{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:39:10Z","timestamp":1791031150835,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/j.phymed.2009.05.002","type":"journal-article","created":{"date-parts":[[2009,6,13]],"date-time":"2009-06-13T05:13:32Z","timestamp":1244870012000},"page":"282-288","source":"Crossref","is-referenced-by-count":86,"title":["In vitro and in vivo antifibrotic effects of rosmarinic acid on experimental liver fibrosis"],"prefix":"10.1016","volume":"17","author":[{"given":"Gui-Sheng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang-Lin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Wei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Wu","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Bo","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Hua","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2009.05.002_bib1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2009.05.002_bib2","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1038\/ki.1997.185","article-title":"Biology of TGF-\u03b21 in knockout and transgenic mouse models","volume":"51","author":"Bottinger","year":"1997","journal-title":"Kidney Int."},{"key":"10.1016\/j.phymed.2009.05.002_bib3","first-page":"241","article-title":"The standard of grading and staging of viral hepatitis","volume":"13","year":"1995","journal-title":"Zhonghua Chuanranbing Zazhi"},{"key":"10.1016\/j.phymed.2009.05.002_bib16","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1021\/jm7011134","article-title":"Reaction of rosmarinic acid with nitrite ions in acidic conditions: discovery of nitro- and dinitrorosmarinic acids as new anti-HIV-1 agents","volume":"51","author":"Dubois","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.phymed.2009.05.002_bib5","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1016\/S0168-8278(02)00429-4","article-title":"Liver fibrosis \u2013 from bench to beside","volume":"38","author":"Friedman","year":"2003","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2009.05.002_bib6","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/13524","article-title":"Tumor\u2013host interactions in the gallbladder suppress distal angiogenesis and tumor growth: involvement of transforming growth factor \u03b21","volume":"5","author":"Gohongi","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2009.05.002_bib7","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1159\/000007493","article-title":"Serum markers as tools to monitor liver fibrosis","volume":"59","author":"Hayasaka","year":"1998","journal-title":"Digestion"},{"key":"10.1016\/j.phymed.2009.05.002_bib24","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.canlet.2005.08.025","article-title":"Rosmarinic acid inhibits angiogenesis and its mechanism of action in vitro","volume":"239","author":"Huang","year":"2006","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phymed.2009.05.002_bib8","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.3748\/wjg.v11.i8.1141","article-title":"Alterations of mast cells and TGF-beta1 on the silymarin treatment for CCl(4)-induced hepatic fibrosis","volume":"11","author":"Jeong","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phymed.2009.05.002_bib9","doi-asserted-by":"crossref","DOI":"10.1097\/SHK.0b013e3181a48e86","article-title":"Rosmarinic acid protects against experimental sepsis by inhibiting proinflammatory factors release and ameliorating hemodynamics","author":"Jiang","year":"2009","journal-title":"Shock"},{"key":"10.1016\/j.phymed.2009.05.002_bib10","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S0168-8278(96)80239-X","article-title":"Serum laminin and hyaluronan in liver cirrhosis: markers of progression with high prognostic value","volume":"25","author":"Korner","year":"1996","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2009.05.002_bib11","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1096\/fj.03-1273rev","article-title":"TGF-beta signaling and the fibrotic response","volume":"18","author":"Leask","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.phymed.2009.05.002_bib12","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.phymed.2007.10.004","article-title":"Antiproliferative activity of triterpenoids from Eclipta prostrata on hepatic stellate cells","volume":"15","author":"Lee","year":"2008","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2009.05.002_bib13","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1046\/j.1440-1746.1999.01928.x","article-title":"Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects for therapy","volume":"14","author":"Li","year":"1999","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2009.05.002_bib14","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/jgm.894","article-title":"Inhibition of connective tissue growth factor by siRNA prevents liver fibrosis in rats","volume":"8","author":"Li","year":"2006","journal-title":"J. Gene Med."},{"key":"10.1016\/j.phymed.2009.05.002_bib15","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/jgm.1223","article-title":"RNA interfering connective tissue growth factor prevents rat hepatic stellate cell activation and extracellular matrix production","volume":"10","author":"Li","year":"2008","journal-title":"J. Gene Med."},{"key":"10.1016\/j.phymed.2009.05.002_bib4","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/ptr.1936","article-title":"A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.)","volume":"20","author":"McKay","year":"2006","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2009.05.002_bib17","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.phymed.2007.10.004","article-title":"Antiproliferative activity of triterpenoids from Eclipta prostrata on hepatic stellate cells","volume":"15","author":"Mi","year":"2008","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2009.05.002_bib18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.phymed.2009.05.002_bib19","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1440-1746.1996.tb00291.x","article-title":"Clinical significance of serum hyaluronan in patients with chronic viral liver disease","volume":"11","author":"Murawaki","year":"1996","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2009.05.002_bib20","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/carcin\/bgh034","article-title":"Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model","volume":"25","author":"Osakabe","year":"2004","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.phymed.2009.05.002_bib21","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/01.LAB.0000017365.18894.D3","article-title":"Effects and regulation of connective tissue growth factor on hepatic stellate cells","volume":"82","author":"Paradis","year":"2002","journal-title":"Lab. Invest."},{"key":"10.1016\/j.phymed.2009.05.002_bib22","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/hep.510300425","article-title":"Expression of connective tissue growth factor in experimental rat and human liver fibrosis","volume":"30","author":"Paradis","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2009.05.002_bib23","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/359693a0","article-title":"Targeted disruption of the mouse transforming growth factor-\u03b21 gene results in multifocal inflammatory disease","volume":"359","author":"Schull","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2009.05.002_bib25","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cca.2005.06.014","article-title":"Mechanisms of liver fibrosis","volume":"364","author":"Tsukada","year":"2006","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.phymed.2009.05.002_bib26","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/S0168-8278(00)80244-5","article-title":"Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells","volume":"32","author":"Williams","year":"2000","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2009.05.002_bib27","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s005350070045","article-title":"Hepatic stellate cells: a target for the treatment of liver fibrosis","volume":"35","author":"Wu","year":"2000","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.phymed.2009.05.002_bib28","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1478-3231.2008.01730.x","article-title":"Disruption of connective tissue growth factor by short hairpin RNA inhibits collagen synthesis and extracellular matrix secretion in hepatic stellate cells","volume":"28","author":"Yu","year":"2008","journal-title":"Liver Int."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471130900124X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471130900124X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T18:05:10Z","timestamp":1558375510000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471130900124X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":28,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S094471130900124X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2009.05.002","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}