{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T13:55:45Z","timestamp":1784210145247,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.phymed.2010.04.007","type":"journal-article","created":{"date-parts":[[2010,6,24]],"date-time":"2010-06-24T09:10:12Z","timestamp":1277370612000},"page":"1076-1081","source":"Crossref","is-referenced-by-count":36,"title":["Effect of combined administration of ginger (Zingiber officinale Roscoe) and atorvastatin on the liver of rats"],"prefix":"10.1016","volume":"17","author":[{"given":"Gehan H.","family":"Heeba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal I.","family":"Abd-Elghany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2010.04.007_bib1","first-page":"604","article-title":"Influence of dietary ginger (Zingiber officinales Rosc) on the antioxidant defense system in rat: comparison with ascorbic acid","volume":"38","author":"Ahmed","year":"2000","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.phymed.2010.04.007_bib2","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/ptr.2412","article-title":"Protective effects of dietary ginger (Zingiber officinales Rosc.) on lindane-induced oxidative stress in rats","volume":"22","author":"Ahmed","year":"2008","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2010.04.007_bib3","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1016\/j.fct.2007.06.001","article-title":"Zingiber officinale Roscoe prevents acetaminophen-induced acute hepatotoxicity by enhancing hepatic antioxidant status","volume":"45","author":"Ajith","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2010.04.007_bib4","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jep.2004.11.011","article-title":"Effect of ethanolic extract of Zingiber officinale on dyslipidaemia in diabetic rats","volume":"97","author":"Bhandari","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2010.04.007_bib5","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s11883-002-0060-0","article-title":"A general assessment of the safety of HMG CoA reductase inhibitors (statins)","volume":"4","author":"Black","year":"2002","journal-title":"Curr. Atheroscler. Rep."},{"key":"10.1016\/j.phymed.2010.04.007_bib6","first-page":"501","article-title":"Inhibitory effects of phenolic on xanthine oxidase","volume":"14","author":"Chang","year":"1994","journal-title":"Anticancer Res."},{"key":"10.1016\/j.phymed.2010.04.007_bib7","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.dld.2006.04.013","article-title":"Brief clinical observation: atorvastatin associated liver disease","volume":"38","author":"Clarke","year":"2006","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.phymed.2010.04.007_bib8","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.fct.2009.04.005","article-title":"Protective effect of ginger extract against bromobenzene-induced hepatotoxicity in male rats","volume":"47","author":"El-Sharaky","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2010.04.007_bib9","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1093\/jn\/130.5.1124","article-title":"Ginger extract consumption reduces plasma cholesterol, inhibits LDL oxidation and attenuates development of atherosclerosis in atherosclerotic, apolipoprotein E-deficient mice","volume":"130","author":"Fuhrman","year":"2000","journal-title":"J. Nutr."},{"key":"10.1016\/j.phymed.2010.04.007_bib10","first-page":"433","article-title":"Effect of ginger on serum cholesterol levels","volume":"21","author":"Giri","year":"1984","journal-title":"Indian J. Nutr. Dietet."},{"key":"10.1016\/j.phymed.2010.04.007_bib11","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1590\/S1807-59322008000600017","article-title":"Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats","volume":"63","author":"Habib","year":"2008","journal-title":"Clinics"},{"key":"10.1016\/j.phymed.2010.04.007_bib12","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1111\/j.1753-4887.1997.tb06100.x","article-title":"Antioxidants and human disease: a general introduction","volume":"55","author":"Halliwell","year":"1997","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.phymed.2010.04.007_bib13","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1600-0773.1990.tb00840.x","article-title":"Biochemical changes and morphological alterations of the liver in guinea-pigs after administration of simvastatin","volume":"67","author":"Horsman","year":"1990","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.phymed.2010.04.007_bib14","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1016\/j.lfs.2003.06.022","article-title":"[6]-Gingerol inhibits nitric oxide synthesis in activated J774.1 mouse macrophages and prevents peroxynitrite-induced oxidation and nitration reactions","volume":"73","author":"Ippoushi","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2010.04.007_bib15","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.fct.2009.11.044","article-title":"Malathion-induced hepatotoxicity in rats: the effects of vitamins C and E","volume":"48","author":"Kalender","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2010.04.007_bib16","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2010.04.007_bib17","doi-asserted-by":"crossref","first-page":"16J","DOI":"10.1016\/0002-9149(88)90003-3","article-title":"Preclinical evaluation of lovastatin","volume":"62","author":"MacDonald","year":"1988","journal-title":"Am. J. Card."},{"key":"10.1016\/j.phymed.2010.04.007_bib18","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.fitote.2007.11.007","article-title":"Ethanol toxicity: rehabilitation of hepatic antioxidant defense system with dietary ginger","volume":"79","author":"Mallikarjuna","year":"2008","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phymed.2010.04.007_bib19","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/biof.552210157","article-title":"Antioxidant properties of gingerol related compounds from ginger","volume":"21","author":"Masuda","year":"2004","journal-title":"Biofactors"},{"key":"10.1016\/j.phymed.2010.04.007_bib20","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0003-2697(78)90342-1","article-title":"Determination of malonaldehyde precursor in tissue by thiobarbituric acid test","volume":"86","author":"Mihara","year":"1978","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.phymed.2010.04.007_bib21","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/S0140-6736(99)00569-3","article-title":"Atorvastatin-induced acute hepatitis with absence of cross-toxicity with simvastatin","volume":"353","author":"Nakad","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2010.04.007_bib22","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S1089-3261(03)00024-2","article-title":"Hepatotoxicity of hypolipidemic drugs","volume":"7","author":"Parra","year":"2003","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.phymed.2010.04.007_bib23","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jhep.2003.12.022","article-title":"Atorvastatin as a trigger of autoimmune hepatitis","volume":"40","author":"Pelli","year":"2004","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2010.04.007_bib24","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/S0168-8278(03)00464-1","article-title":"Fatal liver failure with atorvastatin","volume":"39","author":"Perger","year":"2003","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2010.04.007_bib25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0168-8278(02)00092-2","article-title":"Acute cholestatic hepatitis after reinitiating treatment with atorvastatin","volume":"37","author":"Ridruejo","year":"2002","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2010.04.007_bib26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/abio.2002.5676","article-title":"Spectrophotometric determination of serum nitrite and nitrate by copper\u2013cadmium alloy","volume":"306","author":"Sastry","year":"2002","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.phymed.2010.04.007_bib27","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/(SICI)1099-1573(199609)10:6<517::AID-PTR839>3.0.CO;2-L","article-title":"Hypolipidemic and antiatherosclerotic effect of Zingiber officinale in cholesterol fed rabbits","volume":"10","author":"Sharma","year":"1996","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2010.04.007_bib28","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.fct.2006.11.002","article-title":"Cancer preventive properties of ginger: a brief review","volume":"45","author":"Shukla","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2010.04.007_bib29","first-page":"364","article-title":"The effect of spices on cholesterol 7 alpha-hydroxylase activity and on serum and hepatic cholesterol levels in the rat","volume":"61","author":"Srinivasan","year":"1991","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"10.1016\/j.phymed.2010.04.007_bib30","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.foodchem.2006.06.023","article-title":"Antioxidant activity of ginger extract (Zingiber officinale)","volume":"102","author":"Stoilova","year":"2007","journal-title":"Food Chem."},{"key":"10.1016\/j.phymed.2010.04.007_bib31","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.freeradbiomed.2007.03.024","article-title":"Vitamin E, antioxidant and nothing more","volume":"43","author":"Traber","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2010.04.007_bib32","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1054\/plef.2002.0441","article-title":"The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent","volume":"67","author":"Thomson","year":"2002","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.phymed.2010.04.007_bib33","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1007\/PL00012505","article-title":"Statins: the new aspirin?","volume":"59","author":"Veillard","year":"2002","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.phymed.2010.04.007_bib34","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.phymed.2008.12.018","article-title":"Synergy research: approaching a new generation of phytopharmaceuticals","volume":"16","author":"Wagner","year":"2009","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2010.04.007_bib35","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.cardiores.2004.11.030","article-title":"Statins: is there no end to their usefulness?","volume":"65","author":"Wainwright","year":"2005","journal-title":"Cardiovas. Res."},{"key":"10.1016\/j.phymed.2010.04.007_bib36","doi-asserted-by":"crossref","first-page":"69F","DOI":"10.1016\/j.amjcard.2005.06.028","article-title":"Safety of high-dose atorvastatin therapy","volume":"96","author":"Waters","year":"2005","journal-title":"Am. J. Card."},{"key":"10.1016\/j.phymed.2010.04.007_bib37","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/ptr.1957","article-title":"Protective Effects of Zingiber officinale (Zingiberaceae) against carbon tetrachloride and acetaminophen-induced hepatotoxicity in rats","volume":"20","author":"Yemitan","year":"2006","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2010.04.007_bib38","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jep.2004.09.009","article-title":"Analgesic and anti-inflammatory activities of [6]-gingerol","volume":"96","author":"Young","year":"2005","journal-title":"J. Ethnopharmacol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711310001406?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711310001406?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T02:27:58Z","timestamp":1635560878000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711310001406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":38,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0944711310001406"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2010.04.007","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}