{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:28:49Z","timestamp":1792301329325,"version":"4.4.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"6-7","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1016\/j.phymed.2008.12.003","type":"journal-article","created":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T10:03:43Z","timestamp":1233569023000},"page":"617-622","source":"Crossref","is-referenced-by-count":90,"title":["Adaptogens exert a stress-protective effect by modulation of expression of molecular chaperones"],"prefix":"10.1016","volume":"16","author":[{"given":"Alexander","family":"Panossian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Wikman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punit","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexzander","family":"Asea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2008.12.003_bib1","first-page":"3","article-title":"Release of heat shock proteins: passive vs active release mechanisms","volume":"vol. 1","author":"Asea","year":"2007"},{"key":"10.1016\/j.phymed.2008.12.003_bib2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/9780470754030.ch13","article-title":"Hsp70: a chaperokine","volume":"291","author":"Asea","year":"2008","journal-title":"Novartis Found. Symp."},{"key":"10.1016\/j.phymed.2008.12.003_bib3","volume":"vol. 1","author":"Asea","year":"2007"},{"key":"10.1016\/j.phymed.2008.12.003_bib4","first-page":"34","article-title":"Stress proteins and initiation of immune response: chaperokine activity of hsp72","volume":"11","author":"Asea","year":"2005","journal-title":"Exerc. Immunol. Rev."},{"key":"10.1016\/j.phymed.2008.12.003_bib6","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.4049\/jimmunol.175.5.2900","article-title":"Alternative mechanism by which IFN-gamma enhances tumor recognition: active release of heat shock protein 72","volume":"175","author":"Bausero","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.phymed.2008.12.003_bib7","first-page":"419","article-title":"New substances of plant origin which increase non-specific resistance","volume":"8","author":"Brekhman","year":"1968","journal-title":"Ann. Rev. Pharmacol."},{"key":"10.1016\/j.phymed.2008.12.003_bib9","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1023\/B:MCBI.0000049151.79238.30","article-title":"Schisandrin B protects myocardial ischemia-reperfusion injury partly by inducing Hsp25 and Hsp70 expression in rats","volume":"266","author":"Chiu","year":"2004","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.phymed.2008.12.003_bib10","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1152\/jappl.2000.89.3.1055","article-title":"HSP72 gene expression progressively increases in human skeletal muscle during prolonged, exhaustive exercise","volume":"89","author":"Febbraio","year":"2000","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.phymed.2008.12.003_bib11","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/02656730500088211","article-title":"Endogenous extra-cellular heat shock protein 72: releasing signal(s) and function","volume":"21","author":"Fleshner","year":"2005","journal-title":"Int. J. Hyperthermia"},{"key":"10.1016\/j.phymed.2008.12.003_bib12","doi-asserted-by":"crossref","first-page":"18033","DOI":"10.1074\/jbc.272.29.18033","article-title":"Hsp70 prevents activation of stress kinases. A novel pathway of cellular thermotolerance","volume":"272","author":"Gabai","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2008.12.003_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-5793(98)01242-3","article-title":"Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging","volume":"438","author":"Gabai","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.phymed.2008.12.003_bib14","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0952-7915(00)00191-6","article-title":"Danger signals: SOS to the immune system","volume":"13","author":"Gallucci","year":"2001","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.phymed.2008.12.003_bib15","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1113\/jphysiol.2003.058420","article-title":"Induction, modification and accumulation of HSP70s in the rat liver after acute exercise: early and late responses","volume":"556","author":"Gonz\u00e1lez","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.phymed.2008.12.003_bib16","series-title":"The Biology and Medicine of Rabbits and Rodents","author":"Harkness","year":"1989"},{"key":"10.1016\/j.phymed.2008.12.003_bib17","unstructured":"International Conference on Harmonisation, 1996. ICH topic Q2B validation of analytical procedures: methodology, step 4, consensus guidelines. 6 November, 1996. \u3008www.emea.eu.int\/pdfs\/human\/ich\/028195en.pdf\u3009."},{"key":"10.1016\/j.phymed.2008.12.003_bib18","unstructured":"International Organisation for Standardisation, 2001. EN ISO\/IEC 17 025:2001 standard accreditation requirements for QC laboratories operating under the GxP Compliance Requirements 2001. \u3008http:\/\/www.effichem.com\u3009."},{"key":"10.1016\/j.phymed.2008.12.003_bib19","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1379\/1466-1268(2001)006<0044:EOSBPO>2.0.CO;2","article-title":"Effects of schisandrin B pretreatment on tumor necrosis factor-alpha induced apoptosis and Hsp70 expression in mouse liver","volume":"6","author":"Ip","year":"2001","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.phymed.2008.12.003_bib20","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/02656730500088211","article-title":"Endogenous extra-cellular heat shock protein 72: releasing signal(s) and function","volume":"21","author":"Johnson","year":"2005","journal-title":"Int. J. Hyperthermia"},{"key":"10.1016\/j.phymed.2008.12.003_bib21","first-page":"46","article-title":"Mechanisms of stress-induced cellular HSP72 release: implications for exercise-induced increases in extracellular HSP72","volume":"11","author":"Lancaster","year":"2005","journal-title":"Exerc. Immunol. Rev."},{"key":"10.1016\/j.phymed.2008.12.003_bib22","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1006\/smim.1998.0143","article-title":"An innate sense of danger","volume":"10","author":"Matzinger","year":"1998","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.phymed.2008.12.003_bib37","doi-asserted-by":"crossref","unstructured":"Olsson, E.M.G., von Sch\u00e9ele, B., Panossian, A.G., 2008. A randomized double-blind placebo controlled parallell group study of SHR-5 extract of Rhodiola rosea roots as treatment for patients with stress related fatigue. Planta Med. November 18. \u3008http:\/\/www.thieme-connect.de\/ejournals\/full DOI\/10.1055\/s-0028-1088346\u3009.","DOI":"10.1055\/s-0029-1235006"},{"key":"10.1016\/j.phymed.2008.12.003_bib23","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1089\/107628003322658610","article-title":"Adaptogens: tonic herbs for fatigue and stress","volume":"9","author":"Panossian","year":"2003","journal-title":"Alt. Comp. Ther."},{"key":"10.1016\/j.phymed.2008.12.003_bib24","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/ptr.1751","article-title":"Stimulating effects of adaptogens: an overview of clinical trials of adaptogens with particular reference to their efficacy on single dose administration","volume":"19","author":"Panossian","year":"2005","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2008.12.003_bib25","first-page":"108","article-title":"Effect of adaptogens on the central nervous system","volume":"2","author":"Panossian","year":"2005","journal-title":"Arq. Bras. Fitomed Cient."},{"key":"10.1016\/j.phymed.2008.12.003_bib26","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0944-7113(99)80023-3","article-title":"Plant adaptogens III. Earlier and more recent aspects and concepts on their mode of action","volume":"6","author":"Panossian","year":"1999","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2008.12.003_bib28","first-page":"39","article-title":"The adaptogens rhodiola and schizandra modify the response to immobilization stress in rabbits by suppressing the increase of phosphorylated stress-activated protein kinase, nitric oxide and cortisol","volume":"1","author":"Panossian","year":"2007","journal-title":"Drug Targets Insights"},{"key":"10.1016\/j.phymed.2008.12.003_bib30","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0944-7113(99)80002-6","article-title":"On the mechanism of action of plant adaptogens with particular references on cucurbitacin R diglucoside","volume":"6","author":"Panossian","year":"1999","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2008.12.003_bib31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0944-7113(99)80030-0","article-title":"Effects of heavy physical exercise and adaptogens on nitric oxide content in human saliva","volume":"6","author":"Panossian","year":"1999","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2008.12.003_bib33","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1006\/taap.1995.1223","article-title":"Dosing-induced stress causes hepatocyte apoptosis in rats primed by the rodent nongenotoxic hepatocarcinogen cyproterone acetate","volume":"135","author":"Roberts","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phymed.2008.12.003_bib38","doi-asserted-by":"crossref","first-page":"33097","DOI":"10.1074\/jbc.R500010200","article-title":"Heat shock response modulators as therapeutic tools for deseases of protein conformation","volume":"280","author":"Westerheide","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2008.12.003_bib34","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.2741\/2765","article-title":"Heat shock protein 72: release and biological significance during exercise","volume":"13","author":"Whitham","year":"2008","journal-title":"Front. Biosci."},{"key":"10.1016\/j.phymed.2008.12.003_bib35","first-page":"319","article-title":"Plant adaptogens activate cellular adaptive mechanisms by causing mild damage","volume":"vol. 5","author":"Wiegant","year":"2008"},{"key":"10.1016\/j.phymed.2008.12.003_bib36","article-title":"Plant adaptogens increase life span and stress resistance in C. elegans","author":"Wiegant","year":"2008","journal-title":"Biogerontology"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711308002250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711308002250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T18:47:49Z","timestamp":1558118869000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711308002250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":33,"journal-issue":{"issue":"6-7","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S0944711308002250"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2008.12.003","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}