{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T02:31:45Z","timestamp":1785810705975,"version":"3.56.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.phymed.2010.04.013","type":"journal-article","created":{"date-parts":[[2010,6,29]],"date-time":"2010-06-29T08:24:07Z","timestamp":1277799847000},"page":"1133-1139","source":"Crossref","is-referenced-by-count":53,"title":["Anticancer activity of the Uncaria tomentosa (Willd.) DC. preparations with different oxindole alkaloid composition"],"prefix":"10.1016","volume":"17","author":[{"given":"Rados\u0142aw","family":"Pilarski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Filip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Wietrzyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mieczys\u0142aw","family":"Kura\u015b","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Gulewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2010.04.013_bib1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0378-8741(02)00093-4","article-title":"Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae)","volume":"81","author":"Aguilar","year":"2002","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2010.04.013_bib2","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1016\/j.intimp.2003.07.001","article-title":"An extract of Uncaria tomentosa inhibiting cell division and NF-[kappa]B activity without inducing cell death","volume":"3","author":"\u00c5kesson","year":"2003","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.phymed.2010.04.013_bib3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.intimp.2004.09.028","article-title":"Quinic acid is a biologically active component of the Uncaria tomentosa extract C-Med 100\u00ae","volume":"5","author":"\u00c5kesson","year":"2005","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.phymed.2010.04.013_bib4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1078\/094471103321648629","article-title":"C-Med 100, a hot water extract of Uncaria tomentosa, prolongs lymphocyte survival in vivo","volume":"10","author":"\u00c5kesson","year":"2003","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2010.04.013_bib5","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jep.2006.07.039","article-title":"Treatment of THP-1 cells with Uncaria tomentosa extracts differentially regulates the expression if IL-1[beta] and TNF-[alpha]","volume":"109","author":"Allen-Hall","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2010.04.013_bib6","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1021\/np50074a016","article-title":"Plant metabolites. New compounds and anti-inflammatory activity of Uncaria tomentosa","volume":"54","author":"Aquino","year":"1991","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phymed.2010.04.013_bib7","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1021\/np50064a002","article-title":"Plant metabolites. Structure and in vitro antiviral activity of quinovic acid glycosides from Uncaria tomentosa and Guettarda platypoda","volume":"52","author":"Aquino","year":"1989","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phymed.2010.04.013_bib8","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1365-2141.2005.05907.x","article-title":"Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0\/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells","volume":"132","author":"Bacher","year":"2006","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.phymed.2010.04.013_bib9","first-page":"65","article-title":"Modulating effects of Uncaria tomentosa in experimentally-induced local pneumonia in calves","volume":"46","author":"Bednarek","year":"2002","journal-title":"Bull. Vet. Inst. Pu\u0142."},{"key":"10.1016\/j.phymed.2010.04.013_bib10","first-page":"289","article-title":"Analysis of phenotype and functions of peripheral blood leukocytes in cellular immunity of calves treated with Uncaria tomentosa","volume":"48","author":"Bednarek","year":"2004","journal-title":"Bull. Vet. Inst. Pu\u0142."},{"key":"10.1016\/j.phymed.2010.04.013_bib11","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jep.2004.06.039","article-title":"An Uncaria tomentosa (cat's claw) extract protects mice against ozone-induced lung inflammation","volume":"96","author":"Cisneros","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2010.04.013_bib12","unstructured":"De Jong, W., Melnyk, M., Lozano, L.A., Rosales, M., Garcia, M., 1999. Una de gato: fate and future of a Peruvian forest resource. CIFOR Occasional Paper, Indonesia, Center for International Forestry Research, pp. 1\u201314."},{"key":"10.1016\/j.phymed.2010.04.013_bib13","first-page":"527","article-title":"Alkaloids and procyanidins of an Uncaria sp. from Peru","volume":"31","author":"De Matta","year":"1976","journal-title":"Farmaco [Sci]"},{"key":"10.1016\/j.phymed.2010.04.013_bib14","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.intimp.2005.03.001","article-title":"Uncaria tomentosa extract increases the number of myeloid progenitor cells in the bone marrow of mice infected with Listeria monocytogenes","volume":"5","author":"Eberlin","year":"2005","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.phymed.2010.04.013_bib15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.indcrop.2003.07.008","article-title":"Developmental and ultrastructural effect of Uncaria tomentosa (Willd.) DC extract on the paprika Capsicum annuum L.","volume":"19","author":"Gulewicz","year":"2004","journal-title":"Ind. Crop Prod."},{"key":"10.1016\/j.phymed.2010.04.013_bib16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.phytochem.2004.10.022","article-title":"Ethnobotany, phytochemistry and pharmacology of Uncaria (Rubiaceae)","volume":"66","author":"Heitzman","year":"2005","journal-title":"Phytochemistry"},{"issue":"Suppl","key":"10.1016\/j.phymed.2010.04.013_bib17","doi-asserted-by":"crossref","first-page":"113P","DOI":"10.1111\/j.2042-7158.1974.tb10144.x","article-title":"Proceedings: alkaloids from S. American species of Uncaria (Rubiaceaes)","volume":"26","author":"Hemingway","year":"1974","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.phymed.2010.04.013_bib18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0378-8741(98)00096-8","article-title":"Uncaria tomentosa (Willd.) DC. \u2013 Ethnomedicinal use and new pharmacological, toxicological and botanical results","volume":"64","author":"Keplinger","year":"1999","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2010.04.013_bib19","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1248\/cpb.52.1258","article-title":"New oleanan-type triterpene and cincholic acid glycosides from Peruvian \u201cUna de Gato\u201d (Uncaria tomentosa)","volume":"52","author":"Kitajima","year":"2004","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"10.1016\/j.phymed.2010.04.013_bib20","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jep.2006.03.018","article-title":"Changes in chromosome structure, mitotic activity and nuclear DNA content from cells of Allium Test induced by bark water extract of Uncaria tomentosa (Willd.) DC.","volume":"107","author":"Kura\u015b","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2010.04.013_bib21","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1039\/a705871c","article-title":"Kinetics of isomerization of tetracyclic spiro oxindole alkaloids","volume":"2","author":"Laus","year":"1998","journal-title":"J. Chem. Soc., Perkin Trans."},{"key":"10.1016\/j.phymed.2010.04.013_bib22","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1039\/P29960001931","article-title":"Analysis of the kinetics of isomerization of spiro oxindole alkaloids","volume":"2","author":"Laus","year":"1996","journal-title":"J. Chem. Soc., Perkin Trans."},{"issue":"2","key":"10.1016\/j.phymed.2010.04.013_bib23","first-page":"122","article-title":"Radix Uncariae tomentosae (Willd.) DC. \u2013 a monographic description","volume":"18","author":"Laus","year":"1997","journal-title":"Zeit. Phyt."},{"key":"10.1016\/j.phymed.2010.04.013_bib24","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1055\/s-2006-960860","article-title":"Bioactive indole alkaloids from the bark of Uncaria guianensis","volume":"65","author":"Lee","year":"1999","journal-title":"Planta Med."},{"key":"10.1016\/j.phymed.2010.04.013_bib25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0378-8741(98)00113-5","article-title":"Stimulation of interleukin-1 and -6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa (Una de Gato)","volume":"64","author":"Lemaire","year":"1999","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2010.04.013_bib26","series-title":"Vilcacora w \u015bwietle bada\u0144 naukowych","author":"\u0141ukasiak","year":"2001"},{"key":"10.1016\/j.phymed.2010.04.013_bib27","doi-asserted-by":"crossref","first-page":"114a","DOI":"10.1203\/00006450-199904020-00676","article-title":"The anti-inflammatory actions of the herbal medicine, cat's claw, are due to a suppression of NF-kappa B activation and inhibition of gene expression","volume":"45","author":"Miller","year":"1999","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.phymed.2010.04.013_bib28","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0031-9422(01)00043-7","article-title":"Investigation of Una De Gato I. 7-Deoxyloganic acid and 15N NMR spectroscopic studies on pentacyclic oxindole alkaloids from Uncaria tomentosa","volume":"57","author":"Muhammad","year":"2001","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phymed.2010.04.013_bib29","first-page":"S35","article-title":"An extract of Uncaria tomentosa protects against oxidative stress-induced cell damage","volume":"31","author":"Okuhama","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2010.04.013_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3409\/fb57_3-4.207-212","article-title":"Evaluation of biological activity of Uncaria tomentosa (Willd.) DC. using the chicken embryo model","volume":"57","author":"Pilarski","year":"2009","journal-title":"Folia Biol. (Krak\u00f3w)"},{"key":"10.1016\/j.phymed.2010.04.013_bib31","first-page":"565","article-title":"Antiproliferative activity of various Uncaria tomentosa preparations on HL-60 promelocytic leukemia cells","volume":"59","author":"Pilarski","year":"2007","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.phymed.2010.04.013_bib32","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jep.2005.08.046","article-title":"Antioxidant activity of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.) DC.","volume":"104","author":"Pilarski","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2010.04.013_bib33","first-page":"2457","article-title":"The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line","volume":"21","author":"Riva","year":"2001","journal-title":"Anticancer Res."},{"key":"10.1016\/j.phymed.2010.04.013_bib34","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1046\/j.1365-2036.1998.00424.x","article-title":"Antiinflammatory actions of cat's claw: the role of NF-kappa B","volume":"12","author":"Sandoval-Chacon","year":"1998","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2010.04.013_bib35","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0891-5849(00)00327-0","article-title":"Cat's claw inhibits TNF[alpha] production and scavenges free radicals: role in cytoprotection","volume":"29","author":"Sandoval","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2010.04.013_bib36","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1078\/0944-7113-00117","article-title":"Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content","volume":"9","author":"Sandoval","year":"2002","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2010.04.013_bib37","first-page":"3363","article-title":"Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa","volume":"18","author":"Sheng","year":"1998","journal-title":"Anticancer Res."},{"key":"10.1016\/j.phymed.2010.04.013_bib38","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0944-7113(00)80086-0","article-title":"Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa","volume":"7","author":"Sheng","year":"2000","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2010.04.013_bib39","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/jnci\/82.13.1107","article-title":"New colorimetric cytotoxicity assay for anticancer-drug screening","volume":"82","author":"Skehan","year":"1990","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.phymed.2010.04.013_bib40","first-page":"35","article-title":"Cat's claw: an herb from the Peruvian Amazon","author":"Steinberg","year":"1995","journal-title":"Sidahora"},{"key":"10.1016\/j.phymed.2010.04.013_bib41","first-page":"59","article-title":"A differential sensitivity of oxindole alkaloids to normal and leukemic cell lines","author":"Stuppner","year":"1993","journal-title":"Planta Med."},{"key":"10.1016\/j.phymed.2010.04.013_bib42","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1055\/s-2007-969537","article-title":"The alkaloids of Uncaria tomentosa and their phagocytosis-stimulating action","author":"Wagner","year":"1985","journal-title":"Planta Med."},{"key":"10.1016\/j.phymed.2010.04.013_bib43","series-title":"Immunologisch aktive pentazyklishe Oxindolalkaloide aus Uncaria tomentosa","author":"Wurm","year":"1997"},{"key":"10.1016\/j.phymed.2010.04.013_bib44","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1055\/s-2006-957561","article-title":"Pentacyclic oxindole alkaloids from Uncaria tomentosa induce human endothelial cells to release a lymphocyte-proliferation-regulating factor","volume":"64","author":"Wurm","year":"1998","journal-title":"Planta Med."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711310001467?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711310001467?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T04:22:45Z","timestamp":1544415765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711310001467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":44,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0944711310001467"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2010.04.013","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}