{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:19:00Z","timestamp":1790093940105,"version":"4.0.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.phymed.2011.09.079","type":"journal-article","created":{"date-parts":[[2011,10,29]],"date-time":"2011-10-29T00:34:59Z","timestamp":1319848499000},"page":"193-205","source":"Crossref","is-referenced-by-count":35,"title":["Effects of ethanolic extract from Radix Scrophulariae on ventricular remodeling in rats"],"prefix":"10.1016","volume":"19","author":[{"given":"Xiao Yan","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Xun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue Mei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi Min","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2011.09.079_bib0005","first-page":"333","article-title":"Experimental ischemic cardiomypathy: insights into remodeling, physiological adaptation, and humoral response","volume":"36","author":"Agnoletti","year":"2006","journal-title":"Ann. Clin. Lab. Sci."},{"key":"10.1016\/j.phymed.2011.09.079_bib0010","first-page":"484","article-title":"Myocardial response to infarction in the rat. Morphometric measurement of infarct size and myocyte cellular hypertrophy","volume":"118","author":"Anversa","year":"1985","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.phymed.2011.09.079_bib0015","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S0008-6363(01)00503-X","article-title":"Tumor necrosis factor-alpha and myocardial remodeling in progression of heart failure: a current perspective","volume":"53","author":"Bradham","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.phymed.2011.09.079_bib0020","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.ejcts.2006.07.006","article-title":"The relationship between myocardial extracellular matrix remodeling and ventricular function","volume":"30","author":"Brower","year":"2006","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.phymed.2011.09.079_bib0025","doi-asserted-by":"crossref","first-page":"H3057","DOI":"10.1152\/ajpheart.00447.2006","article-title":"Inhibition of matrix metalloproteinase activity by ACE inhibitors prevents left ventricular remodeling in a rat model of heart failure","volume":"292","author":"Brower","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.phymed.2011.09.079_bib0030","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s00059-002-2354-y","article-title":"Cardiac fibrosis as a cause of diastolic dysfunction","volume":"27","author":"Burlew","year":"2002","journal-title":"Herz"},{"key":"10.1016\/j.phymed.2011.09.079_bib0035","first-page":"57","article-title":"Experimental myocardial infarction in the rat: qualitative and quantitative changes during pathologic evolution","volume":"90","author":"Fishbein","year":"1978","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.phymed.2011.09.079_bib0040","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S0735-1097(00)01055-X","article-title":"Interaction between paracrine tumor necrosis factor-alpha and paracrine angiotensin II during myocardial ischemia","volume":"37","author":"Frolkis","year":"2001","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.phymed.2011.09.079_bib0045","first-page":"III1","article-title":"Diastolic dysfunction and congestive heart failure","volume":"81","author":"Grossman","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2011.09.079_bib0050","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/00043798-200110000-00006","article-title":"Effect of losartan on circulating TNF alpha levels and left ventricular systolic performance in patients with heart failure","volume":"8","author":"Gurlek","year":"2001","journal-title":"J. Cardiovasc. Risk"},{"key":"10.1016\/j.phymed.2011.09.079_bib0055","first-page":"770","article-title":"Effects of Chinese herb medicine Radix Scrophulariae on ventricular remodeling","volume":"65","author":"Gu","year":"2010","journal-title":"Pharmazie"},{"key":"10.1016\/j.phymed.2011.09.079_bib0060","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1161\/01.CIR.89.5.1934","article-title":"N-terminal proatrial natriuretic factor. An independent predictor of long-term prognosis after myocardial infarction","volume":"89","author":"Hall","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2011.09.079_bib0065","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/path.1395","article-title":"The dynamic extracellular matrix: intervention strategies during heart failure and atherosclerosis","volume":"200","author":"Heeneman","year":"2003","journal-title":"J. Pathol."},{"key":"10.1016\/j.phymed.2011.09.079_bib0070","first-page":"210","article-title":"Increased superoxide radical with a decrease in vascular endothelial growth factor and inducible nitric oxide synthase level leads to the progression of left ventricular hypertrophy in a pressure-overload rat heart model","volume":"14","author":"Ji","year":"2008","journal-title":"Ann. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.phymed.2011.09.079_bib0075","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1023\/A:1009884820941","article-title":"Incidence and epidemiology of heart failure","volume":"5","author":"Kannel","year":"2000","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.phymed.2011.09.079_bib0080","doi-asserted-by":"crossref","first-page":"21491","DOI":"10.1074\/jbc.274.31.21491","article-title":"Matrix metalloproteinase","volume":"274","author":"Nagase","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2011.09.079_bib0085","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1023\/B:HREV.0000011395.11179.af","article-title":"Matrix metalloproteinase inhibitor development and the remodeling of drug discovery","volume":"9","author":"Peterson","year":"2004","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.phymed.2011.09.079_bib0090","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1056\/NEJM199209033271001","article-title":"Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators","volume":"327","author":"Pfeffer","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2011.09.079_bib0095","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1161\/01.RES.44.4.503","article-title":"Myocardial infarct size and ventricular function in rats","volume":"44","author":"Pfeffer","year":"1979","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2011.09.079_bib0180","doi-asserted-by":"crossref","first-page":"s65","DOI":"10.1136\/hrt.72.3_Suppl.S65","article-title":"Neuroendocrine activation after myocardial infaretion","volume":"72","author":"Remes","year":"1994","journal-title":"Br. Heart J."},{"key":"10.1016\/j.phymed.2011.09.079_bib0105","doi-asserted-by":"crossref","first-page":"s28","DOI":"10.1136\/hrt.72.2_Suppl.S28","article-title":"Neuroendocrine excitation in heart failure","volume":"72","author":"Riegger","year":"1994","journal-title":"Br. Heart J."},{"key":"10.1016\/j.phymed.2011.09.079_bib0110","first-page":"2352","article-title":"Recombinant human growth hormone secreted from tissue-engineered bioartificial muscle improves left ventricular function in rat with acute myocardial infarction","volume":"122","author":"Rong","year":"2009","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.phymed.2011.09.079_bib0115","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/ajh.2008.174","article-title":"Natriuretic peptides: an update on bioactivity, potential therapeutic use, and implication in cardiovascular diseases","volume":"21","author":"Rubattu","year":"2008","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.phymed.2011.09.079_bib0120","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/384353a0","article-title":"Inhibition of myoeardial endothelin pathway improves long-term survival in heart failure","volume":"384","author":"Sakai","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2011.09.079_bib0125","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cardiores.2004.02.005","article-title":"Cross-regulation between the renin\u2013angiotensin system and inflammatory mediators in cardiac hypertrophy and failure","volume":"63","author":"Sekiguchi","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.phymed.2011.09.079_bib0130","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000075549","article-title":"Tissue kallikrein increases duration of survival after prolonged coronary artery ligation in hypertensive rats","volume":"70","author":"Sharma","year":"2004","journal-title":"Pharmacology"},{"key":"10.1016\/j.phymed.2011.09.079_bib0135","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1291\/hypres.30.863","article-title":"Beneficial effects of pioglitazone on left ventricular hypertrophy in genetically hypertensive rats","volume":"30","author":"Shinzato","year":"2007","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.phymed.2011.09.079_bib0140","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1006\/jmcc.1996.0080","article-title":"Angiotensin converting enzyme and myofibroblasts during tissue repair in the rat heart","volume":"28","author":"Sun","year":"1996","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.phymed.2011.09.079_bib0145","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF00877314","article-title":"Left ventricular dysfunction in ischemic heart disease: fundamental importance of the fibrous matrix","volume":"8","author":"Swan","year":"1994","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.phymed.2011.09.079_bib0150","first-page":"146","article-title":"Combined effects of ramipril and angiotensin II receptor blocker TCV116 on rat congestive heart failure after myocardial infarction","volume":"118","author":"Tao","year":"2005","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.phymed.2011.09.079_bib0155","volume":"vol. II","author":"Wagner","year":"2011"},{"key":"10.1016\/j.phymed.2011.09.079_bib0160","doi-asserted-by":"crossref","first-page":"H1282","DOI":"10.1152\/ajpheart.00910.2006","article-title":"Regulation of collagen synthesis by inhibitory Smad7 in cardiac myofibroblasts","volume":"293","author":"Wang","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.phymed.2011.09.079_bib0165","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/0735-1097(89)90360-4","article-title":"Cardiac interstitium in health and disease: the fibrillar collagen network","volume":"13","author":"Weber","year":"1989","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.phymed.2011.09.079_bib0170","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1111\/j.1745-7254.2006.00447.x","article-title":"Effects of endothelin ETA receptor blocker LU 135252 on cardiac remodeling and survival in a hypertensive rat model of chronic heart failure","volume":"27","author":"Xia","year":"2006","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2011.09.079_bib0175","first-page":"150","article-title":"Ventricular remodeling after myocardial infarction: concepts and clinical implications","volume":"92","author":"Zornoff","year":"2009","journal-title":"Arq. Bras. Cardiol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711311004880?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711311004880?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T03:20:37Z","timestamp":1543461637000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711311004880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":35,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0944711311004880"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2011.09.079","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}