{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:56:08Z","timestamp":1791050168785,"version":"4.1.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1016\/j.phymed.2006.09.005","type":"journal-article","created":{"date-parts":[[2006,11,8]],"date-time":"2006-11-08T12:34:18Z","timestamp":1162989258000},"page":"338-343","source":"Crossref","is-referenced-by-count":39,"title":["Down-regulation of prostate specific antigen in LNCaP cells by flavonoids from the pollen of Brassica napus L."],"prefix":"10.1016","volume":"14","author":[{"given":"H.Y.","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.L.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.P.","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.S.","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2006.09.005_bib1","series-title":"Carbon-13 NMR of Flavonoids","author":"Agrawal","year":"1989"},{"key":"10.1016\/j.phymed.2006.09.005_bib2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/sj.ijir.3901017","article-title":"Medical therapy for benign prostatic hyperplasia: sexual dysfunction and impact on quality of life","volume":"15","author":"Carbone","year":"2003","journal-title":"International Journal of Impotence Research"},{"key":"10.1016\/j.phymed.2006.09.005_bib3","first-page":"571","article-title":"Effects of finasteride on prostate volume and prostate-specific antigen","volume":"67","author":"Chiu","year":"2004","journal-title":"J. Chin. Med. Assoc."},{"key":"10.1016\/j.phymed.2006.09.005_bib4","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1210\/edrv-10-4-393","article-title":"The glandular kallikrein family of enzymes: tissue-specific expression and hormonal regulation","volume":"10","author":"Clements","year":"1989","journal-title":"Endocrine Rev."},{"key":"10.1016\/j.phymed.2006.09.005_bib5","first-page":"1091","article-title":"Inhibition of prostate specific antigen expression by genistein in prostate cancer cells","volume":"16","author":"Davis","year":"2000","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.phymed.2006.09.005_bib6","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3390\/70200245","article-title":"An acylated kaempferol glycoside from flowers of Foeniculum vulgare and F. dulce","volume":"7","author":"Fathy","year":"2002","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2006.09.005_bib7","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1056\/NEJM199101243240406","article-title":"Carcinoma of the prostate","volume":"324","author":"Gittes","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2006.09.005_bib8","first-page":"1809","article-title":"LNCaP model of human prostatic carcinoma","volume":"43","author":"Horoszewicz","year":"1983","journal-title":"Cancer Res."},{"key":"10.1016\/j.phymed.2006.09.005_bib23","first-page":"53","article-title":"The evaluation of the anti-prostate benign hyperplasia effects of six drugs","volume":"11","author":"Jianping","year":"1990","journal-title":"Chinese Journal of Urology"},{"key":"10.1016\/j.phymed.2006.09.005_bib9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/mc.10053","article-title":"Expression of prostate-specific antigen is transcriptionally regulated by genistein in prostate cancer cells","volume":"34","author":"Joanne","year":"2002","journal-title":"Mol. Carcinogenesis"},{"key":"10.1016\/j.phymed.2006.09.005_bib10","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/jcb.20228","article-title":"Prostate specific antigen gene regulation by androgen receptor","volume":"93","author":"Kim","year":"2004","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.phymed.2006.09.005_bib11","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/S0025-7125(05)70159-0","article-title":"Benign prostatic hyperplasia (the aging prostate)","volume":"83","author":"Medina","year":"1999","journal-title":"The Medical Clinics of North America"},{"key":"10.1016\/j.phymed.2006.09.005_bib12","first-page":"539","article-title":"A Japanese version of the national institutes of health chronic prostatitis symptom index (NIH-CPSI, Okayama version) and the clinical evaluation of cernitin pollen extract for chronic non-bacterial prostatitis","volume":"93","author":"Monden","year":"2002","journal-title":"Nippon Hinyokika Gakkai Zasshi"},{"key":"10.1016\/j.phymed.2006.09.005_bib13","doi-asserted-by":"crossref","unstructured":"Onozawa, M., Fukuda, K., Ohtani, M., Akaza, H., Sugimura, T., Wakabayashi, K., 1998. Effects of soybean isoflavones on cell growth and apoptosis of the human prostatic cancer cell line LNCaP. Jpn J. Clin. Oncol. 28, 360\u2013363.","DOI":"10.1093\/jjco\/28.6.360"},{"key":"10.1016\/j.phymed.2006.09.005_bib14","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1023\/A:1006422302173","article-title":"Steroid hormone activity of flavonoids and related compounds","volume":"62","author":"Rachel","year":"2000","journal-title":"Breast Cancer Res. Treat"},{"key":"10.1016\/j.phymed.2006.09.005_bib15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0009-8981(01)00698-2","article-title":"Flavonoids can block PSA production by breast and prostate cancer cell lines","volume":"317","author":"Rachel","year":"2002","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.phymed.2006.09.005_bib16","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0090-4295(99)00232-0","article-title":"Serum prostate-specific antigen and prostate volume predict long-term changes in symptoms and flow rate: results of a four-year, randomized trial comparing finasteride versus placebo","volume":"54","author":"Roehrborn","year":"1999","journal-title":"Urology"},{"key":"10.1016\/j.phymed.2006.09.005_bib17","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0090-4295(98)00654-2","article-title":"Serum prostate-specific antigen is a powerful predictor of acute urinary retention and the need for surgery in men with clinical benign prostatic hyperplasia","volume":"53","author":"Roehrborn","year":"1999","journal-title":"Urology"},{"key":"10.1016\/j.phymed.2006.09.005_bib18","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/j.1875-9114.1993.tb02739.x","article-title":"Finasteride: the first 5\u03b1-reductase inhibitor","volume":"13","author":"Sudduth","year":"1993","journal-title":"Pharmacotherapy"},{"issue":"2","key":"10.1016\/j.phymed.2006.09.005_bib19","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0031-9422(00)97104-8","article-title":"Highly oxygenated bioactive flavones from tamarix1","volume":"36","author":"Virinder","year":"1994","journal-title":"Phytochemistry"},{"issue":"10","key":"10.1016\/j.phymed.2006.09.005_bib20","first-page":"765","article-title":"Studies on chemical constituents of Vicia amoena Fisch [J]","volume":"32","author":"Wei","year":"1997","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.phymed.2006.09.005_bib21","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/0149-2918(95)80009-3","article-title":"Clinical evaluation of long-term treatment using cernitin pollen extract in patients with benign prostatic hyperplasia","volume":"17","author":"Yasumoto","year":"1995","journal-title":"Clin. Ther."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711306001346?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711306001346?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T14:59:22Z","timestamp":1628089162000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711306001346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["S0944711306001346"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2006.09.005","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}