{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:20:19Z","timestamp":1788582019169,"version":"build-2803163510"},"reference-count":37,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.phymed.2010.01.014","type":"journal-article","created":{"date-parts":[[2010,2,21]],"date-time":"2010-02-21T09:39:46Z","timestamp":1266745186000},"page":"404-409","source":"Crossref","is-referenced-by-count":105,"title":["Potentiating effect of spinosin, a C-glycoside flavonoid of Semen Ziziphi spinosae, on pentobarbital-induced sleep may be related to postsynaptic 5-HT1A receptors"],"prefix":"10.1016","volume":"17","author":[{"given":"L.-E.","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.-Y.","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.-Y.","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-X.","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-H.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.-Y.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-J.","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-Y.","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2010.01.014_bib1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0091-3057(96)00339-5","article-title":"The 5-HT1A receptor antagonist p-MPPI blocks responses mediated by postsynaptic and presynaptic 5-HT1A receptors","volume":"57","author":"Allen","year":"1997","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phymed.2010.01.014_bib2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0006-8993(95)00689-N","article-title":"Sleep effects following intrathecal administration the 5-HT1A agonist 8-OH-DPAT and the NMDA antagonist AP-5 in rats","volume":"692","author":"Bj\u00f8rkum","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.phymed.2010.01.014_bib3","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0361-9230(96)00029-9","article-title":"Sleep\/waking effects following intrathecal administration of the 5-HT1A agonist 8-OH-DPAT alone and in combination with the 5-HT1A antagonist NAN-190 in rats","volume":"39","author":"Bj\u00f8rkum","year":"1996","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.phymed.2010.01.014_bib4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0014-2999(98)00530-5","article-title":"The 5-HT1A receptor antagonist p-MPPI blocks 5-HT1A autoreceptors and increases dorsal raphe unit activity in awake cats","volume":"356","author":"Bjorvatn","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2010.01.014_bib5","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1515\/REVNEURO.1998.9.4.265","article-title":"Changes in sleep and wakefulness following 5-HT1A ligands given systemically and locally in different brain regions","volume":"9","author":"Bjorvatn","year":"1998","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.phymed.2010.01.014_bib6","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0006-8993(97)00758-0","article-title":"Sleep\/waking effects of a selective 5-HT1A receptor agonist given systemically as well as perfused in the dorsal raphe nucleus in rats","volume":"770","author":"Bjorvatn","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.phymed.2010.01.014_bib8","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/0028-3908(92)90140-K","article-title":"5-HT1-like receptor agonists enhance wakefulness","volume":"31","author":"Dzoljic","year":"1992","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phymed.2010.01.014_bib9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ejphar.2005.02.039","article-title":"Synergistic interaction between hesperidin, a natural flavonoid, and diazepam","volume":"512","author":"Fern\u00e1ndez","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2010.01.014_bib10","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S0022-3565(25)22545-9","article-title":"Single-unit responses of serotonergic dorsal raphe neurons to 5-HT1A agonist and antagonist drug administration in behaving cats","volume":"270","author":"Fornal","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.phymed.2010.01.014_bib11","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.phymed.2008.12.020","article-title":"Kaempferol from the leaves of Apocynum venetum possesses anxiolytic activities in the elevated plus maze test in mice","volume":"16","author":"Grundmann","year":"2009","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2010.01.014_bib13","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF01276574","article-title":"8-Hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT, a potent and selective simplifies ergot congener with central 5-HT receptor stimulating activity","volume":"55","author":"Hjorth","year":"1982","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.phymed.2010.01.014_bib14","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/BF00179315","article-title":"The 5-HT1A agonist, 8-OH-DPAT, preferentially activates cell 5-HT autoreceptors in rat brain in vivo","volume":"338","author":"Hjorth","year":"1988","journal-title":"N-S Arch. Pharmacol."},{"key":"10.1016\/j.phymed.2010.01.014_bib15","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/(SICI)1097-4547(19961215)46:6<697::AID-JNR7>3.0.CO;2-A","article-title":"Ultrastructural localization of 5-hydroxytryptamine1A receptors in the rat brain","volume":"46","author":"Kia","year":"1996","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.phymed.2010.01.014_bib16","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1073\/pnas.0306975101","article-title":"Modulation of rhythmic brain activity by diazepam: GABAA receptor subtype and state specificity","volume":"101","author":"Kopp","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.phymed.2010.01.014_bib17","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ejphar.2007.11.011","article-title":"Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines","volume":"580","author":"Loscalzo","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2010.01.014_bib18","doi-asserted-by":"crossref","first-page":"853","DOI":"10.2174\/1568026023393462","article-title":"GABAA-receptor ligands of flavonoid structure","volume":"2","author":"Marder","year":"2002","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.phymed.2010.01.014_bib19","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0091-3057(03)00121-7","article-title":"6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS","volume":"75","author":"Marder","year":"2003","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phymed.2010.01.014_bib20","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1023\/A:1027303609517","article-title":"Overview \u2013 flavonoids: a new family of benzodiazepine receptor ligands","volume":"22","author":"Medina","year":"1997","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.phymed.2010.01.014_bib21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1365-2869.1992.tb00033.x","article-title":"Dose-dependent effects of the 5-HT1A receptor agonist 8-OH-DPAT on sleep and wakefulness in the rat","volume":"1","author":"Monti","year":"1992","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.phymed.2010.01.014_bib22","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0028-3908(94)90176-7","article-title":"Stereoselective antagonism by the pindolol enantiomers of 8-OH-DPAT-induced changes of sleep and wakefulness","volume":"33","author":"Monti","year":"1994","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phymed.2010.01.014_bib23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0924-977X(01)00133-X","article-title":"Increased REM sleep after intra-dorsal raphe nucleus injection of flesinoxan or 8-OH-DPAT: prevention with WAY 100635","volume":"12","author":"Monti","year":"2002","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.phymed.2010.01.014_bib24","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1523\/JNEUROSCI.16-08-02820.1996","article-title":"Microdialysis perfusion of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the dorsal raphe nucleus decreases serotonin release and increases rapid eye movement sleep in the freely moving cat","volume":"16","author":"Portas","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phymed.2010.01.014_bib25","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.pbb.2009.06.018","article-title":"D1\/D2 receptor-targeting l-stepholidine, an active ingredient of the Chinese herb Stephonia, induces non-rapid eye movement sleep in mice","volume":"94","author":"Qiu","year":"2009","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phymed.2010.01.014_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-0186(91)90029-D","article-title":"Autoradiography of serotonin receptor subtypes in the central nervous system","volume":"18","author":"Radja","year":"1991","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.phymed.2010.01.014_bib27","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/(SICI)1096-9861(20000207)417:2<181::AID-CNE4>3.0.CO;2-A","article-title":"Somatodendritic localization of 5-HT1A and preterminal axonal localization of 5-HT1B serotonin receptors in adult rat brain","volume":"417","author":"Riad","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.phymed.2010.01.014_bib28","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00213-003-1727-0","article-title":"Effects of three hypnotics on the sleep\u2013wakefulness cycle in sleep-disturbed rats","volume":"173","author":"Shinomiya","year":"2004","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.phymed.2010.01.014_bib29","first-page":"695","article-title":"p-MPPI antagonizes sleep as well as behavioral effects of 8-OH-DPAT in the freely moving rat","volume":"24","author":"S\u00f8rensen","year":"1998","journal-title":"Soc. Neurosci. Abstr."},{"key":"10.1016\/j.phymed.2010.01.014_bib30","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0166-4328(00)00219-9","article-title":"Sleep\u2013wake effects following the selective 5-HT1A receptor antagonist p-MPPI in the freely moving rat","volume":"114","author":"S\u00f8rensen","year":"2000","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.phymed.2010.01.014_bib31","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0006-8993(01)02101-1","article-title":"Sleep and waking following microdialysis perfusion of the selective 5-HT1A receptor antagonist p-MPPI into the dorsal raphe nucleus in the freely moving rat","volume":"897","author":"S\u00f8rensen","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.phymed.2010.01.014_bib32","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0166-4328(01)00163-2","article-title":"The selective 5-HT1A receptor antagonist p-MPPI antagonizes sleep\u2013waking and behavioural effects of 8-OH-DPAT in rats","volume":"121","author":"S\u00f8rensen","year":"2001","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.phymed.2010.01.014_bib33","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1111\/j.1460-9568.1990.tb00026.x","article-title":"Direct immunohistochemical evidence of the existence of 5-HT1A autoreceptors on serotonergic neurons in the midbrain raphe nuclei","volume":"2","author":"Sotelo","year":"1990","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.phymed.2010.01.014_bib34","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0014-2999(86)90782-X","article-title":"(-)-Propanolol blocks the inhibition of serotonergic dorsal raphe cell firing by 5-HT1A selective agonists","volume":"128","author":"Sprouse","year":"1986","journal-title":"Eur. J. Pharmacol"},{"key":"10.1016\/j.phymed.2010.01.014_bib35","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0024-3205(96)00026-4","article-title":"Flunitrazepam effects on human sleep EEG spectra: differences in MREM, REM and individual responses","volume":"58","author":"Uchida","year":"1996","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2010.01.014_bib36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1053\/smrv.2001.0174","article-title":"Serotonin and sleep","volume":"6","author":"Ursin","year":"2002","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.phymed.2010.01.014_bib37","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.pbb.2008.03.022","article-title":"Spinosin, a C-glycoside flavonoid from semen Ziziphi spinosae, potentiated pentobarbital induced sleep via the serotonergic system","volume":"90","author":"Wang","year":"2008","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phymed.2010.01.014_bib38","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0924-977X(97)00102-8","article-title":"The effects of benzodiazepine (triazolam), cyclopyrrolone (zopiclone) and imidazopyridine (zolpidem) hypnotics on the frequency of hippocampal theta activity and sleep structure in rats","volume":"9","author":"Yoshimoto","year":"1999","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.phymed.2010.01.014_bib39","first-page":"34","article-title":"Sedative and hypnotic constituents of flavonoids in the seeds of Ziziphus spinosae","volume":"12","author":"Yuan","year":"1987","journal-title":"Zhong Yao Tong Bao (China J. Chin. Mater. Med.)"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711310000309?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711310000309?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T18:46:26Z","timestamp":1739904386000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711310000309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0944711310000309"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2010.01.014","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}