{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:38:41Z","timestamp":1792082321907,"version":"4.4.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"8-9","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.phymed.2009.10.008","type":"journal-article","created":{"date-parts":[[2009,12,5]],"date-time":"2009-12-05T09:22:00Z","timestamp":1260004920000},"page":"646-652","source":"Crossref","is-referenced-by-count":90,"title":["Pharmacological effects of Catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission"],"prefix":"10.1016","volume":"17","author":[{"given":"David M.","family":"Pereira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Ferreres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge M.A.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds","family":"Gaspar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Faria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Valent\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Sottomayor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula B.","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2009.10.008_bib1","doi-asserted-by":"crossref","first-page":"4092","DOI":"10.1016\/j.bmc.2005.03.045","article-title":"Indole alkaloids from Tabernaemontana australis (M\u00fcell. Arg) Miers that inhibit acetylcholinesterase enzyme","volume":"13","author":"Andrade","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.phymed.2009.10.008_bib2","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/1097-0134(20010201)42:2<182::AID-PROT50>3.0.CO;2-1","article-title":"Three-dimensional structure of a complex of galanthamine (Nivalin\u00ae) with acetylcholinesterase from Torpedo californica: implications for the design of new anti-Alzheimer drugs","volume":"42","author":"Bartolucci","year":"2001","journal-title":"Proteins"},{"key":"10.1016\/j.phymed.2009.10.008_bib3","series-title":"The Alkaloids","first-page":"1","article-title":"Isolation, structure elucidation, and biosynthesis of the bisindole alkaloids of Catharanthus","author":"Blasko","year":"1990"},{"key":"10.1016\/j.phymed.2009.10.008_bib5","series-title":"Chopra's indigenous drugs of India","author":"Chopra","year":"1958"},{"key":"10.1016\/j.phymed.2009.10.008_bib6","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/0031-9422(95)00627-J","article-title":"Structural studies of vinblastine alkaloids by exciton coupled circular dichroism","volume":"40","author":"Dong","year":"1995","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phymed.2009.10.008_bib7","doi-asserted-by":"crossref","unstructured":"Ferreres, F., Pereira, D.M., Valent\u00e3o, P., Oliveira, J.M.A., Faria, J., Gaspar, L., Sottomayor, M., Andrade, P.B., 2009. Simple and reproducible HPLC-DAD-ESI-MS\/MS analysis of alkaloids in Catharanthus roseus roots. J. Pharm. Biomed. Anal. 51, 65\u201369","DOI":"10.1016\/j.jpba.2009.08.005"},{"key":"10.1016\/j.phymed.2009.10.008_bib8","doi-asserted-by":"crossref","first-page":"15405","DOI":"10.1021\/ja0466154","article-title":"The complex of a bivalent derivative of galanthamine with Torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design","volume":"126","author":"Greenblatt","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.phymed.2009.10.008_bib9","doi-asserted-by":"crossref","first-page":"825","DOI":"10.2174\/138527206776894410","article-title":"Natural product inhibitors of acetylcholinesterase","volume":"10","author":"Hostettmann","year":"2006","journal-title":"Curr. Org. Chem."},{"key":"10.1016\/j.phymed.2009.10.008_bib10","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0197-0186(97)00123-X","article-title":"Anticholinesterases: dramatic aspects of their use and misuse","volume":"32","author":"Karczmar","year":"1998","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.phymed.2009.10.008_bib11","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/BF02976997","article-title":"Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase","volume":"25","author":"Kim","year":"2002","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.phymed.2009.10.008_bib12","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/BF02975117","article-title":"Acetylcholinesterase inhibitors from the aerial parts of Corydalis speciosa. Arch","volume":"27","author":"Kim","year":"2004","journal-title":"Pharm. Res."},{"key":"10.1016\/j.phymed.2009.10.008_bib13","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.2174\/092986708784310422","article-title":"Natural products and their derivatives as cholinesterase inhibitors in the treatment of neurodegenerative disorders: an update","volume":"15","author":"Loizzo","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.phymed.2009.10.008_bib14","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1016\/S0024-3205(02)02034-9","article-title":"Acetylcholinesterase inhibitory activity of some Amaryllidaceae alkaloids and Narcissus extracts","volume":"71","author":"Lopez","year":"2002","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2009.10.008_bib15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jep.2003.11.016","article-title":"Acetylcholinesterase and butyrylcholinesterase inhibitory activity of some Turkish medicinal plants","volume":"91","author":"Orhan","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2009.10.008_bib16","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2174\/157488909787002582","article-title":"Contemporary anticholinesterase pharmaceuticals of natural origin and their synthetic analogues for the treatment of Alzheimer's disease","volume":"4","author":"Orhan","year":"2009","journal-title":"Recent Pat. CNS Drug Discov."},{"key":"10.1016\/j.phymed.2009.10.008_bib17","series-title":"An Introduction to Medicinal Chemistry","author":"Patrick","year":"2005"},{"key":"10.1016\/j.phymed.2009.10.008_bib18","series-title":"Les nouveaux r\u00e8medes naturels","author":"Pelt","year":"2001"},{"key":"10.1016\/j.phymed.2009.10.008_bib19","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.fct.2009.03.012","article-title":"Targeted metabolite analysis of Catharanthus roseus and its biological potential","volume":"47","author":"Pereira","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2009.10.008_bib20","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1351\/pac200173030555","article-title":"Bioactive natural products as a potential source of new pharmacophores. A theory of memory","volume":"73","author":"Rahman","year":"2001","journal-title":"Pure Appl. Chem."},{"key":"10.1016\/j.phymed.2009.10.008_bib21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0021-9673(01)00624-0","article-title":"Screening for acetylcholinesterase inhibitors from Amaryllidaceae using silica gel thin-layer chromatography in combination with bioactivity staining","volume":"915","author":"Rhee","year":"2001","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.phymed.2009.10.008_bib22","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1016\/S0031-9422(00)98055-5","article-title":"The acetylcholinesterase-inhibitory activity of steroidal glycoalkaloids and their aglycones","volume":"28","author":"Roddick","year":"1989","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phymed.2009.10.008_bib23","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0028-3908(98)00164-6","article-title":"A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066","volume":"38","author":"Snape","year":"1999","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phymed.2009.10.008_bib24","series-title":"Studies in Natural Products Chemistry (Bioactive Natural Products)","article-title":"The Vinca alkaloids: from biosynthesis and accumulation in plant cells, to uptake, activity and metabolism in animal cells","author":"Sottomayor","year":"2005"},{"key":"10.1016\/j.phymed.2009.10.008_bib25","doi-asserted-by":"crossref","first-page":"607","DOI":"10.2174\/0929867043455846","article-title":"The Catharanthus alkaloids: pharmacognosy and biotechnology","volume":"11","author":"Van der Heijden","year":"2004","journal-title":"Curr. Med. Chem."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711309002633?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711309002633?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T08:18:32Z","timestamp":1558685912000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711309002633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":24,"journal-issue":{"issue":"8-9","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0944711309002633"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2009.10.008","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}