{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:02:25Z","timestamp":1789902145965,"version":"4.0.1"},"reference-count":185,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016305","name":"First Affiliated Hospital of Zhengzhou University","doi-asserted-by":"publisher","award":["ZYCXTD2023005"],"award-info":[{"award-number":["ZYCXTD2023005"]}],"id":[{"id":"10.13039\/501100016305","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016305","name":"First Affiliated Hospital of Zhengzhou University","doi-asserted-by":"publisher","award":["2025XKPY027"],"award-info":[{"award-number":["2025XKPY027"]}],"id":[{"id":"10.13039\/501100016305","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2023\\u201002\\u20101"],"award-info":[{"award-number":["320.6750.2023\\u201002\\u20101"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370976"],"award-info":[{"award-number":["32370976"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004773","name":"Henan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004773","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014717","name":"Youth Science Fund Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.phrs.2026.108442","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:50:07Z","timestamp":1788969007000},"page":"108442","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Neural\u2013metabolic crosstalk governing cell death and therapy resistance in tumors"],"prefix":"10.1016","volume":"232","author":[{"given":"Yiming","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra Sekhar","family":"Bhol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam","family":"Sethi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2026.108442_bib1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3389\/fimmu.2017.00248","article-title":"Metabolic hallmarks of tumor and immune cells in the tumor microenvironment","volume":"8","author":"Renner","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phrs.2026.108442_bib2","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3389\/fonc.2018.00284","article-title":"Metabolic switch in the tumor microenvironment determines immune responses to anti-cancer therapy","volume":"8","author":"Wegiel","year":"2018","journal-title":"Front. Oncol."},{"key":"10.1016\/j.phrs.2026.108442_bib3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41420-025-02376-1","article-title":"Cell death in tumor microenvironment: an insight for exploiting novel therapeutic approaches","volume":"11","author":"Wang","year":"2025","journal-title":"Cell. Death Discov."},{"key":"10.1016\/j.phrs.2026.108442_bib4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13045-023-01398-5","article-title":"Protein degradation: expanding the toolbox to restrain cancer drug resistance","volume":"16","author":"Ming","year":"2023","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.phrs.2026.108442_bib5","doi-asserted-by":"crossref","first-page":"7068","DOI":"10.3390\/ijms22137068","article-title":"Nitric Oxide Modulates Metabolic Processes in the Tumor Immune Microenvironment","volume":"22","author":"McGinity","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2026.108442_bib6","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3389\/fonc.2020.00396","article-title":"Nutritional Exchanges Within Tumor Microenvironment: Impact for Cancer Aggressiveness","volume":"10","author":"Comito","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.phrs.2026.108442_bib7","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.1038\/s41467-023-40457-w","article-title":"Characterizing cancer metabolism from bulk and single-cell RNA-seq data using METAFlux","volume":"14","author":"Huang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2026.108442_bib8","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s12943-025-02413-8","article-title":"Neurotransmitters: an emerging target for therapeutic resistance to tumor immune checkpoint inhibitors","volume":"24","author":"Yang","year":"2025","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.phrs.2026.108442_bib9","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1083\/jcb.201702003","article-title":"Neurons eat glutamate to stay alive","volume":"216","author":"Fendt","year":"2017","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.phrs.2026.108442_bib10","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s00262-025-04074-4","article-title":"Glutamate transporter SLC1A6 promotes resistance to immunotherapy in cancer","volume":"74","author":"Li","year":"2025","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.phrs.2026.108442_bib11","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.immuni.2022.12.017","article-title":"Dopamine inhibits group 2 innate lymphoid cell-driven allergic lung inflammation by dampening mitochondrial activity","volume":"56","author":"Cao","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.phrs.2026.108442_bib12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/imm.13127","article-title":"T cell addiction: can pathogenic T cells be controlled using dopamine receptors?","volume":"158","author":"Bain","year":"2019","journal-title":"Immunology"},{"key":"10.1016\/j.phrs.2026.108442_bib13","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/jcmm.13008","article-title":"Ferroptosis, a new form of cell death, and its relationships with tumourous diseases","volume":"21","author":"Yu","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.phrs.2026.108442_bib14","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.7150\/ijbs.76162","article-title":"Platelet-derived extracellular vesicles inhibit ferroptosis and promote distant metastasis of nasopharyngeal carcinoma by upregulating ITGB3","volume":"18","author":"Li","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.phrs.2026.108442_bib15","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s41392-022-01229-y","article-title":"Copper homeostasis and cuproptosis in health and disease","volume":"7","author":"Chen","year":"2022","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phrs.2026.108442_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2024.189124","article-title":"Ferroptosis and cuproptosis: Metal-dependent cell death pathways activated in response to classical chemotherapy - Significance for cancer treatment?","volume":"1879","author":"Kciuk","year":"2024","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.phrs.2026.108442_bib17","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/s12964-023-01267-1","article-title":"Iron and copper: critical executioners of ferroptosis, cuproptosis and other forms of cell death","volume":"21","author":"Li","year":"2023","journal-title":"Cell. Commun. Signal."},{"key":"10.1016\/j.phrs.2026.108442_bib18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s12943-025-02412-9","article-title":"Integrating neuroscience and oncology: neuroimmune crosstalk in the initiation and progression of digestive system tumors","volume":"24","author":"Sun","year":"2025","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.phrs.2026.108442_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.136093","article-title":"m6A RNA methyltransferase METTL16 induces Cr(VI) carcinogenesis and lung cancer development through glutamine biosynthesis and GLUL expression","volume":"480","author":"Xie","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.phrs.2026.108442_bib20","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1158\/1078-0432.CCR-11-1217","article-title":"Molecular pathways: dysregulated glutamatergic signaling pathways in cancer","volume":"18","author":"Prickett","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.phrs.2026.108442_bib21","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/nrc.2016.71","article-title":"From Krebs to clinic: glutamine metabolism to cancer therapy","volume":"16","author":"Altman","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.phrs.2026.108442_bib22","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.3390\/cancers11111628","article-title":"Glutamine Metabolism in Brain Tumors","volume":"11","author":"Natarajan","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.phrs.2026.108442_bib23","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40170-021-00256-7","article-title":"Pyruvate carboxylase and cancer progression","volume":"9","author":"Kiesel","year":"2021","journal-title":"Cancer Metab."},{"key":"10.1016\/j.phrs.2026.108442_bib24","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.3390\/biom10101370","article-title":"Take Advantage of Glutamine Anaplerosis, the Kernel of the Metabolic Rewiring in Malignant Gliomas","volume":"10","author":"Martins","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.phrs.2026.108442_bib25","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.ccell.2021.01.006","article-title":"Proteogenomic and metabolomic characterization of human glioblastoma","volume":"39","author":"Wang","year":"2021","journal-title":"Cancer Cell."},{"key":"10.1016\/j.phrs.2026.108442_bib26","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1093\/neuonc\/noac042","article-title":"Distinct metabolic hallmarks of WHO classified adult glioma subtypes","volume":"24","author":"Bj\u00f6rkblom","year":"2022","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.phrs.2026.108442_bib27","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nrclinonc.2016.108","article-title":"Non-invasive metabolic imaging of brain tumours in the era of precision medicine","volume":"13","author":"Kim","year":"2016","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.phrs.2026.108442_bib28","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1001\/jamapsychiatry.2013.2615","article-title":"Making progress with magnetic resonance spectroscopy","volume":"70","author":"\u00d6ng\u00fcr","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.phrs.2026.108442_bib29","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/nm.2682","article-title":"2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas","volume":"18","author":"Choi","year":"2012","journal-title":"Nat. Med."},{"issue":"116","key":"10.1016\/j.phrs.2026.108442_bib30","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3002693","article-title":"Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy","volume":"4","author":"Andronesi","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.phrs.2026.108442_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217612","article-title":"SLC7A5\/E2F1\/PTBP1\/PKM2 axis mediates progression and therapy effect of triple-negative breast cancer through the crosstalk of amino acid metabolism and glycolysis pathway","volume":"617","author":"Jiang","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phrs.2026.108442_bib32","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2026.108442_bib33","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","article-title":"Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy","volume":"12","author":"Koppula","year":"2021","journal-title":"Protein Cell."},{"key":"10.1016\/j.phrs.2026.108442_bib34","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1111\/j.1471-4159.2006.03921.x","article-title":"Cooperative action of glutamate transporters and cystine\/glutamate antiporter system Xc- protects from oxidative glutamate toxicity","volume":"98","author":"Lewerenz","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phrs.2026.108442_bib35","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","article-title":"Glutaminolysis and Transferrin Regulate Ferroptosis","volume":"59","author":"Gao","year":"2015","journal-title":"Mol. Cell."},{"key":"10.1016\/j.phrs.2026.108442_bib36","doi-asserted-by":"crossref","first-page":"14240","DOI":"10.1074\/jbc.M117.798405","article-title":"The glutamate\/cystine antiporter SLC7A11\/xCT enhances cancer cell dependency on glucose by exporting glutamate","volume":"292","author":"Koppula","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2026.108442_bib37","doi-asserted-by":"crossref","first-page":"260","DOI":"10.7555\/JBR.34.20190037","article-title":"Glutamate in cancers: from metabolism to signaling","volume":"34","author":"Yi","year":"2019","journal-title":"J. Biomed. Res."},{"key":"10.1016\/j.phrs.2026.108442_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2024.127858","article-title":"Gut microbiota modulates neurotransmitter and gut-brain signaling","volume":"287","author":"Qu","year":"2024","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.phrs.2026.108442_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.neo.2023.100894","article-title":"Dopamine receptor D2 regulates glioblastoma survival and death through MET and death receptor 4\/5","volume":"39","author":"Jeon","year":"2023","journal-title":"Neoplasia"},{"key":"10.1016\/j.phrs.2026.108442_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.655861","article-title":"Dopamine Pathway Mediated by DRD5 Facilitates Tumor Growth via Enhancing Warburg Effect in Esophageal Cancer","volume":"11","author":"Qian","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.phrs.2026.108442_bib41","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.7150\/thno.70762","article-title":"5-HT2B-mediated serotonin activation in enterocytes suppresses colitis-associated cancer initiation and promotes cancer progression","volume":"12","author":"Mao","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.phrs.2026.108442_bib42","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1002\/hep.23441","article-title":"Serotonin promotes tumor growth in human hepatocellular cancer","volume":"51","author":"Soll","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.phrs.2026.108442_bib43","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1053\/j.gastro.2017.03.008","article-title":"Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells Under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice","volume":"153","author":"Jiang","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phrs.2026.108442_bib44","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1126\/science.aah5072","article-title":"Adrenergic nerves activate an angio-metabolic switch in prostate cancer","volume":"358","author":"Zahalka","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.phrs.2026.108442_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2014.12.035","article-title":"Lactate dehydrogenase 5: an old friend and a new hope in the war on cancer","volume":"358","author":"Augoff","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phrs.2026.108442_bib46","doi-asserted-by":"crossref","first-page":"6124","DOI":"10.1002\/cam4.1820","article-title":"Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy","volume":"7","author":"Feng","year":"2018","journal-title":"Cancer Med."},{"key":"10.1016\/j.phrs.2026.108442_bib47","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41392-024-02082-x","article-title":"Lactate and lactylation in cancer","volume":"10","author":"Chen","year":"2025","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phrs.2026.108442_bib48","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1111\/jdv.16145","article-title":"The Warburg effect and tumour immune microenvironment in extramammary Paget\u2019s disease: overexpression of lactate dehydrogenase A correlates with immune resistance","volume":"34","author":"Urata","year":"2020","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.phrs.2026.108442_bib49","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1111\/febs.17374","article-title":"LDHA\u03b1, a lactate dehydrogenase A isoform, promotes glycolysis and tumor progression","volume":"292","author":"Huang","year":"2025","journal-title":"FEBS J."},{"key":"10.1016\/j.phrs.2026.108442_bib50","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1186\/s12967-024-05543-7","article-title":"Lactate dehydrogenase A (LDHA)-mediated lactate generation promotes pulmonary vascular remodeling in pulmonary hypertension","volume":"22","author":"Wu","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.phrs.2026.108442_bib51","doi-asserted-by":"crossref","DOI":"10.1172\/JCI159839","article-title":"Hypoxia-inducible factors: cancer progression and clinical translation","volume":"132","author":"Wicks","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phrs.2026.108442_bib52","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.trecan.2016.10.016","article-title":"Hypoxia-Inducible Factors: Master Regulators of Cancer Progression","volume":"2","author":"Schito","year":"2016","journal-title":"Trends Cancer"},{"key":"10.1016\/j.phrs.2026.108442_bib53","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/s41575-023-00890-0","article-title":"Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota-gut-brain axis","volume":"21","author":"Aburto","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phrs.2026.108442_bib54","doi-asserted-by":"crossref","DOI":"10.1126\/science.abc4552","article-title":"The microbiome and human cancer","volume":"371","author":"Sepich-Poore","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.phrs.2026.108442_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102637","article-title":"The complex relationship between gut microbiota and Alzheimer\u2019s disease: A systematic review","volume":"104","author":"Zhou","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.phrs.2026.108442_bib56","doi-asserted-by":"crossref","first-page":"592","DOI":"10.2174\/1389203716666150630135720","article-title":"Interaction between Microbes and Host Intestinal Health: Modulation by Dietary Nutrients and Gut-Brain-Endocrine-Immune Axis","volume":"16","author":"Chen","year":"2015","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.phrs.2026.108442_bib57","doi-asserted-by":"crossref","first-page":"7100","DOI":"10.1021\/acs.jafc.3c07599","article-title":"Ginsenoside Rk3 Regulates Tryptophan Metabolism along the Brain-Gut Axis by Targeting Tryptophan Hydroxylase and Remodeling the Intestinal Microenvironment to Alleviate Depressive-Like Behavior in Mice","volume":"72","author":"Shao","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phrs.2026.108442_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115130","article-title":"Gut microbiome in neuroendocrine and neuroimmune interactions: The case of genistein","volume":"402","author":"Guo","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phrs.2026.108442_bib59","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3390\/cells14050384","article-title":"Tryptophan and Its Metabolite Serotonin Impact Metabolic and Mental Disorders via the Brain-Gut-Microbiome Axis: A Focus on Sex Differences","volume":"14","author":"Xu","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.phrs.2026.108442_bib60","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.748254","article-title":"Crosstalk Between Intestinal Serotonergic System and Pattern Recognition Receptors on the Microbiota-Gut-Brain Axis","volume":"12","author":"Layunta","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.phrs.2026.108442_bib61","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s40168-025-02094-x","article-title":"Cognitive and behavioral benefits of 2\u2019-fucosyllactose in growing mice: the roles of 5-hydroxytryptophan and gut microbiota","volume":"13","author":"Zhu","year":"2025","journal-title":"Microbiome"},{"key":"10.1016\/j.phrs.2026.108442_bib62","article-title":"Intervention and research progress of gut microbiota-immune-nervous system in autism spectrum disorders among students","volume":"16","author":"Zhou","year":"2025","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.phrs.2026.108442_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.141971","article-title":"Enrofloxacin exposure undermines gut health and disrupts neurotransmitters along the microbiota-gut-brain axis in zebrafish","volume":"356","author":"Tian","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.phrs.2026.108442_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114053","article-title":"Heat stress-induced intestinal barrier damage and dimethylglycine alleviates via improving the metabolism function of microbiota gut brain axis","volume":"244","author":"Wang","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.phrs.2026.108442_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.xplc.2021.100188","article-title":"Hypoxia-induced increase in GABA content is essential for restoration of membrane potential and preventing ROS-induced disturbance to ion homeostasis","volume":"2","author":"Wu","year":"2021","journal-title":"Plant. Commun."},{"key":"10.1016\/j.phrs.2026.108442_bib66","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1158\/0008-5472.CAN-23-1012","article-title":"Neurotransmitter Receptor HTR2B Regulates Lipid Metabolism to Inhibit Ferroptosis in Gastric Cancer","volume":"83","author":"Tu","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.phrs.2026.108442_bib67","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cmet.2019.06.012","article-title":"A Physiological Function for Ferroptosis in Tumor Suppression by the Immune System","volume":"30","author":"Stockwell","year":"2019","journal-title":"Cell. Metab."},{"key":"10.1016\/j.phrs.2026.108442_bib68","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2026.108442_bib69","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/s12974-021-02231-x","article-title":"Microglia and macrophage exhibit attenuated inflammatory response and ferroptosis resistance after RSL3 stimulation via increasing Nrf2 expression","volume":"18","author":"Cui","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.phrs.2026.108442_bib70","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41420-021-00468-2","article-title":"O-GlcNAcylation enhances sensitivity to RSL3-induced ferroptosis via the YAP\/TFRC pathway in liver cancer","volume":"7","author":"Zhu","year":"2021","journal-title":"Cell. Death Discov."},{"key":"10.1016\/j.phrs.2026.108442_bib71","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1146\/annurev-nutr-082117-051732","article-title":"Iron and Cancer","volume":"38","author":"Torti","year":"2018","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.phrs.2026.108442_bib72","article-title":"Inhibiting the system xC-\/glutathione axis selectively targets cancers with mutant-p53 accumulation","volume":"8","author":"Liu","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2026.108442_bib73","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3390\/cancers12010164","article-title":"Ferroptosis in Cancer Cell Biology","volume":"12","author":"Bebber","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.phrs.2026.108442_bib74","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2026.108442_bib75","article-title":"Ferroptosis Signature Shapes the Immune Profiles to Enhance the Response to Immune Checkpoint Inhibitors in Head and Neck Cancer","volume":"10","author":"Chung","year":"2023","journal-title":"Adv. Sci. (Weinh. )"},{"key":"10.1016\/j.phrs.2026.108442_bib76","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.chembiol.2020.03.011","article-title":"Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis","volume":"27","author":"Anandhan","year":"2020","journal-title":"Cell. Chem. Biol."},{"key":"10.1016\/j.phrs.2026.108442_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103342","article-title":"Lipocalin-2 aggravates blood-brain barrier dysfunction after intravenous thrombolysis by promoting endothelial cell ferroptosis via regulating the HMGB1\/Nrf2\/HO-1 pathway","volume":"76","author":"Liu","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.phrs.2026.108442_bib78","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/cdd.2016.25","article-title":"Emerging roles for lipids in non-apoptotic cell death","volume":"23","author":"Magtanong","year":"2016","journal-title":"Cell. Death Differ."},{"key":"10.1016\/j.phrs.2026.108442_bib79","doi-asserted-by":"crossref","first-page":"7965","DOI":"10.1038\/s41467-022-35707-2","article-title":"The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis","volume":"13","author":"Lin","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2026.108442_bib80","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2026.108442_bib81","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1158\/0008-5472.CAN-20-0617","article-title":"Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc- for Glutathione Synthesis in Lung Cancer","volume":"81","author":"Guo","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.phrs.2026.108442_bib82","doi-asserted-by":"crossref","first-page":"5650","DOI":"10.7150\/thno.55482","article-title":"Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma","volume":"11","author":"Zhang","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.phrs.2026.108442_bib83","article-title":"Phospholipids and peroxisomes in ferroptosis: the therapeutic target of acupuncture regulating vascular cognitive impairment and dementia","volume":"17","author":"Zhang","year":"2025","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.phrs.2026.108442_bib84","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/s41418-020-00728-1","article-title":"Cellular degradation systems in ferroptosis","volume":"28","author":"Chen","year":"2021","journal-title":"Cell. Death Differ."},{"key":"10.1016\/j.phrs.2026.108442_bib85","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.phrs.2026.108442_bib86","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1152\/physrev.00011.2024","article-title":"Mammalian copper homeostasis: physiological roles and molecular mechanisms","volume":"105","author":"Lutsenko","year":"2025","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phrs.2026.108442_bib87","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.316","article-title":"Role of necroptosis in the pathogenesis of solid organ injury","volume":"6","author":"Zhao","year":"2015","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.phrs.2026.108442_bib88","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41422-022-00653-7","article-title":"Cuproptosis: a copper-triggered modality of mitochondrial cell death","volume":"32","author":"Tang","year":"2022","journal-title":"Cell. Res."},{"key":"10.1016\/j.phrs.2026.108442_bib89","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/j.molcel.2022.05.001","article-title":"Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death","volume":"82","author":"Cobine","year":"2022","journal-title":"Mol. Cell."},{"key":"10.1016\/j.phrs.2026.108442_bib90","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41556-020-0481-4","article-title":"Copper is an essential regulator of the autophagic kinases ULK1\/2 to drive lung adenocarcinoma","volume":"22","author":"Tsang","year":"2020","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.phrs.2026.108442_bib91","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2024.1335122","article-title":"Emerging insights into cuproptosis and copper metabolism: implications for age-related diseases and potential therapeutic strategies","volume":"16","author":"Fan","year":"2024","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.phrs.2026.108442_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109858","article-title":"ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis","volume":"37","author":"Karki","year":"2021","journal-title":"Cell. Rep."},{"key":"10.1016\/j.phrs.2026.108442_bib93","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.4049\/jimmunol.2200508","article-title":"PANoptosis: A Unique Innate Immune Inflammatory Cell Death Modality","volume":"209","author":"Pandian","year":"2022","journal-title":"J. Immunol."},{"key":"10.1016\/j.phrs.2026.108442_bib94","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3389\/fcimb.2020.00237","article-title":"Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)","volume":"10","author":"Christgen","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.phrs.2026.108442_bib95","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1038\/sj.cdd.4402194","article-title":"The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation","volume":"14","author":"Fernandes-Alnemri","year":"2007","journal-title":"Cell. Death Differ."},{"key":"10.1016\/j.phrs.2026.108442_bib96","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/s41423-025-01329-z","article-title":"PANoptosis in cancer: bridging molecular mechanisms to therapeutic innovations","volume":"22","author":"Lin","year":"2025","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.phrs.2026.108442_bib97","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41420-025-02451-7","article-title":"Inhibition of Zbp1-PANoptosome-mediated PANoptosis effectively attenuates acute pancreatitis","volume":"11","author":"Li","year":"2025","journal-title":"Cell. Death Discov."},{"key":"10.1016\/j.phrs.2026.108442_bib98","doi-asserted-by":"crossref","first-page":"568","DOI":"10.4049\/immunohorizons.2100059","article-title":"Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth","volume":"5","author":"Malireddi","year":"2021","journal-title":"Immunohorizons"},{"key":"10.1016\/j.phrs.2026.108442_bib99","doi-asserted-by":"crossref","first-page":"8183","DOI":"10.1097\/JS9.0000000000002968","article-title":"Unraveling molecular characteristics and functional exploration of panoptosis for prognosis stratification in lung adenocarcinoma: a tumor marker prognostic study","volume":"111","author":"Hu","year":"2025","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.phrs.2026.108442_bib100","article-title":"Integrating PANoptosis insights to enhance breast cancer prognosis and therapeutic decision-making","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phrs.2026.108442_bib101","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and Regulation of NLRP3 Inflammasome Activation","volume":"41","author":"He","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.phrs.2026.108442_bib102","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/s41417-024-00765-9","article-title":"PANoptosis: bridging apoptosis, pyroptosis, and necroptosis in cancer progression and treatment","volume":"31","author":"Gao","year":"2024","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.phrs.2026.108442_bib103","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1111\/j.1460-9568.2003.03079.x","article-title":"Glutamate activates NF-kappaB through calpain in neurons","volume":"18","author":"Sch\u00f6lzke","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.phrs.2026.108442_bib104","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1007\/s00262-023-03445-z","article-title":"Nervous regulation: beta-2-adrenergic signaling in immune homeostasis, cancer immunotherapy, and autoimmune diseases","volume":"72","author":"Thapa","year":"2023","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.phrs.2026.108442_bib105","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s10555-025-10241-x","article-title":"Sympathetic nerve signaling rewires the tumor microenvironment: a shift in \u2018microenvironmental-ity","volume":"44","author":"Sattler","year":"2025","journal-title":"Cancer Metastas-.-. Rev."},{"key":"10.1016\/j.phrs.2026.108442_bib106","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3389\/fcimb.2020.00238","article-title":"The PANoptosome: A Deadly Protein Complex Driving Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)","volume":"10","author":"Samir","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.phrs.2026.108442_bib107","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s13046-023-02675-4","article-title":"Disulfidptosis: a new target for metabolic cancer therapy","volume":"42","author":"Zheng","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.phrs.2026.108442_bib108","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41417-019-0134-6","article-title":"Alkaliptosis: a new weapon for cancer therapy","volume":"27","author":"Liu","year":"2020","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.phrs.2026.108442_bib109","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s10495-024-01989-8","article-title":"Disulfidptosis: A new type of cell death","volume":"29","author":"Xiao","year":"2024","journal-title":"Apoptosis"},{"key":"10.1016\/j.phrs.2026.108442_bib110","article-title":"Disulfidptosis: disulfide stress-induced novel cell death pathway","volume":"5","author":"Shuai","year":"2024","journal-title":"MedComm (2020)"},{"key":"10.1016\/j.phrs.2026.108442_bib111","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41556-023-01091-2","article-title":"Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis","volume":"25","author":"Liu","year":"2023","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.phrs.2026.108442_bib112","doi-asserted-by":"crossref","first-page":"6512","DOI":"10.1002\/anie.201811122","article-title":"Dopamine, Oxidative Stress and Protein-Quinone Modifications in Parkinson\u2019s and Other Neurodegenerative Diseases","volume":"58","author":"Monzani","year":"2019","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.phrs.2026.108442_bib113","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.tcb.2023.07.009","article-title":"Disulfidptosis: disulfide stress-induced cell death","volume":"34","author":"Liu","year":"2024","journal-title":"Trends Cell. Biol."},{"key":"10.1016\/j.phrs.2026.108442_bib114","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/mds.27607","article-title":"The usual suspects, dopamine and alpha-synuclein, conspire to cause neurodegeneration","volume":"34","author":"Mor","year":"2019","journal-title":"Mov. Disord."},{"key":"10.1016\/j.phrs.2026.108442_bib115","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1213995","article-title":"Mechanisms of alkaliptosis","volume":"11","author":"Chen","year":"2023","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.phrs.2026.108442_bib116","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1053\/j.gastro.2017.12.004","article-title":"JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice","volume":"154","author":"Song","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phrs.2026.108442_bib117","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1158\/0008-5472.CAN-08-2470","article-title":"Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH","volume":"69","author":"Chiche","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.phrs.2026.108442_bib118","doi-asserted-by":"crossref","first-page":"7155","DOI":"10.1016\/j.cell.2025.11.002","article-title":"Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis","volume":"188","author":"Wang","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2026.108442_bib119","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.187448","article-title":"Mitochondrial metabolic rewiring sensitizes mTORC1 inhibitor persister cells to cuproptosis","volume":"10","author":"Du","year":"2025","journal-title":"JCI Insight"},{"key":"10.1016\/j.phrs.2026.108442_bib120","doi-asserted-by":"crossref","DOI":"10.1172\/JCI173110","article-title":"Midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons","volume":"133","author":"Sun","year":"2023","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phrs.2026.108442_bib121","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1226044","article-title":"ROS induced lipid peroxidation and their role in ferroptosis","volume":"11","author":"Endale","year":"2023","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.phrs.2026.108442_bib122","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: Death by Lipid Peroxidation","volume":"26","author":"Yang","year":"2016","journal-title":"Trends Cell. Biol."},{"key":"10.1016\/j.phrs.2026.108442_bib123","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12943-020-01157-x","article-title":"The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression","volume":"19","author":"Wu","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.phrs.2026.108442_bib124","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2026.108442_bib125","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S1474-4422(14)70117-6","article-title":"The role of iron in brain ageing and neurodegenerative disorders","volume":"13","author":"Ward","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phrs.2026.108442_bib126","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41392-024-02088-5","article-title":"defence of ferroptosis","volume":"10","author":"Alves","year":"2025","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phrs.2026.108442_bib127","doi-asserted-by":"crossref","first-page":"13506","DOI":"10.3390\/ijms252413506","article-title":"Disulfidptosis and Its Hub Gene Slc3a2 Involved in Ulcerative Colitis Pathogenesis, Disease Progression, and Patient Responses to Biologic Therapies","volume":"25","author":"Yang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2026.108442_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101377","article-title":"A functionalized hydroxydopamine quinone links thiol modification to neuronal cell death","volume":"28","author":"Farzam","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.phrs.2026.108442_bib129","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.3390\/ijms20102575","article-title":"The Oxidative Pathway to Dopamine-Protein Conjugates and Their Pro-Oxidant Activities: Implications for the Neurodegeneration of Parkinson\u2019s Disease","volume":"20","author":"Wakamatsu","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"289","key":"10.1016\/j.phrs.2026.108442_bib130","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa8103","article-title":"SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma","volume":"7","author":"Robert","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.phrs.2026.108442_bib131","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.tcb.2020.02.009","article-title":"Emerging Mechanisms and Disease Relevance of Ferroptosis","volume":"30","author":"Stockwell","year":"2020","journal-title":"Trends Cell. Biol."},{"key":"10.1016\/j.phrs.2026.108442_bib132","doi-asserted-by":"crossref","first-page":"13534","DOI":"10.1002\/jcp.28031","article-title":"Sensory plasticity of carotid body is correlated with oxidative stress in paraventricular nucleus during chronic intermittent hypoxia","volume":"234","author":"Liu","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.phrs.2026.108442_bib133","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.2147\/IJN.S496644","article-title":"Application of Nanomaterial-Mediated Ferroptosis Regulation in Kidney Disease","volume":"20","author":"Zhu","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.phrs.2026.108442_bib134","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41420-023-01630-8","article-title":"vitro CRISPR screening uncovers CRTC3 as a regulator of IFN-\u03b3-induced ferroptosis of hepatocellular carcinoma","volume":"9","author":"Li","year":"2023","journal-title":"Cell. Death Discov."},{"key":"10.1016\/j.phrs.2026.108442_bib135","doi-asserted-by":"crossref","DOI":"10.1016\/j.coi.2023.102348","article-title":"PANoptosome signaling and therapeutic implications in infection: central role for ZBP1 to activate the inflammasome and PANoptosis","volume":"83","author":"Karki","year":"2023","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.phrs.2026.108442_bib136","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1295257","article-title":"Tumor-associated macrophages: an effective player of the tumor microenvironment","volume":"14","author":"Basak","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phrs.2026.108442_bib137","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13075-023-03071-1","article-title":"Dopamine D2 receptor on CD4+ T cells is protective against inflammatory responses and signs in a mouse model of rheumatoid arthritis","volume":"25","author":"Wang","year":"2023","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.phrs.2026.108442_bib138","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abc8188","article-title":"Attenuation of peripheral serotonin inhibits tumor growth and enhances immune checkpoint blockade therapy in murine tumor models","volume":"13","author":"Schneider","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.phrs.2026.108442_bib139","doi-asserted-by":"crossref","first-page":"5296","DOI":"10.7150\/thno.55986","article-title":"Role of serotonin receptor signaling in cancer cells and anti-tumor immunity","volume":"11","author":"Karmakar","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.phrs.2026.108442_bib140","doi-asserted-by":"crossref","first-page":"6282","DOI":"10.1039\/D5CS00083A","article-title":"Cuproptosis: mechanisms and nanotherapeutic strategies in cancer and beyond","volume":"54","author":"Mao","year":"2025","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.phrs.2026.108442_bib141","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1124\/jpet.119.256818","article-title":"Cancer and the Dopamine D2 Receptor: A Pharmacological Perspective","volume":"370","author":"Weissenrieder","year":"2019","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.phrs.2026.108442_bib142","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s11658-024-00608-3","article-title":"Cuproptosis in cancer: biological implications and therapeutic opportunities","volume":"29","author":"Li","year":"2024","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.phrs.2026.108442_bib143","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1361373","article-title":"Exploring the gut microbiota\u2019s effect on temporomandibular joint disorder: a two-sample Mendelian randomization analysis","volume":"14","author":"Zhao","year":"2024","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.phrs.2026.108442_bib144","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1348279","article-title":"Dysbiosis of the gut microbiota and its effect on \u03b1-synuclein and prion protein misfolding: consequences for neurodegeneration","volume":"14","author":"Mahbub","year":"2024","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.phrs.2026.108442_bib145","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.chom.2018.05.003","article-title":"Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease","volume":"23","author":"Agus","year":"2018","journal-title":"Cell. Host Microbe"},{"key":"10.1016\/j.phrs.2026.108442_bib146","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.brainres.2018.03.015","article-title":"Neurotransmitter modulation by the gut microbiota","volume":"1693","author":"Strandwitz","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.phrs.2026.108442_bib147","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1372330","article-title":"Regulation of ferroptosis by PI3K\/Akt signaling pathway: a promising therapeutic axis in cancer","volume":"12","author":"Su","year":"2024","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.phrs.2026.108442_bib148","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.neuroscience.2023.06.001","article-title":"GABAB Receptor Activation Attenuates Neuronal Pyroptosis in Post-cardiac Arrest Brain Injury","volume":"526","author":"Sun","year":"2023","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2026.108442_bib149","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neuint.2016.06.011","article-title":"The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis?","volume":"99","author":"Stilling","year":"2016","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.phrs.2026.108442_bib150","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1016\/j.ccell.2025.09.002","article-title":"Ketogenic diet inhibits glioma progression by promoting gut microbiota-derived butyrate production","volume":"43","author":"Chen","year":"2025","journal-title":"Cancer Cell."},{"key":"10.1016\/j.phrs.2026.108442_bib151","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2024.1449696","article-title":"Interactions between tumor-associated macrophages and regulated cell death: therapeutic implications in immuno-oncology","volume":"14","author":"Ge","year":"2024","journal-title":"Front. Oncol."},{"key":"10.1016\/j.phrs.2026.108442_bib152","article-title":"The gut microbiome, immune modulation, and cognitive decline: insights on the gut-brain axis","volume":"16","author":"Zhang","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phrs.2026.108442_bib153","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.cmet.2021.02.015","article-title":"CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability","volume":"33","author":"Ma","year":"2021","journal-title":"Cell. Metab."},{"key":"10.1016\/j.phrs.2026.108442_bib154","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13045-022-01304-5","article-title":"Crosstalk among m6A RNA methylation, hypoxia and metabolic reprogramming in TME: from immunosuppressive microenvironment to clinical application","volume":"15","author":"Zhang","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.phrs.2026.108442_bib155","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12943-019-1089-9","article-title":"Role of hypoxia in cancer therapy by regulating the tumor microenvironment","volume":"18","author":"Jing","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.phrs.2026.108442_bib156","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157321","article-title":"Guilu Erxian glue mitigates spermatogenesis dysfunction through HIF-1\u03b1\/SLC7A11-mediated ferroptosis inhibition: An integrated metabolomics and network pharmacology study","volume":"148","author":"Tang","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phrs.2026.108442_bib157","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.freeradbiomed.2025.06.030","article-title":"Herbacetin alleviates ferroptosis via Hif-1\u03b1\/SLC7A11\/GPX4 axis in traumatic brain injury","volume":"238","author":"Qian","year":"2025","journal-title":"Free. Radic. Biol. Med."},{"key":"10.1016\/j.phrs.2026.108442_bib158","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112945","article-title":"HIF-1\u03b1 drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1","volume":"42","author":"Yang","year":"2023","journal-title":"Cell. Rep."},{"key":"10.1016\/j.phrs.2026.108442_bib159","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107841","article-title":"Lactate in ferroptosis regulation: A new perspective on tumor progression and therapy","volume":"218","author":"Wu","year":"2025","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phrs.2026.108442_bib160","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/s42255-021-00406-7","article-title":"Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells","volume":"3","author":"Schwartz","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.phrs.2026.108442_bib161","doi-asserted-by":"crossref","DOI":"10.1172\/JCI143691","article-title":"HIF-2\u03b1 activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron","volume":"131","author":"Singhal","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phrs.2026.108442_bib162","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1158\/1078-0432.CCR-11-0641","article-title":"Molecular pathways: beta-adrenergic signaling in cancer","volume":"18","author":"Cole","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.phrs.2026.108442_bib163","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ccr.2010.05.024","article-title":"Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors","volume":"18","author":"Qi","year":"2010","journal-title":"Cancer Cell."},{"key":"10.1016\/j.phrs.2026.108442_bib164","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2014.65","article-title":"Chronic stress enhances progression of periodontitis via \u03b11-adrenergic signaling: a potential target for periodontal disease therapy","volume":"46","author":"Lu","year":"2014","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.phrs.2026.108442_bib165","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2024.112417","article-title":"Macrophage NLRP3 inflammasome mediates the effects of sympathetic nerve on cardiac remodeling in obese rats","volume":"596","author":"Xi","year":"2025","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.phrs.2026.108442_bib166","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.intimp.2016.07.002","article-title":"Dopamine D2 receptor suppresses gastric cancer cell invasion and migration via inhibition of EGFR\/AKT\/MMP-13 pathway","volume":"39","author":"Huang","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phrs.2026.108442_bib167","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.neuro.2017.10.006","article-title":"Hypoxia regulates the level of glutamic acid decarboxylase enzymes and interrupts inhibitory synapse stability in primary cultured neurons","volume":"65","author":"Hwang","year":"2018","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.phrs.2026.108442_bib168","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1006\/phrs.2001.0868","article-title":"Baclofen prevents hypoxia-induced consolidation impairment for passive avoidance in rats","volume":"44","author":"Car","year":"2001","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phrs.2026.108442_bib169","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ebiom.2018.03.019","article-title":"GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4+ T Cells and Is Immunosuppressive in Type 1 Diabetes","volume":"30","author":"Bhandage","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.phrs.2026.108442_bib170","article-title":"Increases in 4-Acetaminobutyric Acid Generated by Phosphomevalonate Kinase Suppress CD8+ T Cell Activation and Allow Tumor Immune Escape","volume":"11","author":"Zhou","year":"2024","journal-title":"Adv. Sci. (Weinh. )"},{"key":"10.1016\/j.phrs.2026.108442_bib171","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.173214","article-title":"GABA attenuates neurotoxicity of zinc oxide nanoparticles due to oxidative stress via DAF-16\/FoxO and SKN-1\/Nrf2 pathways","volume":"934","author":"Teng","year":"2024","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.phrs.2026.108442_bib172","doi-asserted-by":"crossref","first-page":"10773","DOI":"10.3390\/ijms241310773","article-title":"Ameliorative Potential of (-) Pseudosemiglabrin in Mice with Pilocarpine-Induced Epilepsy: Antioxidant, Anti-Inflammatory, Anti-Apoptotic, and Neurotransmission Modulation","volume":"24","author":"Balaha","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2026.108442_bib173","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.phrs.2026.108442_bib174","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2025.1611055","article-title":"Comprehensive landscape of cell death mechanisms: from molecular cross-talk to therapeutic innovation in oncology","volume":"13","author":"Qi","year":"2025","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.phrs.2026.108442_bib175","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1158\/2159-8290.CD-20-0789","article-title":"Modes of Regulated Cell Death in Cancer","volume":"11","author":"Koren","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.phrs.2026.108442_bib176","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1038\/s41467-023-38360-5","article-title":"Spatially resolved multi-omics highlights cell-specific metabolic remodeling and interactions in gastric cancer","volume":"14","author":"Sun","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2026.108442_bib177","first-page":"75","article-title":"Leveraging Single-Cell Multi-Omics to Decode Tumor Microenvironment Diversity and Therapeutic Resistance","volume":"18","author":"Sabit","year":"2025","journal-title":"Pharm. (Basel)"},{"key":"10.1016\/j.phrs.2026.108442_bib178","article-title":"Integrating spatial omics and single-cell mass spectrometry imaging reveals tumor-host metabolic interplay in hepatocellular carcinoma","volume":"122","author":"Chen","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.phrs.2026.108442_bib179","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/s41467-023-36707-6","article-title":"Spatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas","volume":"14","author":"Ren","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2026.108442_bib180","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1007\/s10120-017-0720-y","article-title":"Phase 1 study of sulfasalazine and cisplatin for patients with CD44v-positive gastric cancer refractory to cisplatin (EPOC1407)","volume":"20","author":"Shitara","year":"2017","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.phrs.2026.108442_bib181","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1158\/1078-0432.CCR-20-2381","article-title":"Phase I clinical trial of combination propranolol and pembrolizumab in locally advanced and metastatic melanoma: safety, tolerability, and preliminary evidence of antitumor activity","volume":"27","author":"Gandhi","year":"2021","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.phrs.2026.108442_bib182","doi-asserted-by":"crossref","first-page":"4163","DOI":"10.1158\/1078-0432.CCR-16-2658","article-title":"First-in-human clinical trial of oral ONC201 in patients with refractory solid tumors","volume":"23","author":"Stein","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.phrs.2026.108442_bib183","doi-asserted-by":"crossref","DOI":"10.1158\/0008-5472.CAN-23-0186","article-title":"ONC201 in combination with paxalisib for the treatment of H3K27-altered diffuse midline glioma","author":"Jackson","year":"2023","journal-title":"Cancer Res. OF1OF17"},{"key":"10.1016\/j.phrs.2026.108442_bib184","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1126\/science.abf3363","article-title":"Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients","volume":"371","author":"Davar","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.phrs.2026.108442_bib185","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1038\/s41591-023-02453-x","article-title":"Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial","volume":"29","author":"Routy","year":"2023","journal-title":"Nat. Med."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661826003579?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661826003579?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:50:33Z","timestamp":1789901433000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661826003579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":185,"alternative-id":["S1043661826003579"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2026.108442","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neural\u2013metabolic crosstalk governing cell death and therapy resistance in tumors","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2026.108442","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108442"}}