u2019s disease and A\u03b2 plaque management","volume":"26","author":"Cerasuolo","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2025.108074_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101999","article-title":"Insulin-degrading enzyme: roles and pathways in ameliorating cognitive impairment associated with Alzheimer\u2019s disease and diabetes","volume":"90","author":"Tian","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.phrs.2025.108074_bib74","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neuroscience.2024.11.069","article-title":"Long-term potentiation in the hippocampus: from magnesium to memory","volume":"578","author":"Collingridge","year":"2025","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2025.108074_bib75","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13041-024-01118-1","article-title":"The duality of amyloid-\u03b2: its role in normal and Alzheimer\u2019s disease states","volume":"17","author":"Azargoonjahromi","year":"2024","journal-title":"Mol. Brain"},{"key":"10.1016\/j.phrs.2025.108074_bib76","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41392-024-01911-3","article-title":"Recent advances in Alzheimer\u2019s disease: mechanisms, clinical trials and new drug development strategies","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.phrs.2025.108074_bib77","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2024.1406709","article-title":"Therapeutic role of voltage-gated potassium channels in age-related neurodegenerative diseases","volume":"18","author":"Urrutia","year":"2024","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.phrs.2025.108074_bib78","article-title":"Microglial pyroptosis as a therapeutic target after traumatic spinal cord injury: current progress and future directions","volume":"16","author":"Shi","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phrs.2025.108074_bib79","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41392-023-01477-6","article-title":"Spinal cord injury: molecular mechanisms and therapeutic interventions","volume":"8","author":"Hu","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.phrs.2025.108074_bib80","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/procel\/pwad003","article-title":"Recent progress and challenges in the treatment of spinal cord injury","volume":"14","author":"Tian","year":"2023","journal-title":"Protein Cell"},{"issue":"9","key":"10.1016\/j.phrs.2025.108074_bib81","first-page":"823","article-title":"Study of the roles and mechanism of notoginsenoside R1 in regulating mitochondrial function and neuroinflammation after spinal cord injury in rats, Chin","volume":"32","author":"Luo","year":"2022","journal-title":"J. Spine Spinal Cord."},{"key":"10.1016\/j.phrs.2025.108074_bib82","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.4103\/1673-5374.369094","article-title":"Mitochondrial dysfunction as a target in spinal cord injury: intimate correlation between pathological processes and therapeutic approaches","volume":"18","author":"Schmidt","year":"2023","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.phrs.2025.108074_bib83","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.amepre.2025.01.001","article-title":"Global burden of traumatic brain injury in 204 countries and territories from 1990 to 2021","volume":"68","author":"Zhong","year":"2025","journal-title":"Am. J. Prev. Med."},{"key":"10.1016\/j.phrs.2025.108074_bib84","doi-asserted-by":"crossref","first-page":"520","DOI":"10.3390\/biomedicines12030520","article-title":"Pathophysiology-based management of secondary injuries and insults in TBI","volume":"12","author":"de Macedo Filho","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.phrs.2025.108074_bib85","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s00701-025-06549-w","article-title":"Hemostatic disturbances in traumatic brain injury: from mechanism to management","volume":"167","author":"Fletcher-Sandersj\u00f6\u00f6","year":"2025","journal-title":"Acta Neurochir. (Wien. )"},{"key":"10.1016\/j.phrs.2025.108074_bib86","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.3390\/ijms26073002","article-title":"Administration of noggin suppresses fibrinogen leakage into the brain in the acute phase after traumatic brain injury in mice","volume":"26","author":"Yasunaga","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2025.108074_bib87","article-title":"Astrocyte-mediated inflammatory responses in traumatic brain injury: mechanisms and potential interventions","volume":"16","author":"Zhang","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phrs.2025.108074_bib88","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41392-025-02176-0","article-title":"The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy","volume":"10","author":"Vogler","year":"2025","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.phrs.2025.108074_bib89","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41392-024-01738-y","article-title":"Major depressive disorder: hypothesis, mechanism, prevention and treatment","volume":"9","author":"Cui","year":"2024","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.phrs.2025.108074_bib90","article-title":"Temporal and spatial trend analysis of all-cause depression burden based on Global Burden of Disease (GBD) 2019 study","volume":"14","author":"Liu","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2025.108074_bib91","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s43556-024-00205-y","article-title":"Treatment-resistant depression: molecular mechanisms and management","volume":"5","author":"Kajumba","year":"2024","journal-title":"Mol. Biomed."},{"key":"10.1016\/j.phrs.2025.108074_bib92","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/ddr.21847","article-title":"Effects of notoginsenoside R1 on attenuating depressive behavior induced by chronic stress in rats through induction of PI3K\/AKT\/NF-\u03baB pathway","volume":"83","author":"Zhan","year":"2022","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.phrs.2025.108074_bib93","first-page":"5599","article-title":"Integrated network pharmacology and animal experiments reveal the anti-depression effects and molecular mechanisms of notoginsenoside R1","volume":"47","author":"Li","year":"2022","journal-title":"Zhongguo Zhongyao Zazhi (China J. Chin. Mater. Med. )"},{"key":"10.1016\/j.phrs.2025.108074_bib94","article-title":"S. Al-Saffar, Notoginsenoside R1, a metabolite from Panax notoginseng, prevents paclitaxel-induced peripheral neuropathy by restoring endocannabinoid signaling and inhibiting monoacylglycerol lipase","volume":"138","author":"Al-Musailem","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phrs.2025.108074_bib95","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13024-023-00676-7","article-title":"Mitochondrial dysfunction in Parkinson\u2019s disease \u2013 a key disease hallmark with therapeutic potential","volume":"18","author":"Henrich","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.phrs.2025.108074_bib96","article-title":"The role of mitochondrial dysfunction in Huntington\u2019s disease: implications for therapeutic targeting","volume":"189","author":"Joshi","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phrs.2025.108074_bib97","doi-asserted-by":"crossref","first-page":"3854","DOI":"10.3390\/ijms26083854","article-title":"Neuroinflammation and amyotrophic lateral sclerosis: recent advances in anti-inflammatory cytokines as therapeutic strategies","volume":"26","author":"Stacchiotti","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2025.108074_bib98","doi-asserted-by":"crossref","DOI":"10.1002\/cpbi.5","article-title":"The GeneCards Suite: from gene data mining to disease genome sequence analyses","volume":"54","author":"Stelzer","year":"2016","journal-title":"Curr. Protoc. Bioinforma."},{"key":"10.1016\/j.phrs.2025.108074_bib99","doi-asserted-by":"crossref","first-page":"D1038","DOI":"10.1093\/nar\/gky1151","article-title":"OMIM.org: leveraging knowledge across phenotype\u2013gene relationships","volume":"47","author":"Amberger","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phrs.2025.108074_bib100","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkad751","article-title":"TTD: Therapeutic Target Database describing target druggability information","volume":"52","author":"Zhou","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phrs.2025.108074_bib101","first-page":"D845","article-title":"The DisGeNET knowledge platform for disease genomics: 2019 update","volume":"48","author":"Pi\u00f1ero","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phrs.2025.108074_bib102","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J. Chemin.."},{"key":"10.1016\/j.phrs.2025.108074_bib103","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baaf013","article-title":"Integrating AI-powered text mining from PubTator into the manual curation workflow at the Comparative Toxicogenomics Database","author":"Wiegers","year":"2025","journal-title":"Database (Oxf. )"},{"key":"10.1016\/j.phrs.2025.108074_bib104","doi-asserted-by":"crossref","first-page":"D1197","DOI":"10.1093\/nar\/gkaa1063","article-title":"HERB: a high-throughput experiment- and reference-guided database of traditional Chinese medicine","volume":"49","author":"Fang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phrs.2025.108074_bib105","article-title":"Gut\u2013brain axis: mechanisms and potential therapeutic strategies for ischemic stroke through immune functions","volume":"17","author":"Sy","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.phrs.2025.108074_bib106","first-page":"612","article-title":"Blood\u2013brain barrier-targeting nanoparticles: biomaterial properties and biomedical applications in translational neuroscience","volume":"17","author":"Asimakidou","year":"2024","journal-title":"Pharm. (Basel)"},{"key":"10.1016\/j.phrs.2025.108074_bib107","doi-asserted-by":"crossref","first-page":"706","DOI":"10.3390\/pharmaceutics17060706","article-title":"Crossing the blood\u2013brain barrier: innovations in receptor- and transporter-mediated transcytosis strategies","volume":"17","author":"Ding","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.phrs.2025.108074_bib108","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3390\/pharmaceutics17040485","article-title":"Recent advances in vitamin E TPGS-based organic nanocarriers for enhancing the oral bioavailability of active compounds: a systematic review","volume":"17","author":"Wong","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.phrs.2025.108074_bib109","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3390\/pharmaceutics17030281","article-title":"Nanotechnology to overcome blood\u2013brain barrier permeability and damage in neurodegenerative diseases","volume":"17","author":"Jim\u00e9nez","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.phrs.2025.108074_bib110","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12987-021-00257-0","article-title":"Brain pharmacokinetics of two BBB-penetrating bispecific antibodies of different size","volume":"18","author":"Faresj\u00f6","year":"2021","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.phrs.2025.108074_bib111","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3390\/pharmaceutics15030863","article-title":"Naringin: nanotechnological strategies for potential pharmaceutical applications","volume":"15","author":"Ravetti","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.phrs.2025.108074_bib112","doi-asserted-by":"crossref","first-page":"6250","DOI":"10.1021\/acs.biomac.4c00722","article-title":"Stimuli-responsive polymeric nanocarriers accelerate on-demand drug release to combat glioblastoma","volume":"25","author":"Ismail","year":"2024","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.phrs.2025.108074_bib113","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.3390\/pharmaceutics16121492","article-title":"Molecular targeting of ischemic stroke: the promise of na\u00efve and engineered extracellular vesicles","volume":"16","author":"Lee","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.phrs.2025.108074_bib114","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1186\/s12951-025-03352-8","article-title":"Exosome-powered neuropharmaceutics: unlocking the blood\u2013brain barrier for next-gen therapies","volume":"23","author":"Mehdizadeh","year":"2025","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.phrs.2025.108074_bib115","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1186\/s12951-025-03572-y","article-title":"Recent advances of engineering cell membranes for nanomedicine delivery across the blood\u2013brain barrier","volume":"23","author":"Yuan","year":"2025","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.phrs.2025.108074_bib116","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.chembiol.2020.12.001","article-title":"Recent advances in identifying protein targets in drug discovery","volume":"28","author":"Ha","year":"2021","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.phrs.2025.108074_bib117","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.3762\/bjoc.20.199","article-title":"Improved deconvolution of natural products\u2019 protein targets using diagnostic ions from chemical-proteomics linkers","volume":"20","author":"Wiest","year":"2024","journal-title":"Beilstein J. Org. Chem."},{"key":"10.1016\/j.phrs.2025.108074_bib118","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2022.115107","article-title":"Label-free target protein characterization for small-molecule drugs: recent advances in methods and applications","volume":"223","author":"Feng","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.phrs.2025.108074_bib119","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1016\/j.apsb.2022.05.021","article-title":"Cucurbitacin B-induced G2\/M cell-cycle arrest of conjunctival melanoma cells mediated by GRP78\u2013FOXM1\u2013KIF20A pathway","volume":"12","author":"Wei","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phrs.2025.108074_bib120","article-title":"Exploring natural products potential: a similarity-based target prediction tool for natural products","volume":"184","author":"Alhasbary","year":"2025","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.phrs.2025.108074_bib121","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1038\/s41467-024-46089-y","article-title":"Drug target prediction through deep-learning functional representation of gene signatures","volume":"15","author":"Chen","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2025.108074_bib122","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41537-024-00504-x","article-title":"Exploring the molecular targets of fingolimod and siponimod for treating the impaired cognition of schizophrenia using network pharmacology and molecular docking","volume":"10","author":"Li","year":"2024","journal-title":"Schizophr"},{"key":"10.1016\/j.phrs.2025.108074_bib123","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41586-023-05905-z","article-title":"Computational approaches streamlining drug discovery","volume":"616","author":"Sadybekov","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2025.108074_bib124","article-title":"Plant-derived natural products targeting ion channels for pain","volume":"13","author":"G","year":"2023","journal-title":"Neurobiol. Pain."},{"key":"10.1016\/j.phrs.2025.108074_bib125","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.3390\/biomedicines9111682","article-title":"Molecular docking simulation studies identify potential natural-product-derived anti-Wolbachial compounds as filaricides against onchocerciasis","volume":"9","author":"Kwofie","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.phrs.2025.108074_bib126","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ymeth.2024.03.007","article-title":"Isothermal titration calorimetry and surface plasmon resonance methods to probe protein\u2013protein interactions","volume":"225","author":"Upadhyay","year":"2024","journal-title":"Methods"},{"key":"10.1016\/j.phrs.2025.108074_bib127","article-title":"Notoginsenoside R1 attenuates H\/R injury in H9c2 cells by maintaining mitochondrial homeostasis","volume":"47","author":"W. P","year":"2025","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.phrs.2025.108074_bib128","first-page":"3021","article-title":"Targeting glial cells: Unveiling the neuroprotective mechanisms of Ginseng in the brain microenvironment","author":"Wang","year":"2025","journal-title":"Acta Pharm. Sin. B 15"},{"key":"10.1016\/j.phrs.2025.108074_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107578","article-title":"Y. Chen, Ginsenosides Rg1, Rb1 and rare ginsenosides: promising candidate agents for Parkinson\u2019s disease and Alzheimer\u2019s disease and network pharmacology analysis","volume":"212","author":"Jiang","year":"2025","journal-title":"Pharmacol. Res."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661825004992?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661825004992?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T16:57:08Z","timestamp":1778518628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661825004992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":129,"alternative-id":["S1043661825004992"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2025.108074","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-target neuroprotective effects of notoginsenoside R1 in neurodegenerative diseases: From pharmacokinetics to translational prospects","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2025.108074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108074"}}