{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T07:09:04Z","timestamp":1772348944876,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1016\/j.phymed.2006.03.014","type":"journal-article","created":{"date-parts":[[2006,5,20]],"date-time":"2006-05-20T11:22:30Z","timestamp":1148124150000},"page":"100-106","source":"Crossref","is-referenced-by-count":19,"special_numbering":"S1","title":["STW 5 (Iberogast\u00ae) reduces afferent sensitivity in the rat small intestine"],"prefix":"10.1016","volume":"13","author":[{"given":"M.H.","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.-Y.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Glatzle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Weiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Kelber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Enck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Grundy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.E.","family":"Kreis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl. V","key":"10.1016\/j.phymed.2006.03.014_bib24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.phymed.2006.08.004","article-title":"Spasmolytic and tonic effect of Iberogast (STW 5) in intestinal smooth muscle","volume":"13","author":"Ammon","year":"2006","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2006.03.014_bib1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1046\/j.1365-2710.2003.00473.x","article-title":"A systematic review of tegaserod for the treatment of irritable bowel syndrome","volume":"28","author":"Bergmann","year":"2003","journal-title":"J. Clin. Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2006.03.014_bib2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1136\/gut.48.1.125","article-title":"Visceral hypersensitivity: facts, speculations and challenges","volume":"48","author":"Camilleri","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.phymed.2006.03.014_bib3","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1572-0241.2004.04097.x","article-title":"Occurrence of colon ischemia in relation to irritable bowel syndrome","volume":"99","author":"Cole","year":"2004","journal-title":"Am. J. Gastroenterol."},{"issue":"Suppl. I","key":"10.1016\/j.phymed.2006.03.014_bib4","doi-asserted-by":"crossref","first-page":"i2","DOI":"10.1136\/gut.51.suppl_1.i2","article-title":"Neuroanatomy of visceral nociception: vagal and splanchnic afferent","volume":"51","author":"Grundy","year":"2002","journal-title":"Gut"},{"issue":"Suppl. V","key":"10.1016\/j.phymed.2006.03.014_bib25","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.phymed.2006.03.013","article-title":"Intestinal spasmolytic effects of STW 5 (Iberogast) and its components","volume":"13","author":"Heinle","year":"2006","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2006.03.014_bib5","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1469-7793.1998.717bm.x","article-title":"Sensitivity to 5-hydroxytryptamine in different afferent subpopulations within mesenteric nerves supplying the rat jejunum","volume":"509","author":"Hillsley","year":"1998","journal-title":"J. Physiol."},{"key":"10.1016\/j.phymed.2006.03.014_bib6","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1469-7793.1998.551bw.x","article-title":"Direct and indirect actions of 5-hydroxytryptamine on the discharge of mesenteric afferent fibres innervating the rat jejunum","volume":"506","author":"Hillsley","year":"1998","journal-title":"J. Physiol."},{"key":"10.1016\/j.phymed.2006.03.014_bib8","doi-asserted-by":"crossref","first-page":"G612","DOI":"10.1152\/ajpgi.00206.2001","article-title":"Cosensitivity of vagal mucosal afferents to histamine and 5-HT in the rat jejunum","volume":"283","author":"Kreis","year":"2002","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.phymed.2006.03.014_bib9","article-title":"Therapy for irritable bowel syndrome","volume":"1261-3","author":"Lacy","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2006.03.014_bib29","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1111\/j.1365-2982.2004.00576.x","article-title":"The herbal preparation STW 5 (Iberogast) desensitizes intestinal afferents in the rat small intestine","volume":"16","author":"Liu","year":"2004","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.phymed.2006.03.014_bib11","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1469-7793.1999.277ad.x","article-title":"The role of prostaglandins in the bradykinin-induced activation of serosal afferents of the rat jejunum in vitro","volume":"515","author":"Maubach","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/j.phymed.2006.03.014_bib12","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0016-5085(94)90086-8","article-title":"Basic and clinical aspects of visceral hyperalgesia","volume":"107","author":"Mayer","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phymed.2006.03.014_bib13","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1046\/j.1365-2982.2002.00338.x","article-title":"Relationship between colonic motility and cholinergic mechanosensory afferent synaptic input to mouse superior mesenteric ganglion","volume":"14","author":"Miller","year":"2002","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.phymed.2006.03.014_bib14","doi-asserted-by":"crossref","first-page":"227","DOI":"10.17660\/ActaHortic.1993.332.29","article-title":"Gastrointestinal motility modulation with Iberogast","volume":"332","author":"Okpanyi","year":"1993","journal-title":"Acta Hortic."},{"key":"10.1016\/j.phymed.2006.03.014_bib15","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1136\/gut.14.2.125","article-title":"Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome","volume":"14","author":"Ritchie","year":"1973","journal-title":"Gut"},{"issue":"Suppl. V","key":"10.1016\/j.phymed.2006.03.014_bib27","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.phymed.2006.03.022","article-title":"Phytotherapy for functional dyspepsia: a review of the clinical evidence for the herbal preparation STW 5","volume":"13","author":"R\u00f6sch","year":"2006","journal-title":"Phytomedicine"},{"issue":"Suppl. V","key":"10.1016\/j.phymed.2006.03.014_bib28","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.phymed.2006.03.020","article-title":"Region-specific effects of STW 5 and its components in gastric fundus, corpus and antrum","volume":"13","author":"Schemann","year":"2006","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2006.03.014_bib16","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1152\/jn.1990.64.3.796","article-title":"Stimulus-response function studies of esophageal mechanosensitive nociceptors in sympathetic afferents of opossum","volume":"64","author":"Sengupta","year":"1990","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.phymed.2006.03.014_bib17","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0016-5085(98)70263-X","article-title":"Electrophysiology, shape, and chemistry of neurons that project from guinea pig colon to inferior mesenteric ganglia","volume":"115","author":"Sharkey","year":"1998","journal-title":"Gastroenterology"},{"issue":"Suppl. 1","key":"10.1016\/j.phymed.2006.03.014_bib18","first-page":"R22","article-title":"Relevance of the herbal combination of STW 5 for its binding affinity to the muscarinic M3 receptor","volume":"367","author":"Simmen","year":"2003","journal-title":"Naunyn\u2013Schmiedeberg's Arch. Pharmacol."},{"issue":"Suppl. V","key":"10.1016\/j.phymed.2006.03.014_bib26","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.phymed.2006.03.012","article-title":"Binding of STW 5 and its components to intestinal 5-HT, muscarinic M3, and opioid receptors","volume":"13","author":"Simmen","year":"2006","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2006.03.014_bib20","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/S0016-5085(98)70012-5","article-title":"Role of impaired gastric accommodation to a meal in functional dyspepsia","volume":"115","author":"Tack","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phymed.2006.03.014_bib21","first-page":"526","article-title":"Symptoms associated with hypersensitivity to gastric distension in functional dyspepsia","volume":"121","author":"Tack","year":"2001","journal-title":"Am. J. Gastroenterol."},{"issue":"Suppl. II","key":"10.1016\/j.phymed.2006.03.014_bib22","first-page":"37","article-title":"Functional gastroduodenal disorders","volume":"45","author":"Talley","year":"1999","journal-title":"Gut"},{"key":"10.1016\/j.phymed.2006.03.014_bib23","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1146\/annurev.physiol.59.1.457","article-title":"Chemical activators of sensory neurons","volume":"59","author":"Wood","year":"1997","journal-title":"Annu. Rev. Physiol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711306000766?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711306000766?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T23:23:35Z","timestamp":1555629815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711306000766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":26,"alternative-id":["S0944711306000766"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2006.03.014","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2006,11]]}}}