{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:58:33Z","timestamp":1777618713172,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.phymed.2011.03.007","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T05:46:05Z","timestamp":1305179165000},"page":"1126-1129","source":"Crossref","is-referenced-by-count":19,"title":["Effect of honokiol on activity of GAD65 and GAD67 in the cortex and hippocampus of mice"],"prefix":"10.1016","volume":"18","author":[{"given":"Tien-Hsiung","family":"Ku","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yih-Jing","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Jane","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Hua","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu-Tai","family":"Tien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2011.03.007_bib0005","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1006\/bbrc.1996.1898","article-title":"Mice lacking the 65kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures","volume":"229","author":"Asada","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"Suppl. 2","key":"10.1016\/j.phymed.2011.03.007_bib0015","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0022-3956(90)90040-W","article-title":"The GABAA\/benzodiazepine receptor: implications for the molecular basis of anxiety","author":"Breier","year":"1990","journal-title":"J. Psychiatry Res."},{"key":"10.1016\/j.phymed.2011.03.007_bib0020","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/YCO.0b013e32831a473d","article-title":"Current use of benzodiazepines in anxiety disorders","volume":"22","author":"Cloos","year":"2009","journal-title":"Curr. Opin. Psychiatry"},{"key":"10.1016\/j.phymed.2011.03.007_bib0025","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0165-6147(00)88973-7","article-title":"Use of the elevated plus-maze in the search for novel anxiolytic agents","volume":"16","author":"Dawson","year":"1995","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.phymed.2011.03.007_bib0030","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0896-6273(91)90077-D","article-title":"Two genes encode distinct glutamate decarboxylase","volume":"7","author":"Erlander","year":"1991","journal-title":"Neuron"},{"key":"10.1016\/j.phymed.2011.03.007_bib0035","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/S0306-4522(03)00299-9","article-title":"Changes in the brain kappa-opioid receptor levels of rats in withdrawal from physical dependence upon butorphanol","volume":"121","author":"Fan","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.phymed.2011.03.007_bib0040","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1248\/yakushi1947.93.4_429","article-title":"Studies on the components of Magnolia obovata Thunb. 3. Occurrence of magnolol and honokiol in M. obovata and other allied plants","volume":"93","author":"Fujita","year":"1973","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.phymed.2011.03.007_bib0045","first-page":"135","article-title":"Benzodiazepine tolerance and dependence: GABAA receptor complex locus of change","volume":"59","author":"Gallager","year":"1993","journal-title":"Biochem. Soc. Symp."},{"key":"10.1016\/j.phymed.2011.03.007_bib0050","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/00004311-198802640-00005","article-title":"Benzodiazepines","volume":"26","author":"Haefely","year":"1988","journal-title":"Int. Anesthesiol. Clin."},{"key":"10.1016\/j.phymed.2011.03.007_bib0055","doi-asserted-by":"crossref","first-page":"14060","DOI":"10.1073\/pnas.94.25.14060","article-title":"Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase","volume":"94","author":"Kash","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phymed.2011.03.007_bib0060","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1073\/pnas.96.4.1698","article-title":"Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase","volume":"96","author":"Kash","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phymed.2011.03.007_bib0065","first-page":"219","article-title":"Animal behavioral models for testing antianxiety agents","volume":"18","author":"Kulkarni","year":"1996","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/j.phymed.2011.03.007_bib0145","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/j.2042-7158.1998.tb07146.x","article-title":"Behavioural pharmacological characteristics of honokiol, an anxiolytic agent present in extracts of Magnolia bark, evaluated by an elevated plus-maze test in mice","volume":"50","author":"Kuribara","year":"1998","journal-title":"J Pharm Pharmacol."},{"key":"10.1016\/j.phymed.2011.03.007_bib0075","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1211\/0022357991772008","article-title":"Honokiol, a putative anxiolytic agent extracted from magnolia bark, has no diazepam-like side-effects in mice","volume":"51","author":"Kuribara","year":"1999","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.phymed.2011.03.007_bib0080","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1586\/14737175.8.8.1189","article-title":"Effectiveness of benzodiazepines: do they work or not?","volume":"8","author":"Lader","year":"2008","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.phymed.2011.03.007_bib0085","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/BF00177912","article-title":"The use of a plus-maze to measure anxiety in the mouse","volume":"92","author":"Lister","year":"1987","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.phymed.2011.03.007_bib0090","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1021\/np9702446","article-title":"Identification of magnolol and honokiol in the anxiolytic extracts of Saiboku-to, an oriental herbal medicine","volume":"61","author":"Maruyama","year":"1998","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phymed.2011.03.007_bib0095","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/978-3-540-74806-9_16","article-title":"Midazolam and other benzodiazepines","volume":"182","author":"Olkkola","year":"2008","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.phymed.2011.03.007_bib0100","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1471-4159.2006.03741.x","article-title":"Evidence that GAD65 mediates increased GABA synthesis during intense neuronal activity in vivo","volume":"97","author":"Patel","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phymed.2011.03.007_bib0105","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0165-0270(85)90031-7","article-title":"Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat","volume":"14","author":"Pellow","year":"1985","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.phymed.2011.03.007_bib0110","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0091-3057(95)00138-M","article-title":"Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety","volume":"52","author":"Rodgers","year":"1995","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phymed.2011.03.007_bib0115","first-page":"1","article-title":"Clinical use of the benzodiazepines","volume":"15","author":"Shader","year":"1981","journal-title":"Ration. Drug Ther."},{"key":"10.1016\/j.phymed.2011.03.007_bib0120","first-page":"765","article-title":"Detoxification: the use of benzodiazepines","volume":"30","author":"Shaw","year":"1995","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.phymed.2011.03.007_bib0125","first-page":"24","article-title":"Pharmacology of benzodiazepine receptors: an update","volume":"19","author":"Sieghart","year":"1994","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.phymed.2011.03.007_bib0130","first-page":"111","article-title":"Type A gamma-aminobutyric acid (GABAA) receptor subunits and benzodiazepine binding: significance to clinical syndromes and their treatment","volume":"58","author":"Smith","year":"2001","journal-title":"Br. J. Biomed. Sci."},{"key":"10.1016\/j.phymed.2011.03.007_bib0135","first-page":"107","article-title":"Benzodiazepine dependence: a shadowy diagnosis","volume":"59","author":"Tyrer","year":"1993","journal-title":"Biochem. Soc. Symp."},{"key":"10.1016\/j.phymed.2011.03.007_bib0140","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.coph.2005.08.005","article-title":"GABA-A receptors: a viable target for novel anxiolytics?","volume":"6","author":"Whiting","year":"2006","journal-title":"Curr. Opin. Pharmacol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471131100119X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471131100119X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T17:44:49Z","timestamp":1712425489000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471131100119X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":27,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S094471131100119X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2011.03.007","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}