{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:02:49Z","timestamp":1789902169144,"version":"4.0.1"},"reference-count":118,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["2024SF2-GJHX-67"],"award-info":[{"award-number":["2024SF2-GJHX-67"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["2024SF-YBXM-482"],"award-info":[{"award-number":["2024SF-YBXM-482"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017605","name":"Shaanxi University of Chinese Medicine","doi-asserted-by":"publisher","award":["2023-KJXX-05"],"award-info":[{"award-number":["2023-KJXX-05"]}],"id":[{"id":"10.13039\/501100017605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017550","name":"Shaanxi Science and Technology Association","doi-asserted-by":"publisher","award":["20240325"],"award-info":[{"award-number":["20240325"]}],"id":[{"id":"10.13039\/501100017550","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.phrs.2026.108417","type":"journal-article","created":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T05:49:13Z","timestamp":1788068953000},"page":"108417","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Pharmacological inhibition of the SUMOylation pathway: Mechanisms, inhibitors and therapeutic opportunities"],"prefix":"10.1016","volume":"232","author":[{"given":"Jiajie","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianuo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5782-1107","authenticated-orcid":false,"given":"Yuwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/brv.12905","article-title":"A review of visualisations of protein fold networks and their relationship with sequence and function","volume":"98","author":"Sykes","year":"2023","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"issue":"D1","key":"10.1016\/j.phrs.2026.108417_bib2","doi-asserted-by":"crossref","first-page":"D471","DOI":"10.1093\/nar\/gkab1017","article-title":"dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications","volume":"50","author":"Li","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phrs.2026.108417_bib3","first-page":"2021","article-title":"Posttranslational modifications in proteins: resources, tools and prediction methods","author":"Ramazi","year":"2021","journal-title":"Database (Oxf. )"},{"issue":"3","key":"10.1016\/j.phrs.2026.108417_bib4","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jgg.2023.07.002","article-title":"Protein post-translational modifications in auxin signaling","volume":"51","author":"Cui","year":"2024","journal-title":"J. Genet. Genom."},{"issue":"4","key":"10.1016\/j.phrs.2026.108417_bib5","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.gendis.2022.03.009","article-title":"Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities","volume":"10","author":"Zhao","year":"2023","journal-title":"Genes. Dis."},{"key":"10.1016\/j.phrs.2026.108417_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2024.1481426","article-title":"Deciphering the potential role of post-translational modifications of histones in gastrointestinal cancers: a proteomics-based review with therapeutic challenges and opportunities","volume":"14","author":"Farrokhi Yekta","year":"2024","journal-title":"Front. Oncol."},{"issue":"5","key":"10.1016\/j.phrs.2026.108417_bib7","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1074\/mcp.M116.063719","article-title":"Global Analysis of SUMO-Binding Proteins Identifies SUMOylation as a Key Regulator of the INO80 Chromatin Remodeling Complex","volume":"16","author":"Cox","year":"2017","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.phrs.2026.108417_bib8","article-title":"Exploring potential targets for natural product therapy of DN: the role of SUMOylation","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.phrs.2026.108417_bib9","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1124\/pharmrev.122.000784","article-title":"Paradoxes of Cellular SUMOylation Regulation: A Role of Biomolecular Condensates?","volume":"75","author":"Cheng","year":"2023","journal-title":"Pharmacol. Rev."},{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/cells13010008","article-title":"Paralogue-Specific Roles of SUMO1 and SUMO2\/3 in Protein Quality Control and Associated Diseases","volume":"13","author":"Wang","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.phrs.2026.108417_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2021.100164","article-title":"Identification of SUMO Targets Associated With the Pluripotent State in Human Stem Cells","volume":"20","author":"Mojsa","year":"2021","journal-title":"Mol. Cell. Proteom."},{"issue":"10","key":"10.1016\/j.phrs.2026.108417_bib12","doi-asserted-by":"crossref","first-page":"5501","DOI":"10.1007\/s11010-025-05336-6","article-title":"Synthetic inhibition of the SUMO pathway by targeting the SAE1 component via TAK-981 compound impairs growth and chemosensitizes embryonal and alveolar rhabdomyosarcoma cell lines","volume":"480","author":"Codenotti","year":"2025","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.phrs.2026.108417_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122085","article-title":"SUMOylation and DeSUMOylation: Prospective therapeutic targets in cancer","volume":"332","author":"Wu","year":"2023","journal-title":"Life Sci."},{"issue":"11","key":"10.1016\/j.phrs.2026.108417_bib14","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/s41580-022-00500-y","article-title":"Signalling mechanisms and cellular functions of SUMO","volume":"23","author":"Vertegaal","year":"2022","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"6","key":"10.1016\/j.phrs.2026.108417_bib15","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/s12276-020-0457-2","article-title":"SUMO and cellular adaptive mechanisms","volume":"52","author":"Ryu","year":"2020","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib16","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12929-024-01060-3","article-title":"Dual inhibition of SUMOylation and MEK conquers MYC-expressing KRAS-mutant cancers by accumulating DNA damage","volume":"31","author":"Kotani","year":"2024","journal-title":"J. Biomed. Sci."},{"issue":"11","key":"10.1016\/j.phrs.2026.108417_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105280","article-title":"SUMOylation indirectly suppresses activity of the HIF-1\u03b1 pathway in intestinal epithelial cells","volume":"299","author":"Malkov","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2026.108417_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2023.137118","article-title":"Reduced SUMOylation of Nrf2 signaling contributes to its inhibition induced by amyloid-\u03b2","volume":"799","author":"Wang","year":"2023","journal-title":"Neurosci. Lett."},{"issue":"11","key":"10.1016\/j.phrs.2026.108417_bib19","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1136\/gutjnl-2021-324834","article-title":"Targeting pancreatic cancer by TAK-981: a SUMOylation inhibitor that activates the immune system and blocks cancer cell cycle progression in a preclinical model","volume":"71","author":"Kumar","year":"2022","journal-title":"Gut"},{"issue":"5","key":"10.1016\/j.phrs.2026.108417_bib20","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1021\/acs.jmedchem.0c01491","article-title":"Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer","volume":"64","author":"Langston","year":"2021","journal-title":"J. Med. Chem."},{"issue":"4","key":"10.1016\/j.phrs.2026.108417_bib21","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1152\/physrev.00025.2019","article-title":"SUMO: From Bench to Bedside","volume":"100","author":"Chang","year":"2020","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1515\/bmc-2016-0030","article-title":"SUMO conjugation - a mechanistic view","volume":"8","author":"Pichler","year":"2017","journal-title":"Biomol. Concepts"},{"issue":"20","key":"10.1016\/j.phrs.2026.108417_bib23","doi-asserted-by":"crossref","first-page":"3892","DOI":"10.2174\/0929867327666200810135039","article-title":"Current Status of SUMOylation Inhibitors","volume":"28","author":"Brackett","year":"2021","journal-title":"Curr. Med. Chem."},{"issue":"11","key":"10.1016\/j.phrs.2026.108417_bib24","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/nchembio.2463","article-title":"Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor","volume":"13","author":"He","year":"2017","journal-title":"Nat. Chem. Biol."},{"issue":"11","key":"10.1016\/j.phrs.2026.108417_bib25","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1158\/2767-9764.CRC-25-0243","article-title":"A First-In-Human Study of the SUMOylation Inhibitor Subasumstat in Patients with Advanced\/Metastatic Solid Tumors or Relapsed\/Refractory Hematologic Malignancies","volume":"5","author":"Juric","year":"2025","journal-title":"Cancer Res. Commun."},{"issue":"4","key":"10.1016\/j.phrs.2026.108417_bib26","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.bmcl.2014.01.010","article-title":"Synthesis of 2\u2032,3\u2032,4\u2032-trihydroxyflavone (2-D08), an inhibitor of protein sumoylation","volume":"24","author":"Kim","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"12","key":"10.1016\/j.phrs.2026.108417_bib27","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1021\/cb400630z","article-title":"Spectomycin B1 as a novel SUMOylation inhibitor that directly binds to SUMO E2","volume":"8","author":"Hirohama","year":"2013","journal-title":"ACS Chem. Biol."},{"issue":"7","key":"10.1016\/j.phrs.2026.108417_bib28","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1021\/cb400177q","article-title":"Identification and characterization of a new chemotype of noncovalent SENP inhibitors","volume":"8","author":"Madu","year":"2013","journal-title":"ACS Chem. Biol."},{"issue":"11","key":"10.1016\/j.phrs.2026.108417_bib29","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.3390\/cells10112825","article-title":"SUMO Interacting Motifs: Structure and Function","volume":"10","author":"Yau","year":"2021","journal-title":"Cells"},{"issue":"8","key":"10.1016\/j.phrs.2026.108417_bib30","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1136\/gutjnl-2018-317856","article-title":"SUMO pathway inhibition targets an aggressive pancreatic cancer subtype","volume":"69","author":"Biederst\u00e4dt","year":"2020","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.phrs.2026.108417_bib31","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14696","article-title":"AZD1390, an ataxia telangiectasia mutated inhibitor, attenuates microglia-mediated neuroinflammation and ischemic brain injury","volume":"30","author":"Lan","year":"2024","journal-title":"CNS Neurosci. Ther."},{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib32","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3390\/ijms25010299","article-title":"RanBP2\/Nup358 mediates sumoylation of STAT1 and antagonizes interferon-\u03b1-mediated antiviral innate immunity","volume":"25","author":"Li","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.phrs.2026.108417_bib33","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202301450RR","article-title":"N-MYC-interacting protein enhances type II interferon signaling by inhibiting STAT1 sumoylation","volume":"37","author":"Feng","year":"2023","journal-title":"Faseb J."},{"issue":"19","key":"10.1016\/j.phrs.2026.108417_bib34","doi-asserted-by":"crossref","first-page":"8032","DOI":"10.18632\/aging.204333","article-title":"SENP3 affects the expression of PYCR1 to promote bladder cancer proliferation and EMT transformation by deSUMOylation of STAT3","volume":"14","author":"Li","year":"2022","journal-title":"Aging (Albany NY)"},{"issue":"11","key":"10.1016\/j.phrs.2026.108417_bib35","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.210043","article-title":"Regulation of transforming growth factor-\u03b2 signalling by SUMOylation and its role in fibrosis","volume":"11","author":"Wang","year":"2021","journal-title":"Open. Biol."},{"issue":"2","key":"10.1016\/j.phrs.2026.108417_bib36","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1161\/CIRCRESAHA.123.323398","article-title":"SUMOylation Fine-Tunes Endothelial HEY1 in the Regulation of Angiogenesis","volume":"134","author":"Ren","year":"2024","journal-title":"Circ. Res."},{"issue":"8","key":"10.1016\/j.phrs.2026.108417_bib37","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.1007\/s00018-021-03826-6","article-title":"SUMOylation modulates the stability and function of PI3K-p110\u03b2","volume":"78","author":"El Motiam","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"issue":"9","key":"10.1016\/j.phrs.2026.108417_bib38","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1080\/15548627.2020.1817279","article-title":"PDPK1 regulates autophagosome biogenesis by binding to PIK3C3","volume":"17","author":"Hu","year":"2021","journal-title":"Autophagy"},{"issue":"4","key":"10.1016\/j.phrs.2026.108417_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.105778","article-title":"SUMO modifies G\u03b2L and mediates mTOR signaling","volume":"300","author":"Park","year":"2024","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib40","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.bbrc.2004.09.068","article-title":"Sumoylation increases HIF-1alpha stability and its transcriptional activity","volume":"324","author":"Bae","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.phrs.2026.108417_bib41","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.cell.2007.08.045","article-title":"SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia","volume":"131","author":"Cheng","year":"2007","journal-title":"Cell"},{"issue":"41","key":"10.1016\/j.phrs.2026.108417_bib42","doi-asserted-by":"crossref","first-page":"5568","DOI":"10.1038\/onc.2010.297","article-title":"PIASy stimulates HIF1\u03b1 SUMOylation and negatively regulates HIF1\u03b1 activity in response to hypoxia","volume":"29","author":"Kang","year":"2010","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.phrs.2026.108417_bib43","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/ncb1716","article-title":"RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation","volume":"10","author":"Tatham","year":"2008","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.phrs.2026.108417_bib44","article-title":"SUMOylation Wrestles With the Occurrence and Development of Breast Cancer","volume":"11","author":"Qin","year":"2021","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib45","doi-asserted-by":"crossref","first-page":"178","DOI":"10.7150\/ijbs.51458","article-title":"MYC dysfunction modulates stemness and tumorigenesis in breast cancer","volume":"17","author":"Liu","year":"2021","journal-title":"Int. J. Biol. Sci."},{"issue":"4","key":"10.1016\/j.phrs.2026.108417_bib46","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.cmet.2017.09.009","article-title":"MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation","volume":"26","author":"Lee","year":"2017","journal-title":"Cell. Metab."},{"issue":"16","key":"10.1016\/j.phrs.2026.108417_bib47","doi-asserted-by":"crossref","first-page":"9519","DOI":"10.1093\/nar\/gkae653","article-title":"Central role of SUMOylation in the regulation of chromatin interactions and transcriptional outputs of the androgen receptor in prostate cancer cells","volume":"52","author":"Launonen","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"9","key":"10.1016\/j.phrs.2026.108417_bib48","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adh8493","article-title":"N-MYC regulates cell survival via eIF4G1 in inv(16) acute myeloid leukemia","volume":"10","author":"Peramangalam","year":"2024","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib49","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3390\/ijms23010514","article-title":"Acute Myeloid Leukemia-Related Proteins Modified by Ubiquitin and Ubiquitin-like Proteins","volume":"23","author":"Park","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"24","key":"10.1016\/j.phrs.2026.108417_bib50","doi-asserted-by":"crossref","first-page":"6310","DOI":"10.1038\/s44318-024-00299-8","article-title":"METTL3\/MYCN cooperation drives neural crest differentiation and provides therapeutic vulnerability in neuroblastoma","volume":"43","author":"Thombare","year":"2024","journal-title":"EMBO J."},{"issue":"14","key":"10.1016\/j.phrs.2026.108417_bib51","doi-asserted-by":"crossref","DOI":"10.1172\/JCI176655","article-title":"Disruption of the KLHL37-N-Myc complex restores N-Myc degradation and arrests neuroblastoma growth in mouse models","volume":"135","author":"Xiang","year":"2025","journal-title":"J. Clin. Invest."},{"issue":"19","key":"10.1016\/j.phrs.2026.108417_bib52","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/s41388-025-03302-6","article-title":"SENP1-mediated deSUMOylation of YBX1 promotes colorectal cancer development through the SENP1-YBX1-AKT signaling axis","volume":"44","author":"Sheng","year":"2025","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib53","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s12672-025-02614-z","article-title":"SUMOylation-regulated genes in colon cancer: expression patterns and clinical implications","volume":"16","author":"Peng","year":"2025","journal-title":"Discov. Oncol."},{"issue":"22","key":"10.1016\/j.phrs.2026.108417_bib54","doi-asserted-by":"crossref","first-page":"5700","DOI":"10.3390\/cancers13225700","article-title":"The Role of Protein SUMOylation in Human Hepatocellular Carcinoma: A Potential Target of New Drug Discovery and Development","volume":"13","author":"Yuan","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.labinv.2022.100011","article-title":"Increased Small Ubiquitin-like Modifier-Activating Enzyme SAE1 Promotes Hepatocellular Carcinoma by Enhancing mTOR SUMOylation","volume":"103","author":"Chen","year":"2023","journal-title":"Lab. Invest."},{"issue":"8","key":"10.1016\/j.phrs.2026.108417_bib56","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1002\/art.41677","article-title":"Aim2 Couples With Ube2i for Sumoylation-Mediated Repression of Interferon Signatures in Systemic Lupus Erythematosus","volume":"73","author":"Lu","year":"2021","journal-title":"Arthritis Rheumatol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib57","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006156","article-title":"SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing","volume":"13","author":"Cui","year":"2017","journal-title":"PLoS. Pathog."},{"key":"10.1016\/j.phrs.2026.108417_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2019.05.006","article-title":"The role of protein SUMOylation in rheumatoid arthritis","volume":"102","author":"Dehnavi","year":"2019","journal-title":"J. Autoimmun."},{"issue":"12","key":"10.1016\/j.phrs.2026.108417_bib59","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1093\/rheumatology\/keac297","article-title":"The SUMO components in rheumatoid arthritis","volume":"61","author":"Wu","year":"2022","journal-title":"Rheumatology"},{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib60","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.yexcr.2018.12.011","article-title":"Role of small ubiquitin-like modifier proteins-1 (SUMO-1) in regulating migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis","volume":"375","author":"Lao","year":"2019","journal-title":"Exp. Cell. Res."},{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib61","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3390\/biomedicines12010016","article-title":"The Dynamic SUMOylation Changes and Their Potential Role in the Senescence of APOE4 Mice","volume":"12","author":"Xu","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.phrs.2026.108417_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2022.136771","article-title":"Abeta-induced presynaptic release of UBC9 through extracellular vesicles involves SNAP23","volume":"785","author":"Long","year":"2022","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.phrs.2026.108417_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2023.120660","article-title":"Degeneration of nigrostriatal dopaminergic neurons in the early to intermediate stage of dementia with Lewy bodies and Parkinson's disease","volume":"449","author":"Okitsu","year":"2023","journal-title":"J. Neurol. Sci."},{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib64","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10565-025-10126-3","article-title":"UBC9 mediates mitophagy to attenuate oxidative stress by regulating SUMOylation of PINK1 in the Parkinson\u2019s disease progression","volume":"42","author":"Liu","year":"2025","journal-title":"Cell. Biol. Toxicol."},{"key":"10.1016\/j.phrs.2026.108417_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2024.103969","article-title":"SUMOylation modulates mitochondrial dynamics in an in vitro rotenone model of Parkinson's disease","volume":"131","author":"Soares","year":"2024","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.phrs.2026.108417_bib66","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.689332","article-title":"Huntingtin and the Synapse","volume":"15","author":"Barron","year":"2021","journal-title":"Front. Cell. Neurosci."},{"issue":"5","key":"10.1016\/j.phrs.2026.108417_bib67","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2107187119","article-title":"Deletion of SUMO1 attenuates behavioral and anatomical deficits by regulating autophagic activities in Huntington disease","volume":"119","author":"Ram\u00edrez-Jarqu\u00edn","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.phrs.2026.108417_bib68","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1093\/brain\/awae319","article-title":"Dysregulation of protein SUMOylation networks in Huntington's disease R6\/2 mouse striatum","volume":"148","author":"Kachemov","year":"2025","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib69","doi-asserted-by":"crossref","first-page":"9761","DOI":"10.1038\/s41467-025-64665-8","article-title":"Targeting SUMOylation promotes cBAF complex stabilization and disruption of the SS18::SSX transcriptome in synovial sarcoma","volume":"16","author":"Floros","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2026.108417_bib70","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.csbj.2015.03.001","article-title":"Advances in the development of SUMO specific protease (SENP) inhibitors","volume":"13","author":"Kumar","year":"2015","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"2","key":"10.1016\/j.phrs.2026.108417_bib71","first-page":"224","article-title":"Preliminary study on the synthesis and biological activity of small molecule #br# inhibitor JK043 of SUMO-specific protease 1","volume":"36","author":"CHEN","year":"2016","journal-title":"J. Shanghai Jiao Tong Univ. Med. Sci."},{"issue":"6","key":"10.1016\/j.phrs.2026.108417_bib72","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1177\/2472555216683937","article-title":"A Small-Molecule Microarray Approach for the Identification of E2 Enzyme Inhibitors in Ubiquitin-Like Conjugation Pathways","volume":"22","author":"Zlotkowski","year":"2017","journal-title":"SLAS Discov."},{"issue":"10","key":"10.1016\/j.phrs.2026.108417_bib73","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.chembiol.2021.04.014","article-title":"Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics","volume":"28","author":"Benoit","year":"2021","journal-title":"Cell. Chem. Biol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib74","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s44319-023-00010-8","article-title":"1,10-phenanthroline inhibits sumoylation and reveals that yeast SUMO modifications are highly transient","volume":"25","author":"McNeil","year":"2024","journal-title":"EMBO Rep."},{"issue":"20","key":"10.1016\/j.phrs.2026.108417_bib75","doi-asserted-by":"crossref","first-page":"12085","DOI":"10.3390\/ijms232012085","article-title":"Discovery of a Dual SENP1 and SENP2 Inhibitor","volume":"23","author":"Brand","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib76","doi-asserted-by":"crossref","first-page":"5145","DOI":"10.1038\/s41467-018-07015-1","article-title":"Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme","volume":"9","author":"Lv","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2026.108417_bib77","unstructured":"Huszar D., Nakamura A. Administration of SUMO-activating enzyme inhibitor and anti-CD38 antibodies. WIPO patent WO 2021\/231877 A1. 2021."},{"key":"10.1016\/j.phrs.2026.108417_bib78","author":"Chen","year":"2015","journal-title":"Inhib. small ubiquitin- Modif. Enzym. Substit. pyrrolo[23-b]quinoxalines"},{"issue":"3","key":"10.1016\/j.phrs.2026.108417_bib79","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1021\/ci4007134","article-title":"Identification of 1,2,5-Oxadiazoles as a New Class of SENP2 Inhibitors Using Structure Based Virtual Screening","volume":"54","author":"Kumar","year":"2014","journal-title":"J. Chem. Inf. Model."},{"issue":"37","key":"10.1016\/j.phrs.2026.108417_bib80","doi-asserted-by":"crossref","first-page":"58995","DOI":"10.18632\/oncotarget.10636","article-title":"Momordin Ic, a new natural SENP1 inhibitor, inhibits prostate cancer cell proliferation","volume":"7","author":"Wu","year":"2016","journal-title":"Oncotarget"},{"issue":"Pt 3","key":"10.1016\/j.phrs.2026.108417_bib81","article-title":"Streptooctatin A induces autophagy and promotes \u03b1-synuclein clearance by directly binding to SUMO2 and inhibiting SUMOylation","volume":"242","author":"Roh","year":"2025","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.phrs.2026.108417_bib82","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.chembiol.2009.01.009","article-title":"Ginkgolic Acid Inhibits Protein SUMOylation by Blocking Formation of the E1-SUMO Intermediate","volume":"16","author":"Fukuda","year":"2009","journal-title":"Chem. Biol."},{"issue":"5","key":"10.1016\/j.phrs.2026.108417_bib83","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0217578","article-title":"Using glycyrrhizic acid to target sumoylation processes during Epstein-Barr virus latency","volume":"14","author":"Bentz","year":"2019","journal-title":"PLoS. One"},{"key":"10.1016\/j.phrs.2026.108417_bib84","article-title":"Heteroaryl compounds useful as inhibitors of SUMO activating enzyme","volume":"3164130","author":"Duffey","year":"2019","journal-title":"Eur. Pat. EP"},{"issue":"11","key":"10.1016\/j.phrs.2026.108417_bib85","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.clml.2025.04.020","article-title":"Phase I\/II Study of Subasumstat (TAK-981) in Combination With Rituximab in Relapsed\/Refractory Non-Hodgkin Lymphoma","volume":"25","author":"Assouline","year":"2025","journal-title":"Clin. Lymphoma Myeloma Leuk."},{"key":"10.1016\/j.phrs.2026.108417_bib86","unstructured":"Takeda. A Study of TAK-981 Given With Pembrolizumab in Participants With Select Advanced or Metastatic Solid Tumors: Results. ClinicalTrials.gov Identifier: NCT04381650. https:\/\/clinicaltrials.gov\/study\/NCT04381650?tab=results (accessed August 19, 2026)."},{"key":"10.1016\/j.phrs.2026.108417_bib87","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1200\/JCO.2022.40.16_suppl.2506","article-title":"A phase 1b, multicenter, dose-escalation study of subasumstat (TAK-981) in combination with pembrolizumab in patients (pts) with advanced solid tumors","volume":"40","author":"Goel","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.phrs.2026.108417_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109394","article-title":"Ginkgoic acid impedes gastric cancer cell proliferation, migration and EMT through inhibiting the SUMOylation of IGF-1R","volume":"337","author":"Liu","year":"2021","journal-title":"Chem. Biol. Interact."},{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib89","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s00432-025-06382-9","article-title":"Insights into SUMOylation in gastric cancer: molecular mechanisms and emerging therapeutic opportunities","volume":"152","author":"Tabnak","year":"2025","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib90","doi-asserted-by":"crossref","DOI":"10.1002\/VIW.20250049","article-title":"Attenuation of arsenic trioxide-induced endothelial injury: unveiling the protective role of ginkgolic acid through inhibition of TRPM4 SUMOylation: Evidence from Raman cellular imaging","volume":"7","author":"Tong","year":"2026","journal-title":"VIEW"},{"key":"10.1016\/j.phrs.2026.108417_bib91","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41419-025-07441-2","article-title":"Hypoxia-mediated SUMOylation of FADD exacerbates endothelial cell injury via the RIPK1-RIPK3-MLKL signaling axis","volume":"16","author":"Yang","year":"2025","journal-title":"Cell. Death Dis."},{"issue":"4","key":"10.1016\/j.phrs.2026.108417_bib92","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.chembiol.2013.04.001","article-title":"An electrophoretic mobility shift assay identifies a mechanistically unique inhibitor of protein sumoylation","volume":"20","author":"Kim","year":"2013","journal-title":"Chem. Biol."},{"issue":"4","key":"10.1016\/j.phrs.2026.108417_bib93","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.bbrc.2019.04.079","article-title":"2-D08 as a SUMOylation inhibitor induced ROS accumulation mediates apoptosis of acute myeloid leukemia cells possibly through the deSUMOylation of NOX2","volume":"513","author":"Zhou","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"23","key":"10.1016\/j.phrs.2026.108417_bib94","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1038\/s41388-025-03350-y","article-title":"SUMOylation facilitates the stability of BCR-ABL to promote chronic myeloid leukemia progression","volume":"44","author":"Zhang","year":"2025","journal-title":"Oncogene"},{"key":"10.1016\/j.phrs.2026.108417_bib95","doi-asserted-by":"crossref","first-page":"6403","DOI":"10.1038\/s41467-025-61694-1","article-title":"Structural basis for a nucleoporin exportin complex between RanBP2, SUMO1-RanGAP1, the E2 Ubc9, Crm1 and the Ran GTPase","volume":"16","author":"Baytshtok","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2026.108417_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2021.128504","article-title":"Streptooctatins A and B, fusicoccane-type diterpenoids with autophagic activity from Streptomyces sp. KCB17JA11","volume":"57","author":"Jang","year":"2022","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.phrs.2026.108417_bib97","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41582-024-01043-w","article-title":"\u03b1-Synuclein pathology as a target in neurodegenerative diseases","volume":"21","author":"Park","year":"2025","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.phrs.2026.108417_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113918","article-title":"Discovery and radiosensitization research of ursolic acid derivatives as SENP1 inhibitors","volume":"227","author":"Wei","year":"2022","journal-title":"Eur. J. Med. Chem."},{"issue":"2","key":"10.1016\/j.phrs.2026.108417_bib99","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.chembiol.2018.10.026","article-title":"Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme","volume":"26","author":"Li","year":"2019","journal-title":"Cell. Chem. Biol."},{"issue":"16","key":"10.1016\/j.phrs.2026.108417_bib100","doi-asserted-by":"crossref","first-page":"5169","DOI":"10.1016\/j.bmcl.2012.06.084","article-title":"Discovery of 1-[4-(N-benzylamino)phenyl]-3-phenylurea derivatives as non-peptidic selective SUMO-sentrin specific protease (SENP)1 inhibitors","volume":"22","author":"Uno","year":"2012","journal-title":"Bioorg. & Med. Chem. Lett."},{"issue":"2","key":"10.1016\/j.phrs.2026.108417_bib101","first-page":"224","article-title":"Preliminary study on the synthesis and biological activity of small molecule inhibitor JK043 of SUMO-specific protease 1","volume":"36","author":"Chen","year":"2016","journal-title":"J. Shanghai Jiao Tong Univ. (Med. Sci.)"},{"issue":"6","key":"10.1016\/j.phrs.2026.108417_bib102","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.chembiol.2011.04.010","article-title":"Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors","volume":"18","author":"Ponder","year":"2011","journal-title":"Chem. Biol."},{"issue":"6","key":"10.1016\/j.phrs.2026.108417_bib103","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.chembiol.2011.05.008","article-title":"Development of small molecule inhibitors and probes of human SUMO deconjugating proteases","volume":"18","author":"Albrow","year":"2011","journal-title":"Chem. Biol."},{"issue":"17","key":"10.1016\/j.phrs.2026.108417_bib104","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.3390\/cancers13174402","article-title":"Therapeutic Potential of Targeting the SUMO Pathway in Cancer","volume":"13","author":"Kukkula","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"2","key":"10.1016\/j.phrs.2026.108417_bib105","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3324\/haematol.2022.280995","article-title":"Small-molecule SUMO inhibition for biomarker-informed B-cell lymphoma therapy","volume":"108","author":"Demel","year":"2023","journal-title":"Haematologica"},{"issue":"6","key":"10.1016\/j.phrs.2026.108417_bib106","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.trecan.2020.11.009","article-title":"Targeting SUMO Signaling to Wrestle Cancer","volume":"7","author":"Kroonen","year":"2021","journal-title":"Trends Cancer"},{"issue":"6","key":"10.1016\/j.phrs.2026.108417_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.112555","article-title":"Targeting SUMOylation in ovarian cancer: Sensitivity, resistance, and the role of MYC","volume":"28","author":"Littler","year":"2025","journal-title":"iScience"},{"key":"10.1016\/j.phrs.2026.108417_bib108","article-title":"Unraveling the critical role of SUMOylation in the governing of tumor immunity","volume":"16","author":"Liu","year":"2025","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.phrs.2026.108417_bib109","doi-asserted-by":"crossref","first-page":"973","DOI":"10.7150\/thno.79688","article-title":"Dynamic SUMOylation of MORC2 orchestrates chromatin remodelling and DNA repair in response to DNA damage and drives chemoresistance in breast cancer","volume":"13","author":"Zhang","year":"2023","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib110","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12929-024-01003-y","article-title":"Mechanisms and functions of SUMOylation in health and disease: a review focusing on immune cells","volume":"31","author":"Huang","year":"2024","journal-title":"J. Biomed. Sci."},{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib111","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/s41392-025-02422-5","article-title":"Limited SUMOylation inhibitor administration enhances eradication of Burkitt\u2019s lymphoma with CD19 CAR-T therapy","volume":"10","author":"Kotani","year":"2025","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib112","doi-asserted-by":"crossref","first-page":"4764","DOI":"10.1038\/s41467-025-60029-4","article-title":"Structural basis for the human SENP5's SUMO isoform discrimination","volume":"16","author":"S\u00e1nchez-Alba","year":"2025","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.phrs.2026.108417_bib113","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1038\/s41594-025-01681-8","article-title":"Cryo-EM structures reveal the molecular mechanism of SUMO E1\u2013E2 thioester transfer","volume":"32","author":"Nayak","year":"2025","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib114","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1038\/s41467-024-47613-w","article-title":"Prospective de novo drug design with deep interactome learning","volume":"15","author":"Atz","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib115","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/s42004-025-01635-7","article-title":"Optimizing drug design by merging generative AI with a physics-based active learning framework","volume":"8","author":"Filella-Merce","year":"2025","journal-title":"Commun. Chem."},{"key":"10.1016\/j.phrs.2026.108417_bib116","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/s41580-024-00729-9","article-title":"Targeted protein degradation: from mechanisms to clinic","volume":"25","author":"Tsai","year":"2024","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.phrs.2026.108417_bib117","doi-asserted-by":"crossref","first-page":"6671","DOI":"10.1038\/s41467-021-26807-6","article-title":"Identification of proximal SUMO-dependent interactors using SUMO-ID","volume":"12","author":"Barroso-Gomila","year":"2021","journal-title":"Nat. Commun."},{"issue":"18","key":"10.1016\/j.phrs.2026.108417_bib118","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1182\/blood.2021014267","article-title":"The SUMOylation inhibitor subasumstat potentiates rituximab activity by IFN1-dependent macrophage and NK cell stimulation","volume":"139","author":"Nakamura","year":"2022","journal-title":"Blood"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661826003324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661826003324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:59:37Z","timestamp":1789901977000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661826003324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":118,"alternative-id":["S1043661826003324"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2026.108417","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacological inhibition of the SUMOylation pathway: Mechanisms, inhibitors and therapeutic opportunities","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2026.108417","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108417"}}