{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:51:34Z","timestamp":1790988694192,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2005,5]]},"DOI":"10.1016\/j.phymed.2003.06.009","type":"journal-article","created":{"date-parts":[[2005,8,18]],"date-time":"2005-08-18T11:37:07Z","timestamp":1124365027000},"page":"345-350","source":"Crossref","is-referenced-by-count":37,"title":["Preliminary studies of Mammea americana L. (Guttiferae) bark\/latex extract point to an effective antiulcer effect on gastric ulcer models in mice"],"prefix":"10.1016","volume":"12","author":[{"given":"W.","family":"Toma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.A.","family":"Hiruma-Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.O.","family":"Guerrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.R.M.","family":"Souza Brito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2003.06.009_bib1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0378-8741(98)00126-3","article-title":"Pharmacological screening of the anti-ulcerogenic effects of some Jordanian medicinal plants in rats","volume":"67","author":"Alkofahi","year":"1999","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2003.06.009_bib2","first-page":"69","article-title":"Recurrence during maintenance therapy with histamine H2 receptors antagonist in cases of gastric ulcers","volume":"28","author":"Ariyphisi","year":"1986","journal-title":"Nikon University J. Med."},{"key":"10.1016\/j.phymed.2003.06.009_bib3","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/1099-1573(200012)14:8<581::AID-PTR776>3.0.CO;2-S","article-title":"The plant kingdom as a source of anti-ulcer remedies","volume":"14","author":"Borrelli","year":"2000","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2003.06.009_bib4","first-page":"1152","article-title":"Antimalarial experimental chemotherapy using natural products","volume":"37","author":"Brand\u00e3o","year":"1985","journal-title":"Cienc. Cult."},{"key":"10.1016\/j.phymed.2003.06.009_bib5","unstructured":"Correa, M.P., 1994. Dicion\u00e1rio das plantas \u00fateis do Brasil e das ex\u00f3ticas cultivadas. Imprensa Nacional, Rio de Janeiro, pp. 11\u201312."},{"key":"10.1016\/j.phymed.2003.06.009_bib6","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1002\/jps.2600611012","article-title":"Constituents of Mammea americana L. IX. Oxidation of mammein and mammeisin","volume":"61","author":"Finnegan","year":"1972","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.phymed.2003.06.009_bib7","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1002\/jps.2600611011","article-title":"Constituents of Mammea americana L.","volume":"61","author":"Finnegan","year":"1972","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.phymed.2003.06.009_bib8","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/jps.2600620329","article-title":"Constituents of Mammea americana L. XII. Biological data for xanthones and benzophenones","volume":"62","author":"Finnegan","year":"1973","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.phymed.2003.06.009_bib9","first-page":"243","article-title":"Plants of Puerto Rico with anti-Mycobacterium tuberculosis properties","volume":"17","author":"Frame","year":"1998","journal-title":"PR Health Sci. J."},{"issue":"193","key":"10.1016\/j.phymed.2003.06.009_bib10","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/00365529209096011","article-title":"Adaptation in the pharmaceutical industry with particular reference to gastrointestinal drugs and diseases","volume":"27","author":"Garner","year":"1992","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.phymed.2003.06.009_bib11","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0944-7113(00)80045-8","article-title":"Antiulcerogenic effect of a hydroalcoholic extract and its organic fractions of Neurolaena lobata (L.) R","volume":"7","author":"Gracioso","year":"2000","journal-title":"Br. Phytomedicine"},{"key":"10.1016\/j.phymed.2003.06.009_bib12","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1078\/0944-7113-00017","article-title":"Gastroprotective effect of aparisthman, a diterpene isolated from Aparisthmium cordatum, on experimental gastric ulcer models in rats and mice","volume":"8","author":"Hiruma-Lima","year":"2001","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2003.06.009_bib13","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1078\/09447110260573155","article-title":"Effect of essential oil obtained from Croton cajucara Benth. on gastric ulcer healing and protective factors of the gastric mucosa","volume":"9","author":"Hiruma-Lima","year":"2002","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2003.06.009_bib14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1248\/bpb.18.223","article-title":"Effect of a combination of ecabet sodium and cimetidine on experimentally induced gastric-lesions and gastric-mucosal resistance to ulcerogenic agents in rats","volume":"18","author":"Kinoshita","year":"1995","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.phymed.2003.06.009_bib15","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1080\/00365529850171611","article-title":"Involvement of nitric oxide and prostaglandins in gastroprotection induced by bacterial lipopolysaccharide","volume":"33","author":"Konturek","year":"1998","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.phymed.2003.06.009_bib16","unstructured":"Levine, R.J., 1971. Peptic Ulcer. In: Pfeiffer, C.J. (Ed.), Munksgarrd, Copenhagen, pp. 92\u201397."},{"key":"10.1016\/j.phymed.2003.06.009_bib17","unstructured":"Lorenzi, H., Matos, F.J.A., 2002. Plantas Medicinais no Brasil, nativas e ex\u00f3ticas. Instituto Plantarum de Estudos da flora, Nova Odessa, pp. 231."},{"key":"10.1016\/j.phymed.2003.06.009_bib18","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1179\/000349802125000600","article-title":"Molluscicidal activity of plants from Puerto Rico","volume":"96","author":"Mel\u00e9ndez","year":"2002","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.phymed.2003.06.009_bib19","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1254\/jjp.33.939","article-title":"Effect of polyamines on acidified ethanol-induced gastric lesions in rats","volume":"33","author":"Mizui","year":"1983","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.phymed.2003.06.009_bib20","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1254\/jjp.57.495","article-title":"Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of terprenone and cimetidine","volume":"57","author":"Morimoto","year":"1991","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.phymed.2003.06.009_bib21","first-page":"23S","article-title":"Role of prostaglandins in gastroprotection","volume":"43","author":"Peskar","year":"1998","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.phymed.2003.06.009_bib22","first-page":"1281","article-title":"Gastric ulcerogenicity of non-steroidal anti-inflamatory drugs in mice with mucosa sensitized by cholinomimetic treatment","volume":"27","author":"Rainsford","year":"1978","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2003.06.009_bib23","series-title":"Medicinal Resources of the Tropical Forest","first-page":"318","article-title":"Tramil","author":"Robineou","year":"1996"},{"key":"10.1016\/j.phymed.2003.06.009_bib24","first-page":"43","article-title":"A simple method for the uniform production of gastric ulceration in the rat","volume":"5","author":"Shay","year":"1945","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phymed.2003.06.009_bib25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0378-8741(98)00142-1","article-title":"Evaluation of the gastric activity of fixed oil of Ocimum sanctum (Holy Basil)","volume":"65","author":"Singh","year":"1999","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2003.06.009_bib26","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF00351774","article-title":"Distention ulcer as a model for testing of drugs for ulcerogenic side effects","volume":"41","author":"Szelenyi","year":"1978","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.phymed.2003.06.009_bib27","doi-asserted-by":"crossref","first-page":"19S","DOI":"10.1016\/S0002-9343(00)00631-8","article-title":"Mechanisms of protection and healing","volume":"110","author":"Wallace","year":"2001","journal-title":"Am. J. Med."},{"key":"10.1016\/j.phymed.2003.06.009_bib28","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmerman","year":"1983","journal-title":"Pain"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711304001515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711304001515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T16:22:29Z","timestamp":1548260549000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711304001515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["S0944711304001515"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2003.06.009","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2005,5]]}}}