{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:26:59Z","timestamp":1791278819967,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Belgian National Fund for Scientific Research","award":["2.4555.08"],"award-info":[{"award-number":["2.4555.08"]}]},{"name":"Special Fund for Research"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.phymed.2012.10.010","type":"journal-article","created":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T18:11:42Z","timestamp":1357927902000},"page":"270-274","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Antitrypanosomal compounds from the essential oil and extracts of Keetia leucantha leaves with inhibitor activity on Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase"],"prefix":"10.1016","volume":"20","author":[{"given":"J.","family":"Bero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Beaufay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Hannaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.-F.","family":"H\u00e9rent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.A.","family":"Michels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Quetin-Leclercq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2012.10.010_bib0005","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1248\/bpb.25.1485","article-title":"Ursolic acid as a trypanocidal constituent in rosemary","volume":"25","author":"Abe","year":"2002","journal-title":"Biological and Pharmaceutical Bulletin"},{"key":"10.1016\/j.phymed.2012.10.010_bib0010","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1073\/pnas.96.8.4273","article-title":"Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase","volume":"96","author":"Aronov","year":"1999","journal-title":"Proceedings of the National Academic Science of the United States of America"},{"key":"10.1016\/j.phymed.2012.10.010_bib0015","doi-asserted-by":"crossref","first-page":"14551","DOI":"10.1074\/jbc.274.21.14551","article-title":"What controls glycolysis in bloodstream form Trypanosoma brucei?","volume":"274","author":"Bakker","year":"1999","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.phymed.2012.10.010_bib0020","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jep.2009.02.004","article-title":"In vitro antiplasmodial activity of plants used in Benin in traditional medicine to treat malaria","volume":"122","author":"Bero","year":"2009","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.phymed.2012.10.010_bib0025","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.jep.2011.07.022","article-title":"In vitro antitrypanosomal and antileishmanial activity of plants used in Benin in traditional medicine and bio-guided fractionation of the most active extract","volume":"137","author":"Bero","year":"2011","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.phymed.2012.10.010_bib0030","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.actatropica.2006.04.003","article-title":"Effect of suramin on trypomastigote forms of Trypanosoma cruzi: changes on cell motility and on the ultrastructure of the flagellum-cell body attachment region","volume":"98","author":"Bisaggio","year":"2006","journal-title":"Acta Tropica"},{"key":"10.1016\/j.phymed.2012.10.010_bib0035","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0304-4017(94)90033-7","article-title":"Drug-sensitivity of Chinese Trypanosoma-evansi and Trypanosoma-equiperdum isolates","volume":"52","author":"Brun","year":"1994","journal-title":"Veterinary Parasitology"},{"key":"10.1016\/j.phymed.2012.10.010_bib0040","first-page":"486","article-title":"GC\u2013MS analysis of essential oils from the leaves of Canthium horridum","volume":"27","author":"Chen","year":"2007","journal-title":"Hebei Daxue Xuebao, Ziran Kexueban"},{"key":"10.1016\/j.phymed.2012.10.010_bib0045","doi-asserted-by":"crossref","first-page":"10183","DOI":"10.1021\/bi020082z","article-title":"Exploring the active site of Trypanosoma brucei phosphofructokinase by inhibition studies: specific irreversible inhibition","volume":"41","author":"Claustre","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.phymed.2012.10.010_bib0050","first-page":"7","article-title":"D\u00e9termination des indices de r\u00e9tention de composants d\u2019huiles essentielles","volume":"30","author":"Denayer","year":"1994","journal-title":"Rivista Italiana Eppos"},{"key":"10.1016\/j.phymed.2012.10.010_bib0055","unstructured":"Drugs for Neglected Diseases initiative, 2011. Human African Trypanosomiasis. http:\/\/www.dndi.org\/diseases\/hat.html."},{"key":"10.1016\/j.phymed.2012.10.010_bib0060","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/265270a0","article-title":"New approach to screening drugs for activity against African trypanosomes","volume":"265","author":"Fairlamb","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2012.10.010_bib0140","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1093\/pcp\/pcr146","article-title":"CYP716A Subfamily members are multifunctional oxidases in triterpenoid biosynthesis","volume":"52","author":"Fukushima","year":"2011","journal-title":"Plant and Cell Physiology"},{"key":"10.1016\/j.phymed.2012.10.010_bib0065","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1021\/ed070p805","article-title":"A theoretical approach to the discrimination and characterization of the different classes of reversible inhibitors","volume":"70","author":"Gelpi","year":"1993","journal-title":"Journal of Chemical Education"},{"key":"10.1016\/j.phymed.2012.10.010_bib0070","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1432-1033.1994.00143.x","article-title":"Purification and characterization of the native and the recombinant Leishmania mexicana glycosomal glyceraldehyde-3-phosphate dehydrogenase","volume":"225","author":"Hannaert","year":"1994","journal-title":"European Journal of Biochemistry"},{"key":"10.1016\/j.phymed.2012.10.010_bib0075","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1006\/prep.1995.1031","article-title":"Glycosomal glyceraldehyde-3-phosphate dehydrogenase of Trypanosoma brucei and Trypanosoma cruzi: expression in Escherichia coli, purification, and characterization of the enzymes","volume":"6","author":"Hannaert","year":"1995","journal-title":"Protein Expression and Purification"},{"key":"10.1016\/j.phymed.2012.10.010_bib0080","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.jpba.2006.09.005","article-title":"Determination of new retention indices for quick identification of essential oils compounds","volume":"43","author":"Herent","year":"2007","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"key":"10.1016\/j.phymed.2012.10.010_bib0085","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jep.2003.11.008","article-title":"In vitro antitrypanosomal activity of ethnopharmacologically selected Beninese plants","volume":"91","author":"Hoet","year":"2004","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.phymed.2012.10.010_bib0090","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1021\/np070038q","article-title":"Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds","volume":"70","author":"Hoet","year":"2007","journal-title":"Journal of Natural Products"},{"key":"10.1016\/j.phymed.2012.10.010_bib0095","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1055\/s-2004-818967","article-title":"Alkaloids from Cassytha filiformis and related aporphines: Antitrypanosomal activity, cytotoxicity, and interaction with DNA and topoisomerases","volume":"70","author":"Hoet","year":"2004","journal-title":"Planta Medica"},{"key":"10.1016\/j.phymed.2012.10.010_bib0100","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1055\/s-2005-916255","article-title":"Antitrypanosomal compounds from the leaf essential oil of Strychnos spinosa","volume":"72","author":"Hoet","year":"2006","journal-title":"Planta Medica"},{"key":"10.1016\/j.phymed.2012.10.010_bib0145","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.3390\/molecules14062016","article-title":"Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts","volume":"14","author":"Jager","year":"2009","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2012.10.010_bib0105","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1515\/znc-2002-11-1212","article-title":"Herbal remedies traditionally used against malaria in Ghana: bioassay-guided fractionation of Microglossa pyrifolia (Asteraceae)","volume":"57","author":"Kohler","year":"2002","journal-title":"Zeitschrift fur Naturforschung C"},{"key":"10.1016\/j.phymed.2012.10.010_bib0110","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.fitote.2008.09.005","article-title":"Uapaca genus (Euphorbiaceae), a good source of betulinic acid","volume":"80","author":"Nyasse","year":"2009","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phymed.2012.10.010_bib0115","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1021\/np040059+","article-title":"Triterpenoids from Brazilian Ilex species and their in vitro antitrypanosomal activity","volume":"67","author":"Taketa","year":"2004","journal-title":"Journal of Natural Products"},{"key":"10.1016\/j.phymed.2012.10.010_bib0120","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1054\/drup.2000.0177","article-title":"Glycolysis as a target for the design of new anti-trypanosome drugs","volume":"4","author":"Verlinde","year":"2001","journal-title":"Drug Resistance Updates"},{"key":"10.1016\/j.phymed.2012.10.010_bib0125","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.fitote.2010.11.016","article-title":"Synergy research: approaching a new generation of phytopharmaceuticals","volume":"82","author":"Wagner","year":"2011","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phymed.2012.10.010_bib0130","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1021\/bi00167a028","article-title":"Inhibition of glyceraldehyde-3-phosphate dehydrogenase by phosphorylated epoxides and alpha-enones","volume":"33","author":"Willson","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.phymed.2012.10.010_bib0135","unstructured":"World Health Organisation (WHO), 2012. African trypanosomiasis (sleeping sickness). http:\/\/www.who.int\/mediacentre\/factsheets\/fs259\/en\/."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711312003765?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711312003765?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:02:44Z","timestamp":1760551364000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711312003765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":29,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0944711312003765"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2012.10.010","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antitrypanosomal compounds from the essential oil and extracts of Keetia leucantha leaves with inhibitor activity on Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2012.10.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}