{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:16:15Z","timestamp":1783152975766,"version":"3.54.6"},"reference-count":154,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82405341"],"award-info":[{"award-number":["82405341"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022MD713736"],"award-info":[{"award-number":["2022MD713736"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","award":["AB25069271"],"award-info":[{"award-number":["AB25069271"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2025GXNSFAA0691007"],"award-info":[{"award-number":["2025GXNSFAA0691007"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.phrs.2026.108263","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T16:15:09Z","timestamp":1779725709000},"page":"108263","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Non-coding RNA regulatory networks in post-stroke neuropsychiatric complications: Mechanisms, delivery strategies, and translational challenges"],"prefix":"10.1016","volume":"229","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0370-1723","authenticated-orcid":false,"given":"Dekai","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianbao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.U.","family":"Yuxin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiu","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.phrs.2026.108263_bib1","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1161\/STROKEAHA.125.051002","article-title":"Time window and watch-and-wait: stroke","volume":"56","author":"Ray","year":"2025","journal-title":"Stroke"},{"issue":"6","key":"10.1016\/j.phrs.2026.108263_bib2","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1172\/JCI135530","article-title":"Immune responses to stroke: mechanisms, modulation, and therapeutic potential","volume":"130","author":"Iadecola","year":"2020","journal-title":"J. Clin. Invest"},{"issue":"5","key":"10.1016\/j.phrs.2026.108263_bib3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrneurol.2016.46","article-title":"Neuropsychiatric sequelae of stroke","volume":"12","author":"Ferro","year":"2016","journal-title":"Nat. Rev. Neurol."},{"issue":"6","key":"10.1016\/j.phrs.2026.108263_bib4","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.14336\/AD.2023.0310-2","article-title":"Post-Stroke Neuropsychiatric Complications: Types, Pathogenesis, and Therapeutic Intervention","volume":"14","author":"Zhou","year":"2023","journal-title":"Aging Dis."},{"issue":"8","key":"10.1016\/j.phrs.2026.108263_bib5","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S1474-4422(16)00114-9","article-title":"Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation","volume":"15","author":"Chamorro","year":"2016","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18010135","article-title":"Treating the Synapse in Major Psychiatric Disorders: The Role of Postsynaptic Density Network in Dopamine-Glutamate Interplay and Psychopharmacologic Drugs Molecular Actions","volume":"18","author":"Tomasetti","year":"2017","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.phrs.2026.108263_bib7","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.pharmthera.2017.11.005","article-title":"Post-stroke depression: Mechanisms and pharmacological treatment","volume":"184","author":"Villa","year":"2018","journal-title":"Pharm. Ther."},{"issue":"3","key":"10.1016\/j.phrs.2026.108263_bib8","doi-asserted-by":"crossref","first-page":"330","DOI":"10.5498\/wjp.v5.i3.330","article-title":"Pharmacologic approaches to treatment resistant depression: Evidences and personal experience","volume":"5","author":"Tundo","year":"2015","journal-title":"World J. Psychiatry"},{"key":"10.1016\/j.phrs.2026.108263_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2022.871754","article-title":"The Relationship Between 5-Hydroxytryptamine and Its Metabolite Changes With Post-stroke Depression","volume":"13","author":"Gu","year":"2022","journal-title":"Front Psychiatry"},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib10","article-title":"Hyperbaric oxygen ameliorates cognitive impairment in patients with Alzheimer's disease and amnestic mild cognitive impairment","volume":"6","author":"Chen","year":"2020","journal-title":"Alzheimers Dement (N. Y"},{"issue":"3","key":"10.1016\/j.phrs.2026.108263_bib11","doi-asserted-by":"crossref","DOI":"10.1590\/1414-431x202010010","article-title":"Efficacy of repetitive transcranial magnetic stimulation for post-stroke depression: a systematic review and meta-analysis of randomized clinical trials","volume":"54","author":"Shao","year":"2021","journal-title":"Braz. J. Med Biol. Res"},{"key":"10.1016\/j.phrs.2026.108263_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103622","article-title":"Decoding ischemic stroke: Perspectives on the endoplasmic reticulum, mitochondria, and their crosstalk","volume":"82","author":"Zhang","year":"2025","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.phrs.2026.108263_bib13","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1093\/brain\/awab353","article-title":"Forecasting stroke-like episodes and outcomes in mitochondrial disease","volume":"145","author":"Ng","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.phrs.2026.108263_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2024.109951","article-title":"Peculiarities of ion homeostasis in neurons containing calcium-permeable AMPA receptors","volume":"754","author":"Maiorov","year":"2024","journal-title":"Arch. Biochem Biophys."},{"issue":"2","key":"10.1016\/j.phrs.2026.108263_bib15","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/s41380-021-01312-w","article-title":"Dysregulation of mitochondrial dynamics, mitophagy and apoptosis in major depressive disorder: Does inflammation play a role?","volume":"27","author":"Scaini","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.phrs.2026.108263_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101503","article-title":"Mitochondrial dysfunction, oxidative stress, neuroinflammation, and metabolic alterations in the progression of Alzheimer's disease: A meta-analysis of in vivo magnetic resonance spectroscopy studies","volume":"72","author":"Song","year":"2021","journal-title":"Ageing Res Rev."},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib17","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1186\/s12951-024-02941-3","article-title":"Magnetic targeting enhances the neuroprotective function of human mesenchymal stem cell-derived iron oxide exosomes by delivering miR-1228-5p","volume":"22","author":"Hu","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib18","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s00018-024-05428-4","article-title":"Suppression of neuronal CDK9\/p53\/VDAC signaling provides bioenergetic support and improves post-stroke neuropsychiatric outcomes","volume":"81","author":"Xia","year":"2024","journal-title":"Cell Mol. Life Sci."},{"issue":"4","key":"10.1016\/j.phrs.2026.108263_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurot.2025.e00573","article-title":"ApTOLL ameliorates cognitive dysfunction and brain injury in ischemic stroke by regulating the miR-335-5p\/IRAK1 axis","volume":"22","author":"Qin","year":"2025","journal-title":"Neurotherapeutics"},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib20","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/imcb.12301","article-title":"The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer's disease","volume":"98","author":"Webers","year":"2020","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.phrs.2026.108263_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2019.01.002","article-title":"Neuroinflammation in mild cognitive impairment and Alzheimer's disease: A meta-analysis","volume":"50","author":"Bradburn","year":"2019","journal-title":"Ageing Res Rev."},{"issue":"4","key":"10.1016\/j.phrs.2026.108263_bib22","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1016\/j.apsb.2021.12.009","article-title":"Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles","volume":"12","author":"Deng","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"7","key":"10.1016\/j.phrs.2026.108263_bib23","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/j.apsb.2020.10.018","article-title":"Natural compounds modulate the autophagy with potential implication of stroke","volume":"11","author":"Ahsan","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phrs.2026.108263_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107848","article-title":"Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics","volume":"225","author":"Ajoolabady","year":"2021","journal-title":"Pharm. Ther."},{"key":"10.1016\/j.phrs.2026.108263_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102842","article-title":"Bidirectional regulation of neuronal autophagy in ischemic stroke: Mechanisms and therapeutic potential","volume":"111","author":"Wu","year":"2025","journal-title":"Ageing Res Rev."},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib26","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1080\/00207454.2020.1802265","article-title":"Elevated microRNA-135b-5p relieves neuronal injury and inflammation in post-stroke cognitive impairment by targeting NR3C2","volume":"132","author":"Huang","year":"2022","journal-title":"Int J. Neurosci."},{"key":"10.1016\/j.phrs.2026.108263_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2022.114266","article-title":"RGD1564534 represses NLRP3 inflammasome activity in cerebral injury following ischemia-reperfusion by impairing miR-101a-3p-mediated Dusp1 inhibition","volume":"359","author":"Fan","year":"2023","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib28","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s41065-025-00493-6","article-title":"Silencing LncRNA HCG27 ameliorates cognitive dysfunction after ischemic stroke via miR-27a-3p regulation","volume":"162","author":"Li","year":"2025","journal-title":"Hereditas"},{"issue":"9","key":"10.1016\/j.phrs.2026.108263_bib29","doi-asserted-by":"crossref","first-page":"5512","DOI":"10.1097\/MS9.0000000000003628","article-title":"Electroacupuncture therapy improves cognitive dysfunction after ischemic stroke in Sprague-Dawley rats by adjusting the lncRNA-MEG3\/miR-4640-3p axis","volume":"87","author":"Zhang","year":"2025","journal-title":"Ann. Med Surg. (Lond. )"},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib30","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1186\/s12964-025-02287-9","article-title":"Mechanisms of electroacupuncture-induced neuroprotection in acute stroke rats: the role of astrocyte-mediated mitochondrial transfer","volume":"23","author":"Guo","year":"2025","journal-title":"Cell Commun. Signal"},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib31","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41583-020-00396-7","article-title":"Encouraging an excitable brain state: mechanisms of brain repair in stroke","volume":"22","author":"Joy","year":"2021","journal-title":"Nat. Rev. Neurosci."},{"issue":"4","key":"10.1016\/j.phrs.2026.108263_bib32","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1007\/s10571-022-01264-x","article-title":"Repetitive Transcranial Magnetic Stimulation of the Brain After Ischemic Stroke: Mechanisms from Animal Models","volume":"43","author":"Xing","year":"2023","journal-title":"Cell Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.phrs.2026.108263_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci10030186","article-title":"Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) Combined with Aerobic Exercise on the Recovery of Motor Function in Ischemic Stroke Rat Model","volume":"10","author":"Cui","year":"2020","journal-title":"Brain Sci."},{"key":"10.1016\/j.phrs.2026.108263_bib34","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.arr.2014.03.004","article-title":"Non-coding RNA regulation of synaptic plasticity and memory: implications for aging","volume":"17","author":"Earls","year":"2014","journal-title":"Ageing Res Rev."},{"issue":"1652","key":"10.1016\/j.phrs.2026.108263_bib35","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0504","article-title":"The RNA-centred view of the synapse: non-coding RNAs and synaptic plasticity","volume":"369","author":"Smalheiser","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"issue":"13","key":"10.1016\/j.phrs.2026.108263_bib36","doi-asserted-by":"crossref","first-page":"5776","DOI":"10.7150\/thno.73931","article-title":"Emerging roles of extracellular vesicle-associated non-coding RNAs in hypoxia: Insights from cancer, myocardial infarction and ischemic stroke","volume":"12","author":"Hermann","year":"2022","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.phrs.2026.108263_bib37","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1161\/CIRCULATIONAHA.120.045765","article-title":"Extracellular Vesicle-Mediated Delivery of Circular RNA SCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models","volume":"142","author":"Yang","year":"2020","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.phrs.2026.108263_bib38","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1161\/STROKEAHA.116.015204","article-title":"MicroRNA cluster miR-17-92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats","volume":"48","author":"Xin","year":"2017","journal-title":"Stroke"},{"key":"10.1016\/j.phrs.2026.108263_bib39","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.bbrc.2022.05.038","article-title":"Therapeutic effect of fastigial nucleus stimulation is mediated by the microRNA-182 & microRNA-382\/BDNF signaling pathways in the treatment of post-stroke depression","volume":"627","author":"Zhang","year":"2022","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.phrs.2026.108263_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155224","article-title":"Morroniside improves the symptoms of post-stroke depression in mice through the BDNF signaling pathway mediated by MiR-409-3p","volume":"123","author":"Qian","year":"2024","journal-title":"Phytomedicine"},{"issue":"11","key":"10.1016\/j.phrs.2026.108263_bib41","article-title":"Circulating circular RNAs as novel biomarkers and functional prediction for the early diagnosis in post-stroke cognitive impairment: A single-center prospective study in China","volume":"33","author":"Chen","year":"2024","journal-title":"J. Stroke Cereb. Dis."},{"issue":"7344","key":"10.1016\/j.phrs.2026.108263_bib42","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nature09817","article-title":"Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation","volume":"472","author":"Sahay","year":"2011","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.phrs.2026.108263_bib43","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.cell.2018.03.063","article-title":"Single-Cell Transcriptomics and Fate Mapping of Ependymal Cells Reveals an Absence of Neural Stem Cell Function","volume":"173","author":"Shah","year":"2018","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib44","doi-asserted-by":"crossref","first-page":"5132","DOI":"10.1038\/s41467-025-60187-5","article-title":"Forebrain neural progenitors effectively integrate into host brain circuits and improve neural function after ischemic stroke","volume":"16","author":"He","year":"2025","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.phrs.2026.108263_bib45","first-page":"281","article-title":"Current Biosafety Considerations in Stem Cell Therapy","volume":"18","author":"Mousavinejad","year":"2016","journal-title":"Cell J."},{"issue":"43","key":"10.1016\/j.phrs.2026.108263_bib46","doi-asserted-by":"crossref","first-page":"37783","DOI":"10.1021\/acsnano.5c10672","article-title":"Induced Pluripotent Stem Cell-Derived Extracellular Vesicles Prevent Neural Stem Cell Senescence to Promote Cognitive Recovery after Traumatic Brain Injury","volume":"19","author":"Chen","year":"2025","journal-title":"ACS Nano"},{"issue":"11","key":"10.1016\/j.phrs.2026.108263_bib47","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.4103\/1673-5374.391313","article-title":"Emerging strategies for nerve repair and regeneration in ischemic stroke: neural stem cell therapy","volume":"19","author":"Wang","year":"2024","journal-title":"Neural Regen. Res"},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib48","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s12031-024-02191-w","article-title":"Induced Mesenchymal Stem Cells-Small Extracellular Vesicles Alleviate Post-stroke Cognitive Impairment by Rejuvenating Senescence of Neural Stem Cells","volume":"74","author":"Liu","year":"2024","journal-title":"J. Mol. Neurosci."},{"issue":"Pt 2","key":"10.1016\/j.phrs.2026.108263_bib49","article-title":"Astragaloside IV-preconditioned neural stem cell transplantation promotes neurogenesis and functional recovery via the miR-199a-5p\/Caveolin-1 pathway in a rat model of ischemic stroke","volume":"168","author":"Xu","year":"2026","journal-title":"Int Immunopharmacol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib50","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s00335-025-10177-1","article-title":"E2F2 inhibits hippocampal neurogenesis in poststroke depression rats via the miR-1290\/CBR1 axis","volume":"37","author":"Yang","year":"2025","journal-title":"Mamm. Genome"},{"issue":"7696","key":"10.1016\/j.phrs.2026.108263_bib51","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nature25975","article-title":"Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults","volume":"555","author":"Sorrells","year":"2018","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.phrs.2026.108263_bib52","doi-asserted-by":"crossref","first-page":"4758","DOI":"10.1007\/s12035-021-02426-6","article-title":"Construction of lncRNA-Mediated ceRNA Network for Investigating Immune Pathogenesis of Ischemic Stroke","volume":"58","author":"Li","year":"2021","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib53","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s43556-024-00237-4","article-title":"Profiling immune cell-related gene features and immunoregulatory ceRNA in ischemic stroke","volume":"5","author":"Li","year":"2024","journal-title":"Mol. Biomed."},{"issue":"6","key":"10.1016\/j.phrs.2026.108263_bib54","doi-asserted-by":"crossref","first-page":"567","DOI":"10.4149\/gpb_2024035","article-title":"Silencing lncRNA SIX3OS1 mitigates inflammation and apoptosis in post-stroke cognitive impairment via miR-511-3p","volume":"43","author":"Zeng","year":"2024","journal-title":"Gen. Physiol. Biophys."},{"issue":"7","key":"10.1016\/j.phrs.2026.108263_bib55","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1080\/00207454.2021.1972999","article-title":"LncRNA MALAT1 improves cerebral ischemia-reperfusion injury and cognitive dysfunction by regulating miR-142-3p\/SIRT1 axis","volume":"133","author":"Meng","year":"2023","journal-title":"Int. J. Neurosci."},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib56","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/cac2.12247","article-title":"Increased mitochondrial fission drives the reprogramming of fatty acid metabolism in hepatocellular carcinoma cells through suppression of Sirtuin 1","volume":"42","author":"Wu","year":"2022","journal-title":"Cancer Commun (Lond)"},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib57","doi-asserted-by":"crossref","first-page":"89","DOI":"10.7150\/ijbs.52619","article-title":"The Regulatory Effect of SIRT1 on Extracellular Microenvironment Remodeling","volume":"17","author":"Wang","year":"2021","journal-title":"Int J. Biol. Sci."},{"issue":"4","key":"10.1016\/j.phrs.2026.108263_bib58","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1042\/EBC20200060","article-title":"Circular RNAs as microRNA sponges: evidence and controversies","volume":"65","author":"Jarlstad Olesen","year":"2021","journal-title":"Essays Biochem"},{"issue":"5","key":"10.1016\/j.phrs.2026.108263_bib59","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nrg.2016.20","article-title":"Endogenous microRNA sponges: evidence and controversy","volume":"17","author":"Thomson","year":"2016","journal-title":"Nat. Rev. Genet"},{"issue":"5","key":"10.1016\/j.phrs.2026.108263_bib60","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.molcel.2014.05.023","article-title":"Competitive endogenous RNAs cannot alter microRNA function in vivo","volume":"54","author":"Broderick","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.phrs.2026.108263_bib61","article-title":"A systematic review of the research progress of non-coding RNA in neuroinflammation and immune regulation in cerebral infarction\/ischemia-reperfusion injury","volume":"13","author":"Yang","year":"2022","journal-title":"Front Immunol."},{"issue":"3","key":"10.1016\/j.phrs.2026.108263_bib62","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1004200","article-title":"Prevalence and natural history of depression after stroke: A systematic review and meta-analysis of observational studies","volume":"20","author":"Liu","year":"2023","journal-title":"PLoS Med"},{"issue":"8","key":"10.1016\/j.phrs.2026.108263_bib63","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1161\/CIRCRESAHA.122.319951","article-title":"Post-Stroke Cognitive Impairment and Dementia","volume":"130","author":"Rost","year":"2022","journal-title":"Circ. Res"},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib64","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/prd.12561","article-title":"Understanding exosomes: Part 2-Emerging leaders in regenerative medicine","volume":"94","author":"Miron","year":"2024","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.phrs.2026.108263_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2024.115283","article-title":"RNA therapies for CNS diseases","volume":"208","author":"Di Francesco","year":"2024","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.phrs.2026.108263_bib66","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neurobiolaging.2023.05.001","article-title":"Sex differences in cognitive impairment after focal ischemia in middle-aged rats and the effect of iv miR-20a-3p treatment","volume":"129","author":"Sampath","year":"2023","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.phrs.2026.108263_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.109900","article-title":"MiR-203a-3p\/153-3p improves cognitive impairments induced by ischemia\/reperfusion via blockade of SRC-mediated MAPK signaling pathway in ischemic stroke","volume":"358","author":"Li","year":"2022","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.phrs.2026.108263_bib68","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1601843","article-title":"Exosomes and non-coding RNAs in the regulation of neuroinflammation after ischemic stroke: mechanisms and therapeutic perspectives","volume":"16","author":"Wei","year":"2025","journal-title":"Front Immunol."},{"key":"10.1016\/j.phrs.2026.108263_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.114041","article-title":"Modulating intracellular pathways to improve non-viral delivery of RNA therapeutics","volume":"181","author":"Van de Vyver","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib70","first-page":"11","article-title":"Linc00205\/Mir-495-3p\/Tnfsf15 Axis is Implicated in the Treatment Effect of Hyperbaric Oxygen Therapy on Patients with Post-Stroke Cognitive Impairment","volume":"62","author":"Yang","year":"2025","journal-title":"Noro Psikiyatr Ars"},{"issue":"11","key":"10.1016\/j.phrs.2026.108263_bib71","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1038\/s41587-022-01491-z","article-title":"Unlocking the promise of mRNA therapeutics","volume":"40","author":"Rohner","year":"2022","journal-title":"Nat. Biotechnol."},{"issue":"3","key":"10.1016\/j.phrs.2026.108263_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.110277","article-title":"Tissue differences in the exosomal\/small extracellular vesicle proteome and their potential as indicators of altered tissue metabolism","volume":"38","author":"Garcia-Martin","year":"2022","journal-title":"Cell Rep."},{"issue":"7893","key":"10.1016\/j.phrs.2026.108263_bib73","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/s41586-021-04234-3","article-title":"MicroRNA sequence codes for small extracellular vesicle release and cellular retention","volume":"601","author":"Garcia-Martin","year":"2022","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.phrs.2026.108263_bib74","article-title":"Extracellular vesicle isolation methods identify distinct HIV-1 particles released from chronically infected T-cells","volume":"13","author":"Molnar","year":"2024","journal-title":"J. Extra Vesicles"},{"issue":"9","key":"10.1016\/j.phrs.2026.108263_bib75","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1016\/j.ymthe.2024.02.025","article-title":"Therapeutic potential of RNA-enriched extracellular vesicles: The next generation in RNA delivery via biogenic nanoparticles","volume":"32","author":"Muskan","year":"2024","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib76","doi-asserted-by":"crossref","first-page":"545","DOI":"10.7150\/thno.117143","article-title":"Engineering exosomes for targeted neurodegenerative therapy: innovations in biogenesis, drug loading, and clinical translation","volume":"16","author":"Huang","year":"2026","journal-title":"Theranostics"},{"key":"10.1016\/j.phrs.2026.108263_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121949","article-title":"Exosomes based strategies for brain drug delivery","volume":"293","author":"Rehman","year":"2023","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.phrs.2026.108263_bib78","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1021\/acsnano.0c09873","article-title":"Selection of Fluorescent, Bioluminescent, and Radioactive Tracers to Accurately Reflect Extracellular Vesicle Biodistribution in Vivo","volume":"15","author":"L\u00e1zaro-Ib\u00e1\u00f1ez","year":"2021","journal-title":"ACS Nano"},{"issue":"4","key":"10.1016\/j.phrs.2026.108263_bib79","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s11095-022-03463-z","article-title":"Can Extracellular Vesicles as Drug Delivery Systems Be a Game Changer in Cardiac Disease?","volume":"40","author":"Okamura","year":"2023","journal-title":"Pharm. Res"},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib80","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1080\/10717544.2020.1748758","article-title":"Prospects and challenges of extracellular vesicle-based drug delivery system: considering cell source","volume":"27","author":"Meng","year":"2020","journal-title":"Drug Deliv."},{"issue":"7659","key":"10.1016\/j.phrs.2026.108263_bib81","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature22341","article-title":"Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer","volume":"546","author":"Kamerkar","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib82","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1186\/s12951-025-03528-2","article-title":"Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acids: advances and challenges","volume":"23","author":"Sanadgol","year":"2025","journal-title":"J. Nanobiotechnology"},{"issue":"10","key":"10.1016\/j.phrs.2026.108263_bib83","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics17101336","article-title":"Exosome-Based Drug Delivery: A Next-Generation Platform for Cancer, Infection, Neurological and Immunological Diseases, Gene Therapy and Regenerative Medicine","volume":"17","author":"Serrano","year":"2025","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib84","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1038\/s41467-021-22126-y","article-title":"Quantitative characterization of extracellular vesicle uptake and content delivery within mammalian cells","volume":"12","author":"Bonsergent","year":"2021","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.phrs.2026.108263_bib85","article-title":"Uptake, functionality, and re-release of extracellular vesicle-encapsulated cargo","volume":"39","author":"O'Brien","year":"2022","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib86","article-title":"Hippocampal exosomes from stroke aggravate post-stroke depression by regulating the expression of proBDNF and p75NTR and altering spine density","volume":"14","author":"Huang","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib87","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13287-020-02090-y","article-title":"Biomaterial-supported MSC transplantation enhances cell-cell communication for spinal cord injury","volume":"12","author":"Lv","year":"2021","journal-title":"Stem Cell Res Ther."},{"issue":"22","key":"10.1016\/j.phrs.2026.108263_bib88","doi-asserted-by":"crossref","DOI":"10.3390\/cells13221834","article-title":"The Yin and Yang of Microglia-Derived Extracellular Vesicles in CNS Injury and Diseases","volume":"13","author":"Ghosh","year":"2024","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.phrs.2026.108263_bib89","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics16121492","article-title":"Molecular Targeting of Ischemic Stroke: The Promise of Na\u00efve and Engineered Extracellular Vesicles","volume":"16","author":"Lee","year":"2024","journal-title":"Pharmaceutics"},{"issue":"26","key":"10.1016\/j.phrs.2026.108263_bib90","article-title":"Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation","volume":"13","author":"Lundy","year":"2026","journal-title":"Adv. Sci. (Weinh. )"},{"issue":"10","key":"10.1016\/j.phrs.2026.108263_bib91","article-title":"Beyond basic characterization and omics: Immunomodulatory roles of platelet-derived extracellular vesicles unveiled by functional testing","volume":"13","author":"Palviainen","year":"2024","journal-title":"J. Extra Vesicles"},{"issue":"10","key":"10.1016\/j.phrs.2026.108263_bib92","article-title":"From Bench to Brain: Translating EV and Nanocarrier Research into Parkinson's Disease Therapies","volume":"14","author":"Muttiah","year":"2025","journal-title":"Biol. (Basel)"},{"issue":"18","key":"10.1016\/j.phrs.2026.108263_bib93","doi-asserted-by":"crossref","first-page":"8926","DOI":"10.7150\/thno.62330","article-title":"Engineered exosomes: desirable target-tracking characteristics for cerebrovascular and neurodegenerative disease therapies","volume":"11","author":"Xu","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.phrs.2026.108263_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2024.115291","article-title":"Lipid nanoparticles for RNA delivery: Self-assembling vs driven-assembling strategies","volume":"208","author":"Nele","year":"2024","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"11","key":"10.1016\/j.phrs.2026.108263_bib95","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics17111502","article-title":"Nanoparticles Used for the Delivery of RNAi-Based Therapeutics","volume":"17","author":"Ren","year":"2025","journal-title":"Pharmaceutics"},{"issue":"3","key":"10.1016\/j.phrs.2026.108263_bib96","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1039\/D2BM01790C","article-title":"Harnessing nanobiotechnology for cerebral ischemic stroke management","volume":"11","author":"Tang","year":"2023","journal-title":"Biomater. Sci."},{"issue":"11","key":"10.1016\/j.phrs.2026.108263_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.111112","article-title":"Nanomaterials for stroke diagnosis and treatment","volume":"27","author":"Liu","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.phrs.2026.108263_bib98","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-981-99-6940-1_10","article-title":"Future Trends and Innovation in Nano Drug Delivery for Cancer Therapy, Application of siRNA (Nanoparticle-Based RNA) Therapy, Ultrasound Linked Nano-Cancer Therapeutics, and Application of Exosomes-Based Cancer Therapy","author":"Abbasi","year":"2023","journal-title":"Nano Drug Delivery Cancer Therapy Principles Practices"},{"key":"10.1016\/j.phrs.2026.108263_bib99","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2023.1266660","article-title":"Current trends and future perspectives of stroke management through integrating health care team and nanodrug delivery strategy","volume":"17","author":"Han","year":"2023","journal-title":"Front Cell Neurosci."},{"issue":"12","key":"10.1016\/j.phrs.2026.108263_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.111373","article-title":"The role of nanomaterials in revolutionizing ischemic stroke treatment: Current trends and future prospects","volume":"27","author":"Wang","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.phrs.2026.108263_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117263","article-title":"Facile engineered macrophages-derived exosomes-functionalized PLGA nanocarrier for targeted delivery of dual drug formulation against neuroinflammation by modulation of microglial polarization in a post-stroke depression rat model","volume":"179","author":"Lv","year":"2024","journal-title":"Biomed. Pharm."},{"issue":"13","key":"10.1016\/j.phrs.2026.108263_bib102","doi-asserted-by":"crossref","first-page":"6507","DOI":"10.7150\/thno.56367","article-title":"Targeted delivery of neural progenitor cell-derived extracellular vesicles for anti-inflammation after cerebral ischemia","volume":"11","author":"Tian","year":"2021","journal-title":"Theranostics"},{"issue":"21","key":"10.1016\/j.phrs.2026.108263_bib103","article-title":"Targeted Repair of Spinal Cord Injury Based on miRNA-124-3p-Loaded Mesoporous Silica Camouflaged by Stem Cell Membrane Modified with Rabies Virus Glycoprotein","volume":"11","author":"Fan","year":"2024","journal-title":"Adv. Sci. (Weinh. )"},{"key":"10.1016\/j.phrs.2026.108263_bib104","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jconrel.2023.11.033","article-title":"Targeted delivery of hybrid nanovesicles for enhanced brain penetration to achieve synergistic therapy of glioma","volume":"365","author":"Wang","year":"2024","journal-title":"J. Control Release"},{"issue":"5","key":"10.1016\/j.phrs.2026.108263_bib105","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jcyt.2021.01.001","article-title":"Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles","volume":"23","author":"Gimona","year":"2021","journal-title":"Cytotherapy"},{"issue":"10","key":"10.1016\/j.phrs.2026.108263_bib106","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41574-024-01005-8","article-title":"Circulating non-coding RNA biomarkers of endocrine tumours","volume":"20","author":"Butz","year":"2024","journal-title":"Nat. Rev. Endocrinol."},{"issue":"6","key":"10.1016\/j.phrs.2026.108263_bib107","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1161\/CIRCRESAHA.121.319412","article-title":"CircOGDH Is a Penumbra Biomarker and Therapeutic Target in Acute Ischemic Stroke","volume":"130","author":"Liu","year":"2022","journal-title":"Circ. Res"},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib108","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12987-022-00317-z","article-title":"Non-coding RNAs in the regulation of blood-brain barrier functions in central nervous system disorders","volume":"19","author":"Sun","year":"2022","journal-title":"Fluids Barriers CNS"},{"issue":"8","key":"10.1016\/j.phrs.2026.108263_bib109","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1161\/CIRCRESAHA.122.320110","article-title":"Stroke Proteomics: From Discovery to Diagnostic and Therapeutic Applications","volume":"130","author":"Hochrainer","year":"2022","journal-title":"Circ. Res"},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib110","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000535631","article-title":"Differentially Expressed miR-511-3p in Stroke Patients Predicts the Presence of Post-Stroke Cognitive Impairment","volume":"53","author":"Wang","year":"2024","journal-title":"Dement Geriatr. Cogn. Disord."},{"key":"10.1016\/j.phrs.2026.108263_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2026.111796","article-title":"Research progress of miRNA in post-stroke cognitive impairment","volume":"237","author":"Weng","year":"2026","journal-title":"Brain Res Bull."},{"issue":"8","key":"10.1016\/j.phrs.2026.108263_bib112","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1161\/STROKEAHA.125.051498","article-title":"Implementing Blood Biomarkers in Stroke Research and Clinical Practice","volume":"56","author":"Barba","year":"2025","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.phrs.2026.108263_bib113","doi-asserted-by":"crossref","first-page":"228","DOI":"10.5114\/fn.2022.118187","article-title":"Diagnostic performance of miR-21, miR-124, miR-132, and miR-200b serums in post-stroke cognitive impairment patients","volume":"60","author":"Yuan","year":"2022","journal-title":"Folia Neuropathol."},{"issue":"4","key":"10.1016\/j.phrs.2026.108263_bib114","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S1474-4422(25)00480-6","article-title":"Biomarkers for advancing diagnosis and prognosis in stroke","volume":"25","author":"Tiedt","year":"2026","journal-title":"Lancet Neurol."},{"issue":"11","key":"10.1016\/j.phrs.2026.108263_bib115","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1373\/clinchem.2010.147405","article-title":"The microRNA spectrum in 12 body fluids","volume":"56","author":"Weber","year":"2010","journal-title":"Clin. Chem."},{"issue":"3","key":"10.1016\/j.phrs.2026.108263_bib116","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1161\/STROKEAHA.120.031543","article-title":"Circulatory MicroRNAs as Potential Biomarkers for Stroke Risk: The Rotterdam Study","volume":"52","author":"Mens","year":"2021","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.phrs.2026.108263_bib117","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153691","article-title":"Discordant Expression of Circulating microRNA from Cellular and Extracellular Sources","volume":"11","author":"Shah","year":"2016","journal-title":"PLoS One"},{"issue":"14","key":"10.1016\/j.phrs.2026.108263_bib118","doi-asserted-by":"crossref","DOI":"10.3390\/cells12141911","article-title":"Liquid Biopsy in Neurological Diseases","volume":"12","author":"Malhotra","year":"2023","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib119","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12974-023-02991-8","article-title":"Hypochlorous acid derived from microglial myeloperoxidase could mediate high-mobility group box 1 release from neurons to amplify brain damage in cerebral ischemia-reperfusion injury","volume":"21","author":"Chen","year":"2024","journal-title":"J. Neuroinflamm."},{"issue":"4","key":"10.1016\/j.phrs.2026.108263_bib120","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.4103\/NRR.NRR-D-24-01417","article-title":"Different roles of astrocytes in the blood-brain barrier during the acute and recovery phases of stroke","volume":"21","author":"Cheng","year":"2026","journal-title":"Neural Regen. Res"},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib121","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1039\/D2FO01476A","article-title":"Okanin from Coreopsis tinctoria Nutt. alleviates cognitive impairment in bilateral common carotid artery occlusion mice by regulating the miR-7\/NLRP3 axis in microglia","volume":"14","author":"Mi","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.phrs.2026.108263_bib122","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119700","article-title":"Chaihu-Shugan-San alleviates post-stroke depression in mice: Mechanistic insights into exosome-mediated neuroprotection","volume":"347","author":"Wu","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phrs.2026.108263_bib123","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2024.1375973","article-title":"Post-stroke cognitive impairment: exploring molecular mechanisms and omics biomarkers for early identification and intervention","volume":"17","author":"Lu","year":"2024","journal-title":"Front Mol. Neurosci."},{"issue":"5","key":"10.1016\/j.phrs.2026.108263_bib124","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s41582-020-0350-6","article-title":"Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke","volume":"16","author":"Montaner","year":"2020","journal-title":"Nat. Rev. Neurol."},{"issue":"17","key":"10.1016\/j.phrs.2026.108263_bib125","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202205739","article-title":"Extracellular Vesicles as Delivery Shippers for Noncoding RNA-Based Modulation of Angiogenesis: Insights from Ischemic Stroke and Cancer","volume":"19","author":"Pan","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.phrs.2026.108263_bib126","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101730","article-title":"Multi-omics research strategies in ischemic stroke: A multidimensional perspective","volume":"81","author":"Li","year":"2022","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.phrs.2026.108263_bib127","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2023.1153518","article-title":"Integrated analysis of circRNA-associated ceRNA network in ischemic stroke","volume":"14","author":"Fan","year":"2023","journal-title":"Front Genet"},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib128","article-title":"Identification and validation of the inflammatory response-related LncRNAs as diagnostic biomarkers for acute ischemic stroke","volume":"15","author":"He","year":"2025","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.phrs.2026.108263_bib129","doi-asserted-by":"crossref","first-page":"7335","DOI":"10.1007\/s12035-024-04051-5","article-title":"Considering Context-Specific microRNAs in Ischemic Stroke with Three \"W\": Where, When, and What","volume":"61","author":"Chang","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phrs.2026.108263_bib130","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2022.147921","article-title":"LncRNA NEAT1 stabilized Wnt3a via U2AF2 and activated Wnt\/\u03b2-catenin pathway to alleviate ischemia stroke induced injury","volume":"1788","author":"Zhou","year":"2022","journal-title":"Brain Res"},{"issue":"6","key":"10.1016\/j.phrs.2026.108263_bib131","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/jnc.15692","article-title":"LncRNA nuclear-enriched abundant transcript 1 aggravates cerebral ischemia\/reperfusion injury through activating early growth response-1\/RNA binding motif protein 25 axis","volume":"163","author":"Cao","year":"2022","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib132","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s11658-024-00579-5","article-title":"NEAT1 inhibits the angiogenic activity of cerebral arterial endothelial cells by inducing the M1 polarization of microglia through the AMPK signaling pathway","volume":"29","author":"Chen","year":"2024","journal-title":"Cell Mol. Biol. Lett."},{"issue":"3","key":"10.1016\/j.phrs.2026.108263_bib133","doi-asserted-by":"crossref","first-page":"348","DOI":"10.2174\/011570159X380644250707075513","article-title":"MicroRNAs as Potential Biomarkers and Therapeutic Targets in Ischemic Stroke from the Perspective of Inflammation","volume":"24","author":"Chen","year":"2026","journal-title":"Curr. Neuropharmacol."},{"issue":"6","key":"10.1016\/j.phrs.2026.108263_bib134","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1177\/0271678X221085090","article-title":"Systematic review: Association between circulating microRNA expression & stroke","volume":"42","author":"Fullerton","year":"2022","journal-title":"J. Cereb. Blood Flow. Metab."},{"issue":"17","key":"10.1016\/j.phrs.2026.108263_bib135","article-title":"Unveiling circRNA-mediated ceRNA networks in ischemic stroke by integrative analysis of multi-source gene expression profiling","volume":"10","author":"Zhang","year":"2024","journal-title":"Heliyon"},{"issue":"12","key":"10.1016\/j.phrs.2026.108263_bib136","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1177\/0271678X231196982","article-title":"Expansion of plasma MicroRNAs over the first month following human stroke","volume":"43","author":"Edwardson","year":"2023","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.phrs.2026.108263_bib137","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2021.646072","article-title":"MicroRNAs Instruct and Maintain Cell Type Diversity in the Nervous System","volume":"14","author":"Zolboot","year":"2021","journal-title":"Front Mol. Neurosci."},{"key":"10.1016\/j.phrs.2026.108263_bib138","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13059-016-0932-1","article-title":"Single-cell analysis of long non-coding RNAs in the developing human neocortex","volume":"17","author":"Liu","year":"2016","journal-title":"Genome Biol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib139","doi-asserted-by":"crossref","first-page":"6232","DOI":"10.1038\/s41467-024-50465-z","article-title":"Single-nucleus RNA sequencing reveals glial cell type-specific responses to ischemic stroke in male rodents","volume":"15","author":"Bormann","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2026.108263_bib140","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13578-020-00435-x","article-title":"The functions of long non-coding RNAs in neural stem cell proliferation and differentiation","volume":"10","author":"Zhao","year":"2020","journal-title":"Cell Biosci."},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib141","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24010470","article-title":"Neuronal and Glial Communication via Non-Coding RNAs: Messages in Extracellular Vesicles","volume":"24","author":"Marangon","year":"2022","journal-title":"Int J. Mol. Sci."},{"issue":"9349","key":"10.1016\/j.phrs.2026.108263_bib142","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0140-6736(02)11911-8","article-title":"Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies","volume":"360","author":"Lewington","year":"2002","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.phrs.2026.108263_bib143","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1161\/01.STR.0000153065.39325.fd","article-title":"Ethnic disparities in stroke: epidemiology, acute care, and postacute outcomes","volume":"36","author":"Stansbury","year":"2005","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.phrs.2026.108263_bib144","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1177\/0271678X231212378","article-title":"Post-stroke brain can be protected by modulating the lncRNA FosDT","volume":"44","author":"Mehta","year":"2024","journal-title":"J. Cereb. Blood Flow. Metab."},{"issue":"9","key":"10.1016\/j.phrs.2026.108263_bib145","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.tins.2007.06.009","article-title":"How can we improve the pre-clinical development of drugs for stroke?","volume":"30","author":"Sena","year":"2007","journal-title":"Trends Neurosci."},{"issue":"10","key":"10.1016\/j.phrs.2026.108263_bib146","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41582-022-00703-z","article-title":"The neurovascular unit and systemic biology in stroke - implications for translation and treatment","volume":"18","author":"Tiedt","year":"2022","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib147","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s13046-025-03391-x","article-title":"MicroRNA in cancer therapy: breakthroughs and challenges in early clinical applications","volume":"44","author":"Di Martino","year":"2025","journal-title":"J. Exp. Clin. Cancer Res"},{"issue":"21","key":"10.1016\/j.phrs.2026.108263_bib148","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111596","article-title":"ncRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery","volume":"22","author":"Hueso","year":"2021","journal-title":"Int J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.phrs.2026.108263_bib149","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.tig.2022.02.006","article-title":"Emerging concepts of miRNA therapeutics: from cells to clinic","volume":"38","author":"Diener","year":"2022","journal-title":"Trends Genet"},{"issue":"18","key":"10.1016\/j.phrs.2026.108263_bib150","doi-asserted-by":"crossref","first-page":"8771","DOI":"10.7150\/thno.62642","article-title":"Effective tools for RNA-derived therapeutics: siRNA interference or miRNA mimicry","volume":"11","author":"Wang","year":"2021","journal-title":"Theranostics"},{"issue":"11","key":"10.1016\/j.phrs.2026.108263_bib151","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1038\/s41416-020-0802-1","article-title":"Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours","volume":"122","author":"Hong","year":"2020","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.phrs.2026.108263_bib152","doi-asserted-by":"crossref","DOI":"10.3390\/biom16010066","article-title":"Intermethod Characterization of Commercially Available Extracellular Vesicles as Reference Materials","volume":"16","author":"Poudel","year":"2025","journal-title":"Biomolecules"},{"issue":"7","key":"10.1016\/j.phrs.2026.108263_bib153","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/s41563-023-01472-w","article-title":"Hydrogels for RNA delivery","volume":"22","author":"Zhong","year":"2023","journal-title":"Nat. Mater."},{"issue":"36","key":"10.1016\/j.phrs.2026.108263_bib154","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abg6666","article-title":"Bottom-up assembly of biomedical relevant fully synthetic extracellular vesicles","volume":"7","author":"Staufer","year":"2021","journal-title":"Sci. Adv."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661826001787?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661826001787?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T07:25:21Z","timestamp":1783149921000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661826001787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":154,"alternative-id":["S1043661826001787"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2026.108263","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Non-coding RNA regulatory networks in post-stroke neuropsychiatric complications: Mechanisms, delivery strategies, and translational challenges","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2026.108263","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108263"}}