{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:36:10Z","timestamp":1788910570905,"version":"build-2803163510"},"reference-count":52,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"China Medical University, Taichung, Taiwan","award":["CMU99-NSC-02 (2\/2)"],"award-info":[{"award-number":["CMU99-NSC-02 (2\/2)"]}]},{"name":"Taiwan Department of Health Clinical Trial and Research Center of Excellence","award":["DOH101-TD-B-111-004"],"award-info":[{"award-number":["DOH101-TD-B-111-004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.phymed.2012.07.013","type":"journal-article","created":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T03:15:14Z","timestamp":1345691714000},"page":"1206-1215","source":"Crossref","is-referenced-by-count":71,"title":["Moutan cortex radicis improves lipopolysaccharide-induced acute lung injury in rats through anti-inflammation"],"prefix":"10.1016","volume":"19","author":[{"given":"Pin-Kuei","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Yu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung-Hu","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Liang","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2012.07.013_bib0005","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1165\/ajrcmb.22.4.f184","article-title":"Coagulation abnormalities in acute lung injury and sepsis","volume":"22","author":"Abraham","year":"2000","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"10.1016\/j.phymed.2012.07.013_bib0010","doi-asserted-by":"crossref","first-page":"L1137","DOI":"10.1152\/ajplung.2000.279.6.L1137","article-title":"Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury","volume":"279","author":"Abraham","year":"2000","journal-title":"American Journal of Physiology \u2013 Lung Cellular and Molecular Physiology"},{"key":"10.1016\/j.phymed.2012.07.013_bib0015","doi-asserted-by":"crossref","first-page":"S195","DOI":"10.1097\/01.CCM.0000057843.47705.E8","article-title":"Neutrophils and acute lung injury","volume":"31","author":"Abraham","year":"2003","journal-title":"Critical Care Medicine"},{"key":"10.1016\/j.phymed.2012.07.013_bib0020","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1165\/rcmb.2009-0047TR","article-title":"Mechanisms of neutrophil accumulation in the lungs against bacteria","volume":"43","author":"Balamayooran","year":"2010","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"10.1016\/j.phymed.2012.07.013_bib0025","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1055\/s-2006-948290","article-title":"The role of the coagulation cascade in the continuum of sepsis and acute lung injury and acute respiratory distress syndrome","volume":"27","author":"Bastarache","year":"2006","journal-title":"Seminars in Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.phymed.2012.07.013_bib0030","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1136\/thorax.55.1.46","article-title":"Comparison of systemic cytokine levels in patients with acute respiratory distress syndrome, severe pneumonia, and controls","volume":"55","author":"Bauer","year":"2000","journal-title":"Thorax"},{"key":"10.1016\/j.phymed.2012.07.013_bib0035","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1142\/S0192415X0900676X","article-title":"Inhibition of LPS-induced iNOS, COX-2 and inflammatory mediator expression by paeonol through the MAPKs inactivation in RAW 264. 7 cells","volume":"37","author":"Chae","year":"2009","journal-title":"The American Journal of Chinese Medicine"},{"key":"10.1016\/j.phymed.2012.07.013_bib0040","doi-asserted-by":"crossref","first-page":"L1083","DOI":"10.1152\/ajplung.2000.279.6.L1083","article-title":"Neutrophil recruitment and increased permeability during acute lung injury induced by lipopolysaccharide","volume":"279","author":"Chignard","year":"2000","journal-title":"American Journal of Physiology \u2013 Lung Cellular and Molecular Physiology"},{"key":"10.1016\/j.phymed.2012.07.013_bib0045","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ccm.2004.10.014","article-title":"Acute lung injury and bacterial infection","volume":"26","author":"Dreyfuss","year":"2005","journal-title":"Clinics In Chest Medicine"},{"key":"10.1016\/j.phymed.2012.07.013_bib0050","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2119\/molmed.2010.00138","article-title":"Contribution of neutrophils to acute lung injury","volume":"17","author":"Grommes","year":"2011","journal-title":"Molecular Medicine"},{"key":"10.1016\/j.phymed.2012.07.013_bib0055","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1165\/ajrcmb.15.5.8918372","article-title":"Intra-alveolar macrophage-inflammatory peptide 2 induces rapid neutrophil localization in the lung","volume":"15","author":"Gupta","year":"1996","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"10.1016\/j.phymed.2012.07.013_bib0060","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0049-3848(83)90005-1","article-title":"Studies on the mechanism of antiaggregatory effect of Moutan Cortex","volume":"31","author":"Hirai","year":"1983","journal-title":"Thrombosis Research"},{"key":"10.1016\/j.phymed.2012.07.013_bib0065","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jep.2005.12.027","article-title":"Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats","volume":"106","author":"Hsieh","year":"2006","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.phymed.2012.07.013_bib0070","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jep.2007.07.038","article-title":"Inhibition effects of Moutan Cortex Radicis on secretion of eotaxin in A549 human epithelial cells and eosinophil migration","volume":"114","author":"Kim","year":"2007","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.phymed.2012.07.013_bib0075","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1159\/000052215","article-title":"Neutrophils mediate acute lung injury in rabbits: role of neutrophil elastase","volume":"32","author":"Kinoshita","year":"2000","journal-title":"European Surgical Research"},{"key":"10.1016\/j.phymed.2012.07.013_bib0080","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1378\/chest.113.6.1632","article-title":"Expression of inducible nitric oxide synthase and inflammatory cytokines in alveolar macrophages of ARDS following sepsis","volume":"113","author":"Kobayashi","year":"1998","journal-title":"Chest"},{"key":"10.1016\/j.phymed.2012.07.013_bib0085","first-page":"624","article-title":"Platelet anti-aggregatory and blood anti-coagulant effects of compounds isolated from Paeonia lactiflora and Paeonia suffruticosa","volume":"65","author":"Koo","year":"2010","journal-title":"Pharmazie"},{"key":"10.1016\/j.phymed.2012.07.013_bib0090","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1164\/ajrccm.158.6.9802100","article-title":"Role of inducible nitric oxide synthase in endotoxin-induced acute lung injury","volume":"158","author":"Kristof","year":"1998","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.phymed.2012.07.013_bib0095","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1056\/NEJM199908193410807","article-title":"Disseminated intravascular coagulation","volume":"341","author":"Levi","year":"1999","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.phymed.2012.07.013_bib0100","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1055\/s-1999-14030","article-title":"Aggregation inhibitory activity of minor acetophenones from Paeonia species","volume":"65","author":"Lin","year":"1999","journal-title":"Planta Medica"},{"key":"10.1016\/j.phymed.2012.07.013_bib0105","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1097\/00003246-199909000-00055","article-title":"Oxidant-mediated lung injury in the acute respiratory distress syndrome","volume":"27","author":"Matthay","year":"1999","journal-title":"Critical Care Medicine"},{"key":"10.1016\/j.phymed.2012.07.013_bib0110","doi-asserted-by":"crossref","first-page":"L379","DOI":"10.1152\/ajplung.00010.2008","article-title":"Animal models of acute lung injury","volume":"295","author":"Matute-Bello","year":"2008","journal-title":"American Journal of Physiology \u2013 Lung Cellular and Molecular Physiology"},{"key":"10.1016\/j.phymed.2012.07.013_bib0115","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.intimp.2006.11.004","article-title":"Paeonol suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking p38, ERK and nuclear factor-kappaB signaling pathways","volume":"7","author":"Nizamutdinova","year":"2007","journal-title":"International Immunopharmacology"},{"key":"10.1016\/j.phymed.2012.07.013_bib0120","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1042\/cs1030577","article-title":"Bronchoalveolar lavage fluids of patients with lung injury activate the transcription factor nuclear factor-kappaB in an alveolar cell line","volume":"103","author":"Nys","year":"2002","journal-title":"Clinical Science (London)"},{"key":"10.1016\/j.phymed.2012.07.013_bib0125","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0378-8741(02)00285-4","article-title":"Inhibitory effects of the root cortex of Paeonia suffruticosa on interleukin-8 and macrophage chemoattractant protein-1 secretions in U937 cells","volume":"84","author":"Oh","year":"2003","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.phymed.2012.07.013_bib0130","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1248\/bpb.23.199","article-title":"The inhibition of phenylhydroquinone-induced oxidative DNA cleavage by constituents of Moutan cortex and Paeoniae radix","volume":"23","author":"Okubo","year":"2000","journal-title":"Biological & Pharmaceutical Bulletin"},{"key":"10.1016\/j.phymed.2012.07.013_bib0135","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1152\/ajpregu.00738.2001","article-title":"Chemokines and chemokine receptors in leukocyte trafficking","volume":"283","author":"Olson","year":"2002","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.phymed.2012.07.013_bib0140","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.phymed.2009.04.003","article-title":"Paeonol from Paeonia suffruticosa prevents TNF-alpha-induced monocytic cell adhesion to rat aortic endothelial cells by suppression of VCAM-1 expression","volume":"16","author":"Pan","year":"2009","journal-title":"Phytomedicine: International Journal of Phytotherapy and Phytopharmacology"},{"key":"10.1016\/j.phymed.2012.07.013_bib0145","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/837513","article-title":"Anti-inflammatory and anticoagulative effects of paeonol on LPS-induced acute lung injury in rats","volume":"2012","author":"Fu","year":"2012","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"key":"10.1016\/j.phymed.2012.07.013_bib0150","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1164\/rccm.200306-846OC","article-title":"Pulmonary neutrophil infiltration in murine sepsis: role of inducible nitric oxide synthase","volume":"170","author":"Razavi","year":"2004","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.phymed.2012.07.013_bib0155","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1186\/cc2881","article-title":"Bench-to-bedside review: acute respiratory distress syndrome\u2014how neutrophils migrate into the lung","volume":"8","author":"Reutershan","year":"2004","journal-title":"Critical Care"},{"key":"10.1016\/j.phymed.2012.07.013_bib0160","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1248\/bpb.28.661","article-title":"Inhibition of production of reactive oxygen species and gene expression profile by treatment of ethanol extract of Moutan Cortex Radicis in oxidative stressed PC12 cells","volume":"28","author":"Rho","year":"2005","journal-title":"Biological & Pharmaceutical Bulletin"},{"key":"10.1016\/j.phymed.2012.07.013_bib0165","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s00134-006-0223-5","article-title":"Acute lung injury and the coagulation pathway: potential role of gene polymorphisms in the protein C and fibrinolytic pathways","volume":"32","author":"Sapru","year":"2006","journal-title":"Intensive Care Medicine"},{"key":"10.1016\/j.phymed.2012.07.013_bib0170","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1097\/01.CCM.0000201882.23917.B8","article-title":"Pulmonary coagulopathy as a new target in therapeutic studies of acute lung injury or pneumonia\u2014a review","volume":"34","author":"Schultz","year":"2006","journal-title":"Critical Care Medicine"},{"key":"10.1016\/j.phymed.2012.07.013_bib0175","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1183\/09031936.96.09091858","article-title":"Bronchoalveolar and systemic cytokine profiles in patients with ARDS, severe pneumonia and cardiogenic pulmonary oedema","volume":"9","author":"Schutte","year":"1996","journal-title":"The European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology"},{"key":"10.1016\/j.phymed.2012.07.013_bib0180","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1097\/00005373-199703000-00005","article-title":"Neutrophils mediate pulmonary vasomotor dysfunction in endotoxin-induced acute lung injury","volume":"42","author":"Sheridan","year":"1997","journal-title":"The Journal of Trauma"},{"key":"10.1016\/j.phymed.2012.07.013_bib0185","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1002\/eji.200425097","article-title":"Activated T killer cells induce apoptosis in lung epithelial cells and the release of pro-inflammatory cytokine TNF-alpha","volume":"34","author":"Shinbori","year":"2004","journal-title":"European Journal of Immunology"},{"key":"10.1016\/j.phymed.2012.07.013_bib0190","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/sj.bjp.0706915","article-title":"Inhalation of activated protein C inhibits endotoxin-induced pulmonary inflammation in mice independent of neutrophil recruitment","volume":"149","author":"Slofstra","year":"2006","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.phymed.2012.07.013_bib0195","first-page":"640","article-title":"Acute lung injury: the role of cytokines in the elicitation of neutrophils","volume":"42","author":"Strieter","year":"1994","journal-title":"Journal of Investigative Medicine"},{"key":"10.1016\/j.phymed.2012.07.013_bib0200","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.neulet.2004.08.043","article-title":"Analgesic effect of extracts of Chinese medicinal herbs Moutan cortex and Coicis semen on neuropathic pain in mice","volume":"370","author":"Tatsumi","year":"2004","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.phymed.2012.07.013_bib0205","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3109\/01902149709039228","article-title":"Intratracheal aerosolization of endotoxin (LPS) in the rat: a comprehensive animal model to study adult (acute) respiratory distress syndrome","volume":"23","author":"van Helden","year":"1997","journal-title":"Experimental Lung Research"},{"key":"10.1016\/j.phymed.2012.07.013_bib0210","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1159\/000121471","article-title":"Overview of the pathology of three widely used animal models of acute lung injury","volume":"40","author":"Wang","year":"2008","journal-title":"European Surgical Research"},{"key":"10.1016\/j.phymed.2012.07.013_bib0215","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1056\/NEJM200005043421806","article-title":"The acute respiratory distress syndrome","volume":"342","author":"Ware","year":"2000","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.phymed.2012.07.013_bib0220","doi-asserted-by":"crossref","first-page":"142","DOI":"10.2302\/kjm.54.142","article-title":"Coagulation and fibrinolysis in human acute lung injury\u2014new therapeutic targets?","volume":"54","author":"Ware","year":"2005","journal-title":"The Keio Journal of Medicine"},{"key":"10.1016\/j.phymed.2012.07.013_bib0225","doi-asserted-by":"crossref","first-page":"L307","DOI":"10.1152\/ajplung.00157.2006","article-title":"Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury","volume":"291","author":"Ware","year":"2006","journal-title":"American Journal of Physiology \u2013 Lung Cellular and Molecular Physiology"},{"key":"10.1016\/j.phymed.2012.07.013_bib0230","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1086\/421031","article-title":"Inhibition of the tissue factor\/factor VIIa pathway does not influence the inflammatory or antibacterial response to abdominal sepsis induced by Escherichia coli in mice","volume":"189","author":"Weijer","year":"2004","journal-title":"Journal of Infectious Diseases"},{"key":"10.1016\/j.phymed.2012.07.013_bib0235","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1034\/j.1399-3003.1999.14d04.x","article-title":"Lung injury following pulmonary resection in the isolated, blood-perfused rat lung","volume":"14","author":"Williams","year":"1999","journal-title":"The European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology"},{"key":"10.1016\/j.phymed.2012.07.013_bib0240","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1440-1843.2009.01516.x","article-title":"Attenuation of lipopolysaccharide-induced acute lung injury by treatment with IL-10","volume":"14","author":"Wu","year":"2009","journal-title":"Respirology"},{"key":"10.1016\/j.phymed.2012.07.013_bib0245","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/SHK.0b013e31819962b2","article-title":"Delay of LPS-induced acute lung injury resolution by soluble immune complexes is neutrophil dependent","volume":"32","author":"Wu","year":"2009","journal-title":"Shock"},{"key":"10.1016\/j.phymed.2012.07.013_bib0250","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1160\/TH07-11-0666","article-title":"Current view on alveolar coagulation and fibrinolysis in acute inflammatory and chronic interstitial lung diseases","volume":"99","author":"Wygrecka","year":"2008","journal-title":"Thrombosis and Haemostasis"},{"key":"10.1016\/j.phymed.2012.07.013_bib0255","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1248\/cpb.48.1327","article-title":"Bioactive constituents of Chinese natural medicines, V. Radical scavenging effect of Moutan Cortex. (1): Absolute stereostructures of two monoterpenes, paeonisuffrone and paeonisuffral","volume":"48","author":"Yoshikawa","year":"2000","journal-title":"Chemical & Pharmaceutical Bulletin"},{"key":"10.1016\/j.phymed.2012.07.013_bib0260","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1165\/rcmb.2008-0348TR","article-title":"Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury","volume":"40","author":"Zemans","year":"2009","journal-title":"American Journal of Respiratory Cell and Molecular Biology"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711312002449?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711312002449?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T22:25:20Z","timestamp":1562106320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711312002449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":52,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0944711312002449"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2012.07.013","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}