{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:36:42Z","timestamp":1790145402944,"version":"4.0.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.phymed.2009.07.016","type":"journal-article","created":{"date-parts":[[2009,8,16]],"date-time":"2009-08-16T08:22:57Z","timestamp":1250410977000},"page":"369-374","source":"Crossref","is-referenced-by-count":78,"title":["Volatile components of four Ethiopian Artemisia species extracts and their in vitro antitrypanosomal and cytotoxic activities"],"prefix":"10.1016","volume":"17","author":[{"given":"Endalkachew","family":"Nibret","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2009.07.016_bib1","series-title":"Medicinal Plants and Enigmatic Health Practices of Northern Ethiopia","author":"Abebe","year":"1993"},{"key":"10.1016\/j.phymed.2009.07.016_bib3","series-title":"Illustrated Checklist: Medicinal Plants and Other Useful Plants of Ethiopia","author":"Abebe","year":"2003"},{"key":"10.1016\/j.phymed.2009.07.016_bib4","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/S0031-9422(82)85065-6","article-title":"Constituents of the essential oil of Artemisia rehan","volume":"21","author":"Abegaz","year":"1982","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phymed.2009.07.016_bib5","first-page":"35","article-title":"Secondary metabolites of Artemisia annua and their biological activity","volume":"80","author":"Bhakuni","year":"2001","journal-title":"Curr. Sci."},{"key":"10.1016\/j.phymed.2009.07.016_bib6","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/j.1460-2075.1985.tb03772.x","article-title":"Cultivation in a semi-defined medium of animal infective forms of Trypanosoma brucei, T. equiperdum, T. evansi, T. rhodesiense and T. gambiense","volume":"4","author":"Baltz","year":"1985","journal-title":"EMBO J."},{"key":"10.1016\/j.phymed.2009.07.016_bib7","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/(SICI)1099-1573(199603)10:2<140::AID-PTR792>3.0.CO;2-D","article-title":"Cytotoxicity of Artemisinin, a dimer of dihydroartemisinin, artemisitene and eupatoriopicrin as evaluated by the MTT and clonogenic assay","volume":"10","author":"Beekman","year":"1996","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2009.07.016_bib8","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1055\/s-2006-957533","article-title":"Artemisinin-derived sesquiterpene lactones as potential antitumor compounds: cytotoxic action against bone marrow and tumour cells","volume":"64","author":"Beekman","year":"1998","journal-title":"Planta Med."},{"key":"10.1016\/j.phymed.2009.07.016_bib9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/ptr.691","article-title":"The antioxidant activity of the essential oils of Artemisia afra, Artemisia abyssinica and Juniperus procera","volume":"15","author":"Burits","year":"2001","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2009.07.016_bib10","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0378-8741(94)01187-7","article-title":"Ethiopian traditional herbal drugs. Part III: anti-fertility activity of 70 medicinal plants","volume":"44","author":"Desta","year":"1994","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2009.07.016_bib11","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0001-706X(02)00237-1","article-title":"Antigenic variation and the African trypanosome genome","volume":"85","author":"Donelson","year":"2003","journal-title":"Acta Trop."},{"key":"10.1016\/j.phymed.2009.07.016_bib12","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1055\/s-2007-967138","article-title":"Willmar Schwabe award 2006: antiplasmodial and antitumor activity of artemisinin\u2013from bench to bedside","volume":"73","author":"Efferth","year":"2007","journal-title":"Planta Med."},{"key":"10.1016\/j.phymed.2009.07.016_bib13","unstructured":"Ford, J., Makin, M.J., Grimble, R.J., 1976. Trypanosomiasis Control Programme for Ethiopia. Report to the Ethiopian government of the British technical assistance team appointed to determine a programme for Tsetse fly and trypanosomiasis control and subsequent land use in south-western Ethiopia. Ministry of Overseas Development of the British Government, London."},{"key":"10.1016\/j.phymed.2009.07.016_bib14","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jep.2004.08.021","article-title":"Screening of some medicinal plants of Ethiopia for their anti-microbial properties and chemicals profiles","volume":"97","author":"Geyid","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2009.07.016_bib15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1471-4922(00)01827-4","article-title":"African bovine trypanosomiasis: the problem of drug resistance","volume":"17","author":"Geerts","year":"2001","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.phymed.2009.07.016_bib16","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0001-706X(93)90083-N","article-title":"A Comparison of three methods of estimating EC50 in studies of drug resistance of malaria parasites","volume":"55","author":"Huber","year":"1993","journal-title":"Acta Trop."},{"key":"10.1016\/j.phymed.2009.07.016_bib17","series-title":"Spices, Condiments and Medicinal plants in Ethiopia, Their Taxonomy and Agricultural Significance","author":"Jansen","year":"1981"},{"key":"10.1016\/j.phymed.2009.07.016_bib18","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.trstmh.2005.08.004","article-title":"The herbal tea approach for artemisinin as a therapy for malaria?","volume":"100","author":"Jansen","year":"2006","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.phymed.2009.07.016_bib19","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/0031-9422(79)80167-3","article-title":"Sesquiterpene lactones and systematics of the genus Artemisia","volume":"18","author":"Kelsey","year":"1979","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phymed.2009.07.016_bib20","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1126\/science.3887571","article-title":"Qinghaosu (artemisinin): an antimalarial drug from China","volume":"228","author":"Klayman","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.phymed.2009.07.016_bib21","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/ptr.2650090802","article-title":"Modulatory effects of Artemisia annua extracts on human complement, neutrophil oxidative burst and proliferation of T lymphocytes","volume":"9","author":"Kroes","year":"1995","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2009.07.016_bib22","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1128\/AAC.01544-06","article-title":"Artemisinins inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense in vitro growth","volume":"51","author":"Mishina","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.phymed.2009.07.016_bib23","first-page":"311","article-title":"Phytochemical and biological studies on Artemisia abyssinica and antidiabetic herb used in Arabian folk medicine","volume":"56","author":"Mossa","year":"1985","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phymed.2009.07.016_bib24","series-title":"Artemisia. Medicinal and Aromatic Plants\u2013Industrial Profiles","first-page":"3","article-title":"Introduction to the genus","author":"Mucciarelli","year":"2002"},{"key":"10.1016\/j.phymed.2009.07.016_bib25","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0378-8741(90)90025-O","article-title":"Preliminary toxicity studies on ethanol extracts of the aerial parts of Artemisia abyssinica and A. inculta in mice","volume":"28","author":"Qureshi","year":"1990","journal-title":"J. Ethnopahrmacol."},{"key":"10.1016\/j.phymed.2009.07.016_bib26","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00436-006-0126-y","article-title":"Development of resazurin microtiter assay for drug testing of Trypanosoma cruzi epimastigotes","volume":"99","author":"Rol\u00f3n","year":"2006","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.phymed.2009.07.016_bib27","first-page":"222","article-title":"Asteraceae (Compositae)","volume":"vol. 4, part 2","author":"Tadesse","year":"2004"},{"key":"10.1016\/j.phymed.2009.07.016_bib28","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0014-4894(90)90092-Q","article-title":"Plasmodium berghei: the antimalarial action of artemisinin and sodium artelinate in vivo and in vitro, studied by flow cytometry","volume":"70","author":"van Vianen","year":"1990","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.phymed.2009.07.016_bib29","series-title":"Medicinal Plants of the World","author":"van Wyk","year":"2004"},{"key":"10.1016\/j.phymed.2009.07.016_bib30","doi-asserted-by":"crossref","first-page":"996","DOI":"10.2174\/138920008786927794","article-title":"Evolutionary advantage and molecular modes of action of multi-component mixtures used in phytomedicine","volume":"9","author":"Wink","year":"2008","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.phymed.2009.07.016_bib31","series-title":"Mind-Altering and Poisonous Plants of the World","author":"Wink","year":"2008"},{"key":"10.1016\/j.phymed.2009.07.016_bib32","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ffj.2730080303","article-title":"Volatile constituents of Artemisia annua L. (Asteraceae)","volume":"8","author":"Woerdenbag","year":"1993","journal-title":"Flavour Fragrance J."},{"key":"10.1016\/j.phymed.2009.07.016_bib33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jep.2007.02.001","article-title":"Ethnoveterinary medicinal plants at Bale Mountains National Park, Ethiopia","volume":"112","author":"Yineger","year":"2007","journal-title":"J. Ethnopharmacol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711309001986?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711309001986?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T01:30:23Z","timestamp":1558488623000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711309001986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0944711309001986"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2009.07.016","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}