{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T06:18:23Z","timestamp":1793513903710,"version":"4.5.0"},"reference-count":165,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072707"],"award-info":[{"award-number":["82072707"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.phrs.2026.108254","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T23:02:25Z","timestamp":1779145345000},"page":"108254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["The dual role of the CXCL9\/10\/11-CXCR3 axis in the tumor immune microenvironment: Mechanisms, therapeutic implications, and clinical translation"],"prefix":"10.1016","volume":"229","author":[{"given":"Jingyu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianbao","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2026.108254_bib1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ebiom.2019.08.067","article-title":"Role of CXCR3 signaling in response to anti-PD-1 therapy","volume":"48","author":"Han","year":"2019","journal-title":"EBioMedicine"},{"issue":"2","key":"10.1016\/j.phrs.2026.108254_bib2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1158\/1078-0432.CCR-19-1868","article-title":"Macrophage-derived CXCL9 and CXCL10 are required for antitumor immune responses following immune checkpoint blockade","volume":"26","author":"House","year":"2020","journal-title":"Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.phrs.2026.108254_bib3","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ccell.2021.12.009","article-title":"MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells","volume":"40","author":"Limagne","year":"2022","journal-title":"Cancer Cell"},{"issue":"15","key":"10.1016\/j.phrs.2026.108254_bib4","doi-asserted-by":"crossref","first-page":"7175","DOI":"10.7150\/thno.59056","article-title":"CXCL10 potentiates immune checkpoint blockade therapy in homologous recombination-deficient tumors","volume":"11","author":"Shi","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.phrs.2026.108254_bib5","article-title":"CXCL11 correlates with immune infiltration and impacts patient immunotherapy efficacy: a pan-cancer analysis","volume":"13","author":"Li","year":"2022","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.phrs.2026.108254_bib6","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1084\/jem.184.3.963","article-title":"Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes","volume":"184","author":"Loetscher","year":"1996","journal-title":"J. Exp. Med."},{"issue":"11","key":"10.1016\/j.phrs.2026.108254_bib7","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1084\/jem.20021897","article-title":"An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4","volume":"197","author":"Lasagni","year":"2003","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.phrs.2026.108254_bib8","doi-asserted-by":"crossref","first-page":"C542","DOI":"10.1152\/ajpcell.00378.2019","article-title":"The CC and CXC chemokines: major regulators of tumor progression and the tumor microenvironment","volume":"318","author":"Bikfalvi","year":"2020","journal-title":"Am. J. Physiol.-Cell Physiol."},{"issue":"6","key":"10.1016\/j.phrs.2026.108254_bib9","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.ccell.2019.05.004","article-title":"Cooperation between constitutive and inducible chemokines enables T cell engraftment and immune attack in solid tumors","volume":"35","author":"Dangaj","year":"2019","journal-title":"Cancer Cell"},{"issue":"5","key":"10.1016\/j.phrs.2026.108254_bib10","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1158\/2326-6066.CIR-22-0317","article-title":"HDAC3 inhibition promotes antitumor immunity by enhancing CXCL10-mediated chemotaxis and recruiting of immune cells","volume":"11","author":"Li","year":"2023","journal-title":"Cancer Immunol. Res."},{"issue":"13","key":"10.1016\/j.phrs.2026.108254_bib11","article-title":"Attenuation of sialylation augments antitumor immunity and improves response to immunotherapy in ovarian cancer","volume":"83","author":"KC K","year":"2023","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.phrs.2026.108254_bib12","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1136\/gutjnl-2016-313498","article-title":"Gut microbiota modulate T cell trafficking into human colorectal cancer","volume":"67","author":"Cremonesi","year":"2018","journal-title":"Gut"},{"issue":"8046","key":"10.1016\/j.phrs.2026.108254_bib13","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/s41586-024-08257-4","article-title":"Cancer cells impair monocyte-mediated T cell stimulation to evade immunity","volume":"637","author":"Elewaut","year":"2025","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.phrs.2026.108254_bib14","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1158\/2326-6066.CIR-22-0017","article-title":"Activation of tumor-cell STING primes NK-cell therapy","volume":"10","author":"Knelson","year":"2022","journal-title":"Cancer Immunol. Res."},{"issue":"8","key":"10.1016\/j.phrs.2026.108254_bib15","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/j.ccell.2023.06.008","article-title":"A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity","volume":"41","author":"Meiser","year":"2023","journal-title":"Cancer Cell"},{"issue":"4","key":"10.1016\/j.phrs.2026.108254_bib16","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/s41590-024-01792-2","article-title":"Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy","volume":"25","author":"Chen","year":"2024","journal-title":"Nat. Immunol."},{"issue":"7","key":"10.1016\/j.phrs.2026.108254_bib17","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/j.immuni.2023.06.003","article-title":"CXCR3 expression in regulatory T cells drives interactions with type I dendritic cells in tumors to restrict CD8+ T cell antitumor immunity","volume":"56","author":"Moreno Ayala","year":"2023","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib18","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1038\/s41467-022-33375-w","article-title":"A transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma","volume":"13","author":"Alchahin","year":"2022","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib19","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s13046-024-03073-0","article-title":"ALKBH5 promotes non-small cell lung cancer progression and susceptibility to anti-PD-L1 therapy by modulating interactions between tumor and macrophages","volume":"43","author":"Hua","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.phrs.2026.108254_bib20","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1158\/0008-5472.CAN-23-1448","article-title":"Spatial and single-cell transcriptomics reveal a cancer-associated fibroblast subset in HNSCC that restricts infiltration and antitumor activity of CD8+ T cells","volume":"84","author":"Li","year":"2024","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.phrs.2026.108254_bib21","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.cell.2020.09.064","article-title":"CNS-native myeloid cells drive immune suppression in the brain metastatic niche through Cxcl10","volume":"183","author":"Guldner","year":"2020","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.phrs.2026.108254_bib22","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1007\/s00262-022-03193-6","article-title":"CXCL9-modified CAR T cells improve immune cell infiltration and antitumor efficacy","volume":"71","author":"Tian","year":"2022","journal-title":"Cancer Immunol. Immunother."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib23","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2022.2118210","article-title":"CXCL10-armed oncolytic adenovirus promotes tumor-infiltrating T-cell chemotaxis to enhance anti-PD-1 therapy","volume":"11","author":"Li","year":"2022","journal-title":"OncoImmunology"},{"issue":"25","key":"10.1016\/j.phrs.2026.108254_bib24","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1038\/s41388-023-02711-9","article-title":"Targeting MFAP5 in cancer-associated fibroblasts sensitizes pancreatic cancer to PD-L1-based immunochemotherapy via remodeling the matrix","volume":"42","author":"Duan","year":"2023","journal-title":"Oncogene"},{"issue":"626","key":"10.1016\/j.phrs.2026.108254_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abf0992","article-title":"TRIB3 reduces CD8+ T cell infiltration and induces immune evasion by repressing the STAT1-CXCL10 axis in colorectal cancer","volume":"14","author":"Shang","year":"2022","journal-title":"Sci. Transl. Med."},{"issue":"11","key":"10.1016\/j.phrs.2026.108254_bib26","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-007381","article-title":"Systemic infusion of TLR3-ligand and IFN-\u03b1 in patients with breast cancer reprograms local tumor microenvironments for selective CTL influx","volume":"11","author":"Gandhi","year":"2023","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib27","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2024.2364958","article-title":"Improving STING agonist-based cancer therapy by inhibiting the autophagy-related protein VPS34","volume":"13","author":"Bartolini","year":"2024","journal-title":"OncoImmunology"},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib28","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1038\/s41467-025-57257-z","article-title":"PARP inhibitor radiosensitization enhances anti-PD-L1 immunotherapy through stabilizing chemokine mRNA in small cell lung cancer","volume":"16","author":"Ran","year":"2025","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.phrs.2026.108254_bib29","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.jhep.2022.03.039","article-title":"Uncoupling immune trajectories of response and adverse events from anti-PD-1 immunotherapy in hepatocellular carcinoma","volume":"77","author":"Chuah","year":"2022","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib30","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13073-019-0638-6","article-title":"Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data","volume":"11","author":"Finotello","year":"2019","journal-title":"Genome Med."},{"issue":"23","key":"10.1016\/j.phrs.2026.108254_bib31","doi-asserted-by":"crossref","first-page":"14899","DOI":"10.1074\/jbc.272.23.14899","article-title":"Synergy between interferon-gamma and tumor necrosis factor-alpha in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor kappaB","volume":"272","author":"Ohmori","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.phrs.2026.108254_bib32","first-page":"861","article-title":"Tumor necrosis factor-alpha induces cell type and tissue-specific expression of chemoattractant cytokines in vivo","volume":"142","author":"Ohmori","year":"1993","journal-title":"Am. J. Pathol."},{"issue":"9","key":"10.1016\/j.phrs.2026.108254_bib33","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003521","article-title":"Immune cell and tumor cell-derived CXCL10 is indicative of immunotherapy response in metastatic melanoma","volume":"9","author":"Reschke","year":"2021","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib34","article-title":"Role of CXCL10 in the progression of in situ to invasive carcinoma of the breast","volume":"11","author":"Kim","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib35","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s12964-019-0489-1","article-title":"Expression of E-cadherin and specific CXCR3 isoforms impact each other in prostate cancer","volume":"17","author":"Ma","year":"2019","journal-title":"Cell Commun. Signal."},{"issue":"9","key":"10.1016\/j.phrs.2026.108254_bib36","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/jop.13346","article-title":"CXCR3 isoform A promotes head and neck cancer progression by enhancing stem-like property and chemoresistance","volume":"51","author":"Sun","year":"2022","journal-title":"J. Oral Pathol. Med."},{"issue":"2","key":"10.1016\/j.phrs.2026.108254_bib37","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10549-014-3229-7","article-title":"Divergent roles of CXCR3 isoforms in promoting cancer stem-like cell survival and metastasis","volume":"149","author":"Li","year":"2015","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.phrs.2026.108254_bib38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1476-4598-11-3","article-title":"Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion","volume":"11","author":"Wu","year":"2012","journal-title":"Mol. Cancer"},{"issue":"10","key":"10.1016\/j.phrs.2026.108254_bib39","doi-asserted-by":"crossref","first-page":"6234","DOI":"10.4049\/jimmunol.173.10.6234","article-title":"Identification and partial characterization of a variant of human CXCR3 generated by posttranscriptional exon skipping","volume":"173","author":"Ehlert","year":"2004","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib40","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41420-025-02449-1","article-title":"Non-immune targeting of CXCR3 compromises mitochondrial function and suppresses tumor growth in glioblastoma","volume":"11","author":"Chan","year":"2025","journal-title":"Cell Death Discov."},{"issue":"2","key":"10.1016\/j.phrs.2026.108254_bib41","article-title":"Contribution of CXCR3-mediated signaling in the metastatic cascade of solid malignancies","volume":"1876","author":"Cannon","year":"2021","journal-title":"Biochim. et Biophys. Acta (BBA) - Rev. Cancer"},{"issue":"12","key":"10.1016\/j.phrs.2026.108254_bib42","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.devcel.2023.04.010","article-title":"Immune mechanisms shape the clonal landscape during early progression of prostate cancer","volume":"58","author":"Tshering","year":"2023","journal-title":"Dev. Cell"},{"key":"10.1016\/j.phrs.2026.108254_bib43","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.60646","article-title":"CXCL10\/CXCR3 signaling contributes to an inflammatory microenvironment and its blockade enhances progression of murine pancreatic precancerous lesions","volume":"10","author":"Pandey","year":"2021","journal-title":"eLife"},{"issue":"9","key":"10.1016\/j.phrs.2026.108254_bib44","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00262-024-03761-y","article-title":"Tumor-intrinsic IFN\u03b1 and CXCL10 are critical for immunotherapeutic efficacy by recruiting and activating T lymphocytes in tumor microenvironment","volume":"73","author":"Cheng","year":"2024","journal-title":"Cancer Immunol. Immunother."},{"issue":"4","key":"10.1016\/j.phrs.2026.108254_bib45","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-004302","article-title":"Subtyping of microsatellite stability colorectal cancer reveals guanylate binding protein 2 (GBP2) as a potential immunotherapeutic target","volume":"10","author":"Wang","year":"2022","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib46","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.immuni.2020.06.016","article-title":"An oncogenic alteration creates a microenvironment that promotes tumor progression by conferring a metabolic advantage to regulatory T cells","volume":"53","author":"Kumagai","year":"2020","journal-title":"Immunity"},{"issue":"14","key":"10.1016\/j.phrs.2026.108254_bib47","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202417724","article-title":"The crosstalk with CXCL10-rich tumor-associated mast cells fuels pancreatic cancer progression and immune escape","volume":"12","author":"Yin","year":"2025","journal-title":"Adv. Sci."},{"issue":"3","key":"10.1016\/j.phrs.2026.108254_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167627","article-title":"Exosomal miR-184 facilitates bladder cancer progression by targeting AKR1C3 and inducing immune escape via IRF2-CXCL10 axis","volume":"1871","author":"Ying","year":"2025","journal-title":"Biochim. et Biophys. Acta (BBA) - Mol. Basis Dis."},{"issue":"8","key":"10.1016\/j.phrs.2026.108254_bib49","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1038\/s41423-020-00570-y","article-title":"CD147 regulates antitumor CD8+ T-cell responses to facilitate tumor-immune escape","volume":"18","author":"Chen","year":"2021","journal-title":"Cell. Mol. Immunol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib50","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1038\/s41467-025-57603-1","article-title":"Interleukin-16 enhances anti-tumor immune responses by establishing a Th1 cell-macrophage crosstalk through reprogramming glutamine metabolism in mice","volume":"16","author":"Wen","year":"2025","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.phrs.2026.108254_bib51","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-005088","article-title":"SP140 inhibits STAT1 signaling, induces IFN-\u03b3 in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response","volume":"10","author":"Tanagala","year":"2022","journal-title":"J. Immunother. Cancer"},{"issue":"6","key":"10.1016\/j.phrs.2026.108254_bib52","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1007\/s00262-022-03343-w","article-title":"CXCL9 influences the tumor immune microenvironment by stimulating JAK\/STAT pathway in triple-negative breast cancer","volume":"72","author":"Wu","year":"2023","journal-title":"Cancer Immunol. Immunother."},{"issue":"6","key":"10.1016\/j.phrs.2026.108254_bib53","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.immuni.2021.04.019","article-title":"The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake","volume":"54","author":"de Mingo Pulido","year":"2021","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib54","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s40425-019-0573-5","article-title":"STING agonist inflames the pancreatic cancer immune microenvironment and reduces tumor burden in mouse models","volume":"7","author":"Jing","year":"2019","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib55","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/s41467-021-27658-x","article-title":"GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models","volume":"13","author":"Torphy","year":"2022","journal-title":"Nat. Commun."},{"issue":"42","key":"10.1016\/j.phrs.2026.108254_bib56","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2317694121","article-title":"Transcriptional repression by HDAC3 mediates T cell exclusion from Kras mutant lung tumors","volume":"121","author":"McGuire","year":"2024","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"43","key":"10.1016\/j.phrs.2026.108254_bib57","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202402244","article-title":"SIN3B loss heats up cold tumor microenvironment to boost immunotherapy in pancreatic cancer","volume":"11","author":"Zhang","year":"2024","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib58","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1038\/s41467-023-37807-z","article-title":"Priming a vascular-selective cytokine response permits CD8+ T-cell entry into tumors","volume":"14","author":"Kim","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib59","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2022.2144669","article-title":"Chemokine switch regulated by TGF-\u03b21 in cancer-associated fibroblast subsets determines the efficacy of chemo-immunotherapy","volume":"11","author":"Vienot","year":"2022","journal-title":"OncoImmunology"},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib60","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1038\/s41467-019-10369-9","article-title":"LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy","volume":"10","author":"Pascual-Garc\u00eda","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2026.108254_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114579","article-title":"NCOA3 impairs the efficacy of anti-PD-L1 therapy via HSP90\u03b1\/EZH2\/CXCL9 axis in colon cancer","volume":"155","author":"Liu","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"16","key":"10.1016\/j.phrs.2026.108254_bib62","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1158\/0008-5472.CAN-22-3114","article-title":"Targeting KDM2A enhances T-cell infiltration in NSD1-deficient head and neck squamous cell carcinoma","volume":"83","author":"Chen","year":"2023","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib63","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1038\/s42003-024-07341-9","article-title":"EZH2 elicits CD8+ T-cell desert in esophageal squamous cell carcinoma via suppressing CXCL9 and dendritic cells","volume":"7","author":"Zhu","year":"2024","journal-title":"Commun. Biol."},{"issue":"20","key":"10.1016\/j.phrs.2026.108254_bib64","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020104514","article-title":"m6 A RNA methyltransferases METTL3\/14 regulate immune responses to anti-PD-1 therapy","volume":"39","author":"Wang","year":"2020","journal-title":"EMBO J."},{"issue":"7","key":"10.1016\/j.phrs.2026.108254_bib65","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1158\/2326-6066.CIR-22-0814","article-title":"KRT17 promotes T-lymphocyte infiltration through the YTHDF2-CXCL10 axis in colorectal cancer","volume":"11","author":"Liang","year":"2023","journal-title":"Cancer Immunol. Res."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib66","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1186\/s13046-022-02523-x","article-title":"B3GALT4 remodels the tumor microenvironment through GD2-mediated lipid raft formation and the c-met\/AKT\/mTOR\/IRF-1 axis in neuroblastoma","volume":"41","author":"Sha","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib67","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s12943-019-1027-x","article-title":"Lung adenocarcinoma-intrinsic GBE1 signaling inhibits anti-tumor immunity","volume":"18","author":"Li","year":"2019","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib68","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40425-019-0511-6","article-title":"Cancer-cell-secreted CXCL11 promoted CD8+ T cells infiltration through docetaxel-induced-release of HMGB1 in NSCLC","volume":"7","author":"Gao","year":"2019","journal-title":"J. Immunother. Cancer"},{"issue":"2","key":"10.1016\/j.phrs.2026.108254_bib69","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-005986","article-title":"Downregulation of phosphoserine phosphatase potentiates tumor immune environments to enhance immune checkpoint blockade therapy","volume":"11","author":"Peng","year":"2023","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib70","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2046246","article-title":"Lacticaseibacillus paracasei sh2020 induced antitumor immunity and synergized with anti-programmed cell death 1 to reduce tumor burden in mice","volume":"14","author":"Zhang","year":"2022","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phrs.2026.108254_bib71","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ejca.2021.03.053","article-title":"Intratumour microbiome associated with the infiltration of cytotoxic CD8+ T cells and patient survival in cutaneous melanoma","volume":"151","author":"Zhu","year":"2021","journal-title":"Eur. J. Cancer"},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib72","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40168-020-00811-2","article-title":"Predictable modulation of cancer treatment outcomes by the gut microbiota","volume":"8","author":"Heshiki","year":"2020","journal-title":"Microbiome"},{"issue":"2","key":"10.1016\/j.phrs.2026.108254_bib73","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.145207","article-title":"Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade","volume":"6","author":"Ferrere","year":"2021","journal-title":"JCI Insight"},{"issue":"10","key":"10.1016\/j.phrs.2026.108254_bib74","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1038\/s42255-024-01137-1","article-title":"Acarbose enhances the efficacy of immunotherapy against solid tumours by modulating the gut microbiota","volume":"6","author":"Zhang","year":"2024","journal-title":"Nat. Metab."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib75","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41419-025-07588-y","article-title":"FGFR4 promotes CAF activation through the CXCL10-CXCR3 axis in colon cancer","volume":"16","author":"Sun","year":"2025","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.phrs.2026.108254_bib76","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s00262-022-03338-7","article-title":"Cxcr3 constrains pancreatic cancer dissemination through instructing T cell fate","volume":"72","author":"Burrack","year":"2023","journal-title":"Cancer Immunol. Immunother."},{"issue":"5","key":"10.1016\/j.phrs.2026.108254_bib77","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.ccell.2023.03.015","article-title":"Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma","volume":"41","author":"Gaglia","year":"2023","journal-title":"Cancer Cell"},{"issue":"70","key":"10.1016\/j.phrs.2026.108254_bib78","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abk1692","article-title":"Multiplexed imaging mass cytometry of the chemokine milieus in melanoma characterizes features of the response to immunotherapy","volume":"7","author":"Hoch","year":"2022","journal-title":"Sci. Immunol."},{"issue":"6","key":"10.1016\/j.phrs.2026.108254_bib79","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.ccell.2024.04.011","article-title":"Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeutic efficacy","volume":"42","author":"van Elsas","year":"2024","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib80","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1186\/s12967-024-05339-9","article-title":"Augmentation of tumor expression of HLA-DR, CXCL9, and CXCL10 may improve olfactory neuroblastoma immunotherapeutic responses","volume":"22","author":"Larkin","year":"2024","journal-title":"J. Transl. Med."},{"issue":"2","key":"10.1016\/j.phrs.2026.108254_bib81","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.ymthe.2023.12.010","article-title":"Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8+ T cell activity","volume":"32","author":"Luan","year":"2024","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib82","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-009656","article-title":"MAF1 inhibits hepatocarcinogenesis by fostering an immunostimulatory tumor microenvironment","volume":"13","author":"Cao","year":"2025","journal-title":"J. Immunother. Cancer"},{"issue":"2","key":"10.1016\/j.phrs.2026.108254_bib83","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1158\/2326-6066.CIR-20-0312","article-title":"Targeted deletion of CXCR2 in myeloid cells alters the tumor immune environment to improve antitumor immunity","volume":"9","author":"Yang","year":"2021","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.phrs.2026.108254_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216263","article-title":"CXCL10 mediates CD8+ T cells to facilitate vessel normalization and improve the efficacy of cetuximab combined with PD-1 checkpoint inhibitors in colorectal cancer","volume":"567","author":"Yan","year":"2023","journal-title":"Cancer Lett."},{"issue":"2","key":"10.1016\/j.phrs.2026.108254_bib85","doi-asserted-by":"crossref","first-page":"585","DOI":"10.7150\/ijbs.65019","article-title":"Rocaglamide promotes the infiltration and antitumor immunity of NK cells by activating cGAS-STING signaling in non-small cell lung cancer","volume":"18","author":"Yan","year":"2022","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib86","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13046-023-02918-4","article-title":"NK cell-triggered CCL5\/IFN\u03b3-CXCL9\/10 axis underlies the clinical efficacy of neoadjuvant anti-HER2 antibodies in breast cancer","volume":"43","author":"Santana-Hern\u00e1ndez","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.phrs.2026.108254_bib87","article-title":"Interferon regulatory factor 1(IRF-1) activates anti-tumor immunity via CXCL10\/CXCR3 axis in hepatocellular carcinoma (HCC)","volume":"506","author":"Yang","year":"2021","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib88","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-000599","article-title":"Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-\u03b3, CXCL9 and CXCL10","volume":"8","author":"Bergamaschi","year":"2020","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib89","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003571","article-title":"TIM-3 blockade enhances IL-12-dependent antitumor immunity by promoting CD8+ T cell and XCR1+ dendritic cell spatial co-localization","volume":"10","author":"Gardner","year":"2022","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib90","doi-asserted-by":"crossref","first-page":"502","DOI":"10.18632\/aging.102638","article-title":"CXCL9 chemokine promotes the progression of human pancreatic adenocarcinoma through STAT3-dependent cytotoxic T lymphocyte suppression","volume":"12","author":"Gao","year":"2020","journal-title":"Aging"},{"issue":"12","key":"10.1016\/j.phrs.2026.108254_bib91","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.1172\/JCI128644","article-title":"Hedgehog signaling promotes tumor-associated macrophage polarization to suppress intratumoral CD8+ T cell recruitment","volume":"129","author":"Petty","year":"2019","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib92","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1186\/s40425-019-0757-z","article-title":"IL-17 inhibits CXCL9\/10-mediated recruitment of CD8+ cytotoxic T cells and regulatory T cells to colorectal tumors","volume":"7","author":"Chen","year":"2019","journal-title":"J. Immunother. Cancer"},{"issue":"9","key":"10.1016\/j.phrs.2026.108254_bib93","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1136\/gutjnl-2022-327909","article-title":"Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade","volume":"72","author":"Conche","year":"2023","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.phrs.2026.108254_bib94","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1158\/1078-0432.CCR-24-2183","article-title":"Human pancreatic cancer single-cell atlas reveals association of CXCL10+ fibroblasts and basal subtype tumor cells","volume":"31","author":"Loveless","year":"2025","journal-title":"Clin. Cancer Res."},{"issue":"9","key":"10.1016\/j.phrs.2026.108254_bib95","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-009111","article-title":"Endosialin-positive CAFs promote hepatocellular carcinoma progression by suppressing CD8+ T cell infiltration","volume":"12","author":"Gan","year":"2024","journal-title":"J. Immunother. Cancer"},{"issue":"22","key":"10.1016\/j.phrs.2026.108254_bib96","doi-asserted-by":"crossref","first-page":"10575","DOI":"10.1111\/jcmm.16989","article-title":"Colon cancer cells secreted CXCL11 via RBP-J\u03ba to facilitated tumour-associated macrophage-induced cancer metastasis","volume":"25","author":"Liu","year":"2021","journal-title":"J. Cell. Mol. Med."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib97","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1038\/s41467-020-15188-x","article-title":"Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs","volume":"11","author":"Pein","year":"2020","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.phrs.2026.108254_bib98","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.celrep.2019.07.033","article-title":"Inflammatory activation of astrocytes facilitates melanoma brain tropism via the CXCL10-CXCR3 signaling axis","volume":"28","author":"Doron","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.phrs.2026.108254_bib99","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.canlet.2020.06.019","article-title":"Endothelial cells under therapy-induced senescence secrete CXCL11, which increases aggressiveness of breast cancer cells","volume":"490","author":"Hwang","year":"2020","journal-title":"Cancer Lett."},{"issue":"6","key":"10.1016\/j.phrs.2026.108254_bib100","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/j.immuni.2019.04.010","article-title":"Intratumoral activity of the CXCR3 chemokine system is required for the efficacy of anti-PD-1 therapy","volume":"50","author":"Chow","year":"2019","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.phrs.2026.108254_bib101","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003484","article-title":"ZEB1 transcription factor promotes immune escape in melanoma","volume":"10","author":"Plaschka","year":"2022","journal-title":"J. Immunother. Cancer"},{"issue":"19","key":"10.1016\/j.phrs.2026.108254_bib102","doi-asserted-by":"crossref","first-page":"4505","DOI":"10.1158\/1078-0432.CCR-24-0385","article-title":"Cervical cancer evades the host immune system through the inhibition of type I interferon and CXCL9 by LIF","volume":"30","author":"Bonfill-Teixidor","year":"2024","journal-title":"Clin. Cancer Res."},{"issue":"6","key":"10.1016\/j.phrs.2026.108254_bib103","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1136\/gutjnl-2023-331342","article-title":"Targeting MMP9 in CTNNB1 mutant hepatocellular carcinoma restores CD8+ T cell-mediated antitumour immunity and improves anti-PD-1 efficacy","volume":"73","author":"Cai","year":"2024","journal-title":"Gut"},{"issue":"15","key":"10.1016\/j.phrs.2026.108254_bib104","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1158\/0008-5472.CAN-22-3023","article-title":"PTEN loss confers resistance to anti-PD-1 therapy in non-small cell lung cancer by increasing tumor infiltration of regulatory T cells","volume":"83","author":"Exposito","year":"2023","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib105","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41420-025-02449-1","article-title":"Non-immune targeting of CXCR3 compromises mitochondrial function and suppresses tumor growth in glioblastoma","volume":"11","author":"Chan","year":"2025","journal-title":"Cell Death Discov."},{"issue":"7","key":"10.1016\/j.phrs.2026.108254_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110814","article-title":"WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC","volume":"39","author":"Taniguchi","year":"2022","journal-title":"Cell Rep."},{"issue":"42","key":"10.1016\/j.phrs.2026.108254_bib107","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202308990","article-title":"Gasdermin C promotes stemness and immune evasion in pancreatic cancer via pyroptosis-independent mechanism","volume":"11","author":"Wu","year":"2024","journal-title":"Adv. Sci."},{"issue":"23","key":"10.1016\/j.phrs.2026.108254_bib108","doi-asserted-by":"crossref","first-page":"8007","DOI":"10.1039\/D1BM01299A","article-title":"A nanodrug incorporating siRNA PD-L1 and Birinapant for enhancing tumor immunotherapy","volume":"9","author":"Gong","year":"2021","journal-title":"Biomater. Sci."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib109","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2020.1809947","article-title":"\u03b2-Catenin inhibition shapes tumor immunity and synergizes with immunotherapy in colorectal cancer","volume":"9","author":"Wang","year":"2020","journal-title":"OncoImmunology"},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib110","doi-asserted-by":"crossref","first-page":"7709","DOI":"10.1038\/s41467-023-43462-1","article-title":"Low-dose radiotherapy combined with dual PD-L1 and VEGFA blockade elicits antitumor response in hepatocellular carcinoma mediated by activated intratumoral CD8+ exhausted-like T cells","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.phrs.2026.108254_bib111","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/cac2.12327","article-title":"KRAS-G12D mutation drives immune suppression and the primary resistance of anti-PD-1\/PD-L1 immunotherapy in non-small cell lung cancer","volume":"42","author":"Liu","year":"2022","journal-title":"Cancer Commun."},{"issue":"8","key":"10.1016\/j.phrs.2026.108254_bib112","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.155006","article-title":"Dual IL-6 and CTLA-4 blockade regresses pancreatic tumors in a T cell- and CXCR3-dependent manner","volume":"8","author":"Ware","year":"2023","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib113","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ccell.2019.11.003","article-title":"CDK7 inhibition potentiates genome instability triggering anti-tumor immunity in small cell lung cancer","volume":"37","author":"Zhang","year":"2020","journal-title":"Cancer Cell"},{"issue":"44","key":"10.1016\/j.phrs.2026.108254_bib114","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adl6464","article-title":"Spatial multiplex analysis of lung cancer reveals that regulatory T cells attenuate KRAS-G12C inhibitor-induced immune responses","volume":"10","author":"Cole","year":"2024","journal-title":"Sci. Adv."},{"issue":"7","key":"10.1016\/j.phrs.2026.108254_bib115","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-008811","article-title":"Harnessing lipid metabolism modulation for improved immunotherapy outcomes in lung adenocarcinoma","volume":"12","author":"Chen","year":"2024","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib116","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/hep.32348","article-title":"Monocarboxylate transporter 4 inhibition potentiates hepatocellular carcinoma immunotherapy through enhancing T cell infiltration and immune attack","volume":"77","author":"Fang","year":"2023","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.phrs.2026.108254_bib117","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-002837","article-title":"DPP inhibition alters the CXCR3 axis and enhances NK and CD8+ T cell infiltration to improve anti-PD1 efficacy in murine models of pancreatic ductal adenocarcinoma","volume":"9","author":"Fitzgerald","year":"2021","journal-title":"J. Immunother. Cancer"},{"issue":"7","key":"10.1016\/j.phrs.2026.108254_bib118","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1158\/2326-6066.CIR-20-0499","article-title":"Exercise training improves tumor control by increasing CD8+ T-cell infiltration via CXCR3 signaling and sensitizes breast cancer to immune checkpoint blockade","volume":"9","author":"Gomes-Santos","year":"2021","journal-title":"Cancer Immunol. Res."},{"issue":"7","key":"10.1016\/j.phrs.2026.108254_bib119","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/s41416-022-02132-7","article-title":"Norepinephrine inhibits CD8+ T-cell infiltration and function, inducing anti-PD-1 mAb resistance in lung adenocarcinoma","volume":"128","author":"Geng","year":"2023","journal-title":"Br. J. Cancer"},{"issue":"823","key":"10.1016\/j.phrs.2026.108254_bib120","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.add9139","article-title":"GPCR kinases differentially modulate biased signaling downstream of CXCR3 depending on their subcellular localization","volume":"17","author":"Gardner","year":"2024","journal-title":"Sci. Signal."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib121","doi-asserted-by":"crossref","first-page":"5846","DOI":"10.1038\/s41467-022-33569-2","article-title":"Location bias contributes to functionally selective responses of biased CXCR3 agonists","volume":"13","author":"Eiger","year":"2022","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.phrs.2026.108254_bib122","doi-asserted-by":"crossref","first-page":"746","DOI":"10.3390\/life11080746","article-title":"CXCR3 expression and genome-wide 3\u2032 splice site selection in the TCGA breast cancer cohort","volume":"11","author":"Levesque","year":"2021","journal-title":"Life"},{"key":"10.1016\/j.phrs.2026.108254_bib123","article-title":"The extended N-terminal domain confers atypical chemokine receptor properties to CXCR3-B","volume":"13","author":"D'Uonnolo","year":"2022","journal-title":"Front Immunol."},{"issue":"10","key":"10.1016\/j.phrs.2026.108254_bib124","article-title":"A comparative study of the effects of nine CXCR3 antagonists on macrophage function and the treatment of acute lung injury","volume":"30","author":"Zhang","year":"2025","journal-title":"Front. Biosci. (Landmark Ed.)"},{"issue":"12","key":"10.1016\/j.phrs.2026.108254_bib125","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/s41419-023-06354-2","article-title":"The duality of CXCR3 in glioblastoma: unveiling autocrine and paracrine mechanisms for novel therapeutic approaches","volume":"14","author":"Chan","year":"2023","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.phrs.2026.108254_bib126","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202523331","article-title":"CXC chemokine-driven vascular reprogramming: modulating tumor vasculature to boost therapeutic response","volume":"13","author":"Chen","year":"2026","journal-title":"Adv. Sci."},{"issue":"44","key":"10.1016\/j.phrs.2026.108254_bib127","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202407235","article-title":"Open-source throttling of CD8+ T cells in brain with low-intensity focused ultrasound-guided sequential delivery of CXCL10, IL-2, and aPD-L1 for glioblastoma immunotherapy","volume":"36","author":"Dong","year":"2024","journal-title":"Adv. Mater."},{"issue":"25","key":"10.1016\/j.phrs.2026.108254_bib128","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202209785","article-title":"Recruiting T-cells toward the brain for enhanced glioblastoma immunotherapeutic efficacy by co-delivery of cytokines and immune checkpoint antibodies with macrophage-membrane-camouflaged nanovesicles","volume":"35","author":"Xu","year":"2023","journal-title":"Adv. Mater."},{"issue":"12","key":"10.1016\/j.phrs.2026.108254_bib129","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1016\/j.ymthe.2020.08.005","article-title":"Targeted delivery of CXCL9 and OX40L by mesenchymal stem cells elicits potent antitumor immunity","volume":"28","author":"Yin","year":"2020","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib130","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1038\/s41467-023-37656-w","article-title":"Engineering tumor-specific gene nanomedicine to recruit and activate T cells for enhanced immunotherapy","volume":"14","author":"Wang","year":"2023","journal-title":"Nat. Commun."},{"issue":"15","key":"10.1016\/j.phrs.2026.108254_bib131","doi-asserted-by":"crossref","first-page":"14494","DOI":"10.1021\/acsnano.3c01019","article-title":"Janus silica nanoparticle-based tumor microenvironment modulator for restoring tumor sensitivity to programmed cell death ligand 1 immune checkpoint blockade therapy","volume":"17","author":"Lin","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.phrs.2026.108254_bib132","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/s43018-021-00237-1","article-title":"Autophagy inhibition by targeting PIKfyve potentiates response to immune checkpoint blockade in prostate cancer","volume":"2","author":"Qiao","year":"2021","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.phrs.2026.108254_bib133","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113783","article-title":"HDAC inhibitor HPTA initiates anti-tumor response by CXCL9\/10-recruited CXCR3+CD4+T cells against PAHs carcinogenicity","volume":"176","author":"Chen","year":"2023","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib134","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2024.2358590","article-title":"CXCL10 and IL15 co-expressing chimeric antigen receptor T cells enhance anti-tumor effects in gastric cancer by increasing cytotoxic effector cell accumulation and survival","volume":"13","author":"Nie","year":"2024","journal-title":"OncoImmunology"},{"key":"10.1016\/j.phrs.2026.108254_bib135","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121341","article-title":"IL-12 nanochaperone-engineered CAR T cell for robust tumor-immunotherapy","volume":"281","author":"Luo","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.phrs.2026.108254_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.neo.2024.101065","article-title":"Construction of self-driving anti-\u03b1FR CAR-engineered NK cells based on IFN-\u03b3 and TNF-\u03b1 synergistically induced high expression of CXCL10","volume":"58","author":"He","year":"2024","journal-title":"Neoplasia"},{"issue":"2","key":"10.1016\/j.phrs.2026.108254_bib137","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ccell.2020.11.005","article-title":"Immunogenic chemotherapy enhances recruitment of CAR-T cells to lung tumors and improves antitumor efficacy when combined with checkpoint blockade","volume":"39","author":"Srivastava","year":"2021","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib138","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108944","article-title":"Metabolic modulation by CDK4\/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors","volume":"35","author":"Uzhachenko","year":"2021","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.phrs.2026.108254_bib139","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/s41591-024-02875-1","article-title":"Locoregional delivery of IL-13R\u03b12-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial","volume":"30","author":"Brown","year":"2024","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib140","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ccell.2023.11.011","article-title":"Immune determinants of CAR-T cell expansion in solid tumor patients receiving GD2 CAR-T cell therapy","volume":"42","author":"Kaczanowska","year":"2024","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib141","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ymthe.2022.08.021","article-title":"CXCL11-armed oncolytic adenoviruses enhance CAR-T cell therapeutic efficacy and reprogram tumor microenvironment in glioblastoma","volume":"31","author":"Wang","year":"2023","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib142","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.1038\/s41467-024-49989-1","article-title":"Adeno-associated virus delivered CXCL9 sensitizes glioblastoma to anti-PD-1 immune checkpoint blockade","volume":"15","author":"von Roemeling","year":"2024","journal-title":"Nat. Commun."},{"issue":"45","key":"10.1016\/j.phrs.2026.108254_bib143","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202210487","article-title":"An ion-enhanced oncolytic virus-like nanoparticle for tumor immunotherapy","volume":"61","author":"Wu","year":"2022","journal-title":"Angew. Chem. Int. Ed."},{"issue":"4","key":"10.1016\/j.phrs.2026.108254_bib144","article-title":"CXCL9\/10-engineered dendritic cells promote T cell activation and enhance immune checkpoint blockade for lung cancer","volume":"5","author":"Lim","year":"2024","journal-title":"Cell Rep. Med."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib145","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1038\/s41467-025-58264-w","article-title":"Structural visualization of small molecule recognition by CXCR3 uncovers dual-agonism in the CXCR3-CXCR7 system","volume":"16","author":"Saha","year":"2025","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.phrs.2026.108254_bib146","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/s41594-023-01175-5","article-title":"Structural insights into the activation and inhibition of CXC chemokine receptor 3","volume":"31","author":"Jiao","year":"2024","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"5","key":"10.1016\/j.phrs.2026.108254_bib147","article-title":"Next-generation anti-PD-L1\/IL-15 immunocytokine elicits superior antitumor immunity in cold tumors with minimal toxicity","volume":"5","author":"Shi","year":"2024","journal-title":"Cell Rep. Med."},{"issue":"10","key":"10.1016\/j.phrs.2026.108254_bib148","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/s41565-024-01722-1","article-title":"Oral administration of garlic-derived nanoparticles improves cancer immunotherapy by inducing intestinal IFN\u03b3-producing \u03b3\u03b4 T cells","volume":"19","author":"Xu","year":"2024","journal-title":"Nat. Nanotechnol."},{"issue":"719","key":"10.1016\/j.phrs.2026.108254_bib149","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adj0740","article-title":"The tumor microenvironment state associates with response to HPV therapeutic vaccination in patients with respiratory papillomatosis","volume":"15","author":"Norberg","year":"2023","journal-title":"Sci. Transl. Med."},{"issue":"4","key":"10.1016\/j.phrs.2026.108254_bib150","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-008287","article-title":"Efficacy of LCMV-based cancer immunotherapies is unleashed by intratumoral injections of polyI:C","volume":"12","author":"Gomar","year":"2024","journal-title":"J. Immunother. Cancer"},{"issue":"5","key":"10.1016\/j.phrs.2026.108254_bib151","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003960","article-title":"Intratumoral administration of STING-activating nanovaccine enhances T cell immunotherapy","volume":"10","author":"Jiang","year":"2022","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib152","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1158\/2326-6066.CIR-23-0350","article-title":"Bexmarilimab activates human tumor-associated macrophages to support adaptive immune responses in interferon-poor immune microenvironments","volume":"12","author":"Rannikko","year":"2024","journal-title":"Cancer Immunol. Res."},{"issue":"8","key":"10.1016\/j.phrs.2026.108254_bib153","doi-asserted-by":"crossref","first-page":"6854","DOI":"10.1021\/acs.jmedchem.4c00508","article-title":"Discovery of a novel CSF-1R inhibitor with highly improved pharmacokinetic profiles and superior efficacy in colorectal cancer immunotherapy","volume":"67","author":"Lv","year":"2024","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib154","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41467-023-44308-6","article-title":"T-cell stimulating vaccines empower CD3 bispecific antibody therapy in solid tumors","volume":"15","author":"Middelburg","year":"2024","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.phrs.2026.108254_bib155","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1039\/D3NH00401E","article-title":"Hydrogel-mediated tumor T cell infiltration and immune evasion to reinforce cancer immunotherapy","volume":"9","author":"Xu","year":"2024","journal-title":"Nanoscale Horiz."},{"issue":"11","key":"10.1016\/j.phrs.2026.108254_bib156","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202202757","article-title":"A novel tri-functional liposome re-educates \u201ccold tumor\u201d and abrogates tumor growth by synergizing autophagy inhibition and PD-L1 blockade","volume":"12","author":"Zhou","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.phrs.2026.108254_bib157","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121952","article-title":"Epigenetic reprogramming of carrier free photodynamic modulator to activate tumor immunotherapy by EZH2 inhibition","volume":"293","author":"Zhao","year":"2023","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.phrs.2026.108254_bib158","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-000778","article-title":"M1hot tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer","volume":"8","author":"Garrido-Martin","year":"2020","journal-title":"J. Immunother. Cancer"},{"issue":"6657","key":"10.1016\/j.phrs.2026.108254_bib159","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1126\/science.ade2292","article-title":"CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers","volume":"381","author":"Bill","year":"2023","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.phrs.2026.108254_bib160","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12943-023-01931-7","article-title":"Deciphering tumor microenvironment: CXCL9 and SPP1 as crucial determinants of tumor-associated macrophage polarity and prognostic indicators","volume":"23","author":"Su","year":"2024","journal-title":"Mol. Cancer"},{"issue":"12","key":"10.1016\/j.phrs.2026.108254_bib161","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-009879","article-title":"Spatial patterns and MRI-based radiomic prediction of high peritumoral tertiary lymphoid structure density in hepatocellular carcinoma: a multicenter study","volume":"12","author":"Long","year":"2024","journal-title":"J. Immunother. Cancer"},{"issue":"8","key":"10.1016\/j.phrs.2026.108254_bib162","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-007106","article-title":"Multimodal molecular landscape of response to Y90-resin microsphere radioembolization followed by nivolumab for advanced hepatocellular carcinoma","volume":"11","author":"Kaya","year":"2023","journal-title":"J. Immunother. Cancer"},{"issue":"3","key":"10.1016\/j.phrs.2026.108254_bib163","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1124\/pharmrev.123.000831","article-title":"Adrenoceptor desensitization: current understanding of mechanisms","volume":"76","author":"Maaliki","year":"2024","journal-title":"Pharmacol. Rev."},{"issue":"9","key":"10.1016\/j.phrs.2026.108254_bib164","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nri.2017.49","article-title":"Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy","volume":"17","author":"Nagarsheth","year":"2017","journal-title":"Nat. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.phrs.2026.108254_bib165","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41574-021-00514-0","article-title":"Drug resistance in pituitary tumours: from cell membrane to intracellular signalling","volume":"17","author":"Peverelli","year":"2021","journal-title":"Nat. Rev. Endocrinol."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661826001696?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661826001696?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:21:20Z","timestamp":1783041680000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661826001696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":165,"alternative-id":["S1043661826001696"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2026.108254","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The dual role of the CXCL9\/10\/11-CXCR3 axis in the tumor immune microenvironment: Mechanisms, therapeutic implications, and clinical translation","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2026.108254","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108254"}}