{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T16:49:22Z","timestamp":1773334162329,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of Chin","doi-asserted-by":"crossref","award":["81173534"],"award-info":[{"award-number":["81173534"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Administration of Traditional Chinese Medicine of Guangdong Province of China","award":["20111234"],"award-info":[{"award-number":["20111234"]}]},{"name":"Science and Technology Planning Project of Guangdong Province of China","award":["2009A030100014"],"award-info":[{"award-number":["2009A030100014"]}]},{"name":"Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (2011)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.phymed.2012.08.008","type":"journal-article","created":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T12:46:51Z","timestamp":1353070011000},"page":"77-83","source":"Crossref","is-referenced-by-count":54,"title":["Anti-Candida albicans activity and pharmacokinetics of pogostone isolated from Pogostemonis Herba"],"prefix":"10.1016","volume":"20","author":[{"given":"Yu-Cui","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Chun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Rong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Yang","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dian-Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chu-Wen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong-Feng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Ren","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Ping","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2012.08.008_bib0005","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3314\/jjmm.44.285","article-title":"Anti-Candida albicans activity of essential oils including Lemongrass (Cymbopogon citratus) oil and its component, citral","volume":"44","author":"Abe","year":"2003","journal-title":"Japanese Journal of Medical Mycology"},{"key":"10.1016\/j.phymed.2012.08.008_bib0010","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1080\/10611860500422958","article-title":"Antimicrobial activity of clove oil and its potential in the treatment of vaginal candidiasis","volume":"13","author":"Ahmad","year":"2005","journal-title":"Journal of Drug Targeting"},{"key":"10.1016\/j.phymed.2012.08.008_bib0015","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1128\/JCM.34.9.2154-2157.1996","article-title":"Fluconazole disk diffusion procedure for determining susceptibility of Candida species","volume":"34","author":"Barry","year":"1996","journal-title":"Journal of Clinical Microbiology"},{"key":"10.1016\/j.phymed.2012.08.008_bib0020","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0168-3659(02)00086-X","article-title":"Prolonged antifungal effects of clotrimazole-containing mucoadhesive thermosensitive gels on vaginitis","volume":"82","author":"Chang","year":"2002","journal-title":"Journal of Controlled Release"},{"key":"10.1016\/j.phymed.2012.08.008_bib0025","first-page":"645","article-title":"Determination of pogostone in Pogostemon cablin (Blanco) Benth. by HPLC","volume":"28","author":"Chen","year":"2011","journal-title":"Journal of Guangzhou University of Traditional Chinese Medicine"},{"key":"10.1016\/j.phymed.2012.08.008_bib0030","volume":"vol. 1","author":"Chinese Pharmacopoeia","year":"2010"},{"key":"10.1016\/j.phymed.2012.08.008_bib0035","doi-asserted-by":"crossref","first-page":"935","DOI":"10.2217\/fmb.10.51","article-title":"Mechanisms of antifungal drug resistance in Candida dubliniensis","volume":"5","author":"Coleman","year":"2010","journal-title":"Future Microbiology"},{"key":"10.1016\/j.phymed.2012.08.008_bib0040","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s10096-007-0448-4","article-title":"A first Portuguese epidemiological survey of fungaemia in a university hospital","volume":"27","author":"Costa-de-Oliveira","year":"2008","journal-title":"European Journal of Clinical Microbiology and Infectious Diseases"},{"key":"10.1016\/j.phymed.2012.08.008_bib0045","doi-asserted-by":"crossref","first-page":"658","DOI":"10.2165\/00003495-199550040-00007","article-title":"Fluconazole an update of its pharmacodynamic and pharmacokinetic properties and therapeutic use in major superficial and systemic mycoses in immunocompromised patients","volume":"50","author":"Goa","year":"1995","journal-title":"Drugs"},{"key":"10.1016\/j.phymed.2012.08.008_bib0050","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.1128\/AAC.00565-09","article-title":"Efficacy of Albaconazole against Candida albicans in a vaginitis model","volume":"53","author":"Gonz\u00e1lez","year":"2009","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.phymed.2012.08.008_bib0055","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1128\/JCM.42.4.1519-1527.2004","article-title":"Incidence of bloodstream infections due to Candida species and in vitro susceptibilities of isolates collected from 1998 to 2000 in a population-based active surveillance program","volume":"42","author":"Hajjeh","year":"2004","journal-title":"Journal of Clinical Microbiology"},{"key":"10.1016\/j.phymed.2012.08.008_bib0060","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/jac\/42.5.591","article-title":"In vitro activity of essential oils, in particular Melaleuca alternifolia (tea tree) oil and tea tree oil products, against Candida spp.","volume":"42","author":"Hammer","year":"1998","journal-title":"Journal of Antimicrobial Chemotherapy"},{"key":"10.1016\/j.phymed.2012.08.008_bib0065","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1439-0507.2006.01200.x","article-title":"Utility of the oestrogen-dependent vaginal candidosis murine model in evaluating the efficacy of various therapies against vaginal Candida albicans infection","volume":"49","author":"Hamad","year":"2006","journal-title":"Mycoses"},{"key":"10.1016\/j.phymed.2012.08.008_bib0070","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/S0924-8579(03)00243-7","article-title":"Efficacy of human salivary mucin MUC7-derived peptide and histatin 5 in a murine model of candidiasis","volume":"22","author":"Intini","year":"2003","journal-title":"International Journal of Antimicrobial Agents"},{"key":"10.1016\/j.phymed.2012.08.008_bib0075","first-page":"32","article-title":"The isolation and application in pharmaceutics of pogostone","volume":"6","author":"Kong","year":"1986","journal-title":"Chinese Journal of Hospital Pharmacy"},{"key":"10.1016\/j.phymed.2012.08.008_bib0080","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1053\/jhin.2001.1151","article-title":"Non-albicans Candida spp. causing fungemia, pathogenicity and antifungal resistance","volume":"50","author":"Kremery","year":"2002","journal-title":"Journal of Hospital Infection"},{"key":"10.1016\/j.phymed.2012.08.008_bib0085","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4103\/0973-029X.44575","article-title":"Candida and calcofluor white: study in precancer and cancer","volume":"13","author":"Kumar","year":"2009","journal-title":"Journal of Oral and Maxillofacial Pathology"},{"key":"10.1016\/j.phymed.2012.08.008_bib0090","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1080\/10826076.2011.580486","article-title":"Preparative isolation and purification of five flavonoids from pogostemon cablin benth by high-speed countercurrent chromatography and preparative high-performance liquid chromatography","volume":"34","author":"Li","year":"2011","journal-title":"Journal of Liquid Chromatography and Related Technologies"},{"key":"10.1016\/j.phymed.2012.08.008_bib0095","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0022-3565(25)03549-9","article-title":"A simplified method of evaluating dose-effect experiments","volume":"96","author":"Litchfield","year":"1949","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.phymed.2012.08.008_bib0100","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1258\/095646202760159639","article-title":"Facts and myths on recurrent vulvovaginal candidosis \u2013 a review on epidemiology, clinical manifestations, diagnosis, pathogenesis and therapy","volume":"13","author":"M\u00e5rdh","year":"2002","journal-title":"International Journal of STD and AIDS"},{"key":"10.1016\/j.phymed.2012.08.008_bib0105","first-page":"805","article-title":"Antifungal activity of essential oil of Pogostemonis Herba against plant pathogenic fungi","volume":"27","author":"Mo","year":"2004","journal-title":"Journal of Chinese Medicinal Materials"},{"key":"10.1016\/j.phymed.2012.08.008_bib0110","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/1471-2334-6-158","article-title":"In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species","volume":"6","author":"Mondello","year":"2006","journal-title":"BMC Infectious Diseases"},{"key":"10.1016\/j.phymed.2012.08.008_bib0115","series-title":"National Committee for Clinical Laboratory Standards","article-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts Approved Standard-Second Edition M27-A2","author":"Committee for Clinical Laboratory Standards","year":"2002"},{"key":"10.1016\/j.phymed.2012.08.008_bib0120","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.2174\/138955709789878150","article-title":"Anti-Candida activity of essential oils","volume":"9","author":"Palmeira-de-Oliveira","year":"2009","journal-title":"Mini-Reviews in Medicinal Chemistry"},{"key":"10.1016\/j.phymed.2012.08.008_bib0125","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1471-2334-6-50","article-title":"Candidaemia and cancer: patients are not all the same","volume":"6","author":"Pasqualotto","year":"2006","journal-title":"BMC Infectious Diseases"},{"key":"10.1016\/j.phymed.2012.08.008_bib0130","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/med.20050","article-title":"Anticandidal low molecular compounds from higher plants with special reference to compounds from essential oils","volume":"26","author":"Pauli","year":"2006","journal-title":"Medicinal Research Reviews"},{"key":"10.1016\/j.phymed.2012.08.008_bib0135","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1086\/504490","article-title":"Invasive fungal pathogens: current epidemiological trends","volume":"43","author":"Pfaller","year":"2006","journal-title":"Clinical Infectious Diseases"},{"key":"10.1016\/j.phymed.2012.08.008_bib0140","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0168-3659(94)90156-2","article-title":"Vaginal and reproductive system treatments using a bioadhesive polymer","volume":"28","author":"Robinson","year":"1994","journal-title":"Journal of Controlled Release"},{"key":"10.1016\/j.phymed.2012.08.008_bib0145","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.1128\/JCM.37.12.3856-3859.1999","article-title":"Detection of fluconazole-resistant Candida strains by a disc diffusion screening test","volume":"37","author":"Sandven","year":"1999","journal-title":"Journal of Clinical Microbiology"},{"key":"10.1016\/j.phymed.2012.08.008_bib0150","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1128\/CMR.12.1.40","article-title":"Current and emerging azole antifungal agents","volume":"12","author":"Sheehan","year":"1999","journal-title":"Clinical Microbiology Reviews"},{"key":"10.1016\/j.phymed.2012.08.008_bib0155","unstructured":"Ujihara, Kazuya, Minoo, 2002. Process for producing pyrone compounds. US Patent, No, 6420569B1."},{"key":"10.1016\/j.phymed.2012.08.008_bib0160","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/01.OGX.0000068791.04785.8D","article-title":"Common complementary and alternative therapies for yeast vaginitis and bacterial vaginosis: a systematic review","volume":"58","author":"Van Kessel","year":"2003","journal-title":"Obstetrical and Gynecological Survey"},{"key":"10.1016\/j.phymed.2012.08.008_bib0165","first-page":"307","article-title":"Clinical efficacy of Pogostemonis Herba decoction in treatment of 118 cases of vagianl candidiasis","volume":"32","author":"Wang","year":"1997","journal-title":"Zhejiang Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.phymed.2012.08.008_bib0170","first-page":"9","article-title":"Antifungal activity of the essential oils from Agastache rugosa and Pogostemon cablin against dermatophytes and opportunistic fungi","volume":"35","author":"Yang","year":"2000","journal-title":"Chinese Pharmaceutical Journal"},{"key":"10.1016\/j.phymed.2012.08.008_bib0175","first-page":"318","article-title":"Traditional Chinese medicine Pogostemon cablin antifungal component \u2013 isolation and determination of structure of Pogostone","volume":"22","author":"Yang","year":"1977","journal-title":"Chinese Science Bulletin"},{"key":"10.1016\/j.phymed.2012.08.008_bib0180","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.1111\/j.1439-0507.2009.01852.x","article-title":"Evaluation of anti-Candida potential of geranium oil constituents against clinical isolates of Candida albicans differentially sensitive to fluconazole: inhibition of growth, dimorphism and sensitization","volume":"54","author":"Zore","year":"2011","journal-title":"Mycoses"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711312002826?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711312002826?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T01:24:25Z","timestamp":1745198665000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711312002826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0944711312002826"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2012.08.008","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}