{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:02:37Z","timestamp":1789902157317,"version":"4.0.1"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2024YFHZ0041"],"award-info":[{"award-number":["2024YFHZ0041"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2024ZYD0054"],"award-info":[{"award-number":["2024ZYD0054"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2026NSFSC1906"],"award-info":[{"award-number":["2026NSFSC1906"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010822","name":"Chengdu Science and Technology Bureau","doi-asserted-by":"publisher","award":["2024-YF06-00011-HZ"],"award-info":[{"award-number":["2024-YF06-00011-HZ"]}],"id":[{"id":"10.13039\/501100010822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010822","name":"Chengdu Science and Technology Bureau","doi-asserted-by":"publisher","award":["2022-GH03-00004-HZ"],"award-info":[{"award-number":["2022-GH03-00004-HZ"]}],"id":[{"id":"10.13039\/501100010822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3403304"],"award-info":[{"award-number":["2023YFC3403304"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3403303"],"award-info":[{"award-number":["2023YFC3403303"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["ZYYC23006"],"award-info":[{"award-number":["ZYYC23006"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20735"],"award-info":[{"award-number":["U24A20735"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32471551"],"award-info":[{"award-number":["32471551"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473434"],"award-info":[{"award-number":["82473434"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012842","name":"Nuclear Power Institute of China","doi-asserted-by":"publisher","award":["1-KJ-FWHT-WU-20240150"],"award-info":[{"award-number":["1-KJ-FWHT-WU-20240150"]}],"id":[{"id":"10.13039\/100012842","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2023ZD0503000"],"award-info":[{"award-number":["2023ZD0503000"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["SQ2026AAA161144"],"award-info":[{"award-number":["SQ2026AAA161144"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2023ZD0503004"],"award-info":[{"award-number":["2023ZD0503004"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020207","name":"Health Commission of Sichuan Province","doi-asserted-by":"publisher","award":["Clinical Research Special Project JH2023082"],"award-info":[{"award-number":["Clinical Research Special Project JH2023082"]}],"id":[{"id":"10.13039\/501100020207","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.phrs.2026.108392","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T16:08:59Z","timestamp":1786637339000},"page":"108392","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Oncolytic virus-delivered CEACAM6\/CD3 BiTEs combine with PD-1 blockade to achieve synergistic anticancer efficacy"],"prefix":"10.1016","volume":"232","author":[{"given":"Weiwei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haohan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheran","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangxue","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7042-718X","authenticated-orcid":false,"given":"Xingchen","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7378","key":"10.1016\/j.phrs.2026.108392_bib1","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature10673","article-title":"Cancer immunotherapy comes of age","volume":"480","author":"Mellman","year":"2011","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.phrs.2026.108392_bib2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41420-025-02682-8","article-title":"Empowering hypoxia to convert cold tumors into hot tumors for breast cancer immunotherapy","volume":"11","author":"Liu","year":"2025","journal-title":"Cell. Death Discov."},{"issue":"6","key":"10.1016\/j.phrs.2026.108392_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/v13061128","article-title":"Oncolytic Virotherapy Treatment of Breast Cancer: Barriers and Recent Advances","volume":"13","author":"Kwan","year":"2021","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.phrs.2026.108392_bib4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s13045-022-01341-0","article-title":"Recent advances in therapeutic strategies for triple-negative breast cancer","volume":"15","author":"Li","year":"2022","journal-title":"J. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108392_bib5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12943-023-01805-y","article-title":"Advancements in clinical aspects of targeted therapy and immunotherapy in breast cancer","volume":"22","author":"Ye","year":"2023","journal-title":"Mol. Cancer"},{"issue":"6","key":"10.1016\/j.phrs.2026.108392_bib6","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41575-019-0126-x","article-title":"Immunotherapy in colorectal cancer: rationale, challenges and potential","volume":"16","author":"Ganesh","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"14","key":"10.1016\/j.phrs.2026.108392_bib7","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.7150\/ijbs.64077","article-title":"Immunotherapy in colorectal cancer: current achievements and future perspective","volume":"17","author":"Fan","year":"2021","journal-title":"Int. J. Biol. Sci."},{"issue":"3","key":"10.1016\/j.phrs.2026.108392_bib8","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/icb.2014.93","article-title":"Bispecific T-cell engagers for cancer immunotherapy","volume":"93","author":"Huehls","year":"2015","journal-title":"Immunol. Cell. Biol."},{"issue":"25","key":"10.1016\/j.phrs.2026.108392_bib9","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1200\/JCO.2014.58.3377","article-title":"Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma","volume":"33","author":"Andtbacka","year":"2015","journal-title":"J. Clin. Oncol."},{"issue":"22","key":"10.1016\/j.phrs.2026.108392_bib10","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1200\/JCO.2016.67.1529","article-title":"Talimogene Laherparepvec in Combination With Ipilimumab in Previously Untreated, Unresectable Stage IIIB-IV Melanoma","volume":"34","author":"Puzanov","year":"2016","journal-title":"J. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108392_bib11","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40425-018-0337-7","article-title":"Talimogene Laherparepvec combined with anti-PD-1 based immunotherapy for unresectable stage III-IV melanoma: a case series","volume":"6","author":"Sun","year":"2018","journal-title":"J. Immunother. Cancer"},{"issue":"7","key":"10.1016\/j.phrs.2026.108392_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines8070204","article-title":"Bi- and Tri-Specific T Cell Engager-Armed Oncolytic Viruses: Next-Generation Cancer Immunotherapy","volume":"8","author":"Guo","year":"2020","journal-title":"Biomedicines"},{"issue":"7","key":"10.1016\/j.phrs.2026.108392_bib13","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/s41571-020-0347-5","article-title":"T cell-engaging therapies\u2014BiTEs and beyond","volume":"17","author":"Goebeler","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.phrs.2026.108392_bib14","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/s41573-024-00896-6","article-title":"The present and future of bispecific antibodies for cancer therapy","volume":"23","author":"Klein","year":"2024","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.phrs.2026.108392_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1032664","article-title":"Efficacy and safety of blinatumomab in children with relapsed\/refractory B cell acute lymphoblastic leukemia: A systematic review and meta-analysis","volume":"13","author":"Chen","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.phrs.2026.108392_bib16","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1007\/s40262-016-0405-4","article-title":"Blinatumomab, a Bispecific T-cell Engager (BiTE\u00ae) for CD-19 Targeted Cancer Immunotherapy: Clinical Pharmacology and Its Implications","volume":"55","author":"Zhu","year":"2016","journal-title":"Clin. Pharmacokinet."},{"issue":"1","key":"10.1016\/j.phrs.2026.108392_bib17","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13045-021-01075-5","article-title":"Oncolytic viruses encoding bispecific T cell engagers: a blueprint for emerging immunovirotherapies","volume":"14","author":"Heidbuechel","year":"2021","journal-title":"J. Hematol. & Oncol."},{"issue":"8","key":"10.1016\/j.phrs.2026.108392_bib18","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.3390\/v15081645","article-title":"Oncolytic virus engineering and utilizations: cancer immunotherapy perspective","volume":"15","author":"Muthukutty","year":"2023","journal-title":"Viruses"},{"issue":"11","key":"10.1016\/j.phrs.2026.108392_bib19","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-009901","article-title":"Engineered oncolytic virus expressing B7H3-targeting BiTE enhances antitumor T-cell immune response","volume":"12","author":"Zhu","year":"2024","journal-title":"J. Immunother. Cancer"},{"issue":"4","key":"10.1016\/j.phrs.2026.108392_bib20","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.ajpath.2013.12.013","article-title":"A marker of endocrine receptor-positive cells, CEACAM6, is shared by two major classes of breast cancer: luminal and HER2-enriched","volume":"184","author":"Balk-M\u00f8ller","year":"2014","journal-title":"Am. J. Pathol."},{"issue":"6","key":"10.1016\/j.phrs.2026.108392_bib21","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.3892\/ol.2016.4439","article-title":"FOXP3 and CEACAM6 expression and T cell infiltration in the occurrence and development of colon cancer","volume":"11","author":"Liu","year":"2016","journal-title":"Oncol. Lett."},{"issue":"5","key":"10.1016\/j.phrs.2026.108392_bib22","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.3892\/ol.2017.5938","article-title":"T cell immunity induced by a bivalent Salmonella-based CEACAM6 and 4-1BBL vaccines in a rat colorectal cancer model","volume":"13","author":"Jin","year":"2017","journal-title":"Oncol. Lett."},{"issue":"3","key":"10.1016\/j.phrs.2026.108392_bib23","doi-asserted-by":"crossref","DOI":"10.3892\/ijo.2024.5615","article-title":"The emerging roles of CEACAM6 in human cancer (Review)","volume":"64","author":"Wu","year":"2024","journal-title":"Int. J. Oncol."},{"issue":"10","key":"10.1016\/j.phrs.2026.108392_bib24","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/s41419-023-06187-z","article-title":"Aldolase B-driven lactagenesis and CEACAM6 activation promote cell renewal and chemoresistance in colorectal cancer through the Warburg effect","volume":"14","author":"Chu","year":"2023","journal-title":"Cell. Death Dis."},{"issue":"3-4","key":"10.1016\/j.phrs.2026.108392_bib25","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s10555-013-9444-6","article-title":"Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis","volume":"32","author":"Beauchemin","year":"2013","journal-title":"Cancer Metastas-.-. Rev."},{"issue":"1","key":"10.1016\/j.phrs.2026.108392_bib26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/cas.13437","article-title":"Towards understanding the mechanisms of actions of carcinoembryonic antigen-related cell adhesion molecule 6 in cancer progression","volume":"109","author":"Rizeq","year":"2018","journal-title":"Cancer Sci."},{"issue":"3","key":"10.1016\/j.phrs.2026.108392_bib27","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.bbrc.2004.03.128","article-title":"CEACAM6 as a novel target for indirect type 1 immunotoxin-based therapy in pancreatic adenocarcinoma","volume":"317","author":"Duxbury","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phrs.2026.108392_bib28","doi-asserted-by":"crossref","DOI":"10.1177\/17588359211072621","article-title":"Prognostic value of the immune target CEACAM6 in cancer: a meta-analysis","volume":"14","author":"Burgos","year":"2022","journal-title":"Ther. Adv. Med. Oncol."},{"issue":"6","key":"10.1016\/j.phrs.2026.108392_bib29","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1007\/s10637-020-00955-w","article-title":"The old CEACAMs find their new role in tumor immunotherapy","volume":"38","author":"Han","year":"2020","journal-title":"Invest. New. Drugs"},{"key":"10.1016\/j.phrs.2026.108392_bib30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinforma."},{"issue":"4","key":"10.1016\/j.phrs.2026.108392_bib31","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.immuni.2013.10.003","article-title":"Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer","volume":"39","author":"Bindea","year":"2013","journal-title":"Immunity"},{"issue":"1-2","key":"10.1016\/j.phrs.2026.108392_bib32","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jim.2011.06.017","article-title":"Isolation of functional single domain antibody by whole cell immunization: implications for cancer treatment","volume":"371","author":"Baral","year":"2011","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.phrs.2026.108392_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216760","article-title":"Improved antitumor effects elicited by an oncolytic HSV-1 expressing a novel B7H3nb\/CD3 BsAb","volume":"588","author":"Zhang","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phrs.2026.108392_bib34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/978-1-4939-9814-2_9","article-title":"CRISPR\/Cas9-Based Genome Editing of HSV","volume":"2060","author":"Velusamy","year":"2020","journal-title":"Methods Mol. Biol."},{"issue":"7","key":"10.1016\/j.phrs.2026.108392_bib35","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1158\/0008-5472.CAN-04-3227","article-title":"An oncolytic HSV-1 mutant expressing ICP34.5 under control of a nestin promoter increases survival of animals even when symptomatic from a brain tumor","volume":"65","author":"Kambara","year":"2005","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.phrs.2026.108392_bib36","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/s43018-022-00448-0","article-title":"Specific targeting of glioblastoma with an oncolytic virus expressing a cetuximab-CCL5 fusion protein via innate and adaptive immunity","volume":"3","author":"Tian","year":"2022","journal-title":"Nat. Cancer"},{"issue":"1","key":"10.1016\/j.phrs.2026.108392_bib37","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12967-023-03875-4","article-title":"A drug screening to identify novel combinatorial strategies for boosting cancer immunotherapy efficacy","volume":"21","author":"Zhang","year":"2023","journal-title":"J. Transl. Med."},{"issue":"6349","key":"10.1016\/j.phrs.2026.108392_bib38","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.aan6733","article-title":"Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade","volume":"357","author":"Le","year":"2017","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.phrs.2026.108392_bib39","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.3192","article-title":"Spatial reconstruction of single-cell gene expression data","volume":"33","author":"Satija","year":"2015","journal-title":"Nat. Biotechnol."},{"issue":"7","key":"10.1016\/j.phrs.2026.108392_bib40","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive Integration of Single-Cell Data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.phrs.2026.108392_bib41","doi-asserted-by":"crossref","first-page":"5416","DOI":"10.1038\/s41467-019-13056-x","article-title":"The art of using t-SNE for single-cell transcriptomics","volume":"10","author":"Kobak","year":"2019","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.phrs.2026.108392_bib42","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s41592-018-0308-4","article-title":"Fast interpolation-based t-SNE for improved visualization of single-cell RNA-seq data","volume":"16","author":"Linderman","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.phrs.2026.108392_bib43","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/978-1-0716-0301-7_8","article-title":"Visualization of Single Cell RNA-Seq Data Using t-SNE in R","volume":"2117","author":"Zhou","year":"2020","journal-title":"Methods Mol. Biol."},{"issue":"3 Pt 2","key":"10.1016\/j.phrs.2026.108392_bib44","article-title":"Unfolding communities in large complex networks: combining defensive and offensive label propagation for core extraction","volume":"83","author":"Subelj","year":"2011","journal-title":"Phys. Rev. E Stat. Nonlin Soft Matter Phys."},{"issue":"10","key":"10.1016\/j.phrs.2026.108392_bib45","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1101\/gr.6202607","article-title":"A systems biology approach for pathway level analysis","volume":"17","author":"Draghici","year":"2007","journal-title":"Genome Res."},{"issue":"1","key":"10.1016\/j.phrs.2026.108392_bib46","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.phrs.2026.108392_bib47","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","article-title":"Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage","volume":"20","author":"Aran","year":"2019","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.phrs.2026.108392_bib48","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2017.1285992","article-title":"Oncolytic measles virus encoding interleukin-12 mediates potent antitumor effects through T cell activation","volume":"6","author":"Veinalde","year":"2017","journal-title":"Oncoimmunology"},{"issue":"4","key":"10.1016\/j.phrs.2026.108392_bib49","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.ccell.2023.02.008","article-title":"The pre-existing T cell landscape determines the response to bispecific T cell engagers in multiple myeloma patients","volume":"41","author":"Friedrich","year":"2023","journal-title":"Cancer Cell."},{"issue":"3","key":"10.1016\/j.phrs.2026.108392_bib50","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41571-022-00719-w","article-title":"Therapy with oncolytic viruses: progress and challenges","volume":"20","author":"Shalhout","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108392_bib51","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s40425-018-0458-z","article-title":"Oncolytic virus immunotherapy: future prospects for oncology","volume":"6","author":"Raja","year":"2018","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.phrs.2026.108392_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.790150","article-title":"Oncolytic Virotherapy: From Bench to Bedside","volume":"9","author":"Yang","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"issue":"2","key":"10.1016\/j.phrs.2026.108392_bib53","doi-asserted-by":"crossref","first-page":"100","DOI":"10.2174\/2212697X02666150602215823","article-title":"Emerging Role and Targeting of Carcinoembryonic Antigen-related Cell Adhesion Molecule 6 (CEACAM6) in Human Malignancies","volume":"2","author":"Johnson","year":"2015","journal-title":"Clin. Cancer Drugs"},{"issue":"19","key":"10.1016\/j.phrs.2026.108392_bib54","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.1200\/JCO.2003.55.135","article-title":"Expression of CEACAM6 in resectable colorectal cancer: a factor of independent prognostic significance","volume":"21","author":"Jantscheff","year":"2003","journal-title":"J. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.phrs.2026.108392_bib55","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.ejca.2012.07.019","article-title":"Single domain antibody against carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) inhibits proliferation, migration, invasion and angiogenesis of pancreatic cancer cells","volume":"50","author":"Cheng","year":"2014","journal-title":"Eur. J. Cancer"},{"issue":"1","key":"10.1016\/j.phrs.2026.108392_bib56","doi-asserted-by":"crossref","first-page":"18347","DOI":"10.1038\/s41598-019-54545-9","article-title":"Carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) in Pancreatic Ductal Adenocarcinoma (PDA): An integrative analysis of a novel therapeutic target","volume":"9","author":"Pandey","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2026.108392_bib57","doi-asserted-by":"crossref","first-page":"805","DOI":"10.3389\/fonc.2020.00805","article-title":"Evaluation of the Anti-Tumor Activity of the Humanized Monoclonal Antibody NEO-201 in Preclinical Models of Ovarian Cancer","volume":"10","author":"Zeligs","year":"2020","journal-title":"Front. Oncol."},{"issue":"22","key":"10.1016\/j.phrs.2026.108392_bib58","doi-asserted-by":"crossref","first-page":"4493","DOI":"10.1182\/blood-2012-05-429415","article-title":"Tumor cells in multiple myeloma patients inhibit myeloma-reactive T cells through carcinoembryonic antigen-related cell adhesion molecule-6","volume":"121","author":"Witzens-Harig","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.phrs.2026.108392_bib59","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.biomaterials.2015.07.012","article-title":"Therapeutic effect of anti CEACAM6 monoclonal antibody against lung adenocarcinoma by enhancing anoikis sensitivity","volume":"67","author":"Hong","year":"2015","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.phrs.2026.108392_bib60","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.trecan.2022.10.003","article-title":"The emerging field of oncolytic virus-based cancer immunotherapy","volume":"9","author":"Ma","year":"2023","journal-title":"Trends Cancer"},{"issue":"3","key":"10.1016\/j.phrs.2026.108392_bib61","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s11684-023-1048-0","article-title":"Immune landscape and response to oncolytic virus-based immunotherapy","volume":"18","author":"Lin","year":"2024","journal-title":"Front. Med."},{"issue":"4","key":"10.1016\/j.phrs.2026.108392_bib62","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/sj.gt.3301885","article-title":"ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties","volume":"10","author":"Liu","year":"2003","journal-title":"Gene Ther."},{"key":"10.1016\/j.phrs.2026.108392_bib63","first-page":"31","article-title":"Oncolytic virus therapy for cancer","volume":"2","author":"Goldufsky","year":"2013","journal-title":"Oncolytic Virother"},{"issue":"8","key":"10.1016\/j.phrs.2026.108392_bib64","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.1128\/JVI.00017-12","article-title":"Effect of \u03b334.5 deletions on oncolytic herpes simplex virus activity in brain tumors","volume":"86","author":"Kanai","year":"2012","journal-title":"J. Virol."},{"issue":"6","key":"10.1016\/j.phrs.2026.108392_bib65","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2017.08.027","article-title":"Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy","volume":"170","author":"Ribas","year":"2017","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.phrs.2026.108392_bib66","doi-asserted-by":"crossref","DOI":"10.1172\/JCI150807","article-title":"CAR T cell manufacturing from naive\/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome","volume":"132","author":"Arcangeli","year":"2022","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.phrs.2026.108392_bib67","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.cell.2018.10.038","article-title":"Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma","volume":"175","author":"Sade-Feldman","year":"2018","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.phrs.2026.108392_bib68","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/s41591-019-0522-3","article-title":"Clonal replacement of tumor-specific T cells following PD-1 blockade","volume":"25","author":"Yost","year":"2019","journal-title":"Nat. Med."},{"issue":"31","key":"10.1016\/j.phrs.2026.108392_bib69","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aao4310","article-title":"Tumor-infiltrating human CD4(+) regulatory T cells display a distinct TCR repertoire and exhibit tumor and neoantigen reactivity","volume":"4","author":"Ahmadzadeh","year":"2019","journal-title":"Sci. Immunol."},{"issue":"3","key":"10.1016\/j.phrs.2026.108392_bib70","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1158\/1535-7163.MCT-24-0444","article-title":"Broad-Spectrum Efficacy of CEACAM6-Targeted Antibody-Drug Conjugate with BET Protein Degrader in Colorectal, Lung, and Breast Cancer Mouse Models","volume":"24","author":"Kogai","year":"2025","journal-title":"Mol. Cancer Ther."},{"issue":"44","key":"10.1016\/j.phrs.2026.108392_bib71","article-title":"SPP1(+) TAM Regulates the Metastatic Colonization of CXCR4(+) Metastasis-Associated Tumor Cells by Remodeling the Lymph Node Microenvironment","volume":"11","author":"Dong","year":"2024","journal-title":"Adv. Sci. (Weinh. )"},{"issue":"1","key":"10.1016\/j.phrs.2026.108392_bib72","doi-asserted-by":"crossref","DOI":"10.1080\/21645515.2024.2350101","article-title":"SPP1 expression indicates outcome of immunotherapy plus tyrosine kinase inhibition in advanced renal cell carcinoma","volume":"20","author":"Xu","year":"2024","journal-title":"Hum. Vaccin. Immunother."},{"issue":"8","key":"10.1016\/j.phrs.2026.108392_bib73","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15082250","article-title":"The Significance of SPP1 in Lung Cancers and Its Impact as a Marker for Protumor Tumor-Associated Macrophages","volume":"15","author":"Matsubara","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.phrs.2026.108392_bib74","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s12967-023-04688-1","article-title":"Potential crosstalk between SPP1\u2009+\u2009TAMs and CD8\u2009+\u2009exhausted T cells promotes an immunosuppressive environment in gastric metastatic cancer","volume":"22","author":"Du","year":"2024","journal-title":"J. Transl. Med."},{"issue":"3","key":"10.1016\/j.phrs.2026.108392_bib75","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.tem.2008.10.004","article-title":"Nampt: linking NAD biology, metabolism and cancer","volume":"20","author":"Garten","year":"2009","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2026.108392_bib76","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fendo.2014.00004","article-title":"Angiopoietin-like proteins: a comprehensive look","volume":"5","author":"Santulli","year":"2014","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"8","key":"10.1016\/j.phrs.2026.108392_bib77","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1039\/c2mt20081c","article-title":"Mammalian metallothioneins: properties and functions","volume":"4","author":"Babula","year":"2012","journal-title":"Metallomics"},{"issue":"9","key":"10.1016\/j.phrs.2026.108392_bib78","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nrc.2016.73","article-title":"The biology and function of fibroblasts in cancer","volume":"16","author":"Kalluri","year":"2016","journal-title":"Nat. Rev. Cancer"},{"issue":"11","key":"10.1016\/j.phrs.2026.108392_bib79","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.phrs.2026.108392_bib80","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.immuni.2011.07.010","article-title":"CD8(+) T cells: foot soldiers of the immune system","volume":"35","author":"Zhang","year":"2011","journal-title":"Immunity"},{"issue":"10","key":"10.1016\/j.phrs.2026.108392_bib81","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1084\/jem.20080132","article-title":"Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein","volume":"205","author":"Cheng","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.phrs.2026.108392_bib82","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1146\/annurev-immunol-032713-120145","article-title":"Chemokines and chemokine receptors: positioning cells for host defense and immunity","volume":"32","author":"Griffith","year":"2014","journal-title":"Annu. Rev. Immunol."},{"issue":"10","key":"10.1016\/j.phrs.2026.108392_bib83","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/nm.2446","article-title":"A human memory T cell subset with stem cell-like properties","volume":"17","author":"Gattinoni","year":"2011","journal-title":"Nat. Med."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661826003075?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661826003075?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:55:34Z","timestamp":1789901734000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661826003075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":83,"alternative-id":["S1043661826003075"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2026.108392","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oncolytic virus-delivered CEACAM6\/CD3 BiTEs combine with PD-1 blockade to achieve synergistic anticancer efficacy","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2026.108392","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108392"}}