{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:22:02Z","timestamp":1791400922592,"version":"4.3.3"},"reference-count":245,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2023209901"],"award-info":[{"award-number":["H2023209901"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2026-JYB-XJSJJ007"],"award-info":[{"award-number":["2026-JYB-XJSJJ007"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2023ZD0502605"],"award-info":[{"award-number":["2023ZD0502605"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2025ZD1801500"],"award-info":[{"award-number":["2025ZD1801500"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374420"],"award-info":[{"award-number":["82374420"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004846","name":"Beijing University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004846","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["KYG-202403"],"award-info":[{"award-number":["KYG-202403"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.phrs.2026.108204","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T16:08:01Z","timestamp":1776787681000},"page":"108204","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Dual modulation of lipophagy: From molecular mechanisms to therapeutic interventions in cardiovascular health and disease"],"prefix":"10.1016","volume":"228","author":[{"given":"Yunxia","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanjing","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.phrs.2026.108204_bib1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cmet.2012.04.006","article-title":"Lipid metabolism and toxicity in the heart","volume":"15","author":"Goldberg","year":"2012","journal-title":"Cell Metab."},{"issue":"11","key":"10.1016\/j.phrs.2026.108204_bib2","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1161\/CIRCRESAHA.116.306842","article-title":"Lipid use and misuse by the heart","volume":"118","author":"Schulze","year":"2016","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.phrs.2026.108204_bib3","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1152\/physrev.00030.2020","article-title":"Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications","volume":"101","author":"Ren","year":"2021","journal-title":"Physiol. Rev."},{"issue":"8","key":"10.1016\/j.phrs.2026.108204_bib4","first-page":"423","article-title":"Cardiac remodeling in a rat model of diet-induced obesity","volume":"26","author":"Leopoldo","year":"2010","journal-title":"Can. J. Cardiol."},{"issue":"12","key":"10.1016\/j.phrs.2026.108204_bib5","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1093\/eurheartj\/ehy903","article-title":"Obesity-induced activation of JunD promotes myocardial lipid accumulation and metabolic cardiomyopathy","volume":"40","author":"Costantino","year":"2019","journal-title":"Eur. Heart J."},{"issue":"22","key":"10.1016\/j.phrs.2026.108204_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252212161","article-title":"The protective role of miR-130b-3p against palmitate-induced lipotoxicity in cardiomyocytes through PPAR\u03b3 pathway","volume":"25","author":"Alonso-Villa","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.phrs.2026.108204_bib7","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1161\/CIRCULATIONAHA.118.033704","article-title":"Deciphering the role of lipid droplets in cardiovascular disease: a report from the 2017 national heart, lung, and blood institute workshop","volume":"138","author":"Goldberg","year":"2018","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.phrs.2026.108204_bib8","doi-asserted-by":"crossref","first-page":"3710","DOI":"10.7150\/ijbs.95216","article-title":"Lipid homeostasis in diabetic kidney disease","volume":"20","author":"Wang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"19","key":"10.1016\/j.phrs.2026.108204_bib9","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1042\/CS20210127","article-title":"Lipotoxicity: a driver of heart failure with preserved ejection fraction?","volume":"135","author":"Leggat","year":"2021","journal-title":"Clin. Sci."},{"key":"10.1016\/j.phrs.2026.108204_bib10","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fcvm.2018.00038","article-title":"Autophagic Regulation of Lipid Homeostasis in Cardiometabolic Syndrome","volume":"5","author":"Yang","year":"2018","journal-title":"Front Cardiovasc Med"},{"issue":"29","key":"10.1016\/j.phrs.2026.108204_bib11","article-title":"Targeting Rab7-Rilp Mediated Microlipophagy Alleviates Lipid Toxicity in Diabetic Cardiomyopathy","volume":"11","author":"Ke","year":"2024","journal-title":"Adv. Sci. (Weinh. )"},{"issue":"7","key":"10.1016\/j.phrs.2026.108204_bib12","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/s41569-023-00885-z","article-title":"A role for lipophagy in atherosclerosis","volume":"20","author":"Laval","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.phrs.2026.108204_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103705","article-title":"Crosstalk of autophagy and ferroptosis in cardiovascular diseases: from pathophysiology to novel therapy","volume":"84","author":"Hu","year":"2025","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.phrs.2026.108204_bib14","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41419-022-04593-3","article-title":"The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis."},{"issue":"34","key":"10.1016\/j.phrs.2026.108204_bib15","doi-asserted-by":"crossref","first-page":"E4966","DOI":"10.1073\/pnas.1603244113","article-title":"Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis","volume":"113","author":"Yang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"12","key":"10.1016\/j.phrs.2026.108204_bib16","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1038\/s42255-021-00489-2","article-title":"Peroxisomal \u03b2-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis","volume":"3","author":"Ding","year":"2021","journal-title":"Nat. Metab."},{"issue":"3","key":"10.1016\/j.phrs.2026.108204_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17030387","article-title":"TFE3 Alleviates Hepatic Steatosis through Autophagy-Induced Lipophagy and PGC1\u03b1-Mediated Fatty Acid \u03b2-Oxidation","volume":"17","author":"Xiong","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib18","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/hep.25645","article-title":"Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity","volume":"56","author":"Patterson","year":"2012","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.phrs.2026.108204_bib19","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/s42255-021-00493-6","article-title":"Lipolysis: cellular mechanisms for lipid mobilization from fat stores","volume":"3","author":"Grabner","year":"2021","journal-title":"Nat. Metab."},{"issue":"3","key":"10.1016\/j.phrs.2026.108204_bib20","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41580-018-0085-z","article-title":"Dynamics and functions of lipid droplets","volume":"20","author":"Olzmann","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.phrs.2026.108204_bib21","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1083\/jcb.201505067","article-title":"A conserved family of proteins facilitates nascent lipid droplet budding from the ER","volume":"211","author":"Choudhary","year":"2015","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.phrs.2026.108204_bib22","doi-asserted-by":"crossref","unstructured":"Walther T.C., Chung J., Farese R.V. Lipid Droplet Biogenesis. In: {C}Schekman R., editor.{C} Annual Review of Cell and Developmental Biology, Vol 33. Annual Review of Cell and Developmental Biology. 332017. p. 491-510.","DOI":"10.1146\/annurev-cellbio-100616-060608"},{"issue":"8","key":"10.1016\/j.phrs.2026.108204_bib23","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.bbalip.2016.04.018","article-title":"The physics of lipid droplet nucleation, growth and budding","volume":"1861","author":"Thiam","year":"2016","journal-title":"Biochim. Et. Biophys. Acta-Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.phrs.2026.108204_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102194","article-title":"Lipid droplets, autophagy, and ageing: A cell-specific tale","volume":"94","author":"Maestri","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.phrs.2026.108204_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.765147","article-title":"Regulation of Key Genes for Milk Fat Synthesis in Ruminants","volume":"8","author":"Mu","year":"2021","journal-title":"Front Nutr."},{"issue":"12","key":"10.1016\/j.phrs.2026.108204_bib26","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201898947","article-title":"The assembly of lipid droplets and their roles in challenged cells","volume":"37","author":"Henne","year":"2018","journal-title":"Embo J."},{"key":"10.1016\/j.phrs.2026.108204_bib27","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1146\/annurev-cellbio-100616-060608","article-title":"Lipid Droplet Biogenesis","volume":"33","author":"Walther","year":"2017","journal-title":"Annu Rev. Cell Dev. Biol."},{"issue":"12","key":"10.1016\/j.phrs.2026.108204_bib28","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nrm3699","article-title":"The biophysics and cell biology of lipid droplets","volume":"14","author":"Thiam","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"11","key":"10.1016\/j.phrs.2026.108204_bib29","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1080\/15548627.2021.1886839","article-title":"Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells","volume":"17","author":"Robichaud","year":"2021","journal-title":"Autophagy"},{"issue":"15","key":"10.1016\/j.phrs.2026.108204_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22158144","article-title":"Lipid Droplets and Their Autophagic Turnover via the Raft-Like Vacuolar Microdomains","volume":"22","author":"Rahman","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.phrs.2026.108204_bib31","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.devcel.2015.01.029","article-title":"Fatty acid trafficking in starved cells: regulation by lipid droplet lipolysis, autophagy, and mitochondrial fusion dynamics","volume":"32","author":"Rambold","year":"2015","journal-title":"Dev. Cell"},{"issue":"12","key":"10.1016\/j.phrs.2026.108204_bib32","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1194\/jlr.M017939","article-title":"Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria","volume":"52","author":"Wang","year":"2011","journal-title":"J. Lipid Res"},{"issue":"11","key":"10.1016\/j.phrs.2026.108204_bib33","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.tem.2021.08.010","article-title":"Lipophagy: a new player in CNS disorders","volume":"32","author":"Haidar","year":"2021","journal-title":"Trends Endocrinol. & Metab."},{"issue":"22","key":"10.1016\/j.phrs.2026.108204_bib34","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.1016\/j.molcel.2024.10.022","article-title":"VPS4A is the selective receptor for lipophagy in mice and humans","volume":"84","author":"Das","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.phrs.2026.108204_bib35","doi-asserted-by":"crossref","DOI":"10.1021\/jacs.5c01710","article-title":"Chemical Probe-Enabled Lipid Droplet Proteomics","author":"Xiang","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.phrs.2026.108204_bib36","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1038\/ncomms2581","article-title":"Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes","volume":"4","author":"Sun","year":"2013","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib37","article-title":"ATG14 targets lipid droplets and acts as an autophagic receptor for syntaxin18-regulated lipid droplet turnover","volume":"15","author":"Yuan","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib38","article-title":"Lipophagy: Molecular Mechanisms and Implications in Hepatic Lipid Metabolism","volume":"28","author":"Zeng","year":"2023","journal-title":"Front. Biosci. -Landmark"},{"issue":"11","key":"10.1016\/j.phrs.2026.108204_bib39","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nrm.2017.76","article-title":"Cytosolic lipolysis and lipophagy: two sides of the same coin","volume":"18","author":"Zechner","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"26","key":"10.1016\/j.phrs.2026.108204_bib40","article-title":"A Membrane-Targeting Aggregation-Induced Emission Probe for Monitoring Lipid Droplet Dynamics in Ischemia\/Reperfusion-Induced Cardiomyocyte Ferroptosis","volume":"11","author":"Wang","year":"2024","journal-title":"Adv. Sci. (Weinh. )"},{"issue":"6","key":"10.1016\/j.phrs.2026.108204_bib41","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1-2","key":"10.1016\/j.phrs.2026.108204_bib42","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2026.108204_bib43","article-title":"FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis","author":"Lange","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.phrs.2026.108204_bib44","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4137\/LPI.S11128","article-title":"Lipid Droplets as Signaling Platforms Linking Metabolic and Cellular Functions","volume":"7","author":"Arrese","year":"2014","journal-title":"Lipid Insights"},{"issue":"9","key":"10.1016\/j.phrs.2026.108204_bib45","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202311126","article-title":"A fluorogenic complementation tool kit for interrogating lipid droplet-organelle interaction","volume":"223","author":"Li","year":"2024","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.phrs.2026.108204_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.726261","article-title":"Lipid Droplet-Organelle Contact Sites as Hubs for Fatty Acid Metabolism, Trafficking, and Metabolic Channeling","volume":"9","author":"Renne","year":"2021","journal-title":"Front Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib47","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41419-025-08210-x","article-title":"Loss of TMEM55B modulates lipid metabolism through dysregulated lipophagy and mitochondrial function","volume":"17","author":"Qin","year":"2026","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib48","first-page":"65","article-title":"Phosphatidylcholine: Greasing the Cholesterol Transport Machinery","volume":"8","author":"Lagace","year":"2015","journal-title":"Lipid Insights"},{"issue":"2","key":"10.1016\/j.phrs.2026.108204_bib49","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1080\/15548627.2018.1545821","article-title":"Vacuolar hydrolysis and efflux: current knowledge and unanswered questions","volume":"15","author":"Parzych","year":"2019","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib50","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1038\/s41467-025-57405-5","article-title":"Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites","volume":"16","author":"Bezawork-Geleta","year":"2025","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib51","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1152\/physrev.00015.2009","article-title":"Myocardial fatty acid metabolism in health and disease","volume":"90","author":"Lopaschuk","year":"2010","journal-title":"Physiol. Rev."},{"issue":"11-12","key":"10.1016\/j.phrs.2026.108204_bib52","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1007\/s10495-025-02192-z","article-title":"The impact of lipid metabolism on ferroptosis in myocardial ischemia-reperfusion injury","volume":"30","author":"Li","year":"2025","journal-title":"Apoptosis"},{"issue":"4","key":"10.1016\/j.phrs.2026.108204_bib53","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.cmet.2018.03.003","article-title":"Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion","volume":"27","author":"Benador","year":"2018","journal-title":"Cell Metab."},{"issue":"14","key":"10.1016\/j.phrs.2026.108204_bib54","article-title":"Mfn2\/Hsc70 Complex Mediates the Formation of Mitochondria-Lipid Droplets Membrane Contact and Regulates Myocardial Lipid Metabolism","volume":"11","author":"Hu","year":"2024","journal-title":"Adv. Sci. (Weinh. )"},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib55","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1186\/s12944-025-02759-4","article-title":"Interactions between lipid droplets and mitochondria in metabolic diseases","volume":"24","author":"Wang","year":"2025","journal-title":"Lipids Health Dis."},{"issue":"2","key":"10.1016\/j.phrs.2026.108204_bib56","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.yexcr.2015.10.031","article-title":"Heart lipid droplets and lipid droplet-binding proteins: Biochemistry, physiology, and pathology","volume":"340","author":"Osumi","year":"2016","journal-title":"Exp. Cell Res"},{"issue":"10","key":"10.1016\/j.phrs.2026.108204_bib57","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1161\/CIRCRESAHA.121.318241","article-title":"Cardiac Energy Metabolism in Heart Failure","volume":"128","author":"Lopaschuk","year":"2021","journal-title":"Circ. Res"},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib58","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-023-01504-z","article-title":"The regulatory role of lipophagy in central nervous system diseases","volume":"9","author":"Lan","year":"2023","journal-title":"Cell Death Discov."},{"issue":"7242","key":"10.1016\/j.phrs.2026.108204_bib59","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nature07976","article-title":"Autophagy regulates lipid metabolism","volume":"458","author":"Singh","year":"2009","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib60","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1080\/15548627.2021.1895658","article-title":"The m\u00e9nage \u00e0 trois of autophagy, lipid droplets and liver disease","volume":"18","author":"Filali-Mouncef","year":"2022","journal-title":"Autophagy"},{"issue":"5","key":"10.1016\/j.phrs.2026.108204_bib61","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1080\/15548627.2021.1909410","article-title":"Autophagosome content profiling reveals receptor-specific cargo candidates","volume":"17","author":"Zellner","year":"2021","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.phrs.2026.108204_bib62","doi-asserted-by":"crossref","DOI":"10.3390\/cells14020141","article-title":"Microlipophagy from Simple to Complex Eukaryotes","volume":"14","author":"Kumar","year":"2025","journal-title":"Cells"},{"issue":"51","key":"10.1016\/j.phrs.2026.108204_bib63","doi-asserted-by":"crossref","first-page":"32443","DOI":"10.1073\/pnas.2011442117","article-title":"Direct lysosome-based autophagy of lipid droplets in hepatocytes","volume":"117","author":"Schulze","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"9","key":"10.1016\/j.phrs.2026.108204_bib64","doi-asserted-by":"crossref","DOI":"10.1002\/bies.201800032","article-title":"The Actomyosin Cytoskeleton Drives Micron-Scale Membrane Remodeling In Vivo Via the Generation of Mechanical Forces to Balance Membrane Tension Gradients","volume":"40","author":"Ebrahim","year":"2018","journal-title":"Bioessays"},{"issue":"10","key":"10.1016\/j.phrs.2026.108204_bib65","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1083\/jcb.201611029","article-title":"Evidence for ESCRT- and clathrin-dependent microautophagy","volume":"216","author":"Oku","year":"2017","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib66","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13578-021-00543-2","article-title":"Golgi-associated Rab GTPases implicated in autophagy","volume":"11","author":"Lu","year":"2021","journal-title":"Cell Biosci."},{"issue":"3","key":"10.1016\/j.phrs.2026.108204_bib67","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/cdd.2013.187","article-title":"Regulation of autophagy by the Rab GTPase network","volume":"21","author":"Ao","year":"2014","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.phrs.2026.108204_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.139828","article-title":"A review on evolution, structural characteristics, interactions, and regulation of the membrane transport protein: The family of Rab proteins","volume":"296","author":"Parray","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"6","key":"10.1016\/j.phrs.2026.108204_bib69","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1002\/hep.27667","article-title":"The small GTPase Rab7 as a central regulator of hepatocellular lipophagy","volume":"61","author":"Schroeder","year":"2015","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.phrs.2026.108204_bib70","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-022-04593-3","article-title":"The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death & Dis."},{"issue":"17","key":"10.1016\/j.phrs.2026.108204_bib71","first-page":"3171","article-title":"Cellular functions of Rab GTPases at a glance","volume":"128","author":"Zhen","year":"2015","journal-title":"J. Cell Sci."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib72","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1152\/physrev.00059.2009","article-title":"Role of Rab GTPases in membrane traffic and cell physiology","volume":"91","author":"Hutagalung","year":"2011","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib73","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/cr.2013.153","article-title":"Chaperone-mediated autophagy: roles in disease and aging","volume":"24","author":"Cuervo","year":"2014","journal-title":"Cell Res"},{"issue":"Pt 17","key":"10.1016\/j.phrs.2026.108204_bib74","first-page":"4067","article-title":"Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets","volume":"125","author":"Hsieh","year":"2012","journal-title":"J. Cell Sci."},{"issue":"10","key":"10.1016\/j.phrs.2026.108204_bib75","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1002\/1873-3468.14792","article-title":"Molecular mechanisms of perilipin protein function in lipid droplet metabolism","volume":"598","author":"Griseti","year":"2024","journal-title":"FEBS Lett."},{"issue":"13","key":"10.1016\/j.phrs.2026.108204_bib76","doi-asserted-by":"crossref","first-page":"6664","DOI":"10.1074\/jbc.M115.691048","article-title":"Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1-3","volume":"291","author":"Rowe","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib77","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/s41467-018-03717-8","article-title":"A giant amphipathic helix from a perilipin that is adapted for coating lipid droplets","volume":"9","author":"\u010copi\u010d","year":"2018","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.phrs.2026.108204_bib78","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25063153","article-title":"Research Progress on Lipophagy-Mediated Exercise Intervention in Non-Alcoholic Fatty Liver Disease","volume":"25","author":"Li","year":"2024","journal-title":"Int J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.phrs.2026.108204_bib79","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201910177","article-title":"Seipin and Nem1 establish discrete ER subdomains to initiate yeast lipid droplet biogenesis","volume":"219","author":"Choudhary","year":"2020","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib80","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1038\/s41467-023-38725-w","article-title":"Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation","volume":"14","author":"Choi","year":"2023","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.phrs.2026.108204_bib81","doi-asserted-by":"crossref","first-page":"E699","DOI":"10.1152\/ajpendo.00098.2017","article-title":"Cardiac overexpression of perilipin 2 induces dynamic steatosis: prevention by hormone-sensitive lipase","volume":"313","author":"Ueno","year":"2017","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib82","doi-asserted-by":"crossref","first-page":"6909","DOI":"10.1038\/s41598-019-43335-y","article-title":"Plin2-deficiency reduces lipophagy and results in increased lipid accumulation in the heart","volume":"9","author":"Mardani","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2026.108204_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117547","article-title":"PLIN5 contributes to lipophagy of hepatic stellate cells induced by inorganic arsenic","volume":"290","author":"Li","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"14","key":"10.1016\/j.phrs.2026.108204_bib84","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.devcel.2023.05.006","article-title":"PLIN5 interacts with FATP4 at membrane contact sites to promote lipid droplet-to-mitochondria fatty acid transport","volume":"58","author":"Miner","year":"2023","journal-title":"Dev. Cell"},{"issue":"1-2","key":"10.1016\/j.phrs.2026.108204_bib85","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0014-5793(93)80398-E","article-title":"Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae","volume":"333","author":"Tsukada","year":"1993","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib86","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/cr.2013.168","article-title":"The machinery of macroautophagy","volume":"24","author":"Feng","year":"2014","journal-title":"Cell Res."},{"issue":"3","key":"10.1016\/j.phrs.2026.108204_bib87","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.jhep.2022.03.031","article-title":"Rare ATG7 genetic variants predispose patients to severe fatty liver disease","volume":"77","author":"Baselli","year":"2022","journal-title":"J. Hepatol."},{"issue":"14","key":"10.1016\/j.phrs.2026.108204_bib88","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.devcel.2023.05.009","article-title":"LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy","volume":"58","author":"Omrane","year":"2023","journal-title":"Dev. Cell"},{"issue":"15","key":"10.1016\/j.phrs.2026.108204_bib89","doi-asserted-by":"crossref","first-page":"5386","DOI":"10.1074\/jbc.R117.810366","article-title":"A molecular perspective of mammalian autophagosome biogenesis","volume":"293","author":"Mercer","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"22","key":"10.1016\/j.phrs.2026.108204_bib90","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.1016\/j.molcel.2022.10.017","article-title":"ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation","volume":"82","author":"van Vliet","year":"2022","journal-title":"Mol. Cell"},{"issue":"6","key":"10.1016\/j.phrs.2026.108204_bib91","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1083\/jcb.201811139","article-title":"ATG2 transports lipids to promote autophagosome biogenesis","volume":"218","author":"Valverde","year":"2019","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.phrs.2026.108204_bib92","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41594-019-0203-4","article-title":"Atg2 mediates direct lipid transfer between membranes for autophagosome formation","volume":"26","author":"Osawa","year":"2019","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"8","key":"10.1016\/j.phrs.2026.108204_bib93","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1083\/jcb.201710116","article-title":"Atg9 establishes Atg2-dependent contact sites between the endoplasmic reticulum and phagophores","volume":"217","author":"G\u00f3mez-S\u00e1nchez","year":"2018","journal-title":"J. Cell Biol."},{"issue":"12","key":"10.1016\/j.phrs.2026.108204_bib94","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1038\/s41594-020-00520-2","article-title":"Structure, lipid scrambling activity and role in autophagosome formation of ATG9A","volume":"27","author":"Maeda","year":"2020","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"12","key":"10.1016\/j.phrs.2026.108204_bib95","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/s41594-020-00518-w","article-title":"Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion","volume":"27","author":"Matoba","year":"2020","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.phrs.2026.108204_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2023.155693","article-title":"ATG14 plays a critical role in hepatic lipid droplet homeostasis","volume":"148","author":"Huang","year":"2023","journal-title":"Metabolism"},{"issue":"2","key":"10.1016\/j.phrs.2026.108204_bib97","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1091\/mbc.e13-08-0448","article-title":"Lipid droplet autophagy in the yeast Saccharomyces cerevisiae","volume":"25","author":"van Zutphen","year":"2014","journal-title":"Mol. Biol. Cell"},{"issue":"3","key":"10.1016\/j.phrs.2026.108204_bib98","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1083\/jcb.201404115","article-title":"A sterol-enriched vacuolar microdomain mediates stationary phase lipophagy in budding yeast","volume":"206","author":"Wang","year":"2014","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.phrs.2026.108204_bib99","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.21690","article-title":"AMPK and vacuole-associated Atg14p orchestrate \u03bc-lipophagy for energy production and long-term survival under glucose starvation","volume":"6","author":"Seo","year":"2017","journal-title":"Elife"},{"issue":"7","key":"10.1016\/j.phrs.2026.108204_bib100","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.neo.2016.06.001","article-title":"Upstream and Downstream Co-inhibition of Mitogen-Activated Protein Kinase and PI3K\/Akt\/mTOR Pathways in Pancreatic Ductal Adenocarcinoma","volume":"18","author":"Wong","year":"2016","journal-title":"Neoplasia"},{"issue":"2","key":"10.1016\/j.phrs.2026.108204_bib101","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cell.2017.03.035","article-title":"mTOR Signaling in Growth, Metabolism, and Disease","volume":"169","author":"Saxton","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2026.108204_bib102","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1124003","article-title":"The essential effect of mTORC1-dependent lipophagy in non-alcoholic fatty liver disease","volume":"14","author":"Tan","year":"2023","journal-title":"Front Pharm."},{"issue":"5","key":"10.1016\/j.phrs.2026.108204_bib103","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.celrep.2013.07.030","article-title":"Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression","volume":"4","author":"Wu","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.phrs.2026.108204_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2023.155516","article-title":"Metformin-induced TTP mediates communication between Kupffer cells and hepatocytes to alleviate hepatic steatosis by regulating lipophagy and necroptosis","volume":"141","author":"Park","year":"2023","journal-title":"Metabolism"},{"issue":"3","key":"10.1016\/j.phrs.2026.108204_bib105","first-page":"435","article-title":"Lipid Droplets and the Management of Cellular Stress","volume":"92","author":"Jarc","year":"2019","journal-title":"Yale J. Biol. Med."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib106","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cmet.2011.06.002","article-title":"Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways","volume":"14","author":"Yecies","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.phrs.2026.108204_bib107","doi-asserted-by":"crossref","DOI":"10.1007\/s10753-025-02313-5","article-title":"LARS1 Promotes Tubular Epithelial Cells Epithelial Mesenchymal Transition in Chronic Kidney Disease by Inhibiting Lipophagy","author":"Guo","year":"2025","journal-title":"Inflammation"},{"issue":"6","key":"10.1016\/j.phrs.2026.108204_bib108","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1002\/hep.32048","article-title":"A Mammalian Target of Rapamycin-Perilipin 3 (mTORC1-Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis","volume":"74","author":"Garcia-Macia","year":"2021","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.phrs.2026.108204_bib109","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1080\/15548627.2021.1961072","article-title":"Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy","volume":"18","author":"Liu","year":"2022","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.phrs.2026.108204_bib110","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/s41556-018-0037-z","article-title":"Cargo recognition and degradation by selective autophagy","volume":"20","author":"Gatica","year":"2018","journal-title":"Nat. Cell Biol."},{"issue":"2","key":"10.1016\/j.phrs.2026.108204_bib111","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.molcel.2019.09.005","article-title":"A Diversity of Selective Autophagy Receptors Determines the Specificity of the Autophagy Pathway","volume":"76","author":"Kirkin","year":"2019","journal-title":"Mol. Cell"},{"issue":"9","key":"10.1016\/j.phrs.2026.108204_bib112","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1093\/procel\/pwad005","article-title":"Join the club: ORP8 is a lipophagy receptor","volume":"14","author":"Wang","year":"2023","journal-title":"Protein & Cell"},{"key":"10.1016\/j.phrs.2026.108204_bib113","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.08941","article-title":"Oligomerization of p62 allows for selection of ubiquitinated cargo and isolation membrane during selective autophagy","volume":"4","author":"Wurzer","year":"2015","journal-title":"Elife"},{"issue":"11","key":"10.1016\/j.phrs.2026.108204_bib114","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202208092","article-title":"NBR1: The archetypal selective autophagy receptor","volume":"221","author":"Rasmussen","year":"2022","journal-title":"J. Cell Biol."},{"issue":"11","key":"10.1016\/j.phrs.2026.108204_bib115","doi-asserted-by":"crossref","DOI":"10.3390\/cells9112349","article-title":"Selective Autophagy by Close Encounters of the Ubiquitin Kind","volume":"9","author":"Vainshtein","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib116","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s42003-023-04682-9","article-title":"SB2301-mediated perturbation of membrane composition in lipid droplets induces lipophagy and lipid droplets ubiquitination","volume":"6","author":"Jung","year":"2023","journal-title":"Commun. Biol."},{"issue":"4","key":"10.1016\/j.phrs.2026.108204_bib117","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.repbio.2016.10.001","article-title":"Expression of interferon-stimulated gene ISG15 and ubiquitination enzymes is upregulated in peripheral blood monocyte during early pregnancy in dairy cattle","volume":"16","author":"Haq","year":"2016","journal-title":"Reprod. Biol."},{"issue":"14","key":"10.1016\/j.phrs.2026.108204_bib118","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.246041","article-title":"The ubiquitin-like modifier FAT10-much more than a proteasome-targeting signal","volume":"133","author":"Aichem","year":"2020","journal-title":"J. Cell Sci."},{"issue":"4","key":"10.1016\/j.phrs.2026.108204_bib119","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1002\/hep.31881","article-title":"Hepatic Small Ubiquitin-Related Modifier (SUMO)-Specific Protease 2 Controls Systemic Metabolism Through SUMOylation-Dependent Regulation of Liver-Adipose Tissue Crosstalk","volume":"74","author":"Liu","year":"2021","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.phrs.2026.108204_bib120","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.1074\/jbc.M110.190785","article-title":"Ancient ubiquitous protein 1 (AUP1) localizes to lipid droplets and binds the E2 ubiquitin conjugase G2 (Ube2g2) via its G2 binding region","volume":"286","author":"Spandl","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.phrs.2026.108204_bib121","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2314093121","article-title":"Spartin-mediated lipid transfer facilitates lipid droplet turnover","volume":"121","author":"Wan","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib122","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1074\/jbc.RA118.005556","article-title":"N-terminal acetylation and the N-end rule pathway control degradation of the lipid droplet protein PLIN2","volume":"294","author":"Nguyen","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.phrs.2026.108204_bib123","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1073\/pnas.1213738110","article-title":"Spatial regulation of UBXD8 and p97\/VCP controls ATGL-mediated lipid droplet turnover","volume":"110","author":"Olzmann","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"13","key":"10.1016\/j.phrs.2026.108204_bib124","doi-asserted-by":"crossref","first-page":"9604","DOI":"10.1074\/jbc.M109.043786","article-title":"Fat-specific protein 27 undergoes ubiquitin-dependent degradation regulated by triacylglycerol synthesis and lipid droplet formation","volume":"285","author":"Nian","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.phrs.2026.108204_bib125","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.tcb.2023.09.001","article-title":"The ubiquitous role of ubiquitination in lipid metabolism","volume":"34","author":"Loix","year":"2024","journal-title":"Trends Cell Biol."},{"issue":"18","key":"10.1016\/j.phrs.2026.108204_bib126","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1016\/j.devcel.2023.07.001","article-title":"Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation","volume":"58","author":"Roberts","year":"2023","journal-title":"Dev. Cell"},{"key":"10.1016\/j.phrs.2026.108204_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157032","article-title":"Jiangtang Tiaozhi formula ameliorates MASLD by regulating liver ABCD2\/PEX2\/ATGL axis-mediated fatty acid metabolic reprogramming","volume":"145","author":"Miao","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phrs.2026.108204_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2019.07.005","article-title":"Formononetin alleviates hepatic steatosis by facilitating TFEB-mediated lysosome biogenesis and lipophagy","volume":"73","author":"Wang","year":"2019","journal-title":"J. Nutr. Biochem"},{"issue":"3","key":"10.1016\/j.phrs.2026.108204_bib129","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3390\/ijms17030387","article-title":"TFE3 Alleviates Hepatic Steatosis through Autophagy-Induced Lipophagy and PGC1\u03b1-Mediated Fatty Acid \u03b2-Oxidation","volume":"17","author":"Xiong","year":"2016","journal-title":"Int J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.phrs.2026.108204_bib130","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.1021\/acs.est.4c00421","article-title":"Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate Enhances foxo1-Mediated Lipophagy to Remodel Lipid Metabolism in Zebrafish Liver","volume":"58","author":"Zhou","year":"2024","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib131","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41420-023-01395-0","article-title":"Emerging roles of TFE3 in metabolic regulation","volume":"9","author":"Li","year":"2023","journal-title":"Cell Death Discov."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib132","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12964-025-02117-y","article-title":"TFE3 fusion proteins promote the progression of TFE3 rearranged renal cell carcinoma via enhancing chaperone-mediated lipophagy","volume":"23","author":"Ma","year":"2025","journal-title":"Cell Commun. Signal"},{"issue":"2","key":"10.1016\/j.phrs.2026.108204_bib133","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jhep.2017.11.014","article-title":"Lipotoxicity and the gut-liver axis in NASH pathogenesis","volume":"68","author":"Marra","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phrs.2026.108204_bib134","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102235","article-title":"PERK prevents hepatic lipotoxicity by activating the p62-ULK1 axis-mediated noncanonical KEAP1-Nrf2 pathway","volume":"50","author":"Lee","year":"2022","journal-title":"Redox Biol."},{"issue":"12","key":"10.1016\/j.phrs.2026.108204_bib135","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.433","article-title":"Hypericin-mediated sonodynamic therapy induces autophagy and decreases lipids in THP-1 macrophage by promoting ROS-dependent nuclear translocation of TFEB","volume":"7","author":"Li","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phrs.2026.108204_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.109963","article-title":"Upregulation of the TFEB-mediated lysosome function relieves 4-Hydroxynonenal-Induced apoptosis","volume":"362","author":"Du","year":"2022","journal-title":"Chem. -Biol. Interact."},{"issue":"6","key":"10.1016\/j.phrs.2026.108204_bib137","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/ncb2718","article-title":"TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop","volume":"15","author":"Settembre","year":"2013","journal-title":"Nat. Cell Biol."},{"issue":"10","key":"10.1016\/j.phrs.2026.108204_bib138","doi-asserted-by":"crossref","first-page":"6158","DOI":"10.1021\/acs.jafc.4c07684","article-title":"Morroniside Ameliorates High-Fat and High-Fructose-Driven Chronic Kidney Disease by Motivating AMPK-TFEB Signal Activation to Accelerate Lipophagy and Inhibiting Inflammatory Response","volume":"73","author":"Zhang","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phrs.2026.108204_bib139","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116694","article-title":"The TFEB activator clomiphene citrate ameliorates lipid metabolic syndrome pathology by activating lipophagy and lipolysis","volume":"232","author":"Li","year":"2025","journal-title":"Biochem Pharm."},{"key":"10.1016\/j.phrs.2026.108204_bib140","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2024.1434459","article-title":"The role of SIRT3 in homeostasis and cellular health","volume":"18","author":"Trinh","year":"2024","journal-title":"Front Cell Neurosci."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib141","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41418-019-0356-z","article-title":"SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity","volume":"27","author":"Zhang","year":"2020","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib142","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1186\/s12967-022-03642-x","article-title":"Omentin1 ameliorates myocardial ischemia-induced heart failure via SIRT3\/FOXO3a-dependent mitochondrial dynamical homeostasis and mitophagy","volume":"20","author":"Hu","year":"2022","journal-title":"J. Transl. Med"},{"key":"10.1016\/j.phrs.2026.108204_bib143","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jare.2024.01.027","article-title":"Mechanisms and therapeutic implications of selective autophagy in nonalcoholic fatty liver disease","volume":"67","author":"Jin","year":"2025","journal-title":"J. Adv. Res"},{"issue":"3","key":"10.1016\/j.phrs.2026.108204_bib144","first-page":"435","article-title":"Lipid Droplets and the Management of Cellular Stress","volume":"92","author":"Jarc","year":"2019","journal-title":"Yale J. Biol. Med"},{"issue":"12","key":"10.1016\/j.phrs.2026.108204_bib145","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1194\/jlr.M048553","article-title":"Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells","volume":"55","author":"Dichlberger","year":"2014","journal-title":"J. Lipid Res"},{"issue":"5","key":"10.1016\/j.phrs.2026.108204_bib146","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1189\/jlb.3A0515-206R","article-title":"Adipose triglyceride lipase acts on neutrophil lipid droplets to regulate substrate availability for lipid mediator synthesis","volume":"98","author":"Schlager","year":"2015","journal-title":"J. Leukoc. Biol."},{"issue":"31","key":"10.1016\/j.phrs.2026.108204_bib147","doi-asserted-by":"crossref","first-page":"16001","DOI":"10.1074\/jbc.M116.725937","article-title":"Characterization of Eicosanoids Produced by Adipocyte Lipolysis: IMPLICATION OF CYCLOOXYGENASE-2 IN ADIPOSE INFLAMMATION","volume":"291","author":"Gartung","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.phrs.2026.108204_bib148","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-022-04593-3","article-title":"The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death & Dis."},{"issue":"10","key":"10.1016\/j.phrs.2026.108204_bib149","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.404","article-title":"FoxO1 controls lysosomal acid lipase in adipocytes: implication of lipophagy during nutrient restriction and metformin treatment","volume":"4","author":"Lettieri Barbato","year":"2013","journal-title":"Cell Death Dis."},{"issue":"25","key":"10.1016\/j.phrs.2026.108204_bib150","doi-asserted-by":"crossref","first-page":"40037","DOI":"10.18632\/oncotarget.16673","article-title":"Lysosomal lipid hydrolysis provides substrates for lipid mediator synthesis in murine macrophages","volume":"8","author":"Schlager","year":"2017","journal-title":"Oncotarget"},{"issue":"11","key":"10.1016\/j.phrs.2026.108204_bib151","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1080\/15548627.2017.1371394","article-title":"Recycling the danger via lipid droplet biogenesis after autophagy","volume":"13","author":"Li","year":"2017","journal-title":"Autophagy"},{"issue":"10","key":"10.1016\/j.phrs.2026.108204_bib152","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1038\/s41418-021-00859-z","article-title":"Organelle-specific regulation of ferroptosis","volume":"28","author":"Chen","year":"2021","journal-title":"Cell Death Differ."},{"issue":"9","key":"10.1016\/j.phrs.2026.108204_bib153","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.tcb.2025.01.005","article-title":"Autophagy-dependent versus autophagy-independent ferroptosis","volume":"35","author":"Zhu","year":"2025","journal-title":"Trends Cell Biol."},{"issue":"12","key":"10.1016\/j.phrs.2026.108204_bib154","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1080\/15548627.2025.2522124","article-title":"Mitochondrial protein nmd regulates lipophagy and general autophagy during development","volume":"21","author":"Wang","year":"2025","journal-title":"Autophagy"},{"issue":"9","key":"10.1016\/j.phrs.2026.108204_bib155","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2024.100633","article-title":"Mechanistic insights into metabolic function of dynamin-related protein 1","volume":"65","author":"Li","year":"2024","journal-title":"J. Lipid Res"},{"issue":"4","key":"10.1016\/j.phrs.2026.108204_bib156","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/s41418-020-00728-1","article-title":"Cellular degradation systems in ferroptosis","volume":"28","author":"Chen","year":"2021","journal-title":"Cell Death Differ."},{"issue":"10","key":"10.1016\/j.phrs.2026.108204_bib157","doi-asserted-by":"crossref","first-page":"5309","DOI":"10.1007\/s11010-025-05301-3","article-title":"Ferritinophagy in cardiovascular diseases: mechanisms and potential therapy","volume":"480","author":"Wang","year":"2025","journal-title":"Mol. Cell Biochem"},{"key":"10.1016\/j.phrs.2026.108204_bib158","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.freeradbiomed.2025.11.010","article-title":"Chronic intermittent cold stress-induced lipophagy promotes foamy macrophage susceptibility to ferroptosis and exacerbates atherosclerosis","volume":"242","author":"Zhao","year":"2026","journal-title":"Free Radic. Biol. Med"},{"issue":"12","key":"10.1016\/j.phrs.2026.108204_bib159","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/nrm2529","article-title":"Autophagic cell death: the story of a misnomer","volume":"9","author":"Kroemer","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib160","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1186\/s12944-024-02301-y","article-title":"Rod-shaped mesoporous silica nanoparticles reduce bufalin cardiotoxicity and inhibit colon cancer by blocking lipophagy","volume":"23","author":"Fan","year":"2024","journal-title":"Lipids Health Dis."},{"issue":"7","key":"10.1016\/j.phrs.2026.108204_bib161","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114445","article-title":"Pro-survival signaling regulates lipophagy essential for multiple myeloma resistance to stress-induced death","volume":"43","author":"Peng","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.phrs.2026.108204_bib162","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2025.111622","article-title":"Free fatty acids derived from lipophagy enhanced resistance to anoikis by activating Src in high-invasive clear cell renal cell carcinoma cells","volume":"127","author":"Wu","year":"2025","journal-title":"Cell Signal"},{"key":"10.1016\/j.phrs.2026.108204_bib163","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170724","article-title":"Di (2-ethylhexyl) phthalate induced lipophagy-related renal ferroptosis in quail (Coturnix japonica)","volume":"919","author":"Zhu","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.phrs.2026.108204_bib164","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.bbrc.2018.12.039","article-title":"Lipid storage and lipophagy regulates ferroptosis","volume":"508","author":"Bai","year":"2019","journal-title":"Biochem Biophys. Res Commun."},{"issue":"2","key":"10.1016\/j.phrs.2026.108204_bib165","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s10120-019-01004-z","article-title":"The modification of ferroptosis and abnormal lipometabolism through overexpression and knockdown of potential prognostic biomarker perilipin2 in gastric carcinoma","volume":"23","author":"Sun","year":"2020","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.phrs.2026.108204_bib166","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155079","article-title":"Timosaponin AIII induces lipid peroxidation and ferroptosis by enhancing Rab7-mediated lipophagy in colorectal cancer cells","volume":"122","author":"Shen","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phrs.2026.108204_bib167","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2025.01.016","article-title":"Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism","author":"Jiang","year":"2025","journal-title":"Cell Metab."},{"issue":"48","key":"10.1016\/j.phrs.2026.108204_bib168","doi-asserted-by":"crossref","first-page":"26884","DOI":"10.1021\/acs.jafc.4c06487","article-title":"Fisetin Ameliorates Hepatocyte Lipid Droplet Accumulation via Targeting the Rhythmic Protein BMAL1 to Regulate Cell Death-Inducing DNA Fragmentation Factor-\u03b1-like Effector C-Mediated Lipid Droplet Fusion","volume":"72","author":"Zhang","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phrs.2026.108204_bib169","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.freeradbiomed.2019.03.036","article-title":"An update on lipid oxidation and inflammation in cardiovascular diseases","volume":"144","author":"Zhong","year":"2019","journal-title":"Free Radic. Biol. Med"},{"issue":"4-6","key":"10.1016\/j.phrs.2026.108204_bib170","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1089\/ars.2023.0510","article-title":"Lipotoxicity Induces Cardiomyocyte Ferroptosis via Activating the STING Pathway","volume":"42","author":"Chen","year":"2025","journal-title":"Antioxid. Redox Signal"},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib171","article-title":"Metformin reduces saturated fatty acid-induced lipid accumulation and inflammatory response by restoration of autophagic flux in endothelial cells","volume":"10","author":"Kim","year":"2020","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.phrs.2026.108204_bib172","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s12272-022-01412-3","article-title":"Inhibition of autophagy with chloroquine dysregulates mitochondrial quality control and energetics in adipocytes","volume":"45","author":"Javaid","year":"2022","journal-title":"Arch. Pharm. Res"},{"issue":"7","key":"10.1016\/j.phrs.2026.108204_bib173","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.12413","article-title":"High-dose chloroquine is metabolically cardiotoxic by inducing lysosomes and mitochondria dysfunction in a rat model of pressure overload hypertrophy","volume":"3","author":"Chaanine","year":"2015","journal-title":"Physiol. Rep."},{"issue":"11","key":"10.1016\/j.phrs.2026.108204_bib174","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/nm.2538","article-title":"Atherosclerosis: current pathogenesis and therapeutic options","volume":"17","author":"Weber","year":"2011","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib175","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3803\/EnM.2017.32.1.41","article-title":"The Role of Macrophage Lipophagy in Reverse Cholesterol Transport","volume":"32","author":"Jeong","year":"2017","journal-title":"Endocrinol. Metab. (Seoul. )"},{"issue":"4","key":"10.1016\/j.phrs.2026.108204_bib176","doi-asserted-by":"crossref","DOI":"10.3390\/cells12040522","article-title":"The Role of Macrophages in the Pathogenesis of Atherosclerosis","volume":"12","author":"Blagov","year":"2023","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.phrs.2026.108204_bib177","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.tem.2014.03.010","article-title":"Self-eating in the plaque: what macrophage autophagy reveals about atherosclerosis","volume":"25","author":"Sergin","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2026.108204_bib178","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105169","article-title":"Apoptosis, autophagy and atherosclerosis: Relationships and the role of Hsp27","volume":"166","author":"Shan","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"9","key":"10.1016\/j.phrs.2026.108204_bib179","doi-asserted-by":"crossref","first-page":"4992","DOI":"10.1111\/jcmm.15118","article-title":"FGF21 induces autophagy-mediated cholesterol efflux to inhibit atherogenesis via RACK1 up-regulation","volume":"24","author":"Xiaolong","year":"2020","journal-title":"J. Cell Mol. Med"},{"issue":"12","key":"10.1016\/j.phrs.2026.108204_bib180","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1080\/15548627.2021.1909833","article-title":"Augmenting ATG14 alleviates atherosclerosis and inhibits inflammation via promotion of autophagosome-lysosome fusion in macrophages","volume":"17","author":"Zhang","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.phrs.2026.108204_bib181","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.cca.2020.10.025","article-title":"Lipophagy in atherosclerosis","volume":"511","author":"Liu","year":"2020","journal-title":"Clin. Chim. Acta"},{"issue":"4","key":"10.1016\/j.phrs.2026.108204_bib182","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cmet.2012.01.022","article-title":"Macrophage autophagy plays a protective role in advanced atherosclerosis","volume":"15","author":"Liao","year":"2012","journal-title":"Cell Metab."},{"issue":"7548","key":"10.1016\/j.phrs.2026.108204_bib183","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nature14147","article-title":"ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes","volume":"520","author":"Diao","year":"2015","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.phrs.2026.108204_bib184","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00018-015-2080-2","article-title":"Regulatory T cells in atherosclerosis: critical immune regulatory function and therapeutic potential","volume":"73","author":"Spitz","year":"2016","journal-title":"Cell Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib185","doi-asserted-by":"crossref","DOI":"10.1186\/s12944-023-01891-3","article-title":"Sirt6 enhances macrophage lipophagy and improves lipid metabolism disorder by regulating the Wnt1\/\u00df-catenin pathway in atherosclerosis","volume":"22","author":"Wang","year":"2023","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.phrs.2026.108204_bib186","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jare.2023.11.004","article-title":"ASIC1\/RIP1 accelerates atherosclerosis via disrupting lipophagy","volume":"63","author":"Wang","year":"2024","journal-title":"J. Adv. Res."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib187","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1080\/15548627.2017.1327942","article-title":"Prdx1 (peroxiredoxin 1) deficiency reduces cholesterol efflux via impaired macrophage lipophagic flux","volume":"14","author":"Jeong","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.phrs.2026.108204_bib188","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155617","article-title":"Geniposide ameliorates atherosclerosis by restoring lipophagy via suppressing PARP1\/PI3K\/AKT signaling pathway","volume":"129","author":"Lin","year":"2024","journal-title":"Phytomedicine"},{"issue":"8","key":"10.1016\/j.phrs.2026.108204_bib189","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18257","article-title":"Huayu Qutan Recipe promotes lipophagy and cholesterol efflux through the mTORC1\/TFEB\/ABCA1-SCARB1 signal axis","volume":"28","author":"Li","year":"2024","journal-title":"J. Cell Mol. Med"},{"issue":"Pt 1","key":"10.1016\/j.phrs.2026.108204_bib190","article-title":"Stilbene glycosides alleviate atherosclerosis partly by promoting lipophagy of dendritic cells","volume":"143","author":"Yang","year":"2024","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.phrs.2026.108204_bib191","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155341","article-title":"Gualou-Xiebai herb pair and its active ingredients act against atherosclerosis by suppressing VSMC-derived foam cell formation via regulating P2RY12-mediated lipophagy","volume":"128","author":"Bao","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib192","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s12951-025-03327-9","article-title":"Recombinant high-density lipoprotein targeted delivery of celastrol to promote foam cells lipophagy against early atherosclerosis","volume":"23","author":"Li","year":"2025","journal-title":"J. Nanobiotechnology"},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib193","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1080\/13880209.2025.2509020","article-title":"Apigenin attenuates the atherosclerotic lesions through enhancing selective autophagy\/lipophagy and promoting RCT process","volume":"63","author":"Hu","year":"2025","journal-title":"Pharm. Biol."},{"issue":"31","key":"10.1016\/j.phrs.2026.108204_bib194","doi-asserted-by":"crossref","first-page":"22693","DOI":"10.1074\/jbc.M113.477505","article-title":"Epigallocatechin gallate (EGCG) stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation","volume":"288","author":"Kim","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.phrs.2026.108204_bib195","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1194\/jlr.M065888","article-title":"Ursolic acid enhances macrophage autophagy and attenuates atherogenesis","volume":"57","author":"Leng","year":"2016","journal-title":"J. Lipid Res"},{"key":"10.1016\/j.phrs.2026.108204_bib196","doi-asserted-by":"crossref","DOI":"10.1111\/bph.70035","article-title":"Berberine partially ameliorates cardiolipotoxicity in diabetic cardiomyopathy by modulating SIRT3-mediated lipophagy to remodel lipid droplets homeostasis","author":"Chen","year":"2025","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.phrs.2026.108204_bib197","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.114066","article-title":"Revealment study on the regulation of lipid metabolism by Lingguizhugan Decoction in heart failure treatment based on integrated lipidomics and proteomics","volume":"158","author":"Wang","year":"2023","journal-title":"Biomed. Pharm."},{"issue":"17","key":"10.1016\/j.phrs.2026.108204_bib198","doi-asserted-by":"crossref","first-page":"8822","DOI":"10.7150\/thno.117243","article-title":"Autophagy-driven lipid regulation by an herbal decoction alleviates cardiac lipotoxicity in severe acute pancreatitis","volume":"15","author":"Yang","year":"2025","journal-title":"Theranostics"},{"issue":"16","key":"10.1016\/j.phrs.2026.108204_bib199","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1016\/j.jacc.2013.05.019","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"62","author":"Yancy","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"issue":"39","key":"10.1016\/j.phrs.2026.108204_bib200","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1093\/eurheartj\/eht108","volume":"34","author":"Ryd\u00e9n","year":"2013","journal-title":"Eur. Heart J."},{"issue":"16","key":"10.1016\/j.phrs.2026.108204_bib201","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.jacc.2021.08.020","article-title":"Prevalence and Prognostic Implications of Diabetes With Cardiomyopathy in Community-Dwelling Adults","volume":"78","author":"Segar","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib202","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/s41392-023-01400-z","article-title":"Diabetic vascular diseases: molecular mechanisms and therapeutic strategies","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"issue":"4","key":"10.1016\/j.phrs.2026.108204_bib203","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1161\/CIRCRESAHA.117.311586","article-title":"Diabetic Cardiomyopathy: An Update of Mechanisms Contributing to This Clinical Entity","volume":"122","author":"Jia","year":"2018","journal-title":"Circ. Res"},{"issue":"4","key":"10.1016\/j.phrs.2026.108204_bib204","doi-asserted-by":"crossref","first-page":"R127","DOI":"10.1530\/EJE-17-0724","article-title":"MECHANISMS IN ENDOCRINOLOGY: Diabetic cardiomyopathy: pathophysiology and potential metabolic interventions state of the art review","volume":"178","author":"Levelt","year":"2018","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.phrs.2026.108204_bib205","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103184","article-title":"Sirt5 improves cardiomyocytes fatty acid metabolism and ameliorates cardiac lipotoxicity in diabetic cardiomyopathy via CPT2 de-succinylation","volume":"73","author":"Wu","year":"2024","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib206","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00125-017-4390-4","article-title":"Diabetic cardiomyopathy: a hyperglycaemia- and insulin-resistance-induced heart disease","volume":"61","author":"Jia","year":"2018","journal-title":"Diabetologia"},{"issue":"3","key":"10.1016\/j.phrs.2026.108204_bib207","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1152\/physrev.00006.2004","article-title":"Myocardial substrate metabolism in the normal and failing heart","volume":"85","author":"Stanley","year":"2005","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib208","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70166","article-title":"PINK1 modulates Prdx2 to reduce lipotoxicity-induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction","volume":"15","author":"Zhang","year":"2025","journal-title":"Clin. Transl. Med"},{"key":"10.1016\/j.phrs.2026.108204_bib209","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.124.072194","article-title":"XBP1s-EDEM2 Prevents the Onset and Development of HFpEF by Ameliorating Cardiac Lipotoxicity","author":"Fonseka","year":"2025","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.phrs.2026.108204_bib210","first-page":"774","article-title":"The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge","volume":"38","author":"Heusch","year":"2017","journal-title":"Eur. Heart J."},{"issue":"4","key":"10.1016\/j.phrs.2026.108204_bib211","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrcardio.2016.5","article-title":"Ischaemic conditioning and reperfusion injury","volume":"13","author":"Hausenloy","year":"2016","journal-title":"Nat. Rev. Cardiol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib212","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1172\/JCI62874","article-title":"Myocardial ischemia-reperfusion injury: a neglected therapeutic target","volume":"123","author":"Hausenloy","year":"2013","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.phrs.2026.108204_bib213","article-title":"Saponins in Chinese Herbal Medicine Exerts Protection in Myocardial Ischemia-Reperfusion Injury: Possible Mechanism and Target Analysis","volume":"11","author":"Wang","year":"2020","journal-title":"Front Pharm."},{"issue":"4","key":"10.1016\/j.phrs.2026.108204_bib214","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1093\/eurheartj\/ehab674","article-title":"Defining cardiovascular toxicities of cancer therapies: an International Cardio-Oncology Society (IC-OS) consensus statement","volume":"43","author":"Herrmann","year":"2022","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.phrs.2026.108204_bib215","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113903","article-title":"Research progress of therapeutic drugs for doxorubicin-induced cardiomyopathy","volume":"156","author":"Chen","year":"2022","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.phrs.2026.108204_bib216","article-title":"Burden of chronic diseases among sarcoma survivors treated with anthracycline chemotherapy: results from an observational study","volume":"6","author":"Baker","year":"2020","journal-title":"J. Cancer Metastas-.-. Treat."},{"issue":"13","key":"10.1016\/j.phrs.2026.108204_bib217","doi-asserted-by":"crossref","DOI":"10.3390\/cells13131151","article-title":"Natural Products for Preventing and Managing Anthracycline-Induced Cardiotoxicity: A Comprehensive Review","volume":"13","author":"Szponar","year":"2024","journal-title":"Cells"},{"issue":"9","key":"10.1016\/j.phrs.2026.108204_bib218","article-title":"Research Progress on the Mechanism, Monitoring, and Prevention of Cardiac Injury Caused by Antineoplastic Drugs-Anthracyclines","volume":"13","author":"Chen","year":"2024","journal-title":"Biol. (Basel)"},{"key":"10.1016\/j.phrs.2026.108204_bib219","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.freeradbiomed.2025.02.021","article-title":"Overexpression of hnRNPK and inhibition of cytoplasmic translocation ameliorate lipid disorder in doxorubicin-induced cardiomyopathy via PINK1\/Parkin-mediated mitophagy","volume":"231","author":"Xu","year":"2025","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.phrs.2026.108204_bib220","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.173955","article-title":"Effect of doxorubicin on cardiac lipid metabolism-related transcriptome and the protective activity of Alda-1","volume":"898","author":"da Cunha Menezes Souza","year":"2021","journal-title":"Eur. J. Pharm."},{"issue":"5","key":"10.1016\/j.phrs.2026.108204_bib221","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/s12012-022-09725-x","article-title":"Exploring the Pattern of Metabolic Alterations Causing Energy Imbalance via PPAR\u03b1 Dysregulation in Cardiac Muscle During Doxorubicin Treatment","volume":"22","author":"Renu","year":"2022","journal-title":"Cardiovasc Toxicol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib222","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4062\/biomolther.2023.200","article-title":"Doxorubicin Attenuates Free Fatty Acid-Induced Lipid Accumulation via Stimulation of p53 in HepG2 Cells","volume":"32","author":"Yun","year":"2024","journal-title":"Biomol. Ther. (Seoul. )"},{"issue":"14","key":"10.1016\/j.phrs.2026.108204_bib223","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.4161\/cc.9.14.12181","article-title":"Differential control of ATGL-mediated lipid droplet degradation by CGI-58 and G0S2","volume":"9","author":"Lu","year":"2010","journal-title":"Cell Cycle"},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib224","first-page":"41","article-title":"Cardioprotective effect of lipistat against doxorubicin induced myocardial toxicity in albino rats","volume":"47","author":"Koti","year":"2009","journal-title":"Indian J. Exp. Biol."},{"issue":"2","key":"10.1016\/j.phrs.2026.108204_bib225","first-page":"727","article-title":"Lipid lowering: an important factor in preventing adriamycin-induced heart failure","volume":"150","author":"Iliskovic","year":"1997","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.phrs.2026.108204_bib226","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3181\/00379727-215-44122","article-title":"Protection by taurine against adriamycin-induced proteinuria and hyperlipidemia in rats","volume":"215","author":"Venkatesan","year":"1997","journal-title":"Proc. Soc. Exp. Biol. Med"},{"issue":"9","key":"10.1016\/j.phrs.2026.108204_bib227","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/s41419-020-02948-2","article-title":"Acyl-CoA thioesterase 1 prevents cardiomyocytes from Doxorubicin-induced ferroptosis via shaping the lipid composition","volume":"11","author":"Liu","year":"2020","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib228","article-title":"The function of PCSK9 in doxorubicin-induced cardiotoxicity and its underlying mechanism","volume":"15","author":"Shi","year":"2025","journal-title":"Sci. Rep."},{"issue":"17","key":"10.1016\/j.phrs.2026.108204_bib229","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e36834","article-title":"Pera orange juice (Citrus sinensis L. Osbeck) alters lipid metabolism and attenuates oxidative stress in the heart and liver of rats treated with doxorubicin","volume":"10","author":"Cabral","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.phrs.2026.108204_bib230","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ijcard.2018.02.109","article-title":"Autophagic control of cardiac steatosis through FGF21 in obesity-associated cardiomyopathy","volume":"260","author":"Rup\u00e9rez","year":"2018","journal-title":"Int J. Cardiol."},{"issue":"2","key":"10.1016\/j.phrs.2026.108204_bib231","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.cmet.2008.06.014","article-title":"The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man","volume":"8","author":"G\u00e4lman","year":"2008","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.phrs.2026.108204_bib232","first-page":"354","article-title":"Fibroblast growth factor 21: effects on carbohydrate and lipid metabolism in health and disease","volume":"14","author":"Kralisch","year":"2011","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"issue":"6","key":"10.1016\/j.phrs.2026.108204_bib233","doi-asserted-by":"crossref","first-page":"E1193","DOI":"10.1152\/ajpendo.00227.2019","article-title":"Cardiac overexpression of perilipin 2 induces atrial steatosis, connexin 43 remodeling, and atrial fibrillation in aged mice","volume":"317","author":"Sato","year":"2019","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2026.108204_bib234","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157317","article-title":"Novel AMPK\/ORP8-lipophagy axis: A therapeutic target for asiaticoside-mediated cardioprotection against ischemia-reperfusion injury in hyperlipidemia","volume":"148","author":"Bian","year":"2025","journal-title":"Phytomedicine"},{"issue":"Pt 2","key":"10.1016\/j.phrs.2026.108204_bib235","article-title":"High-throughput screening reveals paeoniflorin's efficacy against Apoc2-deficient hypertriglyceridemia via HNF4A\/PPARA\/LDLR","volume":"242","author":"Li","year":"2025","journal-title":"Biochem Pharm."},{"issue":"11","key":"10.1016\/j.phrs.2026.108204_bib236","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1161\/CIRCRESAHA.116.310078","article-title":"Evolving Concepts of Myocardial Energy Metabolism: More Than Just Fats and Carbohydrates","volume":"119","author":"Lopaschuk","year":"2016","journal-title":"Circ. Res"},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib237","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2017.06.003","article-title":"DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy","volume":"42","author":"Nguyen","year":"2017","journal-title":"Dev. Cell"},{"issue":"3","key":"10.1016\/j.phrs.2026.108204_bib238","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/s41418-023-01241-x","article-title":"Lipid overload-induced RTN3 activation leads to cardiac dysfunction by promoting lipid droplet biogenesis","volume":"31","author":"Guo","year":"2024","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.phrs.2026.108204_bib239","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2021.12.006","article-title":"The role of autophagy in death of cardiomyocytes","volume":"165","author":"Ikeda","year":"2022","journal-title":"J. Mol. Cell Cardiol."},{"issue":"18","key":"10.1016\/j.phrs.2026.108204_bib240","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1016\/j.jacc.2018.02.066","article-title":"Trehalose-Induced Activation of Autophagy Improves Cardiac Remodeling After Myocardial Infarction","volume":"71","author":"Sciarretta","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.phrs.2026.108204_bib241","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/s41418-018-0252-y","article-title":"Autophagy-dependent cell death","volume":"26","author":"Denton","year":"2019","journal-title":"Cell Death Differ."},{"issue":"6","key":"10.1016\/j.phrs.2026.108204_bib242","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1016\/j.gendis.2022.02.012","article-title":"Potential relationship between autophagy and ferroptosis in myocardial ischemia\/reperfusion injury","volume":"10","author":"Yang","year":"2023","journal-title":"Genes Dis."},{"key":"10.1016\/j.phrs.2026.108204_bib243","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1038\/srep02767","article-title":"Endocrine protection of ischemic myocardium by FGF21 from the liver and adipose tissue","volume":"3","author":"Liu","year":"2013","journal-title":"Sci. Rep."},{"issue":"14","key":"10.1016\/j.phrs.2026.108204_bib244","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ade4110","article-title":"An IL-6\/STAT3\/MR\/FGF21 axis mediates heart-liver cross-talk after myocardial infarction","volume":"9","author":"Sun","year":"2023","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.phrs.2026.108204_bib245","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41392-025-02329-1","article-title":"Organ cross-talk: molecular mechanisms, biological functions, and therapeutic interventions for diseases","volume":"11","author":"Che","year":"2026","journal-title":"Signal Transduct. Target Ther."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661826001192?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661826001192?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T13:32:42Z","timestamp":1783085562000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661826001192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":245,"alternative-id":["S1043661826001192"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2026.108204","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual modulation of lipophagy: From molecular mechanisms to therapeutic interventions in cardiovascular health and disease","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2026.108204","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108204"}}