{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:02:57Z","timestamp":1789401777373,"version":"build-2803163510"},"reference-count":257,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003693","name":"Korea Institute of Science and Technology","doi-asserted-by":"publisher","award":["26V0140"],"award-info":[{"award-number":["26V0140"]}],"id":[{"id":"10.13039\/501100003693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003693","name":"Korea Institute of Science and Technology","doi-asserted-by":"publisher","award":["26E0122"],"award-info":[{"award-number":["26E0122"]}],"id":[{"id":"10.13039\/501100003693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006180","name":"Technology Development","doi-asserted-by":"publisher","award":["RS-2025-02217139"],"award-info":[{"award-number":["RS-2025-02217139"]}],"id":[{"id":"10.13039\/100006180","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Korea Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["RS-2025-02253017"],"award-info":[{"award-number":["RS-2025-02253017"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["RS-2023-00211407"],"award-info":[{"award-number":["RS-2023-00211407"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["RS-2024-00334647"],"award-info":[{"award-number":["RS-2024-00334647"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["RS-2025-02217139"],"award-info":[{"award-number":["RS-2025-02217139"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020206","name":"Korea Dementia Research Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020206","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.phrs.2026.108394","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T06:38:04Z","timestamp":1786603084000},"page":"108394","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Distinct roles of AMPA receptor subunits as potential therapeutic targets in Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5361-3500","authenticated-orcid":false,"given":"Jiyeon","family":"Seo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kijin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5589-0624","authenticated-orcid":false,"given":"Mikyoung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.phrs.2026.108394_bib1","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S0166-2236(02)02270-1","article-title":"Regulation of AMPA receptors during synaptic plasticity","volume":"25","author":"Song","year":"2002","journal-title":"Trends Neurosci."},{"issue":"2","key":"10.1016\/j.phrs.2026.108394_bib2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0896-6273(03)00640-8","article-title":"AMPA receptor trafficking at excitatory synapses","volume":"40","author":"Bredt","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2026.108394_bib3","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.mcn.2018.05.002","article-title":"Functional organization of postsynaptic glutamate receptors","volume":"91","author":"Scheefhals","year":"2018","journal-title":"Mol. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib4","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0896-6273(01)00194-5","article-title":"Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons","volume":"29","author":"Lu","year":"2001","journal-title":"Neuron"},{"issue":"5692","key":"10.1016\/j.phrs.2026.108394_bib5","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1126\/science.1102026","article-title":"Recycling endosomes supply AMPA receptors for LTP","volume":"305","author":"Park","year":"2004","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.phrs.2026.108394_bib6","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.neuron.2009.01.015","article-title":"Synaptic AMPA receptor plasticity and behavior","volume":"61","author":"Kessels","year":"2009","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.phrs.2026.108394_bib7","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.cell.2010.02.042","article-title":"Syntaxin-4 defines a domain for activity-dependent exocytosis in dendritic spines","volume":"141","author":"Kennedy","year":"2010","journal-title":"Cell"},{"issue":"36","key":"10.1016\/j.phrs.2026.108394_bib8","doi-asserted-by":"crossref","first-page":"15951","DOI":"10.1073\/pnas.0913875107","article-title":"AMPA receptors are exocytosed in stimulated spines and adjacent dendrites in a Ras-ERK-dependent manner during long-term potentiation","volume":"107","author":"Patterson","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.phrs.2026.108394_bib9","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.conb.2011.12.006","article-title":"Regulation of AMPA receptor trafficking and synaptic plasticity","volume":"22","author":"Anggono","year":"2012","journal-title":"Curr. Opin. Neurobiol."},{"issue":"3","key":"10.1016\/j.phrs.2026.108394_bib10","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.neuron.2013.10.025","article-title":"AMPARs and synaptic plasticity: the last 25 years","volume":"80","author":"Huganir","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2026.108394_bib11","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev.neuro.25.112701.142758","article-title":"AMPA receptor trafficking and synaptic plasticity","volume":"25","author":"Malinow","year":"2002","journal-title":"Annu. Rev. Neurosci."},{"issue":"5718","key":"10.1016\/j.phrs.2026.108394_bib12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1126\/science.1103944","article-title":"Postsynaptic receptor trafficking underlying a form of associative learning","volume":"308","author":"Rumpel","year":"2005","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.phrs.2026.108394_bib13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1460-9568.2010.07339.x","article-title":"AMPA receptor trafficking and learning","volume":"32","author":"Keifer","year":"2010","journal-title":"Eur. J. Neurosci."},{"issue":"20","key":"10.1016\/j.phrs.2026.108394_bib14","doi-asserted-by":"crossref","first-page":"8218","DOI":"10.1073\/pnas.1305235110","article-title":"AMPA receptor exchange underlies transient memory destabilization on retrieval","volume":"110","author":"Hong","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.phrs.2026.108394_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108710","article-title":"AMPA receptor trafficking and LTP: carboxy-termini, amino-termini and TARPs","volume":"197","author":"Diaz-Alonso","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phrs.2026.108394_bib16","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.semcdb.2022.01.009","article-title":"The role of AMPAR lateral diffusion in memory","volume":"125","author":"Choquet","year":"2022","journal-title":"Semin. Cell. Dev. Biol."},{"issue":"9770","key":"10.1016\/j.phrs.2026.108394_bib17","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0140-6736(10)61349-9","article-title":"Alzheimer's disease","volume":"377","author":"Ballard","year":"2011","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.phrs.2026.108394_bib18","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer's disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"issue":"10284","key":"10.1016\/j.phrs.2026.108394_bib19","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer's disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"issue":"42","key":"10.1016\/j.phrs.2026.108394_bib20","doi-asserted-by":"crossref","first-page":"E6526","DOI":"10.1073\/pnas.1614249113","article-title":"Amyloid-beta effects on synapses and memory require AMPA receptor subunit GluA3","volume":"113","author":"Reinders","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.phrs.2026.108394_bib21","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.expneurol.2003.12.010","article-title":"Differential preservation of AMPA receptor subunits in the hippocampi of Alzheimer's disease patients according to Braak stage","volume":"187","author":"Carter","year":"2004","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.phrs.2026.108394_bib22","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.nbd.2005.02.008","article-title":"Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses","volume":"20","author":"Almeida","year":"2005","journal-title":"Neurobiol. Dis."},{"issue":"9","key":"10.1016\/j.phrs.2026.108394_bib23","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1073\/pnas.0507313103","article-title":"AMPA receptor downscaling at the onset of Alzheimer's disease pathology in double knockin mice","volume":"103","author":"Chang","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.phrs.2026.108394_bib24","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.neuron.2006.10.035","article-title":"AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss","volume":"52","author":"Hsieh","year":"2006","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib25","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3233\/JAD-2007-11113","article-title":"Alterations in expression of glutamatergic transporters and receptors in sporadic Alzheimer's disease","volume":"11","author":"Jacob","year":"2007","journal-title":"J. Alzheimers Dis."},{"issue":"8","key":"10.1016\/j.phrs.2026.108394_bib26","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nm1782","article-title":"Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory","volume":"14","author":"Shankar","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.phrs.2026.108394_bib27","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3389\/fnagi.2014.00200","article-title":"Age-dependent modifications of AMPA receptor subunit expression levels and related cognitive effects in 3xTg-AD mice","volume":"6","author":"Cantanelli","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.phrs.2026.108394_bib28","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.brainres.2009.07.056","article-title":"Disruption of glutamate receptors at Shank-postsynaptic platform in Alzheimer's disease","volume":"1292","author":"Gong","year":"2009","journal-title":"Brain Res."},{"issue":"7","key":"10.1016\/j.phrs.2026.108394_bib29","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1111\/ejn.12507","article-title":"Tau phosphorylation and tau mislocalization mediate soluble Abeta oligomer-induced AMPA glutamate receptor signaling deficits","volume":"39","author":"Miller","year":"2014","journal-title":"Eur. J. Neurosci."},{"issue":"7","key":"10.1016\/j.phrs.2026.108394_bib30","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1111\/ejn.12504","article-title":"Tau acts as a mediator for Alzheimer's disease-related synaptic deficits","volume":"39","author":"Liao","year":"2014","journal-title":"Eur. J. Neurosci."},{"issue":"8","key":"10.1016\/j.phrs.2026.108394_bib31","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0166-2236(00)01610-6","article-title":"Ca2+-Zn2+ permeable AMPA or kainate receptors: possible key factors in selective neurodegeneration","volume":"23","author":"Weiss","year":"2000","journal-title":"Trends Neurosci."},{"issue":"3","key":"10.1016\/j.phrs.2026.108394_bib32","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.conb.2006.05.004","article-title":"Calcium-permeable AMPA channels in neurodegenerative disease and ischemia","volume":"16","author":"Kwak","year":"2006","journal-title":"Curr. Opin. Neurobiol."},{"issue":"5","key":"10.1016\/j.phrs.2026.108394_bib33","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1523\/JNEUROSCI.2774-16.2016","article-title":"Pharmacological Rescue of Long-Term Potentiation in Alzheimer Diseased Synapses","volume":"37","author":"Prieto","year":"2017","journal-title":"J. Neurosci."},{"issue":"9","key":"10.1016\/j.phrs.2026.108394_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101465","article-title":"Acetylation of AMPA receptors regulates receptor trafficking and rescues memory deficits in Alzheimer's disease","volume":"23","author":"O'Connor","year":"2020","journal-title":"iScience"},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib35","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s40035-025-00470-z","article-title":"AMPA receptor diffusional trapping machinery as an early therapeutic target in neurodegenerative and neuropsychiatric disorders","volume":"14","author":"Choquet","year":"2025","journal-title":"Transl. Neurodegener."},{"issue":"11","key":"10.1016\/j.phrs.2026.108394_bib36","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1093\/jnen\/nlae093","article-title":"AMPA receptors in Alzheimer disease: pathological changes and potential therapeutic targets","volume":"83","author":"Ning","year":"2024","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"6","key":"10.1016\/j.phrs.2026.108394_bib37","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1007\/BF00294247","article-title":"Down's syndrome and Alzheimer's disease: dendritic spine counts in the hippocampus","volume":"79","author":"Ferrer","year":"1990","journal-title":"Acta Neuropathol."},{"issue":"3","key":"10.1016\/j.phrs.2026.108394_bib38","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1023\/B:NEUR.0000044197.83514.64","article-title":"Dendrite and dendritic spine alterations in Alzheimer models","volume":"33","author":"Moolman","year":"2004","journal-title":"J. Neurocytol."},{"issue":"13","key":"10.1016\/j.phrs.2026.108394_bib39","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.1073\/pnas.0600948103","article-title":"Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease","volume":"103","author":"Jacobsen","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"20","key":"10.1016\/j.phrs.2026.108394_bib40","doi-asserted-by":"crossref","first-page":"8186","DOI":"10.1074\/jbc.M116.774554","article-title":"GluA1 subunit ubiquitination mediates amyloid-beta-induced loss of surface alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors","volume":"292","author":"Guntupalli","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.phrs.2026.108394_bib41","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.3233\/JAD-170879","article-title":"Amyloid-beta induces AMPA receptor ubiquitination and degradation in primary neurons and human brains of Alzheimer's disease","volume":"62","author":"Zhang","year":"2018","journal-title":"J. Alzheimers Dis."},{"issue":"5594","key":"10.1016\/j.phrs.2026.108394_bib42","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1126\/science.1074069","article-title":"Alzheimer's disease is a synaptic failure","volume":"298","author":"Selkoe","year":"2002","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib43","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neuron.2004.09.010","article-title":"Deciphering the molecular basis of memory failure in Alzheimer's disease","volume":"44","author":"Walsh","year":"2004","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.phrs.2026.108394_bib44","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0959-4388(93)90120-N","article-title":"Mammalian ionotropic glutamate receptors","volume":"3","author":"Wisden","year":"1993","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.phrs.2026.108394_bib45","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev.ne.17.030194.000335","article-title":"Cloned glutamate receptors","volume":"17","author":"Hollmann","year":"1994","journal-title":"Annu. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib46","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0031-6997(24)01394-2","article-title":"The glutamate receptor ion channels","volume":"51","author":"Dingledine","year":"1999","journal-title":"Pharmacol. Rev."},{"issue":"3","key":"10.1016\/j.phrs.2026.108394_bib47","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1124\/pr.109.002451","article-title":"Glutamate receptor ion channels: structure, regulation, and function","volume":"62","author":"Traynelis","year":"2010","journal-title":"Pharmacol. Rev."},{"issue":"2","key":"10.1016\/j.phrs.2026.108394_bib48","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.neuron.2009.02.027","article-title":"Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach","volume":"62","author":"Lu","year":"2009","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.phrs.2026.108394_bib49","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.conb.2011.01.001","article-title":"GluA2-lacking, calcium-permeable AMPA receptors--inducers of plasticity?","volume":"21","author":"Man","year":"2011","journal-title":"Curr. Opin. Neurobiol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib50","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1038\/s41467-019-10910-w","article-title":"AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders","volume":"10","author":"Salpietro","year":"2019","journal-title":"Nat. Commun."},{"issue":"8062","key":"10.1016\/j.phrs.2026.108394_bib51","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/s41586-025-08736-2","article-title":"GluA2-containing AMPA receptors form a continuum of Ca(2+)-permeable channels","volume":"641","author":"Miguez-Cabello","year":"2025","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.phrs.2026.108394_bib52","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nrn3192","article-title":"Mechanisms of CaMKII action in long-term potentiation","volume":"13","author":"Lisman","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"issue":"7433","key":"10.1016\/j.phrs.2026.108394_bib53","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nature11775","article-title":"LTP requires a reserve pool of glutamate receptors independent of subunit type","volume":"493","author":"Granger","year":"2013","journal-title":"Nature"},{"issue":"1633","key":"10.1016\/j.phrs.2026.108394_bib54","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0136","article-title":"Expression mechanisms underlying long-term potentiation: a postsynaptic view, 10 years on","volume":"369","author":"Granger","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.phrs.2026.108394_bib55","first-page":"361","article-title":"AMPA Receptor Trafficking for Postsynaptic Potentiation","volume":"12","author":"Park","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.phrs.2026.108394_bib56","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.neures.2021.08.001","article-title":"Molecular mechanism of hippocampal long-term potentiation - Towards multiscale understanding of learning and memory","volume":"175","author":"Hayashi","year":"2022","journal-title":"Neurosci. Res."},{"issue":"5349","key":"10.1016\/j.phrs.2026.108394_bib57","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1126\/science.279.5349.399","article-title":"Postsynaptic membrane fusion and long-term potentiation","volume":"279","author":"Lledo","year":"1998","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.phrs.2026.108394_bib58","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1042\/BST20130081","article-title":"Dendritic trafficking for neuronal growth and plasticity","volume":"41","author":"Ehlers","year":"2013","journal-title":"Biochem. Soc. Trans."},{"issue":"7650","key":"10.1016\/j.phrs.2026.108394_bib59","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature21720","article-title":"Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP","volume":"544","author":"Wu","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2026.108394_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2022.102349","article-title":"Myristoylation-dependent palmitoylation of cyclin Y modulates long-term potentiation and spatial learning","volume":"218","author":"Seo","year":"2022","journal-title":"Prog. Neurobiol."},{"issue":"6889","key":"10.1016\/j.phrs.2026.108394_bib61","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nature00780","article-title":"Regulation of AMPA receptor lateral movements","volume":"417","author":"Borgdorff","year":"2002","journal-title":"Nature"},{"issue":"18","key":"10.1016\/j.phrs.2026.108394_bib62","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.1093\/emboj\/cdg463","article-title":"Direct imaging of lateral movements of AMPA receptors inside synapses","volume":"22","author":"Tardin","year":"2003","journal-title":"EMBO J."},{"issue":"7","key":"10.1016\/j.phrs.2026.108394_bib63","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/nn1270","article-title":"Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors","volume":"7","author":"Groc","year":"2004","journal-title":"Nat. Neurosci."},{"issue":"2","key":"10.1016\/j.phrs.2026.108394_bib64","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.neuron.2006.06.013","article-title":"Synaptic incorporation of AMPA receptors during LTP is controlled by a PKC phosphorylation site on GluR1","volume":"51","author":"Boehm","year":"2006","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.phrs.2026.108394_bib65","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.neuron.2006.09.040","article-title":"Plasticity-induced growth of dendritic spines by exocytic trafficking from recycling endosomes","volume":"52","author":"Park","year":"2006","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.phrs.2026.108394_bib66","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.neuron.2007.04.010","article-title":"Diffusional trapping of GluR1 AMPA receptors by input-specific synaptic activity","volume":"54","author":"Ehlers","year":"2007","journal-title":"Neuron"},{"issue":"5873","key":"10.1016\/j.phrs.2026.108394_bib67","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1126\/science.1152089","article-title":"Surface mobility of postsynaptic AMPARs tunes synaptic transmission","volume":"320","author":"Heine","year":"2008","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.phrs.2026.108394_bib68","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.neuron.2009.08.035","article-title":"AMPA receptor incorporation into synapses during LTP: the role of lateral movement and exocytosis","volume":"64","author":"Makino","year":"2009","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib69","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-71528-3","article-title":"Mechanism underlying hippocampal long-term potentiation and depression based on competition between endocytosis and exocytosis of AMPA receptors","volume":"10","author":"Sumi","year":"2020","journal-title":"Sci. Rep."},{"issue":"5790","key":"10.1016\/j.phrs.2026.108394_bib70","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1126\/science.1128134","article-title":"Learning induces long-term potentiation in the hippocampus","volume":"313","author":"Whitlock","year":"2006","journal-title":"Science"},{"issue":"7672","key":"10.1016\/j.phrs.2026.108394_bib71","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature23658","article-title":"Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors","volume":"549","author":"Penn","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib72","doi-asserted-by":"crossref","first-page":"3622","DOI":"10.1038\/s41467-019-11575-1","article-title":"Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3beta signaling","volume":"10","author":"Xu","year":"2019","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.phrs.2026.108394_bib73","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.neuron.2019.12.005","article-title":"Cortical Synaptic AMPA Receptor Plasticity during Motor Learning","volume":"105","author":"Roth","year":"2020","journal-title":"Neuron"},{"issue":"40","key":"10.1016\/j.phrs.2026.108394_bib74","doi-asserted-by":"crossref","first-page":"25085","DOI":"10.1073\/pnas.2014827117","article-title":"GRIP1 regulates synaptic plasticity and learning and memory","volume":"117","author":"Tan","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"10","key":"10.1016\/j.phrs.2026.108394_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111766","article-title":"Hippo-released WWC1 facilitates AMPA receptor regulatory complexes for hippocampal learning","volume":"41","author":"Stepan","year":"2022","journal-title":"Cell. Rep."},{"key":"10.1016\/j.phrs.2026.108394_bib76","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2023.1171432","article-title":"ICA69 regulates activity-dependent synaptic strengthening and learning and memory","volume":"16","author":"Chiu","year":"2023","journal-title":"Front. Mol. Neurosci."},{"issue":"30","key":"10.1016\/j.phrs.2026.108394_bib77","doi-asserted-by":"crossref","first-page":"5448","DOI":"10.1523\/JNEUROSCI.1542-22.2023","article-title":"Ubiquitination of the GluA1 Subunit of AMPA Receptors Is Required for Synaptic Plasticity, Memory, and Cognitive Flexibility","volume":"43","author":"Guntupalli","year":"2023","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.phrs.2026.108394_bib78","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1152\/physrev.00034.2022","article-title":"Synaptic memory and CaMKII","volume":"103","author":"Nicoll","year":"2023","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib79","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/(SICI)1097-4547(20000401)60:1<65::AID-JNR7>3.0.CO;2-Q","article-title":"Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides","volume":"60","author":"Chen","year":"2000","journal-title":"J. Neurosci. Res."},{"issue":"6880","key":"10.1016\/j.phrs.2026.108394_bib80","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/416535a","article-title":"Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo","volume":"416","author":"Walsh","year":"2002","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.phrs.2026.108394_bib81","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.neuron.2009.05.012","article-title":"Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake","volume":"62","author":"Li","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2026.108394_bib82","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/7969272","article-title":"Emerging link between Alzheimer's disease and homeostatic synaptic plasticity","author":"Jang","year":"2016","journal-title":"Neural Plast. 2016"},{"key":"10.1016\/j.phrs.2026.108394_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106389","article-title":"Novel crosstalk mechanisms between GluA3 and Epac2 in synaptic plasticity and memory in Alzheimer's disease","volume":"191","author":"Zhang","year":"2024","journal-title":"Neurobiol. Dis."},{"issue":"11","key":"10.1016\/j.phrs.2026.108394_bib84","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1523\/JNEUROSCI.4970-06.2007","article-title":"Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway","volume":"27","author":"Shankar","year":"2007","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.phrs.2026.108394_bib85","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.celrep.2017.07.030","article-title":"Crucial roles for SIRT2 and AMPA receptor acetylation in synaptic plasticity and memory","volume":"20","author":"Wang","year":"2017","journal-title":"Cell. Rep."},{"issue":"31","key":"10.1016\/j.phrs.2026.108394_bib86","doi-asserted-by":"crossref","first-page":"27311","DOI":"10.1074\/jbc.M111.227504","article-title":"Soluble oligomers of amyloid-beta peptide disrupt membrane trafficking of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor contributing to early synapse dysfunction","volume":"286","author":"Minano-Molina","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"45","key":"10.1016\/j.phrs.2026.108394_bib87","doi-asserted-by":"crossref","first-page":"10191","DOI":"10.1523\/JNEUROSCI.3432-04.2004","article-title":"Synaptic targeting by Alzheimer's-related amyloid beta oligomers","volume":"24","author":"Lacor","year":"2004","journal-title":"J. Neurosci."},{"issue":"10","key":"10.1016\/j.phrs.2026.108394_bib88","doi-asserted-by":"crossref","first-page":"7619","DOI":"10.1074\/jbc.M109.057182","article-title":"Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption","volume":"285","author":"Zhao","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.phrs.2026.108394_bib89","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction","volume":"39","author":"Oddo","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2026.108394_bib90","first-page":"8","article-title":"Intracellular accumulation of amyloid-Beta - a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease","volume":"2","author":"Bayer","year":"2010","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.phrs.2026.108394_bib91","doi-asserted-by":"crossref","first-page":"10934","DOI":"10.1038\/srep10934","article-title":"Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus","volume":"5","author":"Whitcomb","year":"2015","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.phrs.2026.108394_bib92","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23094656","article-title":"Role of Intracellular Amyloid beta as Pathway Modulator, Biomarker, and Therapy Target","volume":"23","author":"Gallego Villarejo","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.phrs.2026.108394_bib93","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/S0002-9440(10)64463-X","article-title":"Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology","volume":"161","author":"Takahashi","year":"2002","journal-title":"Am. J. Pathol."},{"issue":"14","key":"10.1016\/j.phrs.2026.108394_bib94","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.1523\/JNEUROSCI.5167-03.2004","article-title":"Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain","volume":"24","author":"Takahashi","year":"2004","journal-title":"J. Neurosci."},{"issue":"8","key":"10.1016\/j.phrs.2026.108394_bib95","doi-asserted-by":"crossref","first-page":"656","DOI":"10.2174\/156720510793611592","article-title":"Tau in Alzheimer disease and related tauopathies","volume":"7","author":"Iqbal","year":"2010","journal-title":"Curr. Alzheimer Res."},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib96","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nrn.2015.1","article-title":"Tau in physiology and pathology","volume":"17","author":"Wang","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"issue":"1633","key":"10.1016\/j.phrs.2026.108394_bib97","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0144","article-title":"Microtubule-associated protein tau is essential for long-term depression in the hippocampus","volume":"369","author":"Kimura","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"issue":"12","key":"10.1016\/j.phrs.2026.108394_bib98","doi-asserted-by":"crossref","first-page":"4804","DOI":"10.1523\/JNEUROSCI.2842-14.2015","article-title":"Tau phosphorylation at serine 396 residue is required for hippocampal LTD","volume":"35","author":"Regan","year":"2015","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.phrs.2026.108394_bib99","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cell.2010.06.036","article-title":"Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models","volume":"142","author":"Ittner","year":"2010","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.phrs.2026.108394_bib100","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.tins.2014.08.004","article-title":"Lost after translation: missorting of Tau protein and consequences for Alzheimer disease","volume":"37","author":"Zempel","year":"2014","journal-title":"Trends Neurosci."},{"issue":"2","key":"10.1016\/j.phrs.2026.108394_bib101","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1523\/JNEUROSCI.4152-10.2011","article-title":"Amyloid-beta\/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease","volume":"31","author":"Roberson","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2026.108394_bib102","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1750-1326-6-39","article-title":"Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice","volume":"6","author":"Lasagna-Reeves","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.phrs.2026.108394_bib103","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3389\/fncel.2015.00464","article-title":"Tau oligomers: the toxic player at synapses in Alzheimer's disease","volume":"9","author":"Guerrero-Munoz","year":"2015","journal-title":"Front. Cell. Neurosci."},{"issue":"6","key":"10.1016\/j.phrs.2026.108394_bib104","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.neuron.2010.11.030","article-title":"Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration","volume":"68","author":"Hoover","year":"2010","journal-title":"Neuron"},{"issue":"17","key":"10.1016\/j.phrs.2026.108394_bib105","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1523\/JNEUROSCI.4261-13.2014","article-title":"Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers","volume":"34","author":"Frandemiche","year":"2014","journal-title":"J. Neurosci."},{"issue":"7","key":"10.1016\/j.phrs.2026.108394_bib106","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10071550","article-title":"NMDA and AMPA receptors at synapses: novel targets for tau and alpha-synuclein proteinopathies","volume":"10","author":"Italia","year":"2022","journal-title":"Biomedicines"},{"issue":"5825","key":"10.1016\/j.phrs.2026.108394_bib107","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1126\/science.1141736","article-title":"Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model","volume":"316","author":"Roberson","year":"2007","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.phrs.2026.108394_bib108","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1523\/JNEUROSCI.2610-10.2011","article-title":"Tau protein is required for amyloid beta-induced impairment of hippocampal long-term potentiation","volume":"31","author":"Shipton","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2026.108394_bib109","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3389\/fnmol.2017.00446","article-title":"AMPA receptor trafficking in natural and pathological aging","volume":"10","author":"Jurado","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.phrs.2026.108394_bib110","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3204519","article-title":"Amyloid-beta-induced dysregulation of AMPA receptor trafficking","author":"Guntupalli","year":"2016","journal-title":"Neural Plast. 2016"},{"issue":"18","key":"10.1016\/j.phrs.2026.108394_bib111","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021110242","article-title":"Tau target identification reveals NSF-dependent effects on AMPA receptor trafficking and memory formation","volume":"41","author":"Prikas","year":"2022","journal-title":"EMBO J."},{"issue":"16","key":"10.1016\/j.phrs.2026.108394_bib112","doi-asserted-by":"crossref","first-page":"10639","DOI":"10.1074\/jbc.M806508200","article-title":"beta-Amyloid impairs AMPA receptor trafficking and function by reducing Ca2+\/calmodulin-dependent protein kinase II synaptic distribution","volume":"284","author":"Gu","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.phrs.2026.108394_bib113","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nn910","article-title":"Spatial memory dissociations in mice lacking GluR1","volume":"5","author":"Reisel","year":"2002","journal-title":"Nat. Neurosci."},{"issue":"9","key":"10.1016\/j.phrs.2026.108394_bib114","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.1523\/JNEUROSCI.23-09-03953.2003","article-title":"A within-subjects, within-task demonstration of intact spatial reference memory and impaired spatial working memory in glutamate receptor-A-deficient mice","volume":"23","author":"Schmitt","year":"2003","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.phrs.2026.108394_bib115","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1101\/lm.1339109","article-title":"Enhanced long-term and impaired short-term spatial memory in GluA1 AMPA receptor subunit knockout mice: evidence for a dual-process memory model","volume":"16","author":"Sanderson","year":"2009","journal-title":"Learn. Mem."},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib116","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41398-022-01863-8","article-title":"Distinct contributions of GluA1-containing AMPA receptors of different hippocampal subfields to salience processing, memory and impulse control","volume":"12","author":"Kilonzo","year":"2022","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib117","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41593-017-0030-z","article-title":"The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning","volume":"21","author":"Zhou","year":"2018","journal-title":"Nat. Neurosci."},{"issue":"2","key":"10.1016\/j.phrs.2026.108394_bib118","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.neuron.2016.11.046","article-title":"Motor Learning Requires Purkinje Cell Synaptic Potentiation through Activation of AMPA-Receptor Subunit GluA3","volume":"93","author":"Gutierrez-Castellanos","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2026.108394_bib119","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.65152","article-title":"GluA4 facilitates cerebellar expansion coding and enables associative memory formation","volume":"10","author":"Kita","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.phrs.2026.108394_bib120","doi-asserted-by":"crossref","unstructured":"Kijin Kim, and Mikyoung Park. 2.24 - AMPA receptors in synaptic plasticity and learning and memory. 2.24 - AMPA receptors in synaptic plasticity and learning and memory Academic Press, Oxford. 2025. Series.","DOI":"10.1016\/B978-0-443-15754-7.00056-0"},{"issue":"4","key":"10.1016\/j.phrs.2026.108394_bib121","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"issue":"40","key":"10.1016\/j.phrs.2026.108394_bib122","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2303878120","article-title":"Impairments in endogenous AMPA receptor dynamics correlates with learning deficits in Alzheimer's disease model mice","volume":"120","author":"Lu","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.phrs.2026.108394_bib123","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.neuron.2006.10.007","article-title":"State-dependent mechanisms of LTP expression revealed by optical quantal analysis","volume":"52","author":"Ward","year":"2006","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.phrs.2026.108394_bib124","doi-asserted-by":"crossref","DOI":"10.1111\/bpa.13005","article-title":"Glutamatergic receptor expression changes in the Alzheimer's disease hippocampus and entorhinal cortex","volume":"31","author":"Yeung","year":"2021","journal-title":"Brain Pathol."},{"key":"10.1016\/j.phrs.2026.108394_bib125","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3389\/fnana.2019.00099","article-title":"Subregional Density of Neurons, Neurofibrillary Tangles and Amyloid Plaques in the Hippocampus of Patients With Alzheimer's Disease","volume":"13","author":"Furcila","year":"2019","journal-title":"Front. Neuroanat."},{"issue":"8","key":"10.1016\/j.phrs.2026.108394_bib126","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.neurobiolaging.2014.02.018","article-title":"Hippocampus-specific deficiency in RNA editing of GluA2 in Alzheimer's disease","volume":"35","author":"Gaisler-Salomon","year":"2014","journal-title":"Neurobiol. Aging"},{"issue":"2","key":"10.1016\/j.phrs.2026.108394_bib127","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1261\/rna.054627.115","article-title":"Reduced levels of protein recoding by A-to-I RNA editing in Alzheimer's disease","volume":"22","author":"Khermesh","year":"2016","journal-title":"RNA"},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib128","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.1038\/s41598-018-22701-2","article-title":"Whole transcriptome profiling of Late-Onset Alzheimer's Disease patients provides insights into the molecular changes involved in the disease","volume":"8","author":"Annese","year":"2018","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.phrs.2026.108394_bib129","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbaa384","article-title":"ADeditome provides the genomic landscape of A-to-I RNA editing in Alzheimer's disease","volume":"22","author":"Wu","year":"2021","journal-title":"Brief. Bioinform"},{"issue":"3","key":"10.1016\/j.phrs.2026.108394_bib130","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.nbd.2010.08.008","article-title":"Excitotoxicity through Ca2+-permeable AMPA receptors requires Ca2+-dependent JNK activation","volume":"40","author":"Vieira","year":"2010","journal-title":"Neurobiol. Dis."},{"issue":"25","key":"10.1016\/j.phrs.2026.108394_bib131","doi-asserted-by":"crossref","first-page":"6162","DOI":"10.1523\/JNEUROSCI.3644-16.2017","article-title":"Ca(2+)-Permeable AMPARs Mediate Glutamatergic Transmission and Excitotoxic Damage at the Hair Cell Ribbon Synapse","volume":"37","author":"Sebe","year":"2017","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.phrs.2026.108394_bib132","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1152\/jn.2002.88.3.1279","article-title":"GluR2-dependent properties of AMPA receptors determine the selective vulnerability of motor neurons to excitotoxicity","volume":"88","author":"Van Damme","year":"2002","journal-title":"J. Neurophysiol."},{"issue":"5","key":"10.1016\/j.phrs.2026.108394_bib133","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.neuron.2006.01.025","article-title":"ADAR2-dependent RNA editing of AMPA receptor subunit GluR2 determines vulnerability of neurons in forebrain ischemia","volume":"49","author":"Peng","year":"2006","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib134","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13041-020-0545-1","article-title":"A new mouse line with reduced GluA2 Q\/R site RNA editing exhibits loss of dendritic spines, hippocampal CA1-neuron loss, learning and memory impairments and NMDA receptor-independent seizure vulnerability","volume":"13","author":"Konen","year":"2020","journal-title":"Mol. Brain"},{"issue":"5242","key":"10.1016\/j.phrs.2026.108394_bib135","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1126\/science.270.5242.1677","article-title":"Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice","volume":"270","author":"Brusa","year":"1995","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib136","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/4561","article-title":"Neurological dysfunctions in mice expressing different levels of the Q\/R site-unedited AMPAR subunit GluR-B","volume":"2","author":"Feldmeyer","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phrs.2026.108394_bib137","article-title":"Quantification of AMPA receptor subunits and RNA editing-related proteins in the J20 mouse model of Alzheimer's disease by capillary western blotting","volume":"16","author":"Milham","year":"2023","journal-title":"Front. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib138","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13024-023-00632-5","article-title":"The Q\/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer's disease","volume":"18","author":"Wright","year":"2023","journal-title":"Mol. Neurodegener."},{"issue":"12","key":"10.1016\/j.phrs.2026.108394_bib139","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1002\/glia.23514","article-title":"Heterogeneity of the astrocytic AMPA-receptor transcriptome","volume":"66","author":"Molders","year":"2018","journal-title":"Glia"},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib140","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/glia.20034","article-title":"Heterogeneity and potentiation of AMPA type of glutamate receptors in rat cultured microglia","volume":"47","author":"Hagino","year":"2004","journal-title":"Glia"},{"issue":"26","key":"10.1016\/j.phrs.2026.108394_bib141","doi-asserted-by":"crossref","first-page":"23786","DOI":"10.1074\/jbc.M301360200","article-title":"Glutamate receptor subunit 3 is modified by site-specific limited proteolysis including cleavage by gamma-secretase","volume":"278","author":"Meyer","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.phrs.2026.108394_bib142","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.3233\/JAD-200498","article-title":"Increased Cerebrospinal Fluid Concentration of ZnT3 Is Associated with Cognitive Impairment in Alzheimer's Disease","volume":"77","author":"Enache","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.phrs.2026.108394_bib143","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105539","article-title":"GluA3-containing AMPA receptors: From physiology to synaptic dysfunction in brain disorders","volume":"161","author":"Italia","year":"2021","journal-title":"Neurobiol. Dis."},{"issue":"8","key":"10.1016\/j.phrs.2026.108394_bib144","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11082096","article-title":"The Expression of Epac2 and GluA3 in an Alzheimer's Disease Experimental Model and Postmortem Patient Samples","volume":"11","author":"Zhang","year":"2023","journal-title":"Biomedicines"},{"issue":"7","key":"10.1016\/j.phrs.2026.108394_bib145","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/hipo.22404","article-title":"The organization of AMPA receptor subunits at the postsynaptic membrane","volume":"25","author":"Jacob","year":"2015","journal-title":"Hippocampus"},{"key":"10.1016\/j.phrs.2026.108394_bib146","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.25462","article-title":"Synaptic plasticity through activation of GluA3-containing AMPA-receptors","volume":"6","author":"Renner","year":"2017","journal-title":"Elife"},{"issue":"33","key":"10.1016\/j.phrs.2026.108394_bib147","doi-asserted-by":"crossref","first-page":"11390","DOI":"10.1523\/JNEUROSCI.0757-12.2012","article-title":"Alzheimer's beta-secretase (BACE1) regulates the cAMP\/PKA\/CREB pathway independently of beta-amyloid","volume":"32","author":"Chen","year":"2012","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.phrs.2026.108394_bib148","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3233\/JAD-122236","article-title":"RNA interference-mediated knockdown of long-form phosphodiesterase-4D (PDE4D) enzyme reverses amyloid-beta42-induced memory deficits in mice","volume":"38","author":"Zhang","year":"2014","journal-title":"J. Alzheimers Dis."},{"issue":"10","key":"10.1016\/j.phrs.2026.108394_bib149","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.neurobiolaging.2007.12.004","article-title":"Inhibition of LTP by beta-amyloid is prevented by activation of beta2 adrenoceptors and stimulation of the cAMP\/PKA signalling pathway","volume":"30","author":"Wang","year":"2009","journal-title":"Neurobiol. Aging"},{"issue":"2","key":"10.1016\/j.phrs.2026.108394_bib150","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00213-010-1943-3","article-title":"Inhibition of phosphodiesterase-4 reverses memory deficits produced by Abeta25-35 or Abeta1-40 peptide in rats","volume":"212","author":"Cheng","year":"2010","journal-title":"Psychopharmacol. (Berl. )"},{"issue":"6","key":"10.1016\/j.phrs.2026.108394_bib151","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1017\/S1461145711000836","article-title":"The phosphodiesterase-4 inhibitor rolipram reverses Abeta-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats","volume":"15","author":"Wang","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"11","key":"10.1016\/j.phrs.2026.108394_bib152","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1172\/JCI22831","article-title":"Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment","volume":"114","author":"Gong","year":"2004","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.phrs.2026.108394_bib153","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1016\/j.neurobiolaging.2013.03.011","article-title":"Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease","volume":"34","author":"Perez-Gonzalez","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.phrs.2026.108394_bib154","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.neuropharm.2012.06.048","article-title":"Chronic phosphodiesterase type 2 inhibition improves memory in the APPswe\/PS1dE9 mouse model of Alzheimer's disease","volume":"64","author":"Sierksma","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phrs.2026.108394_bib155","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.neuropharm.2013.09.015","article-title":"Improvement of spatial memory function in APPswe\/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D","volume":"77","author":"Sierksma","year":"2014","journal-title":"Neuropharmacology"},{"issue":"14","key":"10.1016\/j.phrs.2026.108394_bib156","doi-asserted-by":"crossref","first-page":"17380","DOI":"10.18632\/oncotarget.8041","article-title":"The effect of resveratrol on beta amyloid-induced memory impairment involves inhibition of phosphodiesterase-4 related signaling","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"issue":"20","key":"10.1016\/j.phrs.2026.108394_bib157","doi-asserted-by":"crossref","first-page":"13217","DOI":"10.1073\/pnas.172504199","article-title":"Amyloid beta -peptide inhibition of the PKA\/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling","volume":"99","author":"Vitolo","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"12","key":"10.1016\/j.phrs.2026.108394_bib158","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1038\/s41594-025-01666-7","article-title":"GluA4 AMPA receptor gating mechanisms and modulation by auxiliary proteins","volume":"32","author":"Vega-Gutierrez","year":"2025","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.phrs.2026.108394_bib159","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-026-68953-9","article-title":"Structural basis for activation and conformational plasticity of the GluA4 AMPA receptor","author":"Hale","year":"2026","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.phrs.2026.108394_bib160","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1046\/j.1460-9568.1998.00356.x","article-title":"AMPA receptor subunits are differentially expressed in parvalbumin- and calretinin-positive neurons of the rat hippocampus","volume":"10","author":"Catania","year":"1998","journal-title":"Eur. J. Neurosci."},{"issue":"3","key":"10.1016\/j.phrs.2026.108394_bib161","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.cell.2012.02.046","article-title":"Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model","volume":"149","author":"Verret","year":"2012","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.phrs.2026.108394_bib162","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1152\/jn.00435.2015","article-title":"GluA4 subunit of AMPA receptors mediates the early synaptic response to altered network activity in the developing hippocampus","volume":"115","author":"Huupponen","year":"2016","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.phrs.2026.108394_bib163","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.23798","article-title":"NPTX2 and cognitive dysfunction in Alzheimer's Disease","volume":"6","author":"Xiao","year":"2017","journal-title":"Elife"},{"issue":"5","key":"10.1016\/j.phrs.2026.108394_bib164","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1523\/JNEUROSCI.2768-16.2016","article-title":"Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and Inhibitory Synapses","volume":"37","author":"Lee","year":"2017","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.phrs.2026.108394_bib165","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.neuron.2015.02.020","article-title":"Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons","volume":"85","author":"Pelkey","year":"2015","journal-title":"Neuron"},{"issue":"10","key":"10.1016\/j.phrs.2026.108394_bib166","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ng.440","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease","volume":"41","author":"Harold","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.phrs.2026.108394_bib167","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1038\/ncomms4386","article-title":"Decreased CALM expression reduces Abeta42 to total Abeta ratio through clathrin-mediated endocytosis of gamma-secretase","volume":"5","author":"Kanatsu","year":"2014","journal-title":"Nat. Commun."},{"issue":"21","key":"10.1016\/j.phrs.2026.108394_bib168","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abl5032","article-title":"Selective endocytosis of Ca(2+)-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity","volume":"8","author":"Azarnia Tehran","year":"2022","journal-title":"Sci. Adv."},{"issue":"10","key":"10.1016\/j.phrs.2026.108394_bib169","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1161\/01.STR.29.10.2141","article-title":"YM872, a highly water-soluble AMPA receptor antagonist, preserves the hemodynamic penumbra and reduces brain injury after permanent focal ischemia in rats","volume":"29","author":"Shimizu-Sasamata","year":"1998","journal-title":"Stroke"},{"issue":"5","key":"10.1016\/j.phrs.2026.108394_bib170","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/med.20004","article-title":"AMPA receptor ligands: synthetic and pharmacological studies of polyamines and polyamine toxins","volume":"24","author":"Stromgaard","year":"2004","journal-title":"Med. Res. Rev."},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib171","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bpa.2007.09.002","article-title":"Brain protection: current and future options","volume":"22","author":"Sturgess","year":"2008","journal-title":"Best. Pract. Res. Clin. Anaesthesiol."},{"issue":"1-2","key":"10.1016\/j.phrs.2026.108394_bib172","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0006-8993(03)02357-6","article-title":"Positive allosteric modulators of AMPA receptors are neuroprotective against lesions induced by an NMDA agonist in neonatal mouse brain","volume":"970","author":"Dicou","year":"2003","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib173","article-title":"Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement","volume":"11","author":"Suzuki","year":"2021","journal-title":"Sci. Rep."},{"issue":"8063","key":"10.1016\/j.phrs.2026.108394_bib174","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/s41586-025-08770-0","article-title":"Glutamate gating of AMPA-subtype iGluRs at physiological temperatures","volume":"641","author":"Kumar Mondal","year":"2025","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib175","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.bbr.2009.09.048","article-title":"Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors reverses sub-chronic PCP-induced deficits in the novel object recognition task in rats","volume":"207","author":"Damgaard","year":"2010","journal-title":"Behav. Brain Res."},{"issue":"5","key":"10.1016\/j.phrs.2026.108394_bib176","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1517\/13543776.2013.770840","article-title":"AMPA receptor positive allosteric modulators: a patent review","volume":"23","author":"Pirotte","year":"2013","journal-title":"Expert. Opin. Ther. Pat."},{"issue":"6","key":"10.1016\/j.phrs.2026.108394_bib177","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.str.2023.03.013","article-title":"Desensitization dynamics of the AMPA receptor","volume":"31","author":"Aittoniemi","year":"2023","journal-title":"Structure"},{"issue":"12","key":"10.1016\/j.phrs.2026.108394_bib178","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1016\/j.drudis.2021.07.027","article-title":"Positive AMPA receptor modulation in the treatment of neuropsychiatric disorders: long and winding road","volume":"26","author":"Kadriu","year":"2021","journal-title":"Drug. Discov. Today"},{"issue":"8","key":"10.1016\/j.phrs.2026.108394_bib179","first-page":"814","article-title":"CX-516 (Cortex Pharmaceuticals Inc)","volume":"2","author":"Danysz","year":"1999","journal-title":"IDrugs"},{"issue":"7","key":"10.1016\/j.phrs.2026.108394_bib180","first-page":"1081","article-title":"CX-516 Cortex pharmaceuticals","volume":"3","author":"Danysz","year":"2002","journal-title":"Curr. Opin. Investig. Drugs"},{"issue":"6","key":"10.1016\/j.phrs.2026.108394_bib181","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/S0028-3908(01)00133-2","article-title":"Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546","volume":"41","author":"Nagarajan","year":"2001","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.phrs.2026.108394_bib182","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/j.1471-4159.2004.02905.x","article-title":"Ampakine CX546 bolsters energetic response of astrocytes: a novel target for cognitive-enhancing drugs acting as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators","volume":"92","author":"Pellerin","year":"2005","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.phrs.2026.108394_bib183","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1124\/jpet.109.158014","article-title":"Modulation of agonist binding to AMPA receptors by 1-(1,4-benzodioxan-6-ylcarbonyl)piperidine (CX546): differential effects across brain regions and GluA1-4\/transmembrane AMPA receptor regulatory protein combinations","volume":"331","author":"Montgomery","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.phrs.2026.108394_bib184","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.neuropharm.2017.06.009","article-title":"The AMPA receptor positive allosteric modulator S 47445 rescues in vivo CA3-CA1 long-term potentiation and structural synaptic changes in old mice","volume":"123","author":"Giralt","year":"2017","journal-title":"Neuropharmacology"},{"issue":"10","key":"10.1016\/j.phrs.2026.108394_bib185","doi-asserted-by":"crossref","first-page":"5899","DOI":"10.1038\/s41380-020-0794-5","article-title":"Allosteric modulation of AMPA receptors counteracts Tau-related excitotoxic synaptic signaling and memory deficits in stress- and Abeta-evoked hippocampal pathology","volume":"26","author":"Monteiro-Fernandes","year":"2021","journal-title":"Mol. Psychiatry"},{"issue":"7","key":"10.1016\/j.phrs.2026.108394_bib186","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1529\/biophysj.106.095091","article-title":"Targeting AMPA receptor gating processes with allosteric modulators and mutations","volume":"92","author":"Mitchell","year":"2007","journal-title":"Biophys. J."},{"issue":"13","key":"10.1016\/j.phrs.2026.108394_bib187","doi-asserted-by":"crossref","first-page":"7053","DOI":"10.1073\/pnas.94.13.7053","article-title":"7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide: a partial modulator of AMPA receptor desensitization devoid of neurotoxicity","volume":"94","author":"Impagnatiello","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib188","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.neuropharm.2003.07.002","article-title":"The effects of IDRA 21, a positive modulator of the AMPA receptor, on delayed matching performance by young and aged rhesus monkeys","volume":"46","author":"Buccafusco","year":"2004","journal-title":"Neuropharmacology"},{"issue":"8","key":"10.1016\/j.phrs.2026.108394_bib189","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/S0028-3908(00)00195-7","article-title":"LY392098, a novel AMPA receptor potentiator: electrophysiological studies in prefrontal cortical neurons","volume":"40","author":"Baumbarger","year":"2001","journal-title":"Neuropharmacology"},{"issue":"8","key":"10.1016\/j.phrs.2026.108394_bib190","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/S0028-3908(00)00194-5","article-title":"Antidepressant-like actions of an AMPA receptor potentiator (LY392098)","volume":"40","author":"Li","year":"2001","journal-title":"Neuropharmacology"},{"issue":"13","key":"10.1016\/j.phrs.2026.108394_bib191","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1212\/01.wnl.0000260240.46070.7c","article-title":"AMPA potentiator treatment of cognitive deficits in Alzheimer disease","volume":"68","author":"Chappell","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.phrs.2026.108394_bib192","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.neuroscience.2013.01.058","article-title":"Rhythmic theta and delta activity of cortical and hippocampal neuronal networks in genetically or pharmacologically induced N-methyl-D-aspartate receptor hypofunction under urethane anesthesia","volume":"237","author":"Kiss","year":"2013","journal-title":"Neuroscience"},{"issue":"5","key":"10.1016\/j.phrs.2026.108394_bib193","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1017\/S1041610212002141","article-title":"Mibampator (LY451395) randomized clinical trial for agitation\/aggression in Alzheimer's disease","volume":"25","author":"Trzepacz","year":"2013","journal-title":"Int. Psychogeriatr."},{"key":"10.1016\/j.phrs.2026.108394_bib194","doi-asserted-by":"crossref","DOI":"10.1016\/j.vascn.2020.106883","article-title":"The application of electrophysiological methods to characterize AMPA receptors in dissociated adult rat and non-human primate cerebellar neurons for use in neuronal safety pharmacology assessments of the central nervous system","volume":"105","author":"Miraucourt","year":"2020","journal-title":"J. Pharmacol. Toxicol. Methods"},{"issue":"39","key":"10.1016\/j.phrs.2026.108394_bib195","doi-asserted-by":"crossref","first-page":"9027","DOI":"10.1523\/JNEUROSCI.2567-05.2005","article-title":"Mechanism of positive allosteric modulators acting on AMPA receptors","volume":"25","author":"Jin","year":"2005","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.phrs.2026.108394_bib196","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0006-8993(98)00447-8","article-title":"AMPA receptor desensitization modulates synaptic responses induced by repetitive afferent stimulation in hippocampal slices","volume":"799","author":"Arai","year":"1998","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.phrs.2026.108394_bib197","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1111\/ejn.12638","article-title":"Prolonged ampakine exposure prunes dendritic spines and increases presynaptic release probability for enhanced long-term potentiation in the hippocampus","volume":"40","author":"Chang","year":"2014","journal-title":"Eur. J. Neurosci."},{"issue":"12","key":"10.1016\/j.phrs.2026.108394_bib198","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1101\/lm.035220.114","article-title":"Enhanced AMPA receptor function promotes cerebellar long-term depression rather than potentiation","volume":"21","author":"van Beugen","year":"2014","journal-title":"Learn. Mem."},{"issue":"24","key":"10.1016\/j.phrs.2026.108394_bib199","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1093\/hmg\/ddx379","article-title":"Potentiation of excitatory synaptic transmission ameliorates aggression in mice with Stxbp1 haploinsufficiency","volume":"26","author":"Miyamoto","year":"2017","journal-title":"Hum. Mol. Genet."},{"issue":"12","key":"10.1016\/j.phrs.2026.108394_bib200","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1177\/0269881120967857","article-title":"AMPA receptors mediate the pro-cognitive effects of electrical and optogenetic stimulation of the medial prefrontal cortex in antidepressant non-responsive Wistar-Kyoto rats","volume":"34","author":"Papp","year":"2020","journal-title":"J. Psychopharmacol."},{"issue":"344","key":"10.1016\/j.phrs.2026.108394_bib201","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf7151","article-title":"Post-anesthesia AMPA receptor potentiation prevents anesthesia-induced learning and synaptic deficits","volume":"8","author":"Huang","year":"2016","journal-title":"Sci. Transl. Med."},{"issue":"4","key":"10.1016\/j.phrs.2026.108394_bib202","first-page":"267","article-title":"Modulation of AMPA\/kainate receptors by analogues of diazoxide and cyclothiazide in thin slices of rat hippocampus","volume":"1","author":"Bertolino","year":"1993","journal-title":"Recept. & Channels"},{"issue":"13","key":"10.1016\/j.phrs.2026.108394_bib203","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1021\/bi1000678","article-title":"Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator: structures of GluA2 and GluA3 in complexes with PEPA","volume":"49","author":"Ahmed","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.phrs.2026.108394_bib204","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuropharm.2014.05.022","article-title":"Functional insight into development of positive allosteric modulators of AMPA receptors","volume":"85","author":"Weeks","year":"2014","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib205","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1038\/s41467-023-37259-5","article-title":"Modulatory mechanisms of TARP gamma8-selective AMPA receptor therapeutics","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.phrs.2026.108394_bib206","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.tips.2008.04.004","article-title":"Regulation of AMPA receptor gating and pharmacology by TARP auxiliary subunits","volume":"29","author":"Milstein","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"issue":"35","key":"10.1016\/j.phrs.2026.108394_bib207","doi-asserted-by":"crossref","first-page":"11673","DOI":"10.1523\/JNEUROSCI.0383-14.2014","article-title":"Molecular mechanisms contributing to TARP regulation of channel conductance and polyamine block of calcium-permeable AMPA receptors","volume":"34","author":"Soto","year":"2014","journal-title":"J. Neurosci."},{"issue":"10","key":"10.1016\/j.phrs.2026.108394_bib208","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1038\/nn1966","article-title":"Stargazin attenuates intracellular polyamine block of calcium-permeable AMPA receptors","volume":"10","author":"Soto","year":"2007","journal-title":"Nat. Neurosci."},{"issue":"5919","key":"10.1016\/j.phrs.2026.108394_bib209","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1126\/science.1167852","article-title":"Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors","volume":"323","author":"Schwenk","year":"2009","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.phrs.2026.108394_bib210","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.neuron.2013.01.017","article-title":"Cornichon proteins determine the subunit composition of synaptic AMPA receptors","volume":"77","author":"Herring","year":"2013","journal-title":"Neuron"},{"issue":"8080","key":"10.1016\/j.phrs.2026.108394_bib211","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/s41586-025-09325-z","article-title":"Architecture, dynamics and biogenesis of GluA3 AMPA glutamate receptors","volume":"645","author":"Pokharna","year":"2025","journal-title":"Nature"},{"issue":"17","key":"10.1016\/j.phrs.2026.108394_bib212","doi-asserted-by":"crossref","first-page":"12619","DOI":"10.1074\/jbc.M700607200","article-title":"Brain-derived neurotrophic factor regulates the expression and synaptic delivery of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons","volume":"282","author":"Caldeira","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.phrs.2026.108394_bib213","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.nlm.2008.10.002","article-title":"BDNF-induced synaptic delivery of AMPAR subunits is differentially dependent on NMDA receptors and requires ERK","volume":"91","author":"Li","year":"2009","journal-title":"Neurobiol. Learn. Mem."},{"issue":"3","key":"10.1016\/j.phrs.2026.108394_bib214","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nrd3366","article-title":"Potential therapeutic uses of BDNF in neurological and psychiatric disorders","volume":"10","author":"Nagahara","year":"2011","journal-title":"Nat. Rev. Drug. Discov."},{"issue":"1-2","key":"10.1016\/j.phrs.2026.108394_bib215","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0169-328X(03)00003-2","article-title":"Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer's disease, Brain Res","volume":"111","author":"Michalski","year":"2003","journal-title":"Mol. Brain Res."},{"issue":"6","key":"10.1016\/j.phrs.2026.108394_bib216","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1111\/j.1471-4159.2005.03135.x","article-title":"Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease","volume":"93","author":"Peng","year":"2005","journal-title":"J. Neurochem."},{"issue":"45","key":"10.1016\/j.phrs.2026.108394_bib217","doi-asserted-by":"crossref","first-page":"34708","DOI":"10.1074\/jbc.M110.150821","article-title":"Oligomeric amyloid-beta inhibits the proteolytic conversion of brain-derived neurotrophic factor (BDNF), AMPA receptor trafficking, and classical conditioning","volume":"285","author":"Zheng","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.phrs.2026.108394_bib218","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1073\/pnas.96.5.2461","article-title":"Growth factor-mediated Fyn signaling regulates alpha-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor expression in rodent neocortical neurons","volume":"96","author":"Narisawa-Saito","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"43","key":"10.1016\/j.phrs.2026.108394_bib219","doi-asserted-by":"crossref","first-page":"40901","DOI":"10.1074\/jbc.M202158200","article-title":"Brain-derived neurotrophic factor regulates surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptors by enhancing the N-ethylmaleimide-sensitive factor\/GluR2 interaction in developing neocortical neurons","volume":"277","author":"Narisawa-Saito","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"22","key":"10.1016\/j.phrs.2026.108394_bib220","doi-asserted-by":"crossref","first-page":"13069","DOI":"10.1073\/pnas.2131948100","article-title":"Brain-derived neurotrophic factor-dependent unmasking of \"silent\" synapses in the developing mouse barrel cortex","volume":"100","author":"Itami","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.phrs.2026.108394_bib221","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0057124","article-title":"Acute BDNF treatment upregulates GluR1-SAP97 and GluR2-GRIP1 interactions: implications for sustained AMPA receptor expression","volume":"8","author":"Jourdi","year":"2013","journal-title":"PLoS. One"},{"issue":"2","key":"10.1016\/j.phrs.2026.108394_bib222","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1152\/jn.00336.2006","article-title":"Restoration of long-term potentiation in middle-aged hippocampus after induction of brain-derived neurotrophic factor","volume":"96","author":"Rex","year":"2006","journal-title":"J. Neurophysiol."},{"issue":"2","key":"10.1016\/j.phrs.2026.108394_bib223","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ydbio.2003.07.008","article-title":"Brain-derived neurotrophic factor signal enhances and maintains the expression of AMPA receptor-associated PDZ proteins in developing cortical neurons","volume":"263","author":"Jourdi","year":"2003","journal-title":"Dev. Biol."},{"issue":"24","key":"10.1016\/j.phrs.2026.108394_bib224","doi-asserted-by":"crossref","first-page":"8127","DOI":"10.1523\/JNEUROSCI.6034-11.2012","article-title":"Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors","volume":"32","author":"Fortin","year":"2012","journal-title":"J. Neurosci."},{"issue":"47","key":"10.1016\/j.phrs.2026.108394_bib225","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abd2163","article-title":"BDNF-induced local translation of GluA1 is regulated by HNRNP A2\/B1","volume":"6","author":"Jung","year":"2020","journal-title":"Sci. Adv."},{"issue":"8","key":"10.1016\/j.phrs.2026.108394_bib226","doi-asserted-by":"crossref","first-page":"999","DOI":"10.3923\/pjbs.2014.999.1006","article-title":"Isolation of hyperoside and isoquercitrin from Camellia sasanqua as antioxidant agents","volume":"17","author":"Sukito","year":"2014","journal-title":"Pak. J. Biol. Sci."},{"issue":"3","key":"10.1016\/j.phrs.2026.108394_bib227","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2741\/4814","article-title":"Hyperoside exerts potent anticancer activity in skin cancer","volume":"25","author":"Kong","year":"2020","journal-title":"Front. Biosci. (Landmark Ed. )"},{"issue":"2","key":"10.1016\/j.phrs.2026.108394_bib228","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1007\/s10753-014-9989-8","article-title":"Anti-inflammatory effects of hyperoside in human endothelial cells and in mice","volume":"38","author":"Ku","year":"2015","journal-title":"Inflammation"},{"key":"10.1016\/j.phrs.2026.108394_bib229","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105196","article-title":"Long-term oral administration of hyperoside ameliorates AD-related neuropathology and improves cognitive impairment in APP\/PS1 transgenic mice","volume":"151","author":"Chen","year":"2021","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.phrs.2026.108394_bib230","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175188","article-title":"Hyperoside improves learning and memory deficits by amyloid beta(1-42) in mice through regulating synaptic calcium-permeable AMPA receptors","volume":"931","author":"Yi","year":"2022","journal-title":"Eur. J. Pharmacol."},{"issue":"19","key":"10.1016\/j.phrs.2026.108394_bib231","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.1523\/JNEUROSCI.0604-06.2006","article-title":"Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3","volume":"26","author":"Engel","year":"2006","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.phrs.2026.108394_bib232","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1006\/exnr.1997.6581","article-title":"Enhancement by an ampakine of memory encoding in humans","volume":"146","author":"Ingvar","year":"1997","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phrs.2026.108394_bib233","unstructured":"Clinical Trials.gov, Treatment of Alzheimer's Disease With CX516 (Ampalex). https:\/\/clinicaltrials.gov\/study\/NCT00001662, 2008 (accessed 03 July 2026)."},{"key":"10.1016\/j.phrs.2026.108394_bib234","article-title":"Efficacy and safety Of CX516 in elderly participants with mild cognitive impairment","author":"Trials.gov","year":"2018","journal-title":"Org. 24448 Treat. Major. Depress"},{"issue":"3","key":"10.1016\/j.phrs.2026.108394_bib235","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/sj.npp.1301444","article-title":"A placebo-controlled add-on trial of the Ampakine, CX516, for cognitive deficits in schizophrenia","volume":"33","author":"Goff","year":"2008","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib236","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.coph.2005.09.005","article-title":"Glutamate-based therapeutic approaches: ampakines","volume":"6","author":"Lynch","year":"2006","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.phrs.2026.108394_bib237","doi-asserted-by":"crossref","DOI":"10.3389\/fncir.2021.711564","article-title":"Calcium permeable-AMPA receptors and excitotoxicity in neurological disorders","volume":"15","author":"Guo","year":"2021","journal-title":"Front. Neural Circuits"},{"issue":"2","key":"10.1016\/j.phrs.2026.108394_bib238","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1476-5381.2010.00726.x","article-title":"Challenges for and current status of research into positive modulators of AMPA receptors","volume":"160","author":"Ward","year":"2010","journal-title":"Br. J. Pharmacol."},{"issue":"5-6","key":"10.1016\/j.phrs.2026.108394_bib239","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.pneurobio.2007.01.003","article-title":"Role of brain-derived neurotrophic factor in Huntington's disease","volume":"81","author":"Zuccato","year":"2007","journal-title":"Prog. Neurobiol."},{"issue":"12","key":"10.1016\/j.phrs.2026.108394_bib240","doi-asserted-by":"crossref","first-page":"4906","DOI":"10.1073\/pnas.0811228106","article-title":"Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice","volume":"106","author":"Simmons","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib241","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1523\/JNEUROSCI.20-01-00008.2000","article-title":"Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons","volume":"20","author":"Lauterborn","year":"2000","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.phrs.2026.108394_bib242","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1124\/mol.58.4.802","article-title":"Effects of the potent ampakine CX614 on hippocampal and recombinant AMPA receptors: Interactions with cyclothiazide and GYKI 52466","volume":"58","author":"Arai","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.phrs.2026.108394_bib243","unstructured":"ClinicalTrials.gov, A Clinical Trial of AAV2-BDNF Gene Therapy in Early Alzheimer's Disease and Mild Cognitive Impairment. https:\/\/clinicaltrials.gov\/study\/NCT05040217, 2025 (accessed 14 May 2026)."},{"key":"10.1016\/j.phrs.2026.108394_bib244","article-title":"A Phase I Clinical Trial of AAV2-BDNF Gene Therapy for Alzheimer's Disease: Findings, Alzheimer's Association International Conference (AAIC) 2025","author":"Tuszynski","year":"2025","journal-title":"Alzheimer's. & Dement."},{"issue":"7","key":"10.1016\/j.phrs.2026.108394_bib245","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/s41582-025-01094-7","article-title":"Synapse vulnerability and resilience across the clinical spectrum of dementias","volume":"21","author":"Taddei","year":"2025","journal-title":"Nat. Rev. Neurol."},{"issue":"Pt 3","key":"10.1016\/j.phrs.2026.108394_bib246","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1113\/jphysiol.2005.103812","article-title":"Cyclothiazide induces robust epileptiform activity in rat hippocampal neurons both in vitro and in vivo","volume":"571","author":"Qi","year":"2006","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.phrs.2026.108394_bib247","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0197-0186(97)00098-3","article-title":"Characterization of cyclothiazide-enhanced kainate excitotoxicity in rat hippocampal cultures","volume":"32","author":"Ohno","year":"1998","journal-title":"Neurochem. Int."},{"issue":"5","key":"10.1016\/j.phrs.2026.108394_bib248","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/ana.410430517","article-title":"The diazoxide derivative IDRA 21 enhances ischemic hippocampal neuron injury","volume":"43","author":"Yamada","year":"1998","journal-title":"Ann. Neurol."},{"issue":"4","key":"10.1016\/j.phrs.2026.108394_bib249","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/S0306-4522(99)00296-1","article-title":"Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex","volume":"93","author":"Croll","year":"1999","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.phrs.2026.108394_bib250","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1006\/exnr.2002.7869","article-title":"Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor","volume":"174","author":"Scharfman","year":"2002","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.phrs.2026.108394_bib251","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1152\/jn.1997.78.2.1082","article-title":"Hyperexcitability in combined entorhinal\/hippocampal slices of adult rat after exposure to brain-derived neurotrophic factor","volume":"78","author":"Scharfman","year":"1997","journal-title":"J. Neurophysiol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib252","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.neurobiolaging.2014.07.002","article-title":"Region- and age-dependent reductions of hippocampal long-term potentiation and NMDA to AMPA ratio in a genetic model of Alzheimer's disease","volume":"36","author":"Tozzi","year":"2015","journal-title":"Neurobiol. Aging"},{"issue":"7","key":"10.1016\/j.phrs.2026.108394_bib253","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41582-018-0013-z","article-title":"Tau-targeting therapies for Alzheimer disease","volume":"14","author":"Congdon","year":"2018","journal-title":"Nat. Rev. Neurol."},{"issue":"12","key":"10.1016\/j.phrs.2026.108394_bib254","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/s41582-023-00883-2","article-title":"Tau-targeting therapies for Alzheimer disease: current status and future directions","volume":"19","author":"Congdon","year":"2023","journal-title":"Nat. Rev. Neurol."},{"issue":"7","key":"10.1016\/j.phrs.2026.108394_bib255","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.tips.2024.05.005","article-title":"Multi-target drugs for Alzheimer's disease","volume":"45","author":"Turgutalp","year":"2024","journal-title":"Trends Pharmacol. Sci."},{"issue":"4","key":"10.1016\/j.phrs.2026.108394_bib256","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.70131","article-title":"Multi-target drug design in alzheimer's disease treatment: emerging technologies, advantages, challenges, and limitations","volume":"13","author":"Hossain","year":"2025","journal-title":"Pharmacol. Res. Perspect."},{"issue":"1","key":"10.1016\/j.phrs.2026.108394_bib257","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41467-024-54715-y","article-title":"Stereo-seq of the prefrontal cortex in aging and Alzheimer's disease","volume":"16","author":"Gong","year":"2025","journal-title":"Nat. Commun."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661826003099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661826003099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:06:08Z","timestamp":1789398368000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661826003099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":257,"alternative-id":["S1043661826003099"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2026.108394","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distinct roles of AMPA receptor subunits as potential therapeutic targets in Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2026.108394","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108394"}}